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International Journal of Organic Chemistry 2013年第3期3卷 176-184页

作者： pradipta kumar basu Amrita Ghosh Department of Chemistry Hooghly Mohsin College Chinsurah India

A number of doubly-fused [1,2] naphthodifurans have been synthesized from the corresponding diallyl-dihydroxy naphthalene precursors involving N-iodosuccinimide in acetonitrile and also by molecular iodine in aqueous micelle using CTAB as surfactant. The electrophilic cyclization occurs regioselectively by a 5-exo-trig mode of cyclization.

关键词： Di-Allyl-Dihydroxy Naphthalene N-Iodosuccinimide CTAB Micelle 5-Exo-Trig Mode Regioselective Cyclization

Optimized protoplast isolation and transfection with a breakpoint:accelerating Cas9/sgRNA cleavage efficiency validation in monocot and dicot

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aBIOTECH 2024年第2期5卷 151-168页

作者： Debasmita Panda Subhasis Karmakar Manaswini Dash Swagat kumar Tripathy Priya Das Sagar Banerjee Yiping Qi Sanghamitra Samantaray pradipta kumar Mohapatra Mirza J.Baig Kutubuddin A.Molla ICAR National Rice Research Institute CuttackOdisha 753006India Department of Botany Ravenshaw UniversityCuttackOdisha 753003India Department of Plant Science and Landscape Architecture University of MarylandCollege ParkMD 20742USA

The CRISPR-Cas genome editing tools are revolutionizing agriculture and basic biology with their simplicity and precision ability to modify target genomic ***-predicted guide RNAs(gRNAs)often fail to induce efficient cleavage at target *** target loci are inaccessible due to complex chromatin ***,there is no suitable tool available to predict the architecture of genomic target sites and their ***,significant time and resources are spent on performing editing experiments with inefficient *** in vitro-cleavage assay could provide a rough assessment of gRNA efficiency,it largely excludes the interference of native genomic *** in-vivo testing gives a proper assessment of the cleavage ability of editing reagents in a native genomic ***,we developed a modified protocol that offers highly efficient protoplast isolation from rice,Arabidopsis,and chickpea,using a sucrose gradient,transfection using PEG(polyethylene glycol),and validation of single guide RNAs(sgRNAs)cleavage efficiency of *** have optimized various parameters for PEG-mediated protoplast transfection and achieved high transfection efficiency using our protocol in both monocots and *** introduced plasmid vectors containing Cas9 and sgRNAs targeting genes in rice,Arabidopsis,and chickpea *** dual sgRNAs,our CRISPRdeletion strategy offers straightforward detection of genome editing success by simple agarose gel *** sequencing of PCR products confirmed the editing efficiency of specific ***,we demonstrated that isolated protoplasts can be stored for up to 24/48 h with little loss of viability,allowing a pause between isolation and *** high-efficiency protocol for protoplast isolation and transfection enables rapid(less than 7 days)validation of sgRNA cleavage efficiency before proceeding with stable *** isolation and transfection method can als

关键词： Protoplast Genome editing Transgene-free edited plants Rice Chickpea

Novel insights on oral squamous cell carcinoma management using long non-coding RNAs

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Oncology Research 2024年第10期32卷 1589-1612页

作者： SUBHAYAN SUR DIMPLE DAVRAY SOUMYA basu SUPRIYA KHEUR JAYANTA kumar PAL SHUCHI NAGAR AVINASH SANAP BHIMAPPA MRUDAGI SAMIR GUPTA Cancer and Translational Research Centre Dr.D.Y.Patil Biotechnology and Bioinformatics InstituteDr.D.Y.Patil VidyapeethTathawadePune411033India Bioinformatics Centre Dr.D.Y.Patil Biotechnology and Bioinformatics InstituteDr.D.Y.Patil VidyapeethPune411033India Department of Oral Pathology and Microbiology Dr.D.Y.Patil Dental College&HospitalDr.D.Y.Patil VidyapeethPune411018India Department of Surgical Oncology Dr.D.Y.Patil Medical CollegeHospital&Research CentreDr.D.Y.Patil VidyapeethPune411018India

Oral squamous cell carcinoma(OSCC)is one of the most prevalent forms of head and neck squamous cell carcinomas(HNSCC)with a poor overall survival rate(about 50%),particularly in cases of ***-based cancer biomarkers are a relatively advanced concept,and non-coding RNAs currently have shown promising roles in the detection and treatment of various *** review underlines the function of long non-coding RNAs(lncRNAs)in the OSCC and its subsequent clinical ***,a class of non-coding RNAs,are larger than 200 nucleotides and resemble mRNA in numerous ***,unlike mRNA,lncRNA regulates multiple druggable and non-druggable signaling molecules through simultaneous interaction with DNA,RNA,proteins,or microRNAs depending on concentration and localization in *** of oncogenic lncRNAs and downregulation of tumor suppressor lncRNAs are evident in OSCC tissues and body fluids such as blood and saliva indicating their potential as valuable *** inhibition of candidate oncogenic lncRNAs or overexpression of tumor suppressor lncRNAs showed potential therapeutic roles in in-vivo animal *** types of lncRNAs that are expressed differentially in OSCC tissue and bodily fluids have been systematically documented with specificity and *** review thoroughly discusses the biological functions of such lncRNAs in OSCC cell survival,proliferation,invasion,migration,metastasis,angiogenesis,metabolism,epigenetic modification,tumor immune microenvironment,and drug ***,we addressed the diagnostic and therapeutic importance of lncRNAs in OSCC pre-clinical and clinical systems,providing details on ongoing research and outlining potential future directions for advancements in this *** essence,this review could be a valuable resource by offering comprehensive and current insights into lncRNAs in OSCC for researchers in fundamental and clinical domains.

关键词： Oral squamous cell carcinoma(OSCC) Head and neck cancer Non-coding RNA Long non-coding RNA(lncRNA) Cancer diagnosis

Short-term mixed electricity demand and price forecasting using adaptive autoregressive moving average and functional link neural network

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Journal of Modern Power Systems and Clean Energy 2019年第5期7卷 1241-1255页

作者： Sujit kumar DASH pradipta Kishore DASH Siksha O Anusandhan Deemed to be University Bhubaneswar 751030India

A new hybrid adaptive autoregressive moving average(ARMA)and functional link neural network(FLNN)trained by adaptive cubature Kalman filter(ACKF)is presented in this paper for forecasting day-ahead mixed short-term demand and electricity prices in smart *** hybrid forecasting framework is intended to capture the dynamic interaction between the electricity consumers and the forecasted prices resulting in the shift of demand curve in electricity *** proposed model comprises a linear ARMA-FLNN obtained by using a nonlinear expansion of the weighted *** nonlinear functional block helps introduce nonlinearity by expanding the input space to higher dimensional space through basis *** train the ARMA-FLNN,an ACKF is used to obtain faster convergence and higher forecasting *** proposed method is tested on several electricity markets,and the performance metrics such as the mean average percentage error(MAPE)and error variance are compared with other forecasting methods,indicating the improved accuracy of the approach and its suitability for a real-time forecasting.

关键词： Mixed demand and price forecasting Cubature Kalman filter Price spikes Smart grids

Control of Non-Deterministic Systems With μ-Calculus Specifications Using Quotienting

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IEEE/CAA Journal of Automatica Sinica 2021年第5期8卷 953-970页

作者： Samik basu Ratnesh kumar the Department of Computer Science Iowa State UniversityIowa 50011-3060 USA the Department of Electrical and Computer Engineering Iowa State UniversityIowa 50011-3060 USA

The supervisory control problem for discrete event system(DES) under control involves identifying the supervisor, if one exists, which, when synchronously composed with the DES,results in a system that conforms to the control specification. In this context, we consider a non-deterministic DES under complete observation and control specification expressed in action-based propositional μ-calculus. The key to our solution is the process of quotienting the control specification against the plan resulting in a new μ-calculus formula such that a model for the formula is the supervisor. Thus the task of control synthesis is reduced a problem of μ-calculus satisfiability. In contrast to the existing μ-calculus quotienting-based techniques that are developed in deterministic setting, our quotienting rules can handle nondeterminism in the plant models. Another distinguishing feature of our technique is that while existing techniques use a separate μ-calculus formula to describe the controllability constraint(that uncontrollable events of plants are never disabled by a supervisor), we absorb this constraint as part of quotienting which allows us to directly capture more general state-dependent controllability constraints. Finally, we develop a tableau-based technique for verifying satisfiability of quotiented formula and model generation. The runtime for the technique is exponential in terms of the size of the plan and the control specification. A better complexity result that is polynomial to plant size and exponential to specification size is obtained when the controllability property is state-independent. A prototype implementation in a tabled logic programming language as well as some experimental results are presented.

关键词： Discrete event systems(DES) non-deterministic plant μ-calculus supervisory control

Hybrid IWD-DE:A Novel Approach to Model Cooperative Navigation Planning for Multi-robot in Unknown Dynamic Environment

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Journal of Bionic Engineering 2019年第2期16卷 235-252页

作者： Degal Chandrasekhar Rao Manas Ranjan Kabat pradipta kumar Das Prabir kumar Jena Department of Information Technology VSSUTBurlaOdisha 768018India Department of Computer Science&Engineerings VSSUT、Burla Odisha 76801&India Department of Mechanical Engineering VSSUTBurlaOdisha 76801&India

The current study emphasizes inadequacies of earlier research findings on multi-robot navigation and offers a robust approach to guide the robots in an unknown dynamic *** attain the objective,the Intelligent Water Drop(IWD)algorithm is combined with Differential Evolution(DE)in a new conceptual fashion to optimize the navigation path of multiple mobile *** hybrid IWD-DE,basic IWD and DE algorithms are then explored for multi-robot navigation in a dynamic workspace through *** simulation outcomes demonstrate the competency of the proposed method to guide the robot in predicting the nature of the obstacle and to generate an optimal and safe trajectory in a dynamic *** potency of the proposed algorithm is further validated through experimentation with fire bird robot in a real *** outcomes of the simulation and experimentation,by employing IWD-DE algorithm are compared with those of basic IWD and DE *** error estimated for Average Navigation Path Travelled(ANPT),Aggregate Navigation Path Deviation(ANPD)and number of turns between simulation and experimental results by employing IWD-DE is 8.96,9.09,and 11.13,respectively while reaching 16.43,28.61,29.15 for IWD,and 6.66,10.20,14.28 for *** efficiency of the proposed approach is further verified with the state-of-the-art in a dynamic *** outcomes reveal the efficiency and flexibility of the proposed approach in resolving the multi-robot navigation problem as compared to the state-of-the-art in a dynamic workspace.

关键词： multi-robot dynamic environment intelligent water drop differential evolution navigation planning waypoints fire bird robot

Transition metal-based single-atom catalysts(TM-SACs);rising materials for electrochemical CO_(2) reduction

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Journal of Energy Chemistry 2022年第7期31卷 444-471,I0012页

作者： Bishnupad Mohanty Suddhasatwa basu Bikash kumar Jena Materials Chemistry Department CSIR-Institute of Minerals and Materials TechnologyBhubaneswar 751013India Academy of Scientific&Innovative Research(AcSIR) Ghaziabad 201002India

The continuous increase of global atmospheric CO_(2) concentrations brutally damages our environment. A series of methods have been developed to convert CO_(2) to valuable fuels and value-added chemicals to maintain the equilibrium of carbon cycles. The electrochemical CO_(2) reduction reaction(CO_(2)RR) is one of the promising methods to produce fuels and chemicals, and it could offer sustainable paths to decrease carbon intensity and support renewable energy. Thus, significant research efforts and highly efficient catalysts are essential for converting CO_(2) into other valuable chemicals and fuels. Transition metal-based single atoms catalysts(TM-SACs) have recently received much attention and offer outstanding electrochemical applications with high activity and selectivity opportunities. By taking advantage of both heterogeneous and homogeneous catalysts, TM-SACs are the new rising star for electrochemical conversion of CO_(2) to the value-added product with high selectivity. In recent years, enormous research effort has been made to synthesize different TM-SACs with different M–Nxsites and study the electrochemical conversion of CO_(2) to CO. This review has discussed the development and characterization of different TMSACs with various catalytic sites, fundamental understanding of the electrochemical process in CO_(2) RR,intrinsic catalytic activity, and molecular strategics of SACs responsible for CO_(2)RR. Furthermore, we extensively review previous studies on 1 st-row transition metals TM-SACs(Ni, Co, Fe, Cu, Zn, Sn) and dual-atom catalysts(DACs) utilized for electrochemical CO_(2) conversions and highlight the opportunities and challenges.

关键词： CO_(2)RR Single-atom catalyst SACs Dual-atom catalyst DACs Transition metals Support catalysts

Broadband, High Gain, Narrow Width Rectangular Dielectric Resonator Antenna with Air Gap

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Journal of Electronic Science and Technology 2019年第1期17卷 90-96页

作者： Ankit kumar Roy Sukla basu Kalyani Government Engineering College

The broadband, narrow width, rectangular dielectric resonator antenna(RDRA) of aluminum nitride(εr=8.6) was designed and the effect of inclusion of air gap at the bottom of the dielectric resonator antenna(DRA),above the ground plane, was investigated. Gain around 7 dBi was obtained for DRA with air gap(DRAAG) over a broad bandwidth in upper X, Ku, and K bands. Further enhancement in gain could be obtained by placing a metal wall parallel to the length of DRA. However, due to the presence of metal wall, bandwidth was reduced. These structures with the metal wall are capable of operating over a wide band extending from Ku band to lower K band with the gain of around 10 dBi. CST Microwave Studio Software was used to simulate all these *** parameters of DRA with air gap were compared with several broadband DRA structures reported in recent literature. The proposed DRAAG with the metal wall in this paper is capable of operating over a wide bandwidth along with a significant gain.

关键词： Dielectric resonator antenna(DRA) rectangular dielectric resonator antenna(RDRA) wide band dielectric resonator antenna X Ku and K bands dielectric resonator antenna

The evolution of graphene-based electronic devices

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International Journal of Smart and Nano Materials 2010年第3期1卷 201-223页

作者： Joydeep basu Jayanta kumar basu Tarun Kanti Bhattacharyya Department of Electronics and Electrical Communication Engineering Department of Chemical Engineering Indian Institute of TechnologyKharagpur 721302India

Successful isolation of single-layer graphene,the two-dimensional allotrope of carbon from graphite,has fuelled a lot of interest in exploring the feasibility of using it for fabrication of various electronic devices,particularly because of its exceptional electronic *** is poised to save Moore’s law by acting as a successor of silicon-based *** article reviews the success story of this allotrope with a focus on the structure,properties and preparation of graphene as well as its various device applications.

关键词： electronic device FET field effect graphene nanoelectronics

Primary endoscopic stapedotomy using 3 mm nasal endoscope:Audiologic and clinical outcomes

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Journal of Otology 2020年第4期15卷 133-137页

作者： Pradeep Pradhan Chappity Preetam pradipta kumar Parida Department of ENT and Head Neck Surgery All India Institute of Medical SciencesBhubaneswarOdisha751019India

Objective:To report the use of a 3 mm rigid nasal endoscope in primary endoscopic stapedotomy and clinical and audiological *** and methods:Thirty patients diagnosed with primary otosclerosis underwent endoscopic stapedotomy that was performed using a 3 mm nasal endoscope(Karl Storz).At 6 months follow-up,the patients were evaluated for intraoperative findings,postoperative hearing outcomes and ***:Canaloplasty was performed in 2(6.66%)patients,and no curettage of the canal wall was required in 12(40%)*** of the chorda tympani nerve was conducted in 11(36.66%)*** average duration of surgery was 36 min(range 31e65 min).The air-bone gap(ABG)was 35 dB(range 24e50 dB)preoperatively and 14.63 dB(range 9e20 dB)postoperatively(p?0.00).At 6 months follow-up,<20 dB ABG was achieved in 93.33%of the *** major intraoperative/postoperative complications were ***:A 3 mm rigid nasal endoscope can be effectively used in stapedotomy to obtain adequate audiological *** can be considered as a better alternative to the standard microscope or 4 mm endoscope in preserving the posterior canal wall and chorda tympani nerve while minimizing operative time without causing significant complications.

关键词： Endoscope Otosclerosis Outcomes