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Community-centered Disease Severity Assessment of Metabolic Dysfunction-associated Fatty Liver Disease

Journal of Clinical and Translational Hepatology 2023年第5期11卷 1061-1068页

作者： Jee-Fu Huang Pei-Chien Tsai Ming-Lun Yeh Chung-Feng Huang Ching-I Huang Mei-hsuan Lee po-yau hsu Chih-Wen Wang Yu-Ju Wei po-Cheng Liang Yi-Hung Lin Meng-hsuan Hsieh Jeng-Fu Yang Ming-Yen Hsieh Tyng-Yuan Jang Ming-Jong Bair Zu-yau Lin Chia-Yen Dai Ming-Lung Yu Wan-Long Chuang Hepatobiliary Division Department of Internal MedicineKaohsiung Medical University HospitalKaohsiung Medical UniversityKaohsiung Graduate Institute of Clinical Medicine Kaohsiung Medical UniversityKaohsiung Faculty of Internal Medicine College of MedicineKaohsiung Medical UniversityKaohsiung Center for Liquid Biopsy and Cohort Research Kaohsiung Medical UniversityKaohsiung Institute of Clinical Medicine National Yang Ming Chiao Tung UniversityTaipei Department of Preventive Medicine Kaohsiung Medical University HospitalKaohsiung Division of Gastroenterology Department of Internal MedicineTaitung Mackay Memorial HospitalTaitung Mackay Medical College New Taipei City School of Medicine and Doctoral Program of Clinical and Experimental Medicine College of MedicineNational Sun Yat-sen UniversityKaohsiung Center of Excellence for Metabolic Associated Fatty Liver Disease National Sun Yat-sen UniversityKaohsiung

Background and Aims:Disease severity across the different diagnostic categories of metabolic dysfunction-associated fatty liver disease(MAFLD)remains *** study assessed the fibrosis stages and features of MAFLD between different *** also aimed to investigate the associations between advanced fibrosis and risk ***:This multicenter cross-sectional study enrolled adults participating in liver disease screening in the *** were stratified following MAFLD diagnostic criteria,to group A(395 patients)for type 2 diabetes,group B(1,818 patients)for body mass index(BMI)>23 kg/m^(2),and group C(44 patients)for BMI≤23kg/m^(2) with at least two metabolic *** fibrosis was defined as a fibrosis-4 index>***:Between 2009 and 2020,1,948 MAFLD patients were recruited,including 478 with concomitant liver *** fibrosis was observed in 125 patients.A significantly larger proportion of patients in group C(25.0%)than in group A(7.6%)and group B(5.8%)had advanced fibrosis (pportion of lean MAFLD patients with metabolic abnormalities had advanced *** infection was significantly associated with advanced fibrosis.

关键词： Metabolic dysfunction-associated fatty liver disease Fibrosis-4 index Advanced fibrosis Community screening Viral hepatitis

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Dense-Structured Network Based Bearing Remaining Useful Life Prediction System

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Computer Modeling in Engineering & Sciences 2022年第10期131卷 133-151页

作者： Ping-Huan Kuo Ting-Chung Tseng po-Chien Luan Her-Terng yau Department of Mechanical Engineering National Chung Cheng UniversityChiayi62102Taiwan Advanced Institute of Manufacturing with High-Tech Innovations(AIM-HI) National Chung Cheng UniversityChiayi62102Taiwan

This work is focused on developing an effective method for bearing remaining useful life *** method is useful in accurately predicting the remaining useful life of bearings so that machine damage,production outage,and human accidents caused by unexpected bearing failure can be *** study uses the bearing dataset provided by FEMTO-ST Institute,Besancon,*** study starts with the exploration of neural networks,based on which the biaxial vibration signals are modeled and *** paper introduces pre-processing of bearing vibration signals,neural network model training and adjustment of training *** model is trained by optimizing model parameters and verifying its performance through *** proposed model’s superiority is also confirmed through a comparison with other *** this study,the neural network model is trained with various types of bearing data and can successfully predict the remaining useful *** algorithm proposed in this study achieves a prediction accuracy of coefficient of determination as high as 0.99.

