检索结果-南通市图书馆

The Role of RP105 in Cardiovascular Disease through Regulating TLR4 and PI3K Signaling Pathways

在线全文

学校读者我要写书评

暂无评论

Current Medical Science 2019年第2期39卷 185-189页

作者： Jian YANG ping zeng Jun YANG Zhi-xing FAN Department of Cardiology the First College of Clinical Medical ScienceYichang Central People fs HospitalChina Three Gorges UniversityYichang 443000China

Raidoprotective 105(RP105)was first discovered on the surface of mouse B cells and it has been demonstrated that RP105 can function as an inflammatory regulator in cardiovascular disease(CVD),such as myocardial ischemic reperfusion injury(MI/RI),atherosclerosis and myocardial infarction(MI).As a member of Toll-like receptor(TLR)homolog which is capable of regulating toll-like receptor(TLR4)signaling pathway,RP105 is implicated in various biological *** evidence suggests that RP105 regulates the function of TLR4 and phosphoinositide 3-kinase(PI3K)signaling ***,we review the effect of RP105 on CVD through regulating TLR4/PI3K signaling pathways.

关键词： RP105 TLR4 signaling PI3K signaling cardiovascular disease

Effect of Small Needle Knife on Autophagy and TGF-β in Synovial Fluid of KOA Rats

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Journal of Biomedical Engineering(English Edition) 2024年第1期33卷 33-39页

作者： ZHENG Kang-hua LIN zeng-ping CHEN Yong Fujian Provincial 2nd People's Hospital Affiliated Hospital of Fujian University of Traditional Chinese MedicineFuzhou Fujian 350003China College of Integrative Chinese and Western Medicine Fujian University of Traditional Chinese MedicineFuzhou Fujian 350122China

Objective:To explore the effects of small needle knife on the autophagy function of synovium and the expression of TGF-βin synovial fluid of KOA rats,so as to provide a new theoretical basis for the treatment of ***:48 SD rats were randomly divided into blank control group,model group,drug group and acupotomy *** blank control group maintained the original feeding without any intervention,the model group adopted the sodium monoiodoacetate injection method to prepare the KOA rat model without any intervention,the drug group prepared the KOA rat model and then treated with tripterine by gavage,and the needle knife group treated the KOA rat model with small needle *** expression levels of autophagy-related proteins in synovial tissues were detected by immunohistochemistry and Western blotting,and the content of TGF-βin synovial fluid was measured by ***:Compared with the blank control group,Beclin-1,Caspase-3 and Bax were up-regulated and m TOR was down-regulated in the model ***-1,m TOR,Caspase-3 and Bax were up-regulated in the drug *** was no significant difference in the expression of autophagy-related proteins Beclin-1(0.28±0.09)and m TOR(0.45±0.12)between the acupotomy group and the blank control group,while Caspase-3(0.17±0.03)and Bax(0.30±0.01)were *** expression level of TGF-βin synovial fluid in the small needle knife group was(0.29±0.09),which was similar to that in the blank control group,and was significantly higher than that in the model ***:Small needle knife treatment can promote the recovery of synovial autophagy in KOA rats,and reduce the level of TGF-βin synovial fluid,and can play a clinical role in the treatment of KOA by regulating the expression of synovial autophagy and TGF-β.

关键词： small needle knife knee osteoarthritis(KOA) synovium autophagy transforming growth factorβ(TGF-β)

Effect of long-term service on the precipitates in P92 steel

在线全文

学校读者我要写书评

暂无评论

International Journal of Minerals,Metallurgy and Materials 2018年第8期25卷 913-921页

作者： Yan-ping zeng Jin-dou Jia Wen-he Cai Shu-qing Dong Zhi-chun Wang School of Materials Science and Engineering University of Science and Technology BeijingBeijing 100083China North China Electric Power Research Institute Co. Ltd.Beijing 100045China

The precipitates in P92 steel after long-term service in an ultra-supercritical unit were investigated by field-emission scanning electron microscopy and transmission electron microscopy and were found to mainly consist of M23 C6 carbides,Laves phase,and MX *** Z-phase was observed.M23 C6 carbides and Laves phase were found not only on prior austenite grain boundaries,martensite lath boundaries,and subgrain boundaries but also in lath interiors,where two types of MX carbonitrides—Nb-rich and V-rich particles—were also observed but the "winged" complexes were hardly *** kind of precipitate within the martensite laths exhibited multifarious morphologies,suggesting that a morphological change of precipitates occurred during long-term *** M23 C6 carbides and Laves phase coarsened substantially,and the latter grew faster than the ***,MX carbonitrides exhibited a relatively low coarsening *** effect of the evolution of the precipitate phases on the creep rupture strength of P92 steel was discussed.

