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Positive correlation between latent Epstein-barr virus infection and severity of illness in inflammatory bowel disease patients

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World Journal of Gastrointestinal surgery 2023年第3期15卷 420-429页

作者： Hong-tao Wei Xiao-Wei Xue Qing ling Peng-Yan Wang Wei-Xun Zhou Department of Gastroenterology Beijing Friendship HospitalCapital Medical UniversityBeijing 100050China Department of Pathology Molecular Pathology Research CenterPeking Union Medical College HospitalChinese Academy of Medical ScienceBeijing 100730China

bAcKGROUND Emerging studies indicate the critical involvement of microorganisms,such as Epstein-barr virus(EbV),in the pathogenesis of inflammatory bowel disease(IbD).Immunosuppressive therapies for IbD can reactivate latent EbV,complicating the clinical course of ***,the clinical significance of EbV expression in b lymphocytes derived from IbD patients’intestinal tissues has not been explored in *** to explore the clinical significance of latent EbV infection in IbD *** Latent EbV infection was determined by double staining for EbV encoded RNA and cD20 in colon specimens of 43 IbD patients who underwent bowel *** on the staining results,the patients were divided into two groups,according to their latent EbV infection states-negative(n=33)and positive(n=10).Illness severity of IbD were assigned according to crohn’s disease activity index(ulcerative colitis)and Mayo staging system(crohn’s disease).the clinicpathological data were analyzed between the two different latent EbV groups and also between the mild-to-moderate and severe disease *** systolic pressure(P=0.005),variety of disease(P=0.005),the severity of illness(P=0.002),and pre-op corticosteroids(P=0.025)were significantly different between the EbV-negative and EbV-positive *** pressure(P=0.001),variety of disease(P=0.000),pre-op corticosteroids(P=0.011)and EbV infection(P=0.003)were significantly different between the mild-to-moderate and severe disease *** IbD patients with latent EbV infection may manifest more severe *** is suggested that the role of EbV in IbD development should be further investigated,latent EbV infection in patients with serious IbD should be closely monitored,and therapeutic course should be optimized.

关键词： Epstein-barr virus Epstein-barr virus encoded RNA Inflammatory bowel disease crohn’s disease Ulcerative colitis

20(s)-ginsenoside Rh1 alleviates t2DM induced liver injury via the Akt/FOXO1 pathway

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chinese Journal of Natural Medicines 2022年第9期20卷 669-678页

作者： sU Wen-Ya FAN Mei-ling LI Ying HU Jun-Nan cAI En-bo ZHU Hong-Yan sONG Ming-Jie LI Wei college of chinese Medicinal Materials Jilin Agricultural UniversityChangchun 130118China Maternity Diagnosis&treatment center the Affiliated Hospital of Changchun University of Chinese MedicineChangchun 130021China National&Local Joint Engineering Research center for Ginseng breeding and Development Changchun 130118China

Diabetes-associated liver injury becomes a dominant hepatopathy,leading to hepatic failure *** current study was designed to evaluate the ameliorative effects of ginsenoside Rh1(G-Rh1)on liver injury induced by t2DM.A t2DM model was established using c57bL/6 mice through feeding with HFD followed by injection with streptozotocin at 100 mg·kg^(−1).then the mice were continuously administered with G-Rh1(5 and 10 mg·kg^(−1)),to explore the protective effects of G-Rh1 against liver *** showed that G-Rh1 exerted significant effects on maintaining the levels of FbG and insulin,and ameliorated the increased levels of tG,tc and LDL-c induced by ***,apoptosis in liver tissue was relieved by G-Rh1,according to histological ***,in diabetic mice,it was observed that not only the increased secretion of G6Pase and PEPcK in the gluconeogenesis pathway,but also inflammatory factors including NF-κb and NLRP3 were suppressed by G-Rh1 ***,the underlying mechanisms by which G-Rh1 exhibited ameliorative effects was associated with its capacity to inhibit the activation of the Akt/FoxO1 signaling pathway induced by *** together,our preliminary study demonstrated the potential mechnism of G-Rh1 in protecting the liver against t2DM-induced damage.