关键词： Bearing neural network remaining useful life prediction machine learning

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Ensemble Model for Spindle Thermal Displacement Prediction of Machine Tools

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Computer Modeling in Engineering & Sciences 2023年第10期137卷 319-343页

作者： Ping-Huan Kuo Ssu-Chi Chen Chia-Ho Lee po-Chien Luan Her-Terng yau Department of Mechanical Engineering National Chung Cheng UniversityChiayi62102Taiwan Advanced Institute of Manufacturing with High-Tech Innovations(AIM-HI) National Chung Cheng UniversityChiayi62102Taiwan

Numerous factors affect the increased temperature of a machine tool, including prolonged and high-intensity usage,tool-workpiece interaction, mechanical friction, and elevated ambient temperatures, among others. Consequently,spindle thermal displacement occurs, and machining precision suffers. To prevent the errors caused by thetemperature rise of the Spindle fromaffecting the accuracy during themachining process, typically, the factory willwarm up themachine before themanufacturing ***, if there is noway to understand the tool spindle’sthermal deformation, the machining quality will be greatly affected. In order to solve the above problem, thisstudy aims to predict the thermal displacement of the machine tool by using intelligent algorithms. In the practicalapplication, only a few temperature sensors are used to input the information into the prediction model for realtimethermal displacement prediction. This approach has greatly improved the quality of tool ***,each algorithm has different performances in different environments. In this study, an ensemble model is used tointegrate Long Short-TermMemory (LSTM) with Support VectorMachine (SVM). The experimental results showthat the prediction performance of LSTM-SVM is higher than that of other machine learning algorithms.

关键词： Thermal displacement ensemble model LSTM milling machine spindle

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Outreach onsite treatment with a simplified pangenotypic directacting anti-viral regimen for hepatitis C virus micro-elimination in a prison

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World Journal of Gastroenterology 2022年第2期28卷 263-274页

作者： Chun-Ting Chen Ming-Ying Lu Meng-hsuan Hsieh Pei-Chien Tsai Tsai-Yuan Hsieh Ming-Lun Yeh Ching-I Huang Yi-Shan Tsai Yu-Min Ko Ching-Chih Lin Kuan-Yu Chen Yu-Ju Wei po-Yao hsu Cheng-Ting hsu Tyng-Yuan Jang Ta-Wei Liu po-Cheng Liang Ming-Yen Hsieh Zu-yau Lin Chung-Feng Huang Jee-Fu Huang Chia-Yen Dai Wan-Long Chuang Yu-Lueng Shih Ming-Lung Yu Division of Gastroenterology and Hepatology Department of Internal MedicineTri-Service General Hospital Penghu BranchNational Defense Medical CenterPenghu County 88041Taiwan Division of Gastroenterology and Hepatology Department of Internal MedicineTri-Service General HospitalNational Defense Medical CenterTaipei 11490Taiwan Division of Hepatobiliary Department of Internal Medicine and Hepatitis CenterKaohsiung Medical University HospitalKaohsiung 80708Taiwan School of Medicine and Hepatitis Research Center College of Medicineand Center for Liquid Biopsy and Cohort ResearchKaohsiung Medical UniversityKaohsiung 80708Taiwan National Pingtung University of Science and Technology Pingtung 912Taiwan

