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SARS Vaccine:Progress and Challenge

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Cellular & Molecular Immunology 2005年第2期2卷 101-105页

作者： YanZhi JamesM.wilson HaoShen GeneTherapyProgram DivisionofMedicalGeneticsDepartmentofMedicineUniversityofPennsylvaniaHealthSystemPhiladelphiaPA19104USA DepartmentofMicrobiology SchoolofMedicineUniversityofPennsylvaniaPhiladelphiaPA19104USA

Severe acute respiratory syndrome(SARS)emerged in 2002 as a severe and highly contagious infectious disease that rapidly spread to a number of different *** collaborative efforts of the global scientific community have provided,within a short period of time,substantial insights into the molecular biology and immunology of *** the outbreak has been contained,there is continuous concern that the virus may resurface into the human population through seasonal changes,animal reservoirs or laboratory *** severe morbidity and mortality associated with SARS make it imperative that an effective vaccine be developed to prevent reemergence and epidemics in the *** & Molecular Immunology.2005;2(2):101-105.

关键词： SARS vaccine animal model immune response coronavirus emerging infection

Cosmic Wireless Power Transfer System and the Equation for Everything E=mc^(2)=vc^(2)/60=a^(3)/T=G(M_(1)+M_(2))/4π^(2)=(KE+PE)/1.0E15=Q=pa|F=λ/hc=1/2q=VI=1/2LI^(2)=1/2CV=I^(2)R=…

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Journal of High Energy Physics, Gravitation and Cosmology 2018年第4期4卷 588-650页

作者： Greg poole Industrial Tests Inc.RocklinCAUSA

By representing the Earth as a rotating spherical antenna several historic and scientific breakthroughs are *** the Sun as a transmitter and the planets as receivers the solar system can be represented as a long wave radio system operating at Tremendously Low Frequency(TLF).Results again confirm that the“near-field”is Tesla’s“dynamic gravity”,better known to engineers as dynamic braking or to physicists as centripetal acceleration,or simply(g).Timewave theory is invented,and the relationship of reflected timewaves and time travel explored.A new law of the Sun is proposed as well as the merging of Einstein’s equation with acoustics and cosmic superstring theory.A new law of cosmic efficiency is also proposed that equates vibratory force and pressure with volume acceleration of the solar *** force is broken down into centripetal and gravitational ***-dimensional cosmic superstring theory is espoused versus the aging three-dimensional Maxwellian *** antenna patterns for planets are presented and flux transfer frequency is calculated using distance to planets as *** galactic grid operates at a Schumann Resonance of 7.83 Hz,which is derived from the science of dark energy and dark *** Sun and the planets are tuned to transmit and receive electrical power like resonating Tesla *** Earth’s stator winding has been modeled as a toroid tesla coil and the armature as a spherical *** equation for everything is born.

关键词： Cosmic Efficiency Equation for Everything Flux Transfer Events Inductive Coupling Spherical Antenna Time Wave Velocity-Energy Equivalence Wireless Power Transfer

与时俱进:冠心病治疗指南的新思考——明确长效钙通道阻滞剂在冠心病治疗中的地位

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世界核心医学期刊文摘（心脏病学分册） 2005年第7期1卷 1-3页

作者： Philip A.poole wilson 世界心脏联盟

慢性稳定型心绞痛的治疗——近期试验的临床意义

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世界核心医学期刊文摘（心脏病学分册） 2005年第8期1卷 1-3页

作者： Philip A.poole-wilson 世界心脏联盟

A note on quantum odometers

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Science China Mathematics 2023年第7期66卷 1555-1568页

作者： Slawomir Klimek Matt McBride J.wilson Peoples Department of Mathematical Sciences Indiana University-Purdue University IndianapolisIndianapolisIN46202USA Department of Mathematics and Statistics Mississippi State UniversityMississippi StateMS 39762USA Department of Mathematics The Pennsylvania State UniversityUniversity ParkPA 16802USA

We discuss various aspects of noncommutative geometry of smooth subalgebras of Bunce-Deddens-Toeplitz algebras.