关键词： G-Rh1 Liver injury Gluconeogenesis PEPcK G6Pase Akt/FOXO1 Inflammation

blockade of Arf1-mediated lipid metabolism in cancers promotes tumor infiltration of cytotoxic t cells via the LPE-PPARγ-NF-κb-ccL5 pathway

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Life Metabolism 2023年第5期2卷 25-37页

作者： Na Wang tiange Yao chenfei Luo ling sun Yuetong Wang steven X.Hou Department of cell and Developmental biology at school of Life sciences State Key Laboratory of Genetic EngineeringInstitute of Metabolism and Integrative BiologyHuman Phenome InstituteFudan UniversityShanghai 200438China

tumor immunotherapy has achieved breakthroughs in a variety of tumors. However, the systemic absence of t cells in tumors and immunosuppressive tumor microenvironment so far limits the efficacy of immunotherapy to a small population of patients. therefore, novel agents to increase t-cell tumor infiltration are urgently needed in the clinic. We recently found that inhibition of the ADP-ribosylation factor 1 (Arf1)-mediated lipid metabolism not only kills cancer stem cells (cscs) but also elicits an anti-tumor immune response. In this study, we revealed a mechanism that targeting Arf1 promotes the infiltration of cytotoxic t lymphocytes (ctLs) into tumors through the c-c chemokine ligand 5 (ccL5)- c-c chemokine receptor type 5 (ccR5) pathway. We found that blockage of Arf1 induces the production of the unsaturated fatty acid (PE 18:1) that binds and sequestrates peroxisome proliferator- activated receptor-γ (PPARγ) from the PPARγ-nuclear factor-κb (NF-κb) cytoplasmic complex. the released NF-κb was then phospho-rylated and translocated into the nucleus to regulate the transcription of chemokine ccL5. ccL5 promoted infiltration of ctLs for tumor regression. Furthermore, the combination of the Arf1 inhibitor and programmed cell death protein 1 (PD-1) blockade induced an even stronger anti-tumor immunity. therefore, targeting Arf1 represents a novel anti-tumor immune approach by provoking t-cell tumor infiltration and may provide a new strategy for tumor immunotherapy.

关键词： immune checkpoint blockade cancer stem cells cytotoxic t cells PPARγ ccL5-ccR5 pathway Arf1

the Lobster Eye Imager for Astronomy Onboard the sAtech-01 satellite

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天文和天体物理学研究:英文版 2023年第9期23卷 66-78页

作者： Z.X.ling X.J.sun c.Zhang s.L.sun G.Jin s.N.Zhang X.F.Zhang J.b.chang F.s.chen Y.F.chen Z.W.cheng W.Fu Y.X.Han H.Li J.F.Li Y.Li Z.D.Li P.R.Liu Y.H.Lv X.H.Ma Y.J.tang c.b.Wang R.J.Xie Y.L.Xue A.L.Yan Q.Zhang c.Y.bao H.b.cai H.Q.cheng c.Z.cui Y.F.Dai D.W.Fan H.b.Hu J.W.Hu M.H.Huang Z.Q.Jia c.c.Jin D.Y.Li J.Q.Li H.Y.Liu M.J.Liu Y.Liu H.W.Pan Y.L.Qiu M.sugizaki H.sun W.X.Wang Y.L.Wang Q.Y.Wu X.P.Xu Y.F.Xu H.N.Yang X.Yang b.Zhang M.Zhang W.D.Zhang Z.Zhang D.H.Zhao X.Q.cong b.W.Jiang L.H.Li X.b.Qiu J.N.sun D.t.su J.Wang c.Wu Z.Xu X.M.Yang s.K.Zhang Z.Zhang N.Zhang Y.F.Zhu H.Y.ban X.Z.bi Z.M.cai W.chen X.chen Y.H.chen Y.cui X.L.Duan Z.G Feng Y.Gao J.W.He t.He J.J.Huang F.Li J.s.Li t.J.Li t.t.Li H.Q.Liu L.Liu R.Liu s.Liu N.Meng Q.shi A.t.sun Y.M.Wang Y.b.Wang H.c.Wu D.X Xu Y.Q Yang Y.Yang X.s.Yu K.X.Zhang Y.L.Zhang Y.H.Zhang Y.t.Zhang H.Zhou X.c.Zhu J.s.cheng L.Qin L.Wang Q.L.Wang M.bai R.L.Gao Z.Ji Y.R.Liu F.L.Ma Y.J.shi J.su Y.Y.tan J.Z.tong H.t.Xu c.b.Xue G.F.Xue W.Yuan National Astronomical Observatories Chinese Academy of SciencesBeijing 100101China school of Astronomy and space science University of Chinese Academy of SciencesBeijing 100049China shanghai Institute of technical Physics Chinese Academy of SciencesShanghai 200083China North Night Vision technology co. LTDNanjing 211106China Institute of High Energy Physics Chinese Academy of SciencesBeijing 100049China science and technology on Low-Light-Level Night Vision Laboratory Xi'an 710065China Innovation Academy for Microsatellites Chinese Academy of SciencesShanghai 201204China Institute of Electrical Engineering Chinese Academy of ScienceBeijing 100190China National space science center Chinese Academy of ScienceBeijing 100190China