关键词： precipitate P92 steel long-term service ultra supercritical unit

Effects of Long-Term Winter Planted Green Manure on Distribution and Storage of Organic Carbon and Nitrogen in Water-Stable Aggregates of Reddish Paddy Soil Under a Double-Rice Cropping System

在线全文

学校读者我要写书评

暂无评论

Journal of Integrative Agriculture 2014年第8期13卷 1772-1781页

作者： YANG zeng-ping ZHENG Sheng-xian NIE Jun LIAO Yu-lin XIE Jian Soil and Fertilizer Institute of Hunan Province Hunan Academy of Agricultural Sciences Scientifi c Observing and Experimental Station of Arable Land Conservation (Hunan) Ministry of Agriculture

In agricultural systems, maintenance of soil organic matter has long been recognized as a strategy to reduce soil degradation. Manure amendments and green manures are management practices that can increase some nutrient contents and improve soil aggregation. We investigated the effects of 28 yr of winter planted green manure on soil aggregate-size distribution and aggregateassociated carbon（C） and nitrogen（N）. The study was a randomized completed block design with three replicates. The treatments included rice-rice-fallow, rice-rice-rape, rice-rice-Chinese milk vetch and rice-rice-ryegrass. The experiment was established in 1982 on a silty light clayey paddy soil derived from Quaternary red clay（classified as Fe-Accumuli-Stagnic Anthrosols） with continuous early and late rice. In 2009, soil samples were collected（0-15 cm depth） from the field treatment plots and separated into water-stable aggregates of different sizes（i.e., 〉5, 2-5, 1-2, 0.5-1, 0.25-0.5 and 〈0.25 mm） by wet sieving. The long-term winter planted green manure significantly increased total C and N, and the formation of the 2-5-mm water-stable aggregate fraction. Compared with rice-rice-rape, rice-rice-Chinese milk vetch and rice-rice-ryegrass, the rice-rice-fallow significantly reduced 2-5-mm water-stable aggregates, with a significant redistribution of aggregates into micro-aggregates. Long-term winter planted green manure obviously improved C/N ratio and macro-aggregate-associated C and N. The highest contribution to soil fertility was from macro-aggregates of 2-5 mm in most cases.

关键词： green manure organic carbon reddish paddy soil total nitrogen water-stable aggregates

The improved mechanical properties of Al matrix composites reinforced with oriented β-Si3N4 whisker

在线全文

学校读者我要写书评

暂无评论

Journal of Materials Science & Technology 2019年第7期35卷 1345-1353页

作者： Chenxu Zhang Yu-ping zeng Dongxu Yao Jinwei Yin Kaihui Zuo Yongfeng Xia Hanqin Liang State Key Laboratory of High Performance Ceramics and Superfine Microstructure Shanghai Institute of CeramicsChinese Academy of SciencesShanghai 200050China University of Chinese Academy of Sciences Beijing 100049China

The β-Si3N4 whiskers (β-Si3N4w) reinforced A1 matrix com posites were first fabricated by hot pressing, then treated through hot extrusion. The microstructure characterization dem onstrated the preferred orientations of both β-Si3N4w and A1 grains in the as-extruded composites. It indicated th at β-Si3N4w were aligned along the extrusion direction and A1 grains exhibited a distinct ai texture. The interface betw een β-Si3N4w and A1 was in a good bonding status without voids and reaction products. Effects of extrusion process on the mechanical properties of com posites were also investigated. The results indicated the extrusion process had a prom inent strengthening effect on the mechanical properties of composites. The maxim umyield strength and ultim ate tensile strength of com posites reached up to 170 and 289 MPa, respectively, accompanied by a 12.3% elongation at fracture w hen the w hisker fraction was 15 vol.%. This im provem ent was collectively attributed to the densification of composites, the strong interface, and the preferred orientation inside composites. The yield strength of the composites reinforced with 5 vol.%β-Si3N4w corresponded well w ith the theoretical value from different strengthening mechanisms.