关键词： noncommutative geometry derivation smooth subalgebra K-theory

The effectiveness of a 17-week lifestyle intervention on health behaviors among airline pilots during COVID-19

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Journal of Sport and Health Science 2021年第3期10卷 333-340页

作者： Daniel wilson Matthew Driller Ben Johnston Nicholas Gill Te Huataki Waiora School of Health The University of WaikatoHamilton 3216New Zealand Faculty of Health Education and EnvironmentToi Ohomai Institute of TechnologyTauranga 3112New Zealand Sport and Exercise Science Human Services and SportLa Trobe UniversityMelbourne 3086Australia Aviation and Occupational Medicine Unit Wellington School of MedicineOtago UniversityWellington 6242New Zealand New Zealand Rugby Wellington 6011New Zealand

Purpose:The aim of this study was to evaluate the efficacy of a 17-week,3-component lifestyle intervention for enhancing health behaviors during the coronavirus disease 2019(COVID-19)***:A parallel-group(intervention and control)study was conducted amongst 79 airline pilots over a 17-week period during the COVID-19 *** intervention group(n=38)received a personalized sleep,dietary,and physical activity(pa)*** control group(n=41)received no *** measures for sleep,fruit and vegetable intake,pa,and subjective health were measured though an online survey before and after the 17-week *** changes in outcome measures were used to determine the efficacy of the ***:Significant main effects for time￡group were found for International Physical Activity Questionnaire-walk(p=0.02)and for all other outcome measures(ppa(ppa intervention elicit improvements in health behaviors and perceived subjective health in pilots and may improve quality of life during an unprecedented global pandemic.

关键词： COVID-19 Healthy eating Lifestyle health Moderate-to-vigorous physical activity Sleep

Prediction of performance and evaluation of flexible pavement rehabilitation strategies

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Journal of Traffic and Transportation Engineering(English Edition) 2017年第2期4卷 178-184页

作者： Kang-Won Wayne Lee Kathleen wilson Syed Amir Hassan Department of Civil and Environmental Engineering University of Rhode Island Kingston R1 02881 USA Rhode Island Department of Transportation Prouid-ence RI 02903 USA

Five test sections with different additives and strategies were established to rehabilitate a State-maintained highway more effectively in Rhode Island （RI）： control, calcium chloride, asphalt emulsion, Portland cement and geogrid. Resilient moduli of subgrade soils and subbase materials before and after full depth rehabilitation were employed as input pa- rameters to predict the performance of pavement structures using AASHTOWare pave- ment ME Design （pavement ME） software in terms of rutting, cracking and roughness. It was attempted to use Level i input （which includes traffic full spectrum data, climate data and structural layer properties） for pavement ME. Traffic data was obtained from a Weigh- in-Motion （WIM} instrument and Providence station was used for collecting climatic data. Volumetric properties, dynamic modulus and creep compliance were used as input pa- rameters for 19 mm （0.75 in.} warm mix asphalt （WMA） base and 12.S mm （0.5 in.） WMA surface layer. The results indicated that all test sections observed AC top-down （longitu- dinal） cracking except Portland cement section which passed for all criteria. The order in terms of performance （best to worst） for all test sections by pavement ME was Portland cement, calcium chloride, control, geogrid, and asphalt emulsion. It was also observed that all test sections passed for both bottom up and top down fatigue cracking by increasing thickness of either of the two top asphalt layers. Test sections with five different base/ subbase materials were evaluated in last two years through visual condition survey and measurements of deflection and roughness to confirm the prediction, but there was no serious distress and roughness. Thus these experiments allowed selecting the best reha- bilitation/reconstruction techniques for the particular and/or similar highway, and a framework was formulated to select an optimal technique and/or strategy for future rehabilitation/reconstruction projects. Finally, guidelines for lo

关键词： Full depth rehabilitation Resilient modulus AASHTOWare pavement ME design Surface distress

Exercise during weight loss improves hepatic mitophagy

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Sports Medicine and Health Science 2022年第3期4卷 183-189页

