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T_(H)17 cells...Sorting the good out from the bad

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Signal Transduction and Targeted Therapy 2020年第1期5卷 780-781页

作者： Junwei Li Le Jiang Yongxiang Yi pradeep kumar sacitharan College of Veterinary Medicine Qingdao Agricultural University266109 QingdaoChina Department of General Surgery The Second Hospital of NanjingThe Affiliated Hospital of Nanjing University of Chinese Medicine#1 Zhongfu RoadNanjingJiangsu ProvinceChina The Institute of Ageing and Chronic Disease University of LiverpoolLiverpool L78TXUK Xi’an Jiaotong-Liverpool University Department of Biological Sciences#111 Ren’ai RoadSuzhou Industrial Park215123 SuzhouJiangsu ProvinceP.R.China

A recent article by Wu et al.1 demonstrated how targeting inflammatory TH17 cells can be achieved by blocking glycolysis pathway *** findings could lead to potential drugs to selective target“bad”inflammatory TH17 c... 详细信息

关键词： al drugs autoimmune

Mapping the T cell response to COVID-19

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Signal Transduction and Targeted Therapy 2020年第1期5卷 1447-1448页

作者： Junwei Li Junhua Wang Angray S.Kang pradeep kumar sacitharan College of Veterinary Medicine Qingdao Agricultural UniversityQingdao 266109China Centre for Oral Immunobiology and Regenerative Medicine Institute of DentistryBarts and the London School of Medicine and DentistryQueen Mary University of LondonLondon E12ATUK The Institute of Ageing and Chronic Disease University of LiverpoolLiverpool L78TXUK Xi’an Jiaotong-Liverpool University Department of Biological Sciences#111 Ren’ai RoadSuzhou Industrial ParkSuzhouJiangsu Province 215123P.R.China

A recent article by Grifoni et *** demonstrated the ability to measure and understand the human CD4+and CD8+T cell responses to SARS-CoV-2 infection.1 These findings highlighted below gave new insights into the immunopathogenesis of COVID-19,the crossreactivity of the SARS-CoV-2 infections,the potential targets of T cells,and for vaccine design.

关键词： al Mapping vaccine

Targeting IL-22 and IL-22R protects against experimental osteoarthritis

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Cellular & Molecular Immunology 2021年第5期18卷 1329-1331页

作者： Changhua Yi Yongxiang Yi Jie Wei Qingwen Jin Junwei Li pradeep kumar sacitharan Department of Infectious Diseases The Second Hospital of NanjingThe Affiliated Hospital of Nanjing University of Chinese Medicine#1 Zhongfu RoadNanjingJiangsu ProvinceChina College of Medical Laboratory Shaoyang UniversityShaoYang422000Hunan ProvinceChina Department of General Surgery The Second Hospital of NanjingThe Affiliated Hospital of Nanjing University of Chinese Medicine#1 Zhongfu RoadNanjingJiangsu ProvinceChina Department of Neurology The Sir Run Run HospitalNanjing Medical University#109 Longmian AvenueJiangning DistrictNanjingJiangsu ProvinceChina College of Veterinary Medicine Qingdao Agricultural University266109QingdaoChina The Institute of Ageing and Chronic Disease University of LiverpoolLiverpoolL78TXUK Department of Biological Sciences Xi’an Jiaotong-Liverpool University#111 Ren’ai RoadSuzhou Industrial ParkSuzhou215123Jiangsu ProvinceChina

Osteoarthritis(OA)is characterized by cartilage degradation,pain,and synovitis.1 Joint inflammation driven by cytokines has been demonstrated to cause cartilage degradation and pain.2 However,approaches to neutralize cytokines,such as IL-1 and TNF-α,known to be involved in OA have shown poor clinical efficacy.3 There is an unmet clinical need to find better anti-inflammatory and pain targets for OA therapy and to elucidate the role of other cytokines in OA *** studies have shown that IL-22 and its receptor IL-22R play central roles in inflammation and diseases such as psoriasis,ulcerative colitis,graft-versus-host disease,certain infections and tumors,as well as in liver and pancreas damage.4,5 The role of IL-22/IL-22R and the potential for therapeutic targeting of both proteins in OA remain largely unknown,which we sought to investigate.

