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Brain region-specific roles of brain-derived neurotrophic factor in social stress-induced depressive-like behavior

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Neural Regeneration Research 2025年第1期20卷 159-173页

作者： Man Han Deyang Zeng Wei Tan xingxing chen Shuyuan Bai Qiong Wu Yushan chen Zhen Wei Yufei Mei Yan Zeng Brain Science and Advanced Technology Institute Wuhan University of Science and TechnologyWuhanHubei ProvinceChina Geriatric Hospital Affiliated to Wuhan University of Science and Technology WuhanHubei ProvinceChina School of Public Health Wuhan University of Science and TechnologyWuhanHubei ProvinceChina

Brain-derived neurotrophic factor is a key factor in stress adaptation and avoidance of a social stress behavioral *** studies have shown that brain-derived neurotrophic factor expression in stressed mice is brain region–specific,particularly involving the corticolimbic system,including the ventral tegmental area,nucleus accumbens,prefrontal cortex,amygdala,and *** how brain-derived neurotrophic factor participates in stress processing in different brain regions will deepen our understanding of social stress *** this review,we discuss the expression and regulation of brain-derived neurotrophic factor in stress-sensitive brain regions closely related to the pathophysiology of *** focused on associated molecular pathways and neural circuits,with special attention to the brain-derived neurotrophic factor–tropomyosin receptor kinase B signaling pathway and the ventral tegmental area–nucleus accumbens dopamine *** determined that stress-induced alterations in brain-derived neurotrophic factor levels are likely related to the nature,severity,and duration of stress,especially in the above-mentioned brain regions of the corticolimbic ***,BDNF might be a biological indicator regulating stress-related processes in various brain regions.

关键词： amygdala chronic mild stress chronic social defeat stress corticolimbic system depression hippocampus medial prefrontal cortex nucleus accumbens social stress models ventral tegmental area

唐氏综合症患者脑组织中αB-晶状蛋白磷酸化的检测及意义

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现代生物医学进展 2016年第36期16卷 7074-7078页

作者：杨迎春夏建文林雅君杨惠萍陈兴张秋萍同济大学附属杨浦医院儿科上海200090 同济大学医学院上海200092

目的：检测唐氏综合症（DS）患者脑组织中αB-晶状蛋白及其Ser59和Ser45磷酸化形式的表达及分布,探讨αB-晶状蛋白发生磷酸化的程度对唐氏综合症患者脑损伤的意义。方法：收集11例4个月~17岁大的DS患者和5例5个月~23岁大的正常对照者脑... 详细信息

目的：检测唐氏综合症（DS）患者脑组织中αB-晶状蛋白及其Ser59和Ser45磷酸化形式的表达及分布,探讨αB-晶状蛋白发生磷酸化的程度对唐氏综合症患者脑损伤的意义。方法：收集11例4个月~17岁大的DS患者和5例5个月~23岁大的正常对照者脑组织石蜡标本,以及12例9个月~23岁大的正常对照者冰冻脑组织及12例6个月~23岁DS患者冰冻脑组织,通过Western blot技术检测αB-晶状蛋白及其Ser59和Ser45磷酸化形式在脑前额皮层及白质中的表达。采用免疫荧光共聚焦双染及三染技术检测αB-晶状蛋白在脑组织中的定位。结果：αB-晶状蛋白及其Ser59磷酸化形式在DS患者婴幼儿期即可被检测到,但其Ser45磷酸化形式仅能在青少年期被检测到,且表达量较低。αB-晶状蛋白及其两种磷酸化形式在DS患者中的表达量均高于其同龄的正常对照者。免疫荧光共聚焦结果显示,在室管膜损伤区蓄积的GFAP阳性星形细胞同时表达αB-晶状蛋白;而且在正常人和DS患者脑组织中,GFAP/PDGFRα双阳性的细胞也能表达αB-晶状蛋白。结论：由于αB-晶状蛋白的分子伴侣活性和抗凋亡活性是磷酸化依赖的,所以DS患者脑组织中αB-晶状蛋白水平的升高可能反映了DS患者脑组织中的一种细胞保护机制发生了改变,这可能是由21三体编码基因诱导或增强的应激条件造成的。

关键词：唐氏综合症 αB-晶状蛋白磷酸化室管膜损伤

Runtime model based approach to IoT application development

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Frontiers of Computer Science 2015年第4期9卷 540-553页

作者： xing chen College of Mathematics and Computer Science Fuzhou University Fuzhou 350116 China Fujian Provincial Key Laboratory of Networking Computing and Intelligent Information Processing Fuzhou 350116 China Key Laboratory of High Confidence Software Technologies (Ministry of Education) Beijing 100871 China School of Electronics Engineering and Computer Science Peking University Beijing 100871 China

The internet of things （loT） attracts great interest in many application domains concerned with monitoring and ：ontrol of physical phenomena. However, application devel- opment is still one of the main hurdles to a wide adoption of IoT technology. Application development is done at a low level, very close to the operating system and requires pro- grammers to focus on low-level system issues. The under- lying APIs can be very complicated and the amount of data collected can be huge. This can be very hard to deal with as a developer. In this paper, we present a runtime model based approach to IoT application development. First, the manage- ability of sensor devices is abstracted as runtime models that are automatically connected with the corresponding systems. Second, a customized model is constructed according to a personalized application scenario and the synchronization be- tween the customized model and sensor device runtime mod- els is ensured through model transformation. Thus, all the application logic can be carried out by executing programs on the customized model. An experiment on a real-world ap- plication scenario demonstrates the feasibility, effectiveness, and benefits of the new approach to IoT application develop- ment.

