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Simultaneous enantioseparation and simulation studies of atenolol,metoprolol and propranolol on Chiralpak^■IG column using supercritical fluid chromatography

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Journal of Pharmaceutical Analysis 2021年第6期11卷 746-756页

作者： pranav a.pandya Priyanka A.Shah pranav S.Shrivastav Department of Chemistry School of SciencesGujarat UniversityAhmedabad380009India

Enantioseparation of threeβ-blockers,i.e.,atenolol,metoprolol and propranolol,was studied on amylose tris(3-chloro-5-methylphenylcarbamate)immobilized chiral stationary phase using supercritical fluid chromatography(SFC).The effect of organic modifiers(methanol,isopropanol and their mixture),column temperature and back pressure on chiral separation ofβ-blockers was *** chromatographic separation with respect to resolution,retention,and analysis time was achieved using a mixture of CO_(2) and 0.1%isopropyl amine in isopropanol:methanol(50:50,V/V),in 75:25(V/V)*** the optimized conditions,the resolution factors(Rs)and separation factors(a)were greater than3.0 and 1.5,***,with increase in temperature(25-45℃)and pressure(100-150 bars)there was corresponding decrease in retention factors(k),a and ***,a reverse trend(a and Rs)was observed for atenolol with increase in *** thermodynamic data from van’t Hoff plots revealed that the enantioseparation was enthalpy driven for metoprolol and propranolol while entropy driven for *** understand the mechanism of chiral recognition and the elution behavior of the enantiomers,molecular docking studies were *** binding energies obtained from simulation studies were in good agreement with the elution order found experimentally and also with the free energy *** method was validated in the concentration range of 0.5-10μg/m L for all the *** limit of detection and limit of quantitation ranged from 0.126 to 0.137μg/m L and 0.376-0.414μg/m L,*** method was used successfully to analyze these drugs in pharmaceutical preparations.

关键词： Enantioseparation Supercritical fluid chromatography β-blockers Chiralpak^(■)IG column Molecular docking Binding energy

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FAIR Enough:Develop and Assess a FAIR-Compliant Dataset for Large Language Model Training?

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Data Intelligence 2024年第2期6卷 559-585页

作者： Shaina Raza Shardul Ghuge Chen Ding Elham Dolatabadi Deval pandya Vector Institute for Artificial Intelligence TorontoOntarioCanada Toronto Metropolitan University TorontoOntarioCanada York University TorontoOntarioCanada

The rapid evolution of Large Language Models(LLMs) highlights the necessity for ethical considerations and data integrity in AI development, particularly emphasizing the role of FAIR(Findable, Accessible, Interoperable, Reusable) data principles. While these principles are crucial for ethical data stewardship, their specific application in the context of LLM training data remains an under-explored area. This research gap is the focus of our study, which begins with an examination of existing literature to underline the importance of FAIR principles in managing data for LLM training. Building upon this, we propose a novel frame-work designed to integrate FAIR principles into the LLM development lifecycle. A contribution of our work is the development of a comprehensive checklist intended to guide researchers and developers in applying FAIR data principles consistently across the model development process. The utility and effectiveness of our frame-work are validated through a case study on creating a FAIR-compliant dataset aimed at detecting and mitigating biases in LLMs. We present this framework to the community as a tool to foster the creation of technologically advanced, ethically grounded, and socially responsible AI models.

关键词： Responsible Al Large language models FAIR data principles Ethical Al Biases

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Oldest Asian Record of Snapping Shrimps(Malacostraca:Alpheidae)from the Kutch Basin,Western India and Associated Biota:Biostratigraphic,Paleoenvironmental and Paleoecological Significance

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Acta Geologica Sinica(English Edition) 2022年第6期96卷 1867-1883页

