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Genomic profile concordance between pancreatic cyst fluid and neoplastic tissue

World Journal of Gastroenterology 2019年第36期25卷 5530-5542页

作者： Arthur Laquière Arnaud Lagarde Bertrand Napoléon Raphael Bourdariat Alexandre Atkinson Gianfranco Donatelli Bernard pol Laurence Lecomte Laurence Curel Romina Urena-Campos Thierry Helbert Vincent Valantin Francois Mithieux Jean Pascal Buono Philippe Grandval Sylviane Olschwang Department of Gastroenterology Saint Joseph Hospital Marseille 13008 France AP-HM Timone Hospital Marseille 13005 France RGDS Clairval Hospital Marseille 13009 France Aix-Marseille Univ INSERM MMG Marseille 13385 France AP-HM Conception Hospital Marseille 13385 France RGDS Jean Mermoz Hospital Lyon 69008 France RGDS Les Peupliers Hospital Paris 75013 France Department of Digestive Surgery Saint-Joseph Hospital Marseille 13008 France Department of Clinical Research Saint Joseph Hospital Marseille 13008 France European Hospital Marseille 13003 France Pathological Anatomy and Cytology MEDIPATH Eguilles 13510 France

BACKGROUND DNA mutational analysis of pancreatic cystic fluid (CF) is a useful adjunct to the evaluation of pancreatic cysts. KRAS/GNAS or RAF/PTPRD/CTNNB1/RNF43 mutations are highly specific to precancerous or advanced neoplasia. Several studies recently demonstrated the ability of next-generation sequencing (NGS)analysis to detect DNA mutations in pancreatic CF, but few studies have performed a systematic comparative analysis between pancreatic CF and neoplastic surgical tissue (NT). The value of CF-NGS analysis indicators for determining surgical resection necessitates evaluation. AIM To confirm whether CF genomic profiles are a reliable malignancy predictor by comparing NGS mutational analyses of CF and NT. METHODS Patients requiring surgery for high-risk pancreatic cysts were included in a multicenter prospective pilot study. DNA from CF (collected by endoscopic ultrasound-guided fine needle aspiration (known as EUS-FNA)) and NT (collected by surgery) were analyzed by NGS. The primary objective was to compare the mutation profiles of paired DNA samples. The secondary objective was to correlate the presence of specific mutations (KRAS/GNAS, RAF/ PTPRD/CTNNB1/RNF43/polD1/TP53) with a final cancer diagnosis. Sensitivity and specificity were also evaluated. RESULTS Between December 2016 and October 2017, 20 patients were included in this pilot study. Surgery was delayed for 3 patients. Concordant CF-NT genotypes were found in 15/17 paired DNA, with a higher proportion of mutated alleles in CF than in NT. NGS was possible for all pancreatic CF collected by EUS-FNA. In 2 cases, the presence of a KRAS/GNAS mutation was discordant between CF and NT. No mutations were found in 3 patients with NT or pancreatic cysts with high-grade dysplasia. The sensitivity and specificity of KRAS/GNAS mutations in CF to predict an appropriate indication for surgical resection were 0.78 and 0.62, respectively. The sensitivity and specificity of RAF/PTPRD/CTNNB1 /RNF43/polD1/TP53 mutatio

关键词： Pancreatic cancer Pancreatic cystic neoplasms Pancreatic adenocarcinoma Malignancy prediction Neoplastic surgical tissue Pancreatic cystic fluid Molecular analysis Next-generation sequencing DNA mutations

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Intelligent Multi-attribute Decision Making in pol Support Based on Criteria Inference

Intelligent Multi-attribute Decision Making in POL Support B...

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2012 IEEE 3rd International Conference on Emergency Management and ManagementSciences(ICEMMS 2012)

作者： Qingzhong Zhou Department of pol Management Engineering Logistical Engineering University Chong Qing China Huie Zeng Department of Mechanical Engineering Chongqing Science and Technology College Chong Qing China

By analyzing the characteristics of the activities in pol support, the paper proposes novel multi-attribute decision making method based on criteria inference. The thresholds are used to evaluate the inaccuracies in determining the attribute’s values by means of the pseudo criterion of ELECTRE Ⅲ. The dominance attribute sets are constructed via estimating the outranking relationship between the schemes. For ranking the alternative schemes, the criterion inference is implemented using the out-ranking degree algorithm in Graph Theory. The study case shows that the proposed method could achieve multi-attribute decision making in pol support intelligently and effectively, because it has solved the problem in previous numerical models which depend on the exact numerical information gave by the decision-makers.

