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色谱 2017年第10期35卷 1042-1047页

作者： CHEUK Man-Yung LO Yun-Chuen poon wing-tat Department of Pathology Pamela Youde Nethersole Eastern Hospital

The measurement of urine catecholamine and metanephrine concentrations is important for biochemical screening and diagnosis of *** goal of this work was to develop a simple liquid chromatography-tandem mass spectrometry(LC-MS/MS)method for determining catecholamines and metanephrines in urine to replace an existing liquid chromatographic method using electrochemical *** samples were prepared using Oasis weak-cation-exchange *** eluate was analyzed on an Agilent ZORBAX Eclipse Plus Phenyl-Hexyl column in 3 ***,noradrenaline,dopamine,metanephrine,normetanephrine,and their deuterated internal standards were monitored in positive electrospray ionization mode by multiple reaction monitoring(MRM).No evidence of ion suppression was *** assay was linear up to 5μmol/L for adrenaline,5μmol/L for noradrenaline,6.1μmol/L for dopamine,5.6μmol/L for metanephrine,and 34.6μmol/L for normetanephrine,with lower limits of quantification of 5,5,12,6 and 7nmol/L,*** intra-day and inter-day precisions for all analytes ranged from 0.59%to 4.64%and1.98%to 4.80%,*** quality assurance samples were assayed and showed excellent agreement with the target *** simple method provides an improved assay for determining urine catecholamines and metanephrines.

关键词： liquid chromatography-tandem mass spectrometry (LC-MS/MS) metanephrines catecholamines pheochromocytoma urine

The impact of family history of hepatocellular carcinoma on its patients' survival

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Hepatobiliary & Pancreatic Diseases International 2012年第2期11卷 160-164页

作者： wing Chiu Dai Sheung tat Fan Tan To Cheung Kenneth SH Chok Albert CY Chan Simon HY Tsang Ronnie TP poon Chung Mau Lo Department of Surgery The University of Hong Kong 102 Pokfulam Road Hong Kong China State Key Laboratory for Liver Research The University of Hong Kong 102 Pokfulam Road Hong Kong China

BACKGROUND:Family history of hepatocellular carcinoma(HCC) has been identified as a risk factor for the development of the *** aim of this study is to evaluate the impact of such a history on HCC patients’ ***:Data of all HCC patients(n=4532) managed at our center from 1989 to 2008 were prospectively *** patients were quizzed on their various characteristics including family HCC ***:Totally 475(10.48%) patients had a family history of *** presented the disease at a significantly earlier age(median 53 vs 59 years,P<0.0001) and at an earlier stage(the United Network for Organ Sharing staging system).They had significantly better liver function in terms of ChildPugh classification and serum albumin and bilirubin *** more of them presented the disease without symptoms(44.0% vs 29.4%,P<0.0001).They also had significantly better overall survival under these specifications:patients in the whole study cohort,patients who had minor hepatectomy,patients with stage I disease,patients with stage II disease,and patients with stage III ***:Contrary to what is generally believed,we found in this study cohort that patients with a family history of HCC had better overall survival than those without such a *** believe this was in part due to earlier diagnosis of the disease and better liver function in this group of ***,the effects of genetic factors on the risk of HCC cannot be overlooked and are yet to be identified.

关键词： hepatocellular carcinoma family history resection survival risk factor

Pancreaticoduodenectomy with vascular reconstruction for adenocarcinoma of the pancreas with borderline resectability

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World Journal of Gastroenterology 2014年第46期20卷 17448-17455页

作者： Tan To Cheung Ronnie TP poon Kenneth SH Chok Albert CY Chan Simon HY Tsang wing Chiu Dai See Ching Chan Sheung tat Fan Chung Mau Lo Department of Surgery Queen Mary HospitalUniversity of Hong Kong

AIM: To analyze whether pancreaticoduodenectomy with simultaneous resection of tumor-involved vessels is a safe approach with acceptable patient survival.