作者： Vivesh V.KAPUR Kamlesh KUMAR pranav J.pandya Amit KGHOSH Arindam CHAKRABORTY Anupam SHARMA Gaurav CHAUHAN M.G.THAKKAR Birbal Sahni Institute of Palaeosciences 53University RoadLucknow 226007India Department of Biology Shri R.R.Lalan CollegeBhujKachchh DistrictGujaratIndia Institute of Earth Sciences Academia SinicaTaipeiTaiwan 11529China Department of Earth and Environmental Science K.S.K.V.Kachchh UniversityBhujKachchh DistrictGujaratIndia

The oldest Asian record of alpheid shrimps,assigned to genus Alpheus,based on snapping claw fingertips from the Miocene Khari Nadi Formation in the Kutch Basin,western India reported herein,extends the fossil record of the family Alpheidae from Asia by~22 million *** early Miocene(Aquitanian)age is estimated based on the associated assemblage of calcareous nannofossils,Sphenolithus disbelemnos,Cyclicargolithus floridanus,and Reticulofenestra *** co-occurring microbiota includes bony fish otolith remains,identified as“genus Gobiidarum”,isolated teeth of Dasyatis rays,Sphyrna sharks,and teleosts,ctenoid and placoid scales,ostracods,belonging to the genera Paractinocythereis,Alocopocythere,Ruggieria,Aglaiocypris,Bairdoppilata,and echinoid *** together,the microfossil assemblage and data from chemical analyses using Energy Dispersive Spectroscopy,X-Ray Diffraction and Wavelength Dispersive X-Ray Fluorescence of host and associated lithologies suggests prevalence of a shallow(neritic)to coastal marine(intertidal)depositional *** present investigation also provides the oldest fossil evidence on the co-occurrence of Alpheus and gobiids(based on otoliths)that strongly advocates that the mutualistic association between these animal groups had developed by the Aquitanian.

关键词： biostratigraphy Crustacea Caridea Elasmobranchs Gobiidae invertebrate and vertebrate paleontology nannofossils Oligocene-Miocene Indian subcontinent

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Electroanalytical tools to investigate the divalent state of Eu(Ⅲ) and Nd(Ⅲ) ions in non-aqueous medium

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Journal of Rare Earths 2012年第4期30卷 392-396页

作者： Jignasu P Mehta Himanshu M pandya Kahan I pandya Department of Chemistry DST-FIST sponsored Department Mahatma Gandhi Campus Bhavnagar University

The divalent state of Ln（III） ions has attracted much interest because of their ability to serve isomorphously in many biological system of divalent Ca（II） ion. Therefore, present paper deals with the study of divalent state of Eu（III） and Nd（III） ions in non-aqueous medium. In present study, cyclic voltammetry and chronopotentiometry were utilized to establish the divalent state of Eu（III） and Nd（III） ions. The cyclic voltammetric technique showed two-step reduction process at cathode for both Ln（III） ions under specified experimental conditions and chronopotentiometric method also showed two different transition times （r）. Looking to the shape of cyclic voltammogram we calculated het- erogeneous forward rate constant （K^fh, cm/s） and diffusion coefficient （D, cm2/s） for both ions, which suggested that sweep rate had great ef- fect on the shape of cyclic voltammogram of Eu（III） and Nd（III） ions. The result of chronopotentiometry also suggested that stable divalent states of Eu（III） and Nd（III） ions existed with chronopotentiogram with two distinct transition times. The diffusion coefficients （D, cm2/s） were calculated from Sand equation. The diffusion coefficients of both techniques were compared and the results suggested that the system at electrode surface was changing from being reversible to irreversible.