BACKGROUND Prisoners are at risk of hepatitis C virus(HCV)infection,especially among the people who inject drugs(PWID).We implemented an outreach strategy in combination with universal mass screening and immediate onsite treatment with a simplified pan-genotypic direct-acting antivirals(DAA)regimen,12 wk of sofosbuvir/velpatasvir,in a PWID-dominant prison in *** To implement an outreach strategy in combination with universal mass screening and immediate onsite treatment with a simplified pan-genotypic DAA regimen in a PWID-dominant prison in *** HCV-viremic patients were recruited for onsite treatment program for HCV micro-elimination with a pangenotypic DAA regimen,12 wk of sofosbuvir/velpatasvir,from two cohorts in Penghu Prison,either identified by mass screen or in outpatient clinics,in September *** group of HCV-viremic patients identified sporadically in outpatient clinics before mass screening were enrolled as a control *** primary endpoint was sustained virological response(SVR12,defined as undetectable HCV ribonucleic acid(RNA)12 wk after end-of-treatment).RESULTS A total of 212 HCV-viremic subjects were recruited for HCV micro-elimination campaign;91 patients treated with sofosbuvir/Ledipasvir or glecaprevir/pibrentasvir before mass screening were enrolled as a *** HCV microelimination group had significantly lower proportion of diabetes,hypertension,hyperlipidemia,advanced fibrosis and chronic kidney diseases,but higher levels of HCV *** SVR12 rate was comparable between the HCV microelimination and control groups,95.8%(203/212)vs 94.5%(86/91),respectively,in intent-to-treat analysis,and 100%(203/203)vs 98.9%(86/87),respectively,in perprotocol *** was no virological failure,treatment discontinuation,and serious adverse event among sofosbuvir/velpatasvir-treated patients in the HCV micro-elimination *** Outreach mass screening followed by immediate onsite treatment with a simplified pange

关键词： Direct-acting antivirals Sofosbuvir Velpatasvir People who inject drugs Universal screen

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Dynamics of cytokines predicts risk of hepatocellular carcinoma among chronic hepatitis C patients after viral eradication

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World Journal of Gastroenterology 2022年第1期28卷 140-153页

作者： Ming-Ying Lu Ming-Lun Yeh Ching-I Huang Shu-Chi Wang Yi-Shan Tsai Pei-Chien Tsai Yu-Min Ko Ching-Chih Lin Kuan-Yu Chen Yu-Ju Wei po-Yao hsu Cheng-Ting hsu Tyng-Yuan Jang Ta-Wei Liu po-Cheng Liang Ming-Yen Hsieh Zu-yau Lin Shinn-Cherng Chen Chung-Feng Huang Jee-Fu Huang Chia-Yen Dai Wan-Long Chuang Ming-Lung Yu Hepatitis Center and Hepatobiliary Division Department of Internal MedicineKaohsiung Medical University HospitalKaohsiung 80708Taiwan School of Medicine and Hepatitis Research Center College of MedicineCenter for Cancer Research and Center for Liquid BiopsyKaohsiung Medical UniversityKaohsiung 80708Taiwan Department of Medical Laboratory Science and Biotechnology Kaohsiung Medical UniversityKaohsiung 80708Taiwan Health Management Center Department of Community MedicineKaohsiung Medical University HospitalKaohsiung 80708Taiwan Institute of Biomedical Sciences National Sun Yat-Sen UniversityKaohsiung 80708Taiwan

BACKGROUND Chronic hepatitis C virus(HCV)infection induces profound alterations in the cytokine and chemokine signatures in peripheral *** of HCV by antivirals results in host immune modification,which may interfere with immune-mediated cancer *** HCV patients who remain at risk of hepatocellular carcinoma(HCC)following HCV eradication remains an unmet *** hypothesized that antiviral therapy-induced immune reconstruction may be relevant to HCC *** To investigate the impact of differential dynamics of cytokine expression on the development of HCC following successful antiviral *** One hundred treatment-naïve HCV patients with advanced fibrosis(F3/4)treated with direct-acting antivirals(DAAs)or peginterferon/ribavirin who achieved sustained virologic response[SVR,defined as undetectable HCV RNA throughout 12 wk(SVR12)for the DAA group or 24 wk(SVR24)for the interferon group after completion of antiviral therapy]were enrolled since *** primary endpoint was the development of new-onset *** HCC surveillance(abdominal ultrasound andα-fetoprotein)was performed every six months during the ***,64 serum cytokines were detected by the multiplex immunoassay at baseline and 24 wk after *** HCC developed in 12 of the 97 patients over 459 person-years after HCV *** univariate analysis,the Fibrosis-4 index(FIB-4),hemoglobin A1c(HbA1c),the dynamics of tumor necrosis factor-α(TNF-α),and TNF-like weak inducer of apoptosis(TWEAK)after antiviral therapy were significant HCC *** multivariate Cox regression model showed thatΔTNF-α(≤-5.7 pg/mL)was the most important risk factor for HCC(HR=11.54,95%CI:2.27-58.72,P=0.003 in overall cases;HR=9.98,95%CI:1.88-52.87,P=0.007 in the interferon group).An HCC predictive model comprising FIB-4,HbA1c,ΔTNF-α,andΔTWEAK had excellent performance,with 3-,5-,10-,and 13-year areas under the curve of 0.882,0.864,0.903,and 1.000,r

