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Chinese Journal of Structural Chemistry 2007年第9期26卷 1071-1075页

作者： YANG Jian-Guo LI Fang PAN Fu-You JIA wen-ping Office of Assets Administration Taizhou University Taizhou 317000 China Department of Chemistry Taizhou University Taizhou 317000 China

In the ethanol solvent, a nickel（Ⅱ） complex Ni（C12H10N2O2S）2 upon reaction of 2＇-（2-thienylidene）-hydroxybenzoylhydrazide with nickel acetate was synthesized, and its structure was characterized by IR, UV, elemental analysis and X-ray diffraction analysis. The crystal belongs to monoclinic system, space group C2/c with a = 22.052（3）, b = 5.9681（6）, c = 18.522（2）A , β = 110.679（4）°, V = 2280.6（4）A^3, Z = 4, Mr = 551.27, μ = 1.606 mm^-1, Dc = 1.075 g/cm^3, F（000） = 1136 and Rint = 0.0556. The nickel（Ⅱ ） atom in the compound is four-coordinated with two nitrogen atoms from amide and two oxygen atoms from keto group. The biological activities have been measured, show- ing the compound exhibits better anti-bacterial activity than the ligand.

关键词： nickel(Ⅱ) complex 2'-(2-thienylidene)-hydroxybenzoylhydrazide,crystal structure antibacterial activities

含ω-3多不饱和脂肪酸的不同脂肪乳剂营养支持治疗重症患者的疗效比较

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临床药物治疗杂志 2024年第4期22卷 57-61页

作者：叶家宝文萍陶忠义安徽医科大学附属六安医院药学部安徽六安237005

目的比较含ω-3多不饱和脂肪酸(ω-3 PUFA)的不同脂肪乳剂治疗重症患者的疗效。方法回顾性分析安徽医科大学附属六安医院2018年5月至2023年5月接受含ω-3 PUFA的脂肪乳剂治疗重症患者临床资料,根据全肠外营养处方中不同脂肪乳构成,分为... 详细信息

目的比较含ω-3多不饱和脂肪酸(ω-3 PUFA)的不同脂肪乳剂治疗重症患者的疗效。方法回顾性分析安徽医科大学附属六安医院2018年5月至2023年5月接受含ω-3 PUFA的脂肪乳剂治疗重症患者临床资料,根据全肠外营养处方中不同脂肪乳构成,分为多种油脂肪乳组和ω-3鱼油脂肪乳联合长链或中/长链脂肪乳组,比较两组总住院时间、ICU入住时间、脂肪乳总费用、住院总费用、全肠外营养治疗总费用、药品费用占比、保肝药物使用率、患者好转率、总胆红素、白蛋白、AST、ALT、WBC计数、中性粒细胞百分比及C反应蛋白水平。结果共纳入多种油脂肪乳组106例,ω-3鱼油指肪乳联合长链或中/长链脂肪乳组76例。治疗后,两组患者的总住院时间、ICU入住时间、住院总费用、保肝药物使用率及患者好转率比较,差异均无统计学意义(P>0.05);与ω-3鱼油脂肪乳联合长链或中/长链脂肪乳组比较,多种油脂肪乳组可降低脂肪乳总费用、全肠外营养治疗总费用及药品费用占比,差异均有统计学意义(P0.05)。结论在重症患者全肠外营养处方设计时,在控制药品费用占比的情况下,可用多种油脂肪乳替代ω-3鱼油脂肪乳联合长链或中/长链脂肪乳,2种处方临床疗效并无差异。

关键词： ω-3多不饱和脂肪酸多种油脂肪乳全肠外营养重症肝功能药品费用占比

L-type Calcium Channels are Involved in Iron-induced Neurotoxicity in Primary Cultured Ventral Mesencephalon Neurons of Rats

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Neuroscience Bulletin 2020年第2期36卷 165-173页

作者： Yu-Yu Xu wen-ping Wan Sha Zhao Ze-Gang Ma Department of Physiology School of Basic MedicineQingdao UniversityQingdao 266071China Institute of Brain Science and Disorders Qingdao UniversityQingdao 266071China

In the present study,we investigated the mechanisms underlying the mediation of iron transport by Ltype Ca^2+ channels(LTCCs)in primary cultured ventral mesencephalon(VM)neurons from *** found that cotreatment with 100 lmol/L FeSO4 and MPP^+(1-methyl-4-phenylpyridinium)significantly increased the production of intracellular reactive oxygen species,decreased the mitochondrial transmembrane potential and increased the caspase-3 activation compared to MPP^+ treatment ***-treatment with 500 lmol/L CaCl2 further aggravated the FeSO4-induced neurotoxicity in MPP^+-treated VM ***-treatment with 10 lmol/L isradipine,an LTCC blocker,alleviated the neurotoxicity induced by co-application of FeSO4 and FeSO4/*** studies indicated that MPP^+treatment accelerated the iron influx into VM *** addition,FeSO4 treatment significantly increased the intracellular Ca^2+ *** effects were blocked by *** results suggest that elevated extracellular Ca^2+ aggravates ironinduced *** mediate iron transport in dopaminergic neurons and this,in turn,results in elevated intracellular Ca^2+ and further aggravates iron-induced neurotoxicity.