关键词： Eu(IlI) and Nd(III) ions non-aqueous medium cyclic-voltammetry chronopotentiomentry rare earths

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Integration of evacuated solar collectors with an adsorptive ice maker for hot climate region

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Energy and Built Environment 2022年第2期3卷 181-189页

作者： Nishant Modi Bhargav pandya College of Sciences and Engineering University of TasmaniaTasmaniaAustralia School of Chemical Engineering University of BirminghamBirminghamUnited Kingdom

This research study compares the steady-state and dynamic behaviour of a solar-powered activated carbon-35(AC35)/methanol-based vapour adsorption refrigeration system for production of ice at hot climate ***-modynamic comparisons are made with the coefficient of performance(COP),system COP(SCOP),specific refrig-eration capacity(SRC)and critical parameters such as cycle time and ice production rate are ***,the sustainability of the proposed ice maker has proven by integrating economic and environmental *** minimum solar flux required to ensure continuous ice production was found 800 W/m^(2).Moreover,the max-imum ice production rate and COP were decreased by 32.36%and 37.63%respectively when the system was operated under real ambient *** proposed solar adsorptive ice maker achieved maximum SRC of 61.6 g m^(−2)during April month and reduced the CO_(2)emissions by 12.82 ton annually.

关键词： Solar cooling system Adsorption refrigeration cycle Ice production rate Activated carbon-35(AC35)/Methanol GHG emissions Simple payback period

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Enamel biomimetics—fiction or future of dentistry?

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International Journal of Oral Science 2019年第1期11卷 1-9页

作者： Mirali pandya Thomas G.H.Diekwisch Center for Craniofacial Research and Diagnosis Texas A&M College of Dentistry

Tooth enamel is a complex mineralized tissue consisting of long and parallel apatite crystals configured into decussating enamel rods. In recent years, multiple approaches have been introduced to generate or regenerate this highly attractive biomaterial characterized by great mechanical strength paired with relative resilience and tissue compatibility. In the present review, we discuss five pathways toward enamel tissue engineering,(i) enamel synthesis using physico-chemical means,(ii) protein matrix-guided enamel crystal growth,(iii) enamel surface remineralization,(iv) cell-based enamel engineering, and(v) biological enamel regeneration based on de novo induction of tooth morphogenesis. So far, physical synthesis approaches using extreme environmental conditions such as pH, heat and pressure have resulted in the formation of enamel-like crystal *** methods relying on enamel proteins as templating matrices have aided the growth of elongated calcium phosphate crystals. To illustrate the validity of this biochemical approach we have successfully grown enamel-like apatite crystals organized into decussating enamel rods using an organic enamel protein matrix. Other studies reviewed here have employed amelogeninderived peptides or self-assembling dendrimers to re-mineralize mineral-depleted white lesions on tooth surfaces. So far, cell-based enamel tissue engineering has been hampered by the limitations of presently existing ameloblast cell lines. Going forward, these limitations may be overcome by new cell culture technologies. Finally, whole-tooth regeneration through reactivation of the signaling pathways triggered during natural enamel development represents a biological avenue toward faithful enamel regeneration. In the present review we have summarized the state of the art in enamel tissue engineering and provided novel insights into future opportunities to regenerate this arguably most fascinating of all dental tissues.

关键词： complex mineralized Biochemical methods

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Radiofrequency ablation of pancreatic ductal adenocarcinoma:The past,the present and the future

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World Journal of Gastrointestinal Oncology 2015年第2期7卷 6-11页

作者： Garvi J pandya Vishal G Shelat Medicine Ministry of Health Holdings Pte LtdSingapore 308433 Singapore Division of Hepato-pancreatico-biliary Surgery Tan Tock Seng HospitalSingapore 308433Singapore

Pancreatic ductal adenocarcinoma(PDAC)is one of the most aggressive cancers with a grim overall 5-year survival rate of 5%.Advances in surgical techniques,critical care,molecular diagnosis,diagnostic imaging,endosonology and adjuvant therapy have improved outcomes;but still more needs to be *** is an urgent need to discover new avenues that may impact *** ablation(RFA)has attracted attention as an adjunctive treatment in PDAC.A review of English literature in Pub Med was done using the MESH terms for PDAC and *** the articles were reviewed and core information was tabulated for *** a comprehensive review of all articles the data was evaluated to discover the role of RFA in PDAC ***,contraindications,feasibility,success rate,safety,complications and impact on survival were reviewed and are discussed *** appears to be an attractive option for nonmetastatic locally advanced *** is feasible but has a significant *** the present time the integration of RFA into the management of pancreatic ductal adenocarcinoma is *** should be considered as having a complimentary role to current standard therapy in the multimodal management care *** is likely that indications and patient selection for pancreatic RFA will expand.