关键词： Metal-matrix composites (MMC) β-Si3N4 whiskers Preferred orientation Interface Mechanical properties Extrusion

DEVELOPMENT OF SINGLE-PHASED WATER-COOLING RADIATOR FOR COMPUTER CHIP

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of Mechanical Engineering 2007年第2期20卷 77-81页

作者： zeng ping CHENG Guangming LIU Jiulong YANG Zhigang SUN Xiaofeng PENG Taijiang College of Mechanical Engineering and Automatization Jilin University Changchun 130022 China Department of Mechettonics Jilin InsUtute of Chemical Technolgy Jilin 132022 China

In order to cool computer chip efficiently with the least noise, a single phase water-cooling radiator for computer chip driven by piezoelectric pump with two parallel-connection chambers is developed. The structure and work principle of this radiator is described. Material, processing method and design principles of whole radiator are also explained. Finite element analysis （FEA） software, ANSYS, is used to simulate the heat distribution in the radiator. Testing equipments for water-cooling radiator are also listed. By experimental tests, influences of flowrate inside the cooling system and fan on chip cooling are explicated. This water-cooling radiator is proved more efficient than current air-cooling radiator with comparison experiments. During cooling the heater which simulates the working of computer chip with different power, the water-cooling radiator needs shorter time to reach lower steady temperatures than current air-cooling radiator.

关键词： Computer chip Water-cooling Piezoelectric pump Radiator ANSYS simulation Simulative heater

Depth profiling of arsenian pyrite in Carlin-type ores through wet chemistry

在线全文

学校读者我要写书评

暂无评论

Acta Geochimica 2023年第2期42卷 256-265页

作者： Meizhi Yang Quan Wan Xin Nie Suxing Luo Yuhong Fu ping zeng Wenqi Luo State Key Laboratory of Ore Deposit Geochemistry Institute of GeochemistryChinese Academy of SciencesGuiyang 550081China University of Chinese Academy of Sciences Beijing 100049China CAS Center for Excellence in Comparative Planetology Hefei 230026China Department of Chemistry and Chemical Engineering Zunyi Normal CollegeZunyi 563006China School of Geographic and Environmental Sciences Guizhou Normal UniversityGuiyang 550001China

Enrichment of As and Au at the overgrowth rims of arsenian pyrite is a distinctive feature of Carlin-type gold *** distribution of such key elements in high resolution is of fundamental importance yet often proves *** this study,repeated non-oxidative acid etching of ore samples from Shuiyindong gold deposit was applied to enable elemental depth profiling of goldbearing arsenian pyrite ***-OES and AAS were used to determine the dissolved Fe,As,and Au concentrations in each of the etching solutions,and XPS was carried out to exam the etched mineral *** contrast to conventional ion beam etching that may cause substantial sample damage,our acid etching method does not seem to significantly alter the composition and chemical state of the *** etched depths directly converted from the measured elemental concentrations can reproducibly reach a very high resolution of~1 nm,and can be conveniently controlled through varying the etching *** the Fe and As depth profiles consistently reflect the surface oxidation property of arsenian pyrite,the Au profile displaying an obvious upward trend reveals the ore fluid evolution at the late stage of *** on our experimental results,we demonstrate that our wet chemistry method is capable of effective depth profiling of gold ore and perhaps other geological samples,with advantages surpassing many instrumental techniques including negligible sample damage,nanoscale resolution as well as isotropic etching.