关键词： Hepatitis C virus Hepatocellular carcinoma Sustained virologic response Tumor necrosis factor-α Tumor necrosis factor-like weak inducer of apoptosis Cytokine

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Co-infection of SENV-D among chronic hepatitis C patients treated with combination therapy with high-dose interferon-alfa and ribavirin

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World Journal of Gastroenterology 2005年第27期11卷 4241-4245页

作者： Chia-Yen Dai Wan-Long Chuang Wen-Yu Chang Shinn-Chemg Chen Li-po Lee Ming-Yen Hsieh Nei-Jen Hou Zu-yau Un Ming-Yuh Hsieh Liang-Yen Wang Ming-Lung Yu Hepatobiliary Division Department of Internal MedicineKaohsiung Medical University Hospital Kaohsiung Taiwan China Department of Internal Medicine Kaohsiung Municipal Hsiao-Kang Hospital Kaohsiung TaiwanChina Department of Occupational Medicine Kaohsiung Municipal Hsiao-Kang Hospital Kaohsiung Taiwan China

AIM： The clinical significance of co-infection of SENV-D among patients with chronic hepatitis C （CHC） and response of both viruses to combination therapy with high-dose interferon-alfa （IFN） plus ribavirin remain uncertain and are being ***： Total 164 （97 males and 67 females, the mean age 48.1＋11.4 years, range： 20-73 years, 128 histologically proved） naive CHC patients were enrolled in this study. SENV-D DNA was tested by PCR *** of serum HCV RNA was performed using a standardized automated qualitative RT-PCR assay （COBAS AMPLICOR HCV Test, version 2.0）. HCV genotypes la,lb, 2a, 2b, and 3a were determined by using genotypespecific primers. Pretreatment HCV RNA levels were determined by using the branched DNA assay （Quantiplex HCV RNA 3.0）. There are 156 patients receiving combination therapy with IFN 6 MU plus ribavirin for 24 wk and the response to therapy is ***： Sixty-one （37.2%） patients were positive for SENV-D DNA and had higher mean age than those who were negative （50.7＋ 10.6 years vs 46.6＋ 11.6 years,P = 0.026）. The rate of sustained viral response （SVR） for HCV and SENV-D were 67.3% （105/156） and 56.3% （27/48）, respectively. By univariate analysis, the higher rate of SVR was significantly related to HCV genotype non-1b （P〈0.001）, younger ages （P = 0.014）, lower pretreatment levels of HCV RNA （P = 0.019） and higher histological activity index （HAI） score for intralobular regeneration and focal necrosis （P= 0.037）. By multivariate analyses, HCV genotype non-lb, younger age and lower pretreatment HCV RNA levels were significantly associated with HCV SVR （odds ratio （OR）/95% confidence interval （CI）： 12.098/0.02-0.19, 0.936/0.890-0.998, and 3.131/1.080-9.077, respectively）. The SVR of SENV-D was higher among patients clearing SENV-D than those who had viremia at the end of therapy （P = 0.04）.CONCLUSION： Coexistent SENV-D infection, apparently associated with higher ages, is found in more than onethird Taiwan Resi

关键词： Chronic hepatitis C Combination therapy Interferon Ribavirin SENV-D

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The Core Pattern of Chinese Herbal Medicines for Sj（o|¨）gren’s Syndrome in Taiwan from National Health Insurance Research Database between year 2002 to 2011

The Core Pattern of Chinese Herbal Medicines for Sj（o|¨）g...