the Lobster Eye Imager for Astronomy(LEIA),a pathfinder of the Wide-field X-ray telescope of the Einstein Probe mission,was successfully launched onboard the sAtech-01 satellite of the chinese Academy of sciences on2022 July *** this paper,we introduce the design and on-ground test results of the LEIA *** stateof-the-art Micro-Pore Optics(MPO),a wide field of view of 346 square degrees(18.6°×18.6°)of the X-ray imager is *** optical assembly composed of 36 MPO chips is used to focus incident X-ray photons,and four large-format complementary metal-oxide semiconductor(cMOs)sensors,each of size 6 cm×6 cm,are used as the focal plane *** instrument has an angular resolution of 4’-8’(in terms of FWHM)for the central focal spot of the point-spread function,and an effective area of 2-3 cm^(2) at 1 keV in essentially all the directions within the field of *** detection passband is 0.5-4 keV in soft X-rays and the sensitivity is2-3×10^(-11) erg s^(-1) cm^(-2)(about 1 millicrab)with a 1000 s *** total weight of LEIA is 56 kg and the power is 85 *** satellite,with a design lifetime of 2 yr,operates in a sun-synchronous orbit of 500 km with an orbital period of 95 *** is paving the way for future missions by verifying in flight the technologies of both novel focusing imaging optics and cMOs sensors for X-ray observation,and by optimizing the working setups of the instrumental *** addition,LEIA is able to carry out scientific observations to find new transients and to monitor known sources in the soft X-ray band,albeit with limited useful observing time available.

关键词： instrumentation detectors-space vehicles instruments-telescopes-X-rays genera

Observation of the Y(4230)and a new structure in e^(+)e^(-)→K^(+)K^(-)J/Ψ

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chinese Physics c 2022年第11期46卷 7-21页