作者： Megan E.Rosa-Caldwell Kaylee E.poole Andrew Seija Matthew P.Harris Nicholas P.Greene Joshua S.Wooten Cacheixia Research Laboratory Exercise Science Research CenterDepartment of HealthHuman Performanceand RecreationUniversity of ArkansasFayettevilleARUSA Department of Neurology Beth Israel Deaconess Medical CenterBostonMAUSA Department of Applied Health Southern Illinois University EdwardsvilleEdwardsvilleILUSA

Non-alcoholic fatty liver disease(NAFLD)has recently become a public health concern concurrent with the obesity *** work has shown aberrant mitochondrial content/quality and autophagy in models of NAFLD,whereas exercise is known to improve these *** purpose of this study was to examine the effect of different weight-loss modalities on hepatic mitochondrial content,autophagy and mitophagy in ***-eight male C57BL/6J mice were divided into 1 of 4 groups:low fat diet(LFD,10%fat,18 weeks),high fat diet(HFD,60%fat diet,18 weeks),weight-loss by diet(D,60%fat diet for 10 weeks then 10%fat diet for 8 weeks)or weight-loss by diet and physical activity(D/pa,60%fat diet for 10 weeks,then 10%fat diet plus a running wheel for 8 weeks).Immunoblot data were analyzed by one-way analysis of variance(ANOVA)with significance denoted at ppared to LFD.D/pa had 50%more BNIP3 compared to ***1 content was 40%higher in D and D/pa compared to ***/paRKIN levels were 40%lower in HFD,D,and D/pa compared to *** p-UbSer65 was 3-fold higher in ***3II/I ratio was 50%greater in HFD and D/pa,yet p62 protein content was 2.5 fold higher in ***-fat diet causes disruptions in markers of mitochondrial quality *** activity combined with diet were able to ameliorate these derangements and seemingly improve hepatic mitochondrial quality above control values.

关键词： Autophagy High-fat diet Mitochondria Hepatic metabolism

非ST段抬高急性冠状动脉综合征介入治疗的5年结果:英国心脏基金会RITA3随机试验

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世界核心医学期刊文摘(心脏病学分册) 2006年第2期 22-23页

作者： Fox K. A. A. poole-wilson P. Clayton T. C. 孙凯 Centre for Cardiovascular Science Department of Medical and Radiological Sciences University of Edinburgh Edinburgh EH16 4SB United Kingdom Prof.

Background: The long-term outcome of an interventional strategy in patients with non-ST-elevation acute coronary syndrome is unknown. We tested whether an interventional strategy(routine angiography followed by revascularisation) was better than a conservative strategy(ischaemia-driven or symptom-driven angiography) over 5 years' follow-up. Methods: In a multicentre randomised trial, 1810 patients(from 45 hospitals in England and Scotland, UK) with non-ST-elevation acute coronary syndrome were randomly assigned to receive an early intervention(n=895) or a conservative strategy(n=915)within 48 h of the index episode of cardiac pain. In each group, the aim was to provide the best medical treatment, and also to undertake coronary arteriography within 72 h in the interventional strategy with subsequent management guided by the angiographic findings. Analysis was by intention to treat and the primary outcome(composite of death or non-fatal myocardial infarction) had masked independent adjudication. RITA 3 has been assigned the International Standard Randomised Control Trial Number ISRCTN07752711. Findings: At 1-year follow-up, rates of death or non-fatal myocardial infarction were similar. However, at a median of 5 years' follow-up(IQR 4.6-5.0), 142(16.6% ) patients with intervention treatment and 178(20.0% ) with conservative treatment died or had non-fatal myocardial infarction(odds ratio 0.78, 95% CI 0.61-0.99, p=0.044), with a similar benefit for cardiovascular death or myocardial infarction(0.74, 0.56-0.97, p=0.030). 234(102 12% intervention, 132 15% conservative) patients died during follow-up(0.76, 0.58-1.00, p=0.054). The benefits of an intervention strategy were mainly seen in patients at high risk of death or myocardial infarction(p=0.004), and for the highest risk group, the odds ratio of death or non-fatal myocardial infarction was 0.44(0.25-0.76). Interpretation: In patients with non-ST elevation acute coronary syndrome, a routine invasive strategy leads to

关键词：急性冠状动脉综合征患者 RITA3 介入治疗 ST 随机试验概率试验