关键词： Adjuvant therapy Head of pancreas Liver transplant Morbidity Mortality Portal vein resection Survival analysis Whipple operation

Effects of length alteration of OPE-containing mono- and dinuclear alkynylplatinum(II) terpyridine complexes on photophysical, structural and morphological properties

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Nano Research 2024年第10期17卷 8893-8903页

作者： Jason Koon-Lam poon Sammual Yu-Lut Leung Eric Ka-Ho Wong Vivian wing-Wah Yam Institute of Molecular Functional Materials State Key Laboratory of Synthetic Chemistry and Department of ChemistryThe University of Hong KongHong Kong 999077China

A series of mononuclear complexes and unsymmetric dinuclear alkynylplatinum(II)terpyridine complexes with oligo(paraphenylene ethynylene)(OPE)-derived backbone with a variation of the lengths of alkoxy chains and OPE backbones was *** morphological properties,packing lattice and gelation behaviors of the mononuclear complexes were systematically studied,and the thermodynamic parameters and packing lattices of the dinuclear complexes were also investigated,providing further insights into the roles of the non-covalent interactions and their delicate balance in constructing sophisticated supramolecular *** and nanotube formation have been observed upon a delicate control of the intermolecular interactions by altering the lengths and structural dimensions of the complexes.

关键词： supramolecular chemistry self-assembled nanostructures platinum(II)complexes metallogel

Contribution of molecular cladistics to the taxonomy of Rutaceae in China

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Journal of Systematics and Evolution 2009年第2期47卷 144-150页

作者： Paul Pui-Hay BUT Alice wing-Sem poon Pang-Chui SHAW Mark P.SIMMONS Harald GREGER Department of Biology Chinese University of Hong Kong Department of Biochemistry Chinese University of Hong Kong Department of Biology Colorado State UniversityFort Collins Comparative and Ecological Phytochemistry Faculty Center of BotanyUniversity of Vienna

The treatment of Rutaceae in the Chinese flora chose to follow Engler in recognizing Rutoideae and Toddalioideae as two separate *** and chemical comparisons,however,suggested group-ing those two subfamilies in one subfamily,*** move has received support from molecular phyloge-netic analyses,which also showed that the Chinese taxa in Euodia should be placed in Tetradium and Melicope following *** into the chemistry and molecular phylogeny of Murraya also indicated that the species in the section Bergera without yuehchukene should be removed from *** findings clearly show the value of molecular cladistics to the taxonomy of Rutaceae in China and also directions for further inves-tigations.

关键词： Bergera Euodia Melicope Murraya Rutaceae Rutoideae Tetradium Toddalioideae

Improved anterior hepatic transection for isolated hepatocellular carcinoma in the caudate

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Hepatobiliary & Pancreatic Diseases International 2014年第2期13卷 219-222页

作者： TanTo Cheung WaiKey Yuen Ronnie TP poon SeeChing Chan Sheung tat Fan Chung Mau Lo Department of Surgery The University of Hong Kong Department of Surgery State Key Laboratory for Liver Research The University of Hong Kong

BACKGROUND: One of the best treatments for isolated hepatocellular carcinoma in the caudate lobe is major hepatectomy with caudate lobectomy, but it is not suitable for patients with poor liver function reserve. Isolated caudate lobectomy, which is a very difficult operation, is thus an alternative ***: Here we report an isolated caudate lobectomy with an anterior approach in the treatment of a large hepatocellular carcinoma with underlying cirrhosis, with focus on the technical ***: In the operation, both the left and right lobes of the liver were mobilized. Hepatotomy was done along the round ligament where parenchymal transection was minimal. After exposure of the left and middle hepatic veins and the hilar plate the caudate lobe and the tumor were resected en bloc with a5-mm ***: Isolated caudate lobectomy can be performed safely with this anterior approach on patients with poor liver function reserve.

关键词： hepatocellular carcinoma hepatectomy liver cirrhosis

Velocity variation of internal shock waves in gamma ray bursts: Observational properties

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Science China(Physics,Mechanics & Astronomy) 2006年第4期49卷 505-512页

作者： poon Helen Astronomy Department Beijing Normal University

The work uses the data in the TTS mode of BATSE to analyze the time lags and pulse widths of GRB960113 and GRB960722 in high as well as low energy bands. The results show that their time lags increase monotonously. This phenomenon can reasonably be interpreted with the model of internal shock waves of γ-ray bursts (GRB). Perhaps we obtain the direct observational evidence for the fireball model of GRBs for the first time.

关键词： GRB, time lag, shock wave.