作者：麦迪娜 M.N.Achasov P.Adlarson M.Albrecht R.Aliberti A.Amoroso 安美儒安琪白旭红白羽 O.bakina R.baldini Ferroli I.balossino 班勇 V.batozskaya D.becker K.begzsuren N.berger M.bertani D.bettoni F.bianchi J.bloms A.bortone I.boyko R.A.briere A.brueggemann 蔡浩蔡啸 A.calcaterra 曹国富曹宁 s.A.cetin 常劲帆常万玲 G.chelkov 陈琛陈刚陈和生陈玛丽陈申见 t.chen 陈旭荣 X.t.chen 陈元柏陈卓俊成伟帅初晓 G.cibinetto F.cossio 崔佳佳代洪亮代建平 A.Dbeyssi R.Ede boer D.Dedovich 邓子艳 A.Denig I.Denysenko M.Destefanis F.De Mori 丁勇董静董燎原董明义董翔杜书先 P.Egorov 范玉兰方建房双世方文兴方易 R.Farinelli L.Fava F.Feldbauer G.Felici 封常青冯俊华 K.Fischer M.Fritsch c.Fritzsch 傅成栋高涵高原宁高扬 s.Garbolino I.Garzia 葛潘婷耿聪 E.M.Gersabeck A Gilman K.Goetzen 龚丽龚文煊 W.Gradl M.Greco 顾旻皓关春懿郭爱强郭立波郭如盼郭玉萍 A.Guskov 韩婷婷韩文颖郝喜庆 F.A.Harris 何凯凯何康林 F.H.Heinsius c.H.Heinz 衡月昆 c.Herold M.Himmelreich t.Holtmann 侯国一侯颖锐侯治龙胡海明 J.F.Hu 胡涛胡誉黄光顺黄凯旋黄麟钦黄麟钦黄性涛黄燕萍 Z.Huang t.Hussain N Hüsken W.Imoehl M.Irshad J.Jackson s.Jaeger s.Janchiv Q.Ji 姬清平季晓斌季筱璐吉钰瑶贾泽坤姜侯兵姜赛赛江晓山 Y.Jiang 焦健斌焦铮金山金毅荆茂强 t.Johansson N.Kalantar-Nayestanaki 康晓珅 R.Kappert M.Kavatsyuk 柯百谦 I.K.Keshk A.Khoukaz P.Kiese R.Kiuchi R.Kliemt L.Koch O.b.Kolcu b.Kopf M.Kuemmel M.Kuessner A.Kupsc W.Kühn J.J.Lane J.s.Lange P.Larin A.Lavania L.Lavezzi 雷祚弘 H.Leithoff M.Lellmann t.Lenz 李聪李翠李春花李澄李德民李飞李刚李贺 H.Li 李海波李惠静 H.N.Li J.Q.Li 李静舒李井文李科 L.J Li 李龙科李蕾李明浩李培荣李素娴栗帅迎李腾李卫东李卫国李旭红李晓玲李晓宇李紫源梁浩梁昊梁浩梁勇飞梁羽铁廖广睿廖龙洲 J.Libby A.Limphirat c.X.Lin 林德旭 t.Lin 刘北江刘春秀 D.Liu 刘福虎刘芳刘峰 G.M.Liu H.Liu 刘怀民刘欢欢刘汇慧刘建北刘佳俊刘晶译刘凯刘魁勇刘珂刘亮刘美宏刘佩莲刘倩刘树彬刘桐刘维克刘卫民刘翔刘英刘玉斌刘振安刘智青娄辛丑卢飞翔吕海江吕军光陆小玲卢宇卢云鹏卢泽辉罗成林罗民兴罗涛罗小兰吕晓睿吕翌丰马凤才马海龙马连良马明明马秋梅马润秋马瑞廷马骁妍马尧 FEMaas M.Maggiora s.Maldaner s.Malde Q.A.Malik A.Mangoni 冒亚军毛泽普 s.Marcello 孟召霞 J.G.Messchendorp G.Mezzadri H.Miao 闵天觉 R.E.Mitchell 莫晓虎 N.Yu.Muchnoi H.Muramatsu Y.Nefedov F.Nerling I.b.Nikolaev 宁哲 s.Nisar 牛艳 s.L.Olsen 欧阳群 s.Pacetti 潘祥 Y.Pan A.Pathak A.Pathak M.Pelizaeus 彭海平 K.Peters J.Pettersson 平加伦平荣刚 s.Plura s.Pogodin R.Poling V.Prasad 齐法制齐航漆红荣祈鸣齐天钰钱森钱文斌钱圳乔从丰秦佳佳秦丽清覃潇平秦小帅秦中华邱进发屈三强 s.Q.Qu Institute of High Energy Physics Beijing 100049China beihang University Beijing 100191China beijing Institute of Petrochemical technology Beijing 102617China bochum Ruhr-University D-44780 BochumGermany carnegie Mellon University PittsburghPennsylvania 15213USA central china Normal University Wuhan 430079China china center of Advanced science and technology Beijing 100190China cOMsAts University Islamabad Lahore CampusDefence RoadOff Raiwind Road54000 LahorePakistan Fudan University Shanghai 200433China G.I.budker Institute of Nuclear Physics sb RAs(bINP) Novosibirsk 630090Russia GsI Helmholtzcentre for Heavy Ion Research GmbH D-64291 DarmstadtGermany Guangxi Normal University Guilin 541004China Hangzhou Normal University Hangzhou 310036China Helmholtz Institute Mainz Staudinger Weg 18D-55099 MainzGermany Henan Normal University Xinxiang 453007China Henan University of science and technology Luoyang 471003China Henan University of technology Zhengzhou 450001China Huangshan college Huangshan 245000China Hunan Normal University Changsha 410081China Hunan University Changsha 410082China Indian Institute of technology Madras Chennai 600036India Indiana University BloomingtonIndiana 47405USA INFN Laboratori Nazionali di Frascati INFN Laboratori Nazionali di FrascatiI-00044FrascatiItaly INFN Laboratori Nazionali di Frascati INFN Sezione di PerugiaI-06100PerugiaItaly INFN Laboratori Nazionali di Frascati University of PerugiaI-06100PerugiaItaly INFN sezione di Ferrara INFN Sezione di FerraraI-44122FerraraItaly INFN sezione di Ferrara University of FerraraI-44122FerraraItaly Institute of Modern Physics Lanzhou 730000China Institute of Physics and technology Peace Ave.54BUlaanbaatar 13330Mongolia Jilin University Changchun 130012China Johannes Gutenberg University of Mainz Johann-Joachim-Becher-Weg 45D-55099 MainzGermany Joint Institute for Nuclear Research 141980 DubnaMoscow regionRussia Justus-Liebig-Universitaet Giessen II.Physikalisches InstitutHeinrich-Buff-Ring 16