关键词： IoT application development software architec-ture models at runtime

A New Approach to the Quantum Adiabatic Condition

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Chinese Physics Letters 2012年第10期29卷 5-8页

作者： GUO Chu DUAN Qian-Heng chen ping-xing Department of Physics National University of Defense TechnologyChangsha 410073 State Key Laboratory of High Performance Computing National University of Defense TechnologyChangsha 410073

The quantum adiabatic theorem is the basis of adiabatic quantum ***,the exact necessary and sufficient conditions for adiabatic evolution are still under *** discuss the adiabatic condition of a system undergoing a special evolution route,and obtain an explicit formula that is necessary and sufficient for the adiabatic evolution in this *** on this formula,we find that the traditional adiabatic condition is neither sufficient nor ***,we show that no adiabatic process can occur even the evolution speed goes to 0 in some examples,which is surprising since the adiabatic theorem states that if the evolution of a system is slow enough,the adiabatic process could occur.

关键词： computation adiabatic quantum

A Configurable Surface-Electrode Ion Trap Design for Quantum Information Processing

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Chinese Physics Letters 2013年第12期30卷 33-36页

作者： LIU Wei chen Shu-Ming chen ping-xing WU Wei College of Computer National University of Defense TechnologyChangsha 410073 Science and Technology on PDL National University of Defense TechnologyChangsha 410073 College of Science National University of Defense TechnologyChangsha 410073

We propose a configurable surface-electrode ion trap design to alleviate the poor reusability of the existing *** can architecturally and electrically support 5 mainstream modes by design reuse,thus enhancing the trap reusability and reducing the experiment setup *** also develop a corresponding simulation suite which can optimize trap geometries and calculate trap parameters to control the trapped ion's classic *** to our analytical and simulated results,the configurable design can serve as a unified platform for basic research of large-scale quantum information processing.

关键词： architectural Quantum unified

搪玻璃设备管口搪玻璃层内残余应力及其影响因素

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压力容器 2017年第3期34卷 38-43页

作者：童郭凯盛水平邢璐陈海云丁无极陈冰冰浙江工业大学机械工程学院浙江杭州310032 杭州市特种设备检验研究院浙江杭州310032

为了考察搪玻璃设备管口搪玻璃瓷层残余应力分布及其相关影响,利用Abaqus软件模拟了搪玻璃设备搪烧后的冷却过程。模拟结果表明,管口搪玻璃层残余第一主应力最大值均随管口圆角半径R增大而减小,且当基体圆角半径R小于6 mm后,瓷层残余最... 详细信息

为了考察搪玻璃设备管口搪玻璃瓷层残余应力分布及其相关影响,利用Abaqus软件模拟了搪玻璃设备搪烧后的冷却过程。模拟结果表明,管口搪玻璃层残余第一主应力最大值均随管口圆角半径R增大而减小,且当基体圆角半径R小于6 mm后,瓷层残余最大主应力随圆角半径R的减少增加明显;而当圆角半径R增大至15 mm后,残余最大第一主应力减少趋势变得逐渐平缓。另外,搪玻璃层内最大主应力数值随基材与搪玻璃层材料线膨胀系数差减少而减少。管口圆角处搪玻璃层厚度减少可使管口圆角处第一主应力残余应力略减少。

关键词：搪玻璃设备管口圆角半径线膨胀系数搪玻璃层厚度残余应力有限元模拟

A Novel Self-Supervised Learning Network for Binocular Disparity Estimation

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Computer Modeling in Engineering & Sciences 2025年第1期142卷 209-229页

作者： Jiawei Tian Yu Zhou Xiaobing chen Salman A.AlQahtani Hongrong chen Bo Yang Siyu Lu Wenfeng Zheng Department of Computer Science and Engineering Major in Bio Artificial IntelligenceHanyang UniversityAnsan-si15577Republic of Korea School of Electrical and Computer Engineering Louisiana State UniversityBaton RougeLA 70803USA Department of Computer Engineering College of Computer and Information SciencesKing Saud UniversityRiyadh11574Saudi Arabia School of Automation University of Electronic Science and Technology of ChinaChengdu610054China

Two-dimensional endoscopic images are susceptible to interferences such as specular reflections and monotonous texture illumination,hindering accurate three-dimensional lesion reconstruction by surgical *** study proposes a novel end-to-end disparity estimation model to address these *** approach combines a Pseudo-Siamese neural network architecture with pyramid dilated convolutions,integrating multi-scale image information to enhance robustness against lighting *** study introduces a Pseudo-Siamese structure-based disparity regression model that simplifies left-right image comparison,improving accuracy and *** model was evaluated using a dataset of stereo endoscopic videos captured by the Da Vinci surgical robot,comprising simulated silicone heart sequences and real heart video *** results demonstrate significant improvement in the network’s resistance to lighting interference without substantially increasing ***,the model exhibited faster convergence during training,contributing to overall performance *** study advances endoscopic image processing accuracy and has potential implications for surgical robot applications in complex environments.