关键词： L-type Ca^2+channels Iron overload Parkinson’s disease Isradipine Dopamine neuron

Direct Numerical Simulation of Particle Migration in a Simple Shear Flow

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Chinese Physics Letters 2011年第8期28卷 187-190页

作者： LV Hong TANG Sheng-Li ZHOU wen-ping Department of Power Engineering Chongqing UniversityChongqing 400044

Motion of a rectangular particle in a two-dimensional vertical shear flow of Newtonian fluid and viscoelastic fluid with different parameters is studied using the finite element arbitrary Lagrangian–Eulerian domain *** results show that the centerline of the channel is a stable equilibrium position for the neutrally buoyant rectangular particle in a vertical shear *** causes the particle to migrate towards the centerline of the *** addition,a critical elasticity number *** the elasticity number is below the critical value,the rectangular particle migrates to the centerline;otherwise the centerline of the channel is apparently no longer a global attractor of trajectories of the particle.

关键词： flow rectangular elasticity

Two mutations in the transforming growth factor beta-induced gene associated with familial Lattice corneal dystrophy

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International Journal of Ophthalmology(English edition) 2017年第3期10卷 343-347页

作者： wen-ping Cao Hai-Gang Yuan ping Liu Xue Li Qi Hu Eye Hospital the First Affiliated HospitalHarbin Medical University First Affiliated Hospital Heilongjiang University of Chinese Medicine

AIM：To report a phenotypic variant pedigree of lattice corneal dystrophy（LCD）associated with two mutations,R124C and A546 D,in the transforming growth factor betainduced gene（TGFBI）.METHODS：A detailed ocular examination was taken for all participants of a LCD family. Peripheral blood leukocytes from each participant were extracted to obtain the DNA. Polymerase chain reaction（PCR）of all seventeen exons of TGFBI gene was performed. The products were sequenced and analyzed. Histological examination was carried out after a penetrating keratoplasty from the right eye of proband. RESULTS：Genetic analysis showed that the proband and all 6 affected individuals harbored both a heterozygous CGC to TGC mutation at codon 124 and a heterozygous GCC to GAC mutation at codon 546 of TGFBI. None of the 100 control subjects and unaffected family members was positive for these two mutations. Ocular examination displayed multiple refractile lattice-like opacities in anterior stroma of the central cornea and small granular deposits in the peripheral cornea. The deposits were stained positively with Congo red indicating be amyloid in nature and situated mainly in the anterior and middle stroma. CONCLUSION：We observed a novel LCD family which carried two pathogenic mutations（R124C and A546D）in the TGFBI gene. The phenotypic features were apparently different from those associated with corresponding single mutations. The result reveals that although the definite mutation is the most important genetic cause of the disease,some different modifier alleles may influence the phenotype.

关键词： corneal dystrophy mutation phenotype transforming growth factor beta-induced gene

AN AMPEROMETRIC BIOSENSOR BASED ON COVALENT IMMOBILIZATION OF ASCORBATE OXIDASE ON BIOCOMPATIABLE AND LOW-TOXIC POLY(THIOPHENE-3-ACETIC ACID) MATRIX

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Chinese Journal of Polymer Science 2012年第5期30卷 705-718页

作者： Dong Li Yang-ping wen 徐景坤贺浩华 Ming Liu Jiangxi Key Laboratory of Organic Chemistry Jiangxi Science and Technology Normal University Key Laboratory of Crop Physiology Ecology and Genetic BreedingMinistry of EducationKey Laboratory of PhysiologyEcology and Cultivation of Double Cropping RiceMinistry of AgricultureJiangxi Agricultural University