关键词： Pancreatic cancer Radiofrequency ablation

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Advances in endoscopic balloon therapy for weight loss and its limitations

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World Journal of Gastroenterology 2017年第44期23卷 7813-7817页

作者： Dinesh Vyas Kaivalya Deshpande Yagnik pandya Department of Surgery Texas Tech University Department Of Surgery Michigan State University Department of Surgery Metro West Medical Center

The field of medical and surgical weight loss is undergoing an explosion of new techniques and devices. A lot of these are geared towards endoscopic approaches rather than the conventional and more invasive laparoscopic or open approach. One such recent advance is the introduction of intrgastric balloons. In this article, we discuss the recently Food and Drug Administration approved following balloons for weight loss: the Orbera? Intragastric Balloon System(Apollo Endosurgery Inc, Austin, TX, United States), the Re Shape? Integrated Dual Balloon System(Re Shape Medical, Inc., San Clemente, CA, United States), and the Obalon(Obalon? Therapeutics, Inc.). The individual features of each of these balloons, the method of introduction and removal, and the expected weight loss and possible complications are discussed. This review of the various balloons highlights the innovation in the field of weight loss.

关键词： Weight loss Gastric balloons Endoscopic balloons Orbera Obalon Reshape

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Electron inelastic mean free paths in solids:A theoretical approach

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Chinese Physics B 2012年第9期21卷 208-214页

作者： Siddharth H.pandya B.G.Vaishnav K.N.Joshipura Department of Physics Sardar Patel University Physical Research Laboratory

In the present paper, the inelastic mean free path （IMFP） of incident electrons is calculated as a function of energy for silicon （Si）, oxides of silicon （SiO2）, SiO, and A1203 in bulk form by employing atomic/molecular inelastic cross sections derived by using a semi-empirical quantum mechanical method developed earlier. A general agreement of the present results is found with most of the available data. It is of great importance that we have been able to estimate the minimum IMFP, which corresponds to the peak of inelastic interactions of incident electrons in each solid investigated. New results are presented for SiO, for which no comparison is available. The present work is important in view of the lack of experimental data on the IMFP in solids.

关键词： electron inelastic mean free path complex potential inelastic electron scattering cross sections solids

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CONTROL OF VEHICLE PLATOONS FOR HIGHWAY SAFETY AND EFFICIENT UTILITY:CONSENSUS WITH COMMUNICATIONS AND VEHICLE DYNAMICS

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Journal of Systems Science & Complexity 2014年第4期27卷 605-631页

作者： WANG Le Yi SYED Ali YIN Gang George pandya Abhilash ZHANG Hongwei Department of Electrical and Computer Engineering Wayne State University Department of Mathematics Wayne State University Department of Computer Science Wayne State University

Platoon formation of highway vehicles is a critical foundation for autonomous or semiautonomous vehicle control for enhanced safety,improved highway utility,increased fuel economy,and reduced emission toward intelligent transportation *** control encounters great challenges from vehicle control,communications,team coordination,and *** paper introduces a new method for coordinated control of platoons by using integrated network consensus decisions and vehicle *** achieve suitable coordination of the team vehicles based on terrain and environmental conditions,the emerging technology of network consensus control is modified to a weighted and constrained consensus-seeking *** are introduced and their convergence properties are *** methodology employs neighborhood information through on-board sensors and V2 V or V2 I communications,but achieves global coordination of the entire *** ability of the methods in terms of robustness,disturbance rejection,noise attenuation,and cyber-physical interaction is analyzed and demonstrated with simulated case studies.

关键词： Collision avoidance communications consensus control networked systems platoon con-trol safety vehicle dynamics.

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