the cross sections of e^(+)e^(-)→K^(+)K^(-)J/Ψat center-of-mass energies from 4.127 to 4.600 GeV are measured based on 15.6 fb-1data collected with the bEsⅢ detector operating at the bEPcⅡ storage *** resonant structures are observed in the line shape of the cross *** mass and width of the first structure are measured to be(4225.3±2.3±21.5)MeV and(72.9±6.1±30.8)MeV,*** are consistent with those of the established Y(4230).the second structure is observed for the first time with a statistical significance greater than 8σ,denoted as Y(4500).Its mass and width are determined to be(4484.7±13.3±24.1)MeV and(111.1±30.1±15.2)MeV,*** first presented uncertainties are statistical and the second ones are *** product of the electronic partial width with the decay branching fractionΓ(Y(4230)→e^(+)e^(−))b(Y(4230)→K^(+)K^(−)J/Ψ)is reported.

关键词： Y states charmonium-like states bEsⅢ

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中国优生与遗传杂志 2024年第5期32卷 979-985页

作者：郑吉卡闫露露薛江阳李海波吴菱陈圆玲狄亚珍宁波市妇女儿童医院/宁波大学附属妇女儿童医院儿科浙江宁波315012 宁波市妇女儿童医院出生缺陷综合防治中心浙江宁波315012 宁波市胎儿源性疾病重点实验室浙江宁波315012

目的探讨1个NF-κb相关b细胞增殖和t细胞失能性疾病(bENtA)家系遗传学病因,总结其临床特征与基因变异的特点。方法选取2022年3月3日就诊于宁波市妇女儿童医院的1个bENtA家系作为研究对象,收集该家系患者的临床资料,进行全外显子组测序(W... 详细信息