关键词： multiple attribute decision making criteria inference the dominance attribute set preference pol support

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实验感染Lelystad病毒引起猪的神秘病的病

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国外兽医学（畜禽传染病） 1992年第3期12卷 22-23页

作者： pol,JMA 金扩世

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Meso-American Nephropathy in El Salvador: Increasing Farmer Participation in MeN Prevention Efforts

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Occupational Diseases and Environmental Medicine 2019年第2期7卷 50-63页

作者： Keven Bermudez Carlos Orantes Montserrat León Marta Jiménez Nicole Vidal pol De Vos Institute for Global Health and Development Queen Margaret University Edinburgh UK National Health Institute Ministry of Health (MINSAL) of San Salvador San Salvador El Salvador

Objectives: This paper highlights and discusses major factors affecting Salvadoran farmers’ involvement in National Health System-led efforts to prevent MeN in El Salvador and includes some recommendations to enhance their involvement. Methods: The study, conducted in El Salvador in June 2018, involved 10 life-long farmers residing in five MeN-affected communities in Chalatenango and Usulutan Departments who were either MeN-free or MeN-controlled, to understand through semi-structured, qualitative interviews their experience of participation in broader epidemic control efforts. Complementary interviews held with two nephrology teams and a senior representative of the grassroots-level National Health Forum operating in the same area, provided necessary contrast. Interview questions were informed by reference to the Adaptation and Development after Persecution and Trauma (ADAPT) model [1] as applicable in post-conflict environments like El Salvador to analyze contextual factors influencing community participation. Findings: Farmers are scarcely involved in wider MeN prevention efforts in El Salvador despite greater National Health System emphasis on encouraging community participation since the approval of the 2009 Health Reform [2]. This study found that widespread insecurity due to gang warfare, declining family and social networks due to high murder rates and international migration, and unresolved sense of injustice over unremitting poverty are among major factors with potential destructive effect on farmer participation. Conclusions: Health system-led MeN prevention responses need to encompass attention to persisting social vulnerabilities in economically and socially marginalized communities in order to enhance farmer participation in this effort. This paper concludes with some recommendations on how this can be done.

关键词： El Salvador Meso-American Nephropathy CKDu Pesticides Dehydration Heat Stress Farmer Resilience

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高分辨率光学光刻技术——一种准分子激光片子步进机

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电子工业专用设备 1988年第1期 51-56页

作者： Victor pol 刘恩荣电子部四十五所

已研制成一种工作在248.4nm的远紫外分步重复系统,它是利用KnFK准分子激光器和常规设计的石英玻璃聚光镜与投影光路,对一种工业投产的系统进行翻新改造而成的。其5X投影镜头的最小视场尺寸为14.5mm,数值孔径为0.20到0.38可变。例行使用... 详细信息

已研制成一种工作在248.4nm的远紫外分步重复系统,它是利用KnFK准分子激光器和常规设计的石英玻璃聚光镜与投影光路,对一种工业投产的系统进行翻新改造而成的。其5X投影镜头的最小视场尺寸为14.5mm,数值孔径为0.20到0.38可变。例行使用中,该机可在全视场上获得0.5μm的特征分辨率,而在较为受限的条件下,则可达到0.35μm的分辨率。本文介绍此系统及其最新改进措施,并就短波长激光光刻所涉及的某些技术问题捉出讨论。

关键词：视场抗蚀剂特征尺寸光学光刻技术高分辨率高分辨力准分子激光器二聚物激光器

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用于橡胶制品的新型芳纶

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产业用纺织品 1999年第10期17卷 38-41页

作者： Hans van der pol Martien Peter’s Don Lyon 高称意

0 引言芳纶具有别的材料无可比拟的综合性能,所以经常成为橡胶行业选用的材料。尽管其他材料也可能在某些方面有优越的性能,但芳纶的各种性能较为平衡,综合性能优异。由于各种应用对象正对材料性能提出更高的要求,已经开发出适应这些特... 详细信息