Heterogeneous Cu_(x)O Nano‑Skeletons from Waste Electronics for Enhanced Glucose Detection

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Nano-Micro Letters 2024年第11期16卷 554-568页

作者： Yexin Pan Ruohan Yu Yalong Jiang Haosong Zhong Qiaoyaxiao Yuan Connie Kong Wai Lee Rongliang Yang Siyu Chen Yi Chen wing Yan poon Mitch Guijun Li Center on Smart Manufacturing Division of Integrative Systems and DesignThe Hong Kong University of Science and TechnologyClear Water BayKowloonHong Kong SAR 999077People’s Republic of China The Sanya Science and Education Innovation Park of Wuhan University of Technology Sanya 572000People’s Republic of China State Key Laboratory of New Textile Materials and Advanced Processing Technologies Wuhan Textile UniversityWuhan 430200People’s Republic of China

Electronic waste(e-waste)and diabetes are global challenges to modern ***,solving these two challenges together has been challenging until ***,we propose a laser-induced transfer method to fabricate portable glucose sensors by recycling copper from *** bring up a laser-induced full-automatic fabrication method for synthesizing continuous heterogeneous Cu_(x)O(h-Cu_(x)O)nano-skeletons electrode for glucose sensing,offering rapid(tates gluconolactone *** glucose detection device has also been downsized to optimize its scalability and portability for convenient integration into people’s everyday lives.

关键词： Copper oxide Electron 3D tomography E-waste Glucose detection Electrochemical activation

High-intensity focused ultrasound ablation:An effective bridging therapy for hepatocellular carcinoma patients

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World Journal of Gastroenterology 2013年第20期19卷 3083-3089页

作者： Tan To Cheung Sheung tat Fan See Ching Chan Kenneth SH Chok Ferdinand SK Chu Caroline R Jenkins Regina CL Lo James YY Fung Albert CY Chan William W Sharr Simon HY Tsang wing Chiu Dai Ronnie TP poon Chung Mau Lo Department of Surgery the University of Hong Kong State Key Laboratory for Liver Research the University of Hong Kong Department of Diagnostic Radiology the University of Hong Kong Department of Anaesthesiology The University of Hong Kong Department of Pathology the University of Hong Kong Department of Medicine the University of Hong Kong

AIM:To analyze whether high-intensity focused ultrasound(HIFU) ablation is an effective bridging therapy for patients with hepatocellular carcinoma(HCC).METHODS:From January 2007 to December 2010,49 consecutive HCC patients were listed for liver transplantation(UCSF criteria).The median waiting time for transplantation was 9.5 ***-nine patients received transarterial chemoembolization(TACE) as a bringing therapy and 16 patients received no treatment before *** patients received HIFU ablation as a bridging *** five patients with the same tumor staging(within the UCSF criteria) who received HIFU ablation but not on the transplant list were included for *** were comparable in terms of Child-Pugh and model for end-stage liver disease scores,tumor size and number,and cause of ***:The HIFU group and TACE group showed no difference in terms of tumor size and tumor *** patient in the HIFU group and no patient in the TACE group had gross *** median hospital stay was 1 d(range,1-21 d) in the TACE group and two days(range,1-9 d) in the HIFU group(P < 0.000).No HIFU-related complication *** the HIFU group,nine patients(90%) had complete response and one patient(10%) had partial response to the *** the TACE group,only one patient(3%) had response to the treatment while 14 patients(48%) had stable disease and 14 patients(48%) had progressive disease(P = 0.00).Seven patients in the TACE group and no patient in the HIFU group dropped out from the transplant waiting list(P = 0.559).CONCLUSION:HIFU ablation is safe and effective in the treatment of HCC for patients with advanced *** may reduce the drop-out rate of liver transplant candidate.

关键词： Ablation Bridging therapy Cirrhosis Hepatocellular carcinoma High-intensity focused ultrasound Liver transplant New technology

Quality Control of Recycled Aggregates Derived from Construction and Demolition Wastes

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四川大学学报（工程科学版） 2009年第3期41卷 248-257页

作者： poon Chi-sun KOU Shi-cong Dept. of Civil and Structural Engineering the Hong Kong Polytechnic Univ. Hung Horn Kowloon Hong Kong

In 2007,over 24 million tons of Construction and Demolition(C&D) wastes were generated in Hong *** the local landfills will be saturated in about 6 years,it is important to find a viable way to reuse these waste materials as to alleviate the demand on public fill *** order to tackle the problem,the Hong Kong government has set up a temporary recycling facility in Hong Kong in 2002 for producing different sizes of recycled aggregate for use in various construction *** Hong Kong Polytechnic University has been studying the feasible use of recycled aggregates in Hong Kong for a number of years.A substantial amount of experimental results on the properties of recycled aggregates and the effect of recycled aggregates on the properties of concrete and other construction products(*** blocks and granular sub-base) has been *** this paper,the experience of Hong Kong in using recycled aggregates are summarized and a set of quality control guidelines proposed for governing the use of recycled aggregates in Hong Kong is *** experience and guidelines may also be useful for the recycling of waste materials derived from the recent Sichuan earthquake in China.

关键词：建筑物工程质量抗震设计建筑结构