目的探讨1个NF-κb相关b细胞增殖和t细胞失能性疾病(bENtA)家系遗传学病因,总结其临床特征与基因变异的特点。方法选取2022年3月3日就诊于宁波市妇女儿童医院的1个bENtA家系作为研究对象,收集该家系患者的临床资料,进行全外显子组测序(WEs),对候选的基因变异进行sanger测序验证,并进行系统的文献综述。结果患儿表现为淋巴结大、脾大、反复呼吸道感染、关节痛、皮肤紫癜等。其父亲脾大,多处淋巴结大,易呼吸道感染。WEs检测提示患儿携带cARD11基因杂合变异c.368G>A(***123Asp),sanger测序验证证实该变异遗传自父亲,致病变异在家系中共分离。根据美国医学遗传学与基因组学学会(AcMG)相关指南,c.368G>A评级为疑似致病性变异(Ps2+PM2_supporting+PM5)。结论cARD11基因的c.368G>A(***123Asp)变异可能是患儿及其父亲的遗传学病因。上述发现丰富了cARD11基因的表型谱。临床上有b淋巴细胞增多、脾大、反复呼吸道感染的患者需警惕bENtA病,进行基因检测确诊。

关键词： cARD11基因 NF-κb相关b细胞增殖和t细胞失能性疾病全外显子组测序 b淋巴细胞增多

P21-activated kinase 1 (PAK1)-mediated cytoskeleton rearrangement promotes sARs-coV-2 entry and AcE2 autophagic degradation

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signal transduction and targeted therapy 2023年第11期8卷 5353-5367页

作者： Ming Liu bingtai Lu Yue Li shuofeng Yuan Zhen Zhuang Guangyu Li Dong Wang Liuheyi Ma Jianheng Zhu Jinglu Zhao chris chung-sing chan Vincent Kwok-Man poon Kenn Ka-Heng chik Zhiyao Zhao Huifang Xian Jingxian Zhao Jincun Zhao Jasper Fuk-Woo chan Yuxia Zhang Guangzhou Institute of Pediatrics Guangzhou Women and Children's Medical CentreState Key Laboratory of Respiratory DiseasesGuangzhou Medical University510623 GuangzhouGuangdongChina Medical Research Institute Guangdong Provincial People's Hospital(Guangdong Academy of Medical Sciences)Southern Medical UniversityGuangdongChina state Key Laboratory of Emerging Infectious Diseases Carol Yu Centre for InfectionDepartment of MicrobiologySchool of Clinical MedicineLi Ka Shing Faculty of MedineThe University of Hong KongPokfulamHong KongChina Department of clinical Microbiology and Infection control The University of Hong Kong Shenzhen HospitalShenzhenGuangdongChina centre for Virology Vaccinology and TherapeuticsHong Kong Science and Technology ParkHong KongChina state Key Laboratory of Respiratory Disease National Clinical Research Center for Respiratory DiseaseGuangzhou Institute of Respiratory Healththe First Affliated Hospital of Guangzhou Medical UniversityGuangzhouChina the third Afliated Hospital of Zhengzhou University 450052 ZhengzhouChina Guangzhou Laboratory GuangzhouGuangdong ProvinceChina chongqing International Institute for Immunology ChongqingChina

severe acute respiratory syndrome coronavirus 2(sARs-coV-2),the causative agent of coronavirus disease 2019(cOVID-19),has had a significant impact on healthcare systems and economies *** continuous emergence of new viral strains presents a major challenge in the development of effective antiviral *** that possess broad-spectrum antiviral activities are desirable to control sARs-coV-2 ***2,an angiotensin-containing enzyme that prevents the overactivation of the renin angiotensin system,is the receptor for ***2 interacts with the spike protein and facilitates viral attachment and entry into host ***,sARs-coV-2 infection also promotes AcE2 *** restoring AcE2 surface expression has an impact on sARs-coV-2 infection is yet to be ***,we show that the AcE2-spike complex is endocytosed and degraded via autophagy in a manner that depends on clathrin-mediated endocytosis and PAK1-mediated cytoskeleton *** contrast,free cellular spike protein is selectively cleaved into s1 and s2 subunits in a lysosomal-dependent ***,we show that the pan-PAK inhibitor FRAX-486 restores AcE2 surface expression and suppresses infection by different sARs-coV-2 ***-486-treated syrian hamsters exhibit significantly decreased lung viral load and alleviated pulmonary inflammation compared with untreated *** summary,our findings have identified novel pathways regulating viral entry,as well as therapeutic targets and candidate compounds for controlling the emerging strains of sARs-coV-2 infection.