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第十四届全国中药和天然药物学术研讨会

作者： Ching-Mao Chang hsueh-Ting Chu yau-Huei Wei Fang-Pey Chen Shengwen Wang po-Chang Wu Hung-Rong Yen Tzeng-Ji Chen Hen-Hong Chang Taipei Veterans General Hospital Chang Gung University

＜正＞Sjogren’s syndrome（SS）is an auto-immune disease which is mainly involved with exocrine gland,and it also causes gland dysfunction through the manifestation of dry mouth and dry *** SS patients are bothered by discomfort when using conventional western *** Taiwan,Chinese herbal medicine（CHM）has been complementary and

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HYpoPIGMENTATION AND HEALTHY SKIN PROMOTING EFFECT OF A MODIFIED QI BAI SAN

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World Journal of Traditional Chinese Medicine 2016年第2期 81-82页

作者： Elaine Wat yau Tsz Chan Tiffany Hoi Ka Tso Chun Fai Ng Ching po Lau Wing Sum Siu Chun Hay Ko Ka Keung Lau Raymond Hu Clara Bik-San Lau Ping Chung Leung Institute of Chinese Medicine and State Key Laboratory of Phytochemistry and Plant Resources in West China The Chinese University of Hong Kong 5100 Cosmetic Company Ltd.

Introduction:Qi Bai San(QBS,七白散)is a traditional Chinese herbal formula used by ancient ladies for healthy skin and *** it is a popular product in the market,it contains animal drug and toxic herbs which

关键词： MSH HYpoPIGMENTATION AND HEALTHY SKIN PROMOTING EFFECT OF A MODIFIED QI BAI SAN

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中山医学大学医学院如何推动问题导向学习

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中国循证医学杂志 2006年第10期6卷 699-704页

作者：李孟智杨仁宏李淑杏赖德仁黄启洲翁国昌詹明修李洁林俊哲林隆尧周明智林中生蔡宗博周明仁陈家玉刁骧（审校）中山医学大学医学院台湾台中市中山医学大学教师成长中心中山医学大学护理学院不详

自1990年起,中山医学大学医学院根据办学的宗旨、世界医学教育改革的潮流及自身条件,选定推动问题导向学习(Problem-based learning;PBL-)、基础及临床课程整合(Integration of basic and clinical sciences)及成立教师成长中心(Center ... 详细信息

自1990年起,中山医学大学医学院根据办学的宗旨、世界医学教育改革的潮流及自身条件,选定推动问题导向学习(Problem-based learning;PBL-)、基础及临床课程整合(Integration of basic and clinical sciences)及成立教师成长中心(Center for Faculty Development;CFD)为本校教改之主轴。有关推动问题导向学习部分,历经(1)探索期(1994～2000):包括观察及学习国内外医学院校引入PBL的过程与经验。本期关键因素包括政府教改政策与评鉴指标,他校实施成果和本校改革决心与条件。(2)准备期(2000-2002):包括促成师生共识,小组老师之训练,教案之撰写与审查,课程整并与学生小组化安排。本期关键因素为教师间共识与其权益维护,课程整合及学习相关配合措施,并为医学预备科学生安排PBL先导课程(学习法与循证医学)。(3)实施期(2000～2004):包括选择高年级临床医学课程率先实施,学生与小组老师分组,实施时段与空间安排以及课程评价。本期关键因素在于实施小组学习的配套措施是否适当。(4)扩展期(2004-2006):将PBL自临床课程延伸至基础医学课程及医学人文课程。此期关键在于基础医学与人文课程老师的共识、教师训练与奖励措施,基础医学课程的整并及PBL计划的评价与改进。(5)精进期(2006～):预计建构PBL网络学习资源与规划在线实施PBL,并完成发展医学教育的器官化模块课程及其配套的PBL和临床技能训练。本校推动PBL的经验,认为PBL,是医学教育中良好的学习模式之一,可行性高且受到学生欢迎,但路途需步步为营,采取渐进改革,并争取老师与同学的认同是实施的关键。

关键词：问题导向学习小组学习医学教育改革

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