关键词： inflammation clinical pain

Adiponectin exacerbates influenza infection in elderly individuals via IL-18

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Signal Transduction and Targeted Therapy 2020年第1期5卷 2095-2097页

作者： Youzhu Jiang Changhua Yi Yongxiang Yi Qingwen Jin Angray SKang Junwei Li pradeep kumar sacitharan Department of Neurology The Second Hospital of NanjingThe Affiliated Hospital of Nanjing University of Chinese Medicine#1 Zhongfu RoadNanjingJiangsu ProvinceChina Department of Infectious Diseases The Second Hospital of NanjingThe Affiliated Hospital of Nanjing University of Chinese Medicine#1 Zhongfu RoadNanjingJiangsu ProvinceChina Public Health and Therapy Center of Nanjing Nanjing 211113China Department of General Surgery The Second Hospital of NanjingThe Affiliated Hospital of Nanjing University of Chinese Medicine#1 Zhongfu RoadNanjingJiangsu ProvinceChina Department of Neurology The Sir Run Run HospitalNanjing Medical University#109 Longmian AvenueJiangning DistrictNanjingJiangsu ProvinceChina Centre for Oral Immunobiology and Regenerative Medicine Institute of DentistryBarts and the London School of Medicine and DentistryQueen Mary University of LondonLondon E12ATUK College of Veterinary Medicine Qingdao Agricultural UniversityQingdao 266109China The Institute of Ageing and Chronic Disease University of LiverpoolLiverpool L78TXUK Xi’an Jiaotong-Liverpool University Department of Biological Sciences#111 Ren’ai RoadSuzhou Industrial ParkSuzhouJiangsu Province 215123P.R.China

Dear Editor,Influenza affects humans of all ages;however,elderly people have increased susceptibility to infections and are especially predisposed to complications.1 A number of global efforts have increased influenza vaccination administration in elderly people to reduce complications,particularly when seasonal influenza infections peak.2 To date,much is known about how influenza infection and host immunity interact during pathogenesis,which has led to a number of vaccines.3,4 However,the impact of influenza vaccines in older people is modest.2 Hence,the underlying pathophysiological mechanisms responsible for the worsening of influenza infection in old age are still elusive.

关键词： influenza infection immunity

Power Quality Improvement for Grid-connected PV System Based on Distribution Static Compensator with Fuzzy Logic Controller and UVT/ADALINE-based Least Mean Square Controller

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Journal of Modern Power Systems and Clean Energy 2021年第6期9卷 1289-1299页

作者： Amit kumar pradeep kumar Electrical and Electronics Engineering Department Natioanl Institute of Technology Sikkim

This paper presents a novel method of power quality enrichment in a grid-connected photovoltaic(PV) system using a distribution static compensator(DSTATCOM). The paper consists of two-step control processes. In the primary step, a fuzzy logic controller(FLC) is employed in the DC-DC converter to extract the peak power point from the PV panel, where the FLC produces a switching signal for the DC-DC *** the secondary step, a unit vector template(UVT)/adaptive linear neuron(ADALINE)-based least mean square(LMS) controller is adopted in the DC-AC converter, i. e., voltage source converter(VSC). The input to this VSC is the boosted DC voltage, which originates from the PV panel as a result of DC-DC conversion. The VSC shunted with the power grid is known as a DSTATCOM, which can maintain the power quality in the distribution system. The UVT controller generates reference source currents from the grid voltages and DC-link *** ADALINE-based LMS controller calculates the online weight according to the previous weights by the sensed load current. The UVT/ADALINE-based LMS controller of a DSTATCOM performs several tasks such as maintaining the sinusoidal source current, achieving a unity power factor, and performing reactive power compensation. The reference current extracted from the UVT/ADALINE-based LMS controller is fed to the hysteresis current controller to obtain the desired switching signal for the VSC. A 100 k W solar PV system integrated into a three-phase four-wire distribution system through a four-leg VSC is designed in MATLAB/Simulink. The performances of the FLC and UVT/ADALINE-based LMS controllers are demonstrated under various irradiances as well as constant temperature and nonlinear loading conditions.

关键词： Adaptive linear neuron least mean square(LMS) fuzzy logic controller(FLC) maximum power point tracking(MPPT) photovoltaic(PV) unit vector template

Computation of Resonant Frequency of Gap-coupled Ring Microstrip Antennas

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International Journal of Automation and computing 2014年第6期11卷 671-675页

作者： pradeep kumar Department of Electronics and Communication Engineering Jaypee University of Information TechnologyWaknaghat- 173234 India

In this paper, an analytical model for computing the resonant frequency of the gap-coupled ring microstrip patch antennas is developed. The analytical model is based upon the cavity model along with circuit theory. Using the field expressions and boundary conditions, the transcendental equation for the structure is developed. The analytically computed results are compared with the simulated results. The simulation work is carried out by using computer simulation technology(CST) microwave studio *** comparison between simulated and computed results shows good agreement.