关键词： Parallax estimation parallax regression model self-supervised learning Pseudo-Siamese neural network pyramid dilated convolution binocular disparity estimation

Effect of different bottom blowing elements on stirring characteristics of molten bath in converter

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Journal of Iron and Steel Research International 2024年第2期31卷 368-376页

作者： Ming Lv Shuang-ping chen Hong-min Guo Yi-jie Hao Xiang-dong xing School of Metallurgical Engineering Xi’an University of Architecture and TechnologyXi’an710055ShaanxiChina Shaanxi Longmen Steel Company Hancheng715405ShaanxiChina

The bottom blowing element is the key equipment to ensure the bottom blowing effect of the *** types of bottom blowing elements,dispersive type(D1),double circular seam(D2)and straight cylinder type(D3),were built,and the effects of bottom blowing element type on molten bath flow,wall erosion and furnace bottom erosion were *** was found that when the bottom blowing elements of dispersive type(D1)and double circular seam(D2)were used,the dead zone area in the lower part of the molten bath was smaller,and the high-speed zone area was larger;therefore,the stirring effect on the bottom melt was *** the straight cylinder type(D3)bottom blowing element was used,the gas penetrated the molten bath at a faster rate to reach the surface of molten bath and failed to disperse in the bottom molten bath,and the wall shear stress near the nozzle outlet was *** argon was blown by three different bottom blowing elements,the area of the wall shear stress greater than 3 Pa was 4.8,5.6 and 8.7 cm2,respectively,within 0.2 m of the bottom blowing nozzle outlet.

关键词： Converter steelmaking Bottom blowing element Molten bath stirring Wall erosion

Diastereoselective Photoreaction of Ir(III) Amine Complexes for Generation of New Multidentate Ligands in situ via a Postcoordinated Interligand-Coupling Strategy

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Chinese Journal of Chemistry 2021年第11期39卷 2995-3003页

作者： xing-Yang chen Su-Yang Yao Li-ping Li Bao-Hui Ye MOE Key Laboratory of Bioinorganic and Synthetic Chemistry School of ChemistrySun Yat-sen UniversityGuangzhouGuangdong510275 China Department of Chemistry Guangdong University of EducationGuangzhouGuangdong510303 China

The diastereoselective photoreactions of Ir(III)-amine and Ir(III)-diamine complexes are observed in the presence of ***Ʌ-[Ir(pq)_(2)(R-mapy)](PF_(6))(pq is 2-phenylquinoline and mapy is 2-(1-aminoethyl)pyridine)diastereomer is dehydrogenatively oxidized into imine complexɅ-[Ir(pq)_(2)(mapy-2H)](PF_(6))at room temperature,while theɅ-[Ir(pq)_(2)(S-mapy)](PF_(6))diastereomer occurs interligand C—N cross-coupling reaction at 60℃,affording a new tetradentate complexɅ-[Ir(pq)(S-pqpe)](PF_(6))(pqpe is 2-phenyl-N-(1-pyridin-2-yl)ethyl-quinolin-8-amine).The identical cases are also observed in diamine complexesɅ-[Ir(pq)_(2)(R,R-chda)](PF_(6))(chda is 1,2-diaminocyclohexane),Ʌ-[Ir(pq)_(2)(R,S-chda)](PF_(6)),andɅ-[Ir(pq)_(2)(S,S-chda)](PF_(6)),where the R configuration ligand is dehydrogenatively oxidized into imine,while the S configuration is retentive and the bound nitrogen atom is coupling to the C8 of pq ligand,affordingɅ-[Ir(pq)_(2)(chdi)](PF_(6))(chdi is 1,2-diiminocyclohexane),Ʌ-[Ir(pq)(S-pqchim)](PF_(6))(pqchim is N-(2-iminocyclohexyl)-2-phenyl-quinolin-8-amine),andɅ-[Ir(S,S-pqchda)](PF_(6))(pqchda is N',N”-bis(2-phenylquinolin-8-yl)cyclohexane-1,2-diamine),*** provide a new and useful protocol for the synthesis of multidentate ligands in situ via the postcoordinated interligand-coupling strategy under mild conditions.

关键词： Ir(III)complexes Interligand-Coupling Reaction/n-s/fu Photochemistry Diastereoselectivity