关键词： Wet chemistry Acid etching Depth profiling Carlin-type gold deposits Arsenian pyrite

Study on precision piezoelectric rotary step motors with inner anchor/loosen and outer drive

在线全文

学校读者我要写书评

暂无评论

Frontiers of Electrical and Electronic Engineering in China 2008年第3期3卷 364-369页

作者： Jianfang LIU Zhigang YANG ping zeng Zunqiang FAN Chain Transmission Laboratory Jilin UniversityChangchun 130022China

A new precision rotary piezoelectric(PZT)actuator is proposed to improve its drive *** on piezoelectric technology,the actuator adopts the principle of bionics,with a new method of stator inner anchor/loosen/rotor outer drive and a distortion structure of a thin shelf flexible *** structure improves the stability of the anchor/loosen and step *** characteristics are evaluated by finite element *** experiment shows that the new rotary PZT actuator works with higher frequency(40 Hz),higher speed(325 mrad/s),wider movement(360u),high resolution(1 mrad/step)and high torque(30 N?cm).The novel actuator can be applied in wide movement and high resolution driving devices such as those for optics engineering,precision positioning and some other micro-manipulation fields.

关键词： piezoelectric element stator inner anchor/loosen rotor outer drive thin shelf flexible hinge resolution

三七总皂苷调控破骨细胞外泌体中差异miRNA表达抑制成骨细胞铁死亡

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

中国组织工程研究 2025年第19期29卷 4011-4021页

作者：陶红成曾平刘金富田照丁强李晁辉韦建杰李豪广西中医药大学广西壮族自治区南宁市530200 广西中医药大学第一附属医院广西壮族自治区南宁市530023 广西中医基础研究重点实验室广西壮族自治区南宁市530200

背景:激素性股骨头坏死多是由于长期大量使用激素所致,但具体的发病机制尚未明确,有待于进一步研究。目的:筛选出三七总皂苷干预破骨细胞来源外泌体中的差异miRNA,在此基础上构建成骨相关铁死亡调控网络,以探索激素性股骨头坏死发生的... 详细信息

背景:激素性股骨头坏死多是由于长期大量使用激素所致,但具体的发病机制尚未明确,有待于进一步研究。目的:筛选出三七总皂苷干预破骨细胞来源外泌体中的差异miRNA,在此基础上构建成骨相关铁死亡调控网络,以探索激素性股骨头坏死发生的潜在机制及研究方向。方法:MTT实验检测不同浓度地塞米松和不同质量浓度三七总皂苷对Raw264.7细胞系的毒性作用;抗酒石酸酸性磷酸酶染色和TUNEL染色检测三七总皂苷对破骨细胞抑制和凋亡的影响;从三七总皂苷干预的破骨细胞中提取外泌体,对外泌体进行测序找出差异表达miRNA,通过CytoScape 3.9.1构建并可视化差异表达的miRNA与mRNA间的调控网络;通过GO分析和KEGG分析筛选候选mRNA;最后筛选出铁死亡相关的差异基因,构建铁死亡相关基因的调控网络。结果与结论:①通过MTT实验确定了适合干预Raw264.7细胞的地塞米松浓度(0.1μmol/L)和三七总皂苷质量浓度(1736.85μg/mL);②三七总皂苷对破骨细胞有抑制作用并能促进其凋亡;③从破骨细胞来源外泌体样本中鉴定出20个差异miRNA,通过靶标mRNA预测出11种成骨相关的差异miRNA,并构建了4个上调的差异表达miRNA对应于155个下调的候选mRNA以及7个下调的差异表达miRNA对应于238个上调的候选mRNA的调控网络;④在差异基因中筛选出与铁死亡相关的基因24个,最终构建了12个网络(miR-98-5p/PTGS2,miR-23b-3p/PTGS2,miR-425-5p/TFRC,miR-133a-3p/TFRC,miR-185-5p/TFRC,miR-23b-3p/NFE2L2,miR-23b-3p/LAMP2,miR-98-5p/LAMP2,miR-182-5p/LAMP2,miR-182-5p/TLR4,miR-23b-3p/ZFP36,miR-182-5p/ZFP36)。这些结果表明三七总皂苷可能通过调控破骨细胞外泌体来源miRNA的表达来调节成骨细胞铁死亡,为激素性股骨头坏死的机制研究提供新的思路。

关键词：激素性股骨头坏死三七总皂苷破骨细胞外泌体铁死亡调控网络