0 引言芳纶具有别的材料无可比拟的综合性能,所以经常成为橡胶行业选用的材料。尽管其他材料也可能在某些方面有优越的性能,但芳纶的各种性能较为平衡,综合性能优异。由于各种应用对象正对材料性能提出更高的要求,已经开发出适应这些特定需求的新型号的芳纶,有应用于弹道的高强芳纶长丝,光纤用中等模量的芳纶长丝和橡胶工业用具有粘合活性的芳纶长丝。

关键词：橡胶制品芳纶长丝增强材料

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变色甲虫现形记

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小哥白尼（野生动物） 2008年第1期 38-39页

作者：龙跃 Jean pol Vigneron

吉恩天生就是当动物学家的料!这可不是吹捧他,有证据:有一种巴拿马金龟甲虫,小小的.长度只有8毫米左右,很多人都认识它,也知道它会变色——从金黄色变成红色,但却没有人对它变色的奥秘感兴趣。当然,吉恩除外!

关键词：甲虫变色动物学金黄色液体凹槽草毒外壳鲜红色发现

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Barcelona clinic liver cancer nomogram and others staging/scoring systems in a French hepatocellular carcinoma cohort

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World Journal of Gastroenterology 2017年第14期23卷 2545-2555页

作者： Xavier Adhoute Guillaume Pénaranda Jean Luc Raoul Julien Edeline Jean-Frédéric Blanc Bernard pol Manuela Campanile HervéPerrierO livier Bayle Olivier Monnet Patrick Beaurain Cyril Muller Paul Castellani Yves Patrice Le Treut Jean Pierre Bronowicki Marc Bourlière Department of Hepato-Gastroenterology Hopital Saint-Joseph Marseille Alpha Bio Laboratory Marseille Department of Hepato-Gastroenterology and Digestive Oncology Institut Paoli-Calmette Marseille Department of Hepato-Gastroenterology and Digestive Oncology Centre Eugène Marquis Rennes Department of Hepato-Gastroenterology Centre Hospitalo-Universitaire Saint-AndréBordeaux Department of Hepatobiliary Surgery Hopital Saint-Joseph Marseille Department of Radiology Hopital Saint-Joseph Marseille Department of Hepatobiliary Surgery Centre Hospitalo-Universitaire Timone Marseille Department of Hepato-Gastroenterology Centre Hospitalo-Universitaire de Nancy INSERM U954 Universitéde LorraineCHU de NancyVandoeuvre les Nancy

AIM To compare the performances of the Barcelona clinic liver cancer(BCLC) nomogram and others systems(BCLC, HKLC, CLIP, NIACE) for survival prediction in a large hepatocellular carcinoma(HCC) French *** Data were collected retrospectively from 01/2007 to 12/2013 in five French centers. Newly diagnosed HCC patients were analyzed. The discriminatory ability, homogeneity ability, prognostic stratification ability Akaike information criterion(AIC) and C-index were compared among scoring systems. RESULTS The cohort included 1102 patients, mostly men, median age 68 [60-74] years with cirrhosis(81%), child-Pugh A(73%), alcohol-related(41%), HCV-related(27%). HCC were multinodular(59%) and vascular invasion was present in 41% of cases. At time of HCC diagnosis BCLC stages were A(17%), B(16%), C(60%) and D(7%). First line HCC treatment was curative in 23.5%, palliative in 59.5%, BSC in 17% of our population. Median OS was 10.8 mo [4.9-28.0]. Each system distinguished different survival prognosis groups(P < 0.0001). The nomogram had the highest discriminatory ability, the highest C-index value. NIACE score had the lowest AIC value. The nomogram distinguished sixteen different prognosis groups. By classifying unifocal large HCC into tumor burden 1, the nomogram was less powerful. CONCLUSION In this French cohort, the BCLC nomogram and the NIACE score provided the best prognostic information, but the NIACE could even help treatment strategies.