The biocompatiable and low-toxic poly（thiophene-3-aeetic acid）（PTAA） matrix was successfully electrosynthesized in ionic liquid 1-butyl-3-metbylimidazolium hexafluorophosphate （BmimPF6） in comparison with the electrosynthesis of PTAA matrix in acetonitrile （ACN）. Ascorbate oxidase （AO） was used as a model for the development and application of biosensor. Vitamin C （VC） biosensors were facilely fabricated by the covalent immobilization of AO molecules on PTAA matrices electrosynthesized in ACN containing tetrabutylammonium tetrafluoroborate and BmimPF6, respectively. Electrochemical impedance spectroscopy, scanning electron microscopy and FTIR spectroscopy indicated that AO molecules were covalently immobilized on PTAA matrices. Parameters of the as-obtained biosensors such as working potential, pH and temperature have been optimized. The amperometric biosensor based on PTAA matrix electrosynthesized in BmimPF6 exhibited wider linear range, lower detection limit, higher sensitivity and bioaffinity, and better operational and storage stability than that electrosynthesized in ACN under optimal conditions. The as-obtained biosensor based on PTAA matrix electrosynthesized in BmimPF6 was employed for the detection of VC content in comme：rcial juices, and the result was close to the data given by manufacturers. Excellent results indicate that the PTAA matrix electrosynthesized in ionic liquid is a promising platform for the covalent immobilization of biologically-active species and the development of biosensors.

关键词： Poly(thiophene-3-acetic acid) Ionic liquids Ascorbate oxidase Vitamin C Biosensor.

An Estimation Method of Stress in Soft Rock Based on In-situ Measured Stress in Hard Rock

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Journal of China University of Mining and Technology 2007年第3期17卷 310-315,320页

作者： Li wen-ping LI Xiao-qin SUN Ru-hua School of Resources and Earth Science China University of Mining ＆ Technology Xuzhou Jiangsu 221008 China

The law of variation of deep rock stress in gravitational and tectonic stress fields is analyzed based on the Hoek-Brown strength criterion. In the gravitational stress field,the rocks in the shallow area are in an elastic state and the deep,relatively soft rock may be in a plastic state. However,in the tectonic stress field,the relatively soft rock in the shallow area is in a plastic state and the deep rock in an elastic state. A method is proposed to estimate stress values in coal and soft rock based on in-situ measurements of hard rock. Our estimation method relates to the type of stress field and stress state. The equations of rock stress in various stress states are presented for the elastic,plastic and critical states. The critical state is a special stress state,which indicates the conversion of the elastic to the plastic state in the gravitational stress field and the conversion of the plastic to the elastic state in the tectonic stress field. Two cases stud-ies show that the estimation method is feasible.

关键词： rock stress gravity stress tectonic stress critical depth estimation method

Two new phenolic compounds from Ardisia gigantifolia

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Chinese Chemical Letters 2008年第6期19卷 693-695页

作者： Zhu Yang ping wen Nai Li Wang Xin Sheng Yao College of Traditional Chinese Materia Medica Shenyang Pharmaceutical University Shenyang 110016 China Shenzhen Key Laboratory for New Drugs Research of Traditional Chinese Medicines Research Institute of Tsinghua University Shenzhen 518057 China

Two new compounds were isolated from the 60% ethanol extract of the dried rhizome of Ardisia gigantifolia Stapf. The structures were elucidated on the basis of spectroscopic methods as （＋）-5-（1,2-dihydroxypentyl）... 详细信息

关键词： Ardisia gigantifolia Stapf Phenolic compounds 5-(1,2-Dihydroxypentyl)benzene-1,3-diol

A LEAP FROG FINITE DIFFERENCE SCHEME FOR A CLASS OF NONLINEAR SCHRODINGER EQUATIONS OF HIGHORDER

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Journal of Computational Mathematics 1999年第2期17卷 133-138页

作者： wen-ping Zeng(Department of Mathematics, Overseas Chinese University, Quanzhou 562011, China) 华侨大学数学系福建泉州

In this paper, the periodic initial value problem for the following class of nonlinear Schrodinger equation of high order i partial derivative u/partial derivative t + (-1)(m) partial derivative(m)/partial derivative x(m) (a(x)partial derivative(m)u/partial derivative x(m)) + beta(x)q(\u\(2))u + f(x, t)u = g(x, t) is considered. A leap-frog finite difference scheme is given, and convergence and stability is proved. Finally, it is shown by a numerical example that numerical result is coincident with theoretical result.

关键词： high order nonlinear Schrodinger equation leap-frog difference scheme convergence

Tailoring crystal polymorphs of organic semiconductors towards high-performance field-effect transistors

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Chinese Chemical Letters 2016年第8期27卷 1330-1338,1469页

作者： Yong-Gang Zhen Huan-Li Dong Lang Jiang wen-ping Hu Beijing National Laboratory for Molecular Sciences Key Laboratory of Organic Solids Institute of Chemistry Chinese Academy of Sciences Tianjin Key Laboratory of