关键词： AcE2 inflammation rearrangement

不同年龄患者早期复极综合征的动态心电图特征比较

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中国当代医药 2024年第5期31卷 52-54,59页

作者：陈思维郭玲刘娟谷建峰赖小娣杨艳敏江西省萍乡市人民医院心电图室江西萍乡337000

目的探究不同年龄患者早期复极综合征的动态心电图特征。方法选取2020年1月至2022年1月萍乡市人民医院收治的100例早期复极综合征(ERs)患者为研究对象,根据不同年龄分为A组(45岁,n=32)。三组患者均行动态心电图检查,并行心率变异性(HRV... 详细信息

目的探究不同年龄患者早期复极综合征的动态心电图特征。方法选取2020年1月至2022年1月萍乡市人民医院收治的100例早期复极综合征(ERs)患者为研究对象,根据不同年龄分为A组(b组(18~45岁,n=38)和c组(>45岁,n=32)。三组患者均行动态心电图检查,并行心率变异性(HRV)分析。比较三组各项参数包括HRV指标、J波出现的导联情况、st改变程度及参数之间的差异。结果b组和c组的标准差(sDNN)、均值标准差(sDANN)、差值的均方根(rMssD)和差值>50 ms的百分比(PNN50)、极低频(VLF)、低频(LF)、高频(HF)、LF/HF均低于A组,差异有统计学意义(Pb组和c组V2~V3高于A组,V4~V5低于A组,b组的Ⅱ、Ⅲ、aVF低于A组,c组的Ⅱ、Ⅲ、aVF高于A组,差异有统计学意义(Pb组和c组st段抬高距离高于A组,且Q-t离散度高于A组,差异有统计学意义(Ps患者的动态心电图特征存在一定差异,且监测动态心电图对判断ERs患者的预后及评估病情严重程度有重要意义,从不同角度为ERs的临床监测提供新的理论依据,正确评估疾病的进展及预后,对指导临床治疗具有重要意义。

关键词：早期复极综合征动态心电图年龄

日光诱导的人类免疫抑制作用最初由UVb、然后由UVA、最后由两者相互作用的效应引起

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世界核心医学期刊文摘（皮肤病学分册） 2006年第8期2卷 16-17页

作者： poon t.s.c. barnetson R.st.c. Halliday G.M. 任建文 University of sydney DermatologyResearch Laboratories Blackburn Building DO6 Sydney NSW 2006 Australia Prof.

solar- simulated ultraviolet radiation (ssUV) suppresses immunity in humans. the ultraviolet b (UVb) waveband is recognized as immunosuppressive; however the relative significance of UVA to ssUV immunosuppression is unknown. We created dose and time-response curves for UVb-, UVA-, and ssUV-induced suppression of memory immunity to nickel in humans. UVb caused immunosuppression within 24 h. UVA immunosuppression required 48 h and was normalized by 72 h. UVb alone accounts for ssUV immunosuppression at 24 h, but both UVb and UVA contributed at 48 h. by 72 h neither waveband accounted for ssUV immunosuppression. An interaction between these wavebands was therefore the major contributor. to confirm this dose-response curves were used to determine immune protection factors (IPF) for sunscreens with nickel challenge 72 h following ssUV. A sunscreen with good UVA protection had an IPF twice that of a poor UVA protector, despite providing similar protection from sunburn. thus UVA was a major contributor to ssUV-induced immunosuppression at 72 h but only with the cooperation of UVb. Hence, UVb initiates immunosuppressive signals within 24 h, followed by UVA at 48 h, then an interaction between UVb and UVA. by 72 h following ssUV exposure, neither UVb nor UVA, but an interaction between them is the major cause of sunlight-induced immunosuppression.

关键词：免疫抑制作用 UVA 相互作用 UVb 人类光诱导紫外线照射量效曲线防护作用