关键词： Barcelona clinical liver cancer Hong kong liver cancer NIACE CLIP Hepatocellular carcinoma

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Tilted pulse front pumping techniques for efficient terahertz pulse generation

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Light(Science & Applications) 2023年第11期12卷 2291-2308页

作者： Gyorgy Toth Gyula polonyi Janos Hebling University of Pecs Pecs 7624Hungary Szentagothai Research Centre Pecs 7624Hungary HUN-REN-PTE High-Field Terahertz Research Group Pecs 7624Hungary

Optical rectification of femtosecond laser pulses has emerged as the dominant technique for generating single-and few-cycle terahertz(THz)*** advent of the tilted pulse front pumping(TPFP)velocity matching technique,proposed and implemented two decades ago,has ushered in significant advancements of these THz sources,which are pivotal in the realm of THz pump-probe and material control experiments,which need THz pulses with microjoule energies and several hundred kV/cm electric field ***,these THz sources are poised to play a crucial role in the realization of THz-driven particle accelerators,necessitating millijoule-level pulses with tens of MV/cm electric field *** has enabled the efficient velocity matching in lithium niobate crystals renowned for their extraordinary high nonlinear ***,its adaptation to semiconductor THz sources has resulted in a two-hundred-times enhancement in conversion *** this comprehensive review,we present the seminal achievements of the past two *** expound on the conventional TPFP setup,delineate its scaling limits,and elucidate the novel generation TPFP configurations proposed to surmount these constraints,accompanied by their preliminary ***,we provide an in-depth analysis of the THz absorption,refractive index,and nonlinear coefficient spectra of lithium niobate and widely used semiconductors employed as THz generators,which dictate their suitability as THz *** underscore the far-reaching advantages of tilted pulse front pumping,not only for LN and semiconductor-based THz sources but also for selected organic crystal-based sources and Yb-laserpumped GaP sources,previously regarded as velocity-matched in the literature.

关键词： pumping pulse realization

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Comprehensive review of telbivudine in pregnant women with chronic hepatitis B

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World Journal of Hepatology 2016年第9期8卷 452-460页

作者： Teerha Piratvisuth Guo Rong Han Stanislas pol Yuhong Dong Aldo Trylesinski Department of Medicine NKC Institute of Gastroenterology and Hepatology Prince of Songkla University Department of Gynecology and Obstetrics the Second Affiliated Hospital of the Southeast University Département d’Hépatologie Inserm USM20 Institut Pasteur AP-HP hopital Cochin Université Paris Descartes Novartis Pharma AG

AIM:To achieve an evidence-based conclusion regarding the safety and efficacy of telbivudine during ***:A pooled analysis of data from a literature search reported 1739 pregnancy outcomes(1673 live births)from 1725 non-overlapping pregnant women treated with *** prevalence of live birth defects(3.6/1000)was similar to that of the nonantiviral controls(3.0/1000)and not increased as compared with overall prevalence(14.5 to 60/1000).No target organ toxicity was *** prevalence of spontaneous abortion in pregnant women treated with telbivudine(4.2/1000)was not increased compared with the overall prevalence(16/1000).The mother-to-child transmission rate was significantly reduced in pregnant women treated with telbivudine(0.70%)compared to those treated with the non-antiviral controls(11.9%;P<0.0001)or compared to the historical rates of hepatitis B virus(HBV)-infected population without antiviral treatment(10%-15%).RESULTS:Cumulatively 489 pregnancy cases have been reported in the telbivudine pharmacovigilance database(with a cut-off date 31 August 2014),of those,308 had known pregnancy outcomes with 249 cases of live births(239 cases of live birth without congenital anomaly and 10 cases of live birth with congenital anomaly).In the latest antiretroviral pregnancy registry report(1 January 1989 through 31 January 2015)of27 patients exposed to telbivudine during pregnancy(18,6 and 3 during first,second and third trimester,respectively)19 live births were reported and there were no cases of birth defects ***:Telbivudine treatment during pregnancy presents a favorable safety profile without increased rates of live birth defects,spontaneous abortion or elective termination,or fetal/neonatal *** to telbivudine in the first,second and third trimester of pregnancy has been shown to significantly reduce the risk of HBV transmission from mother to child on the basis of standard immune prophylaxis procedure.

关键词： Telbivudine Hepatitis B virus Pregnancy Mother-to-child transmission Vertical transmission

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