关键词： Ring microstrip antenna gap-coupling resonant frequency analytic model parasitic element

Herbal anthelmintic agents: a narrative review

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Journal of Traditional Chinese Medicine 2022年第4期42卷 641-651页

作者： Manjusa Adak pradeep kumar Department of Pharmaceutical Sciences and Natural Products Central University of PunjabGhuddaBathindaPunjab 151401India

Helminths or Parasitic worms of humans may cause chronic and sometimes deadly diseases,considered as neglected tropical diseases(NTDs)that infect around two billion people *** have been used as anthelmintics from ancient *** review is a compilation of plants as source of anthelmintic *** information presented in this review article regarding the anthelmintic activities of plants from 2005 and has been acquired by approaching various electronic databases,including Scopus,Google scholar,Web of science and *** was surveyed for anthelmintic activity of plants which showed that secondary metabolites of plants like terpenes,glycosides,saponins,flavonoids,tannins and alkaloids were having anthelmintic *** this review is a compilation of anthelmintic activity of plants from the year 2005,it will definitely be a fruitful study for researchers working in this field.

关键词： helminths helminthiasis anthelmintics biological products

CHEMICAL SYNTHESIS,SPECTRAL CHARACTERIZATION AND STABILITY OF SOME ELECTRICALLY CONDUCTING POLYMERS

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Chinese Journal of Polymer Science 2010年第2期28卷 191-197页

作者： pradeep kumar Upadhyay Afaq Ahmad Department of Chemistry Aligarh Muslim University

The synthesis, characterization, thermal degradation and stability of polyaniline （PANI）, poly（m-nitroaniline）, poly（m-chloroaniline） and poly（o-methylaniline） were reported. Different properties were measured and compared with PANI to find out the effect of electron donating groups （-CH3） and electron withdrawing groups （-Cl, -NO2）. It was found that the presence of any type of substitution in the benzene ring of aniline increased the solubility but reduced the yield, thermal stability and electrical conductivity. Two probe methods were used to measure the electrical conductivity of these polymers. The structural properties of these polymers were characterized by using FTIR and UV-Vis spectroscopic methods. Thermal degradation and stability of these polymers were explained by using thermogravimetric analysis （TGA） and conductivity measurements.

关键词： Polyaniline Electrical conductivity Yield Thermal degradation Stability.

Numerical investigation of the effect of transitory strand opening on mixing in a multistrand tundish

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International Journal of Minerals,Metallurgy and Materials 2011年第5期18卷 535-542页

作者： Sabin kumar Mishra pradeep kumar Jha Satish Chandra Sharma Satish kumar Ajmani Department of Mechanical and Industrial Engineering Indian Institute of Technology RoorkeeRoorkee 247667UttarakhandIndia Steelmaking and Casting Research Group Tata SteelR&DBurma MinesJamshedpur 831007JharkhandIndia

In a multistrand,the outlet near the inlet produces short circuiting *** leads to the formation of dead zones inside the tundish,and consequently,the mean residence time *** the present study,numerical investigation of mixing inside a delta shaped tundish with sloping boundaries was carried out by solving the Navier-Stokes equation and employing the standard turbulence *** decrease the dead zone volume inside the tundish,the effect of closing the outlet near the inlet for a small amount of time and further opening it on the mixing behavior of the tundish was *** outlets near the inlet were closed for varying amount of time,and the transient analysis of fluid flow and the tracer dispersion study were carried out to find the mixing parameters of the tundish,namely,mean residence time and the ratio of mixed to dead volume of the *** optimum closure time of the near outlet has been found,which yields best mixing inside the *** numerical code was validated against the experimental observation by performing the tracer dispersion study inside a multistrand tundish and the reasonably good match between the experimental and numerical results in terms of residence time distribution （RTD） *** results obtained from the present study confirm the strong role of choosing the right time for opening and closing the outlets to get improved characteristics for the fluid flow and mixing behavior of the *** educational version of computational fluid dynamics （CFD） software PHOENICS was used to solve the governing equations and interpret the results in different forms.

关键词： continuous casting billets tundish flow simulation mean residence time dead volume computational fluid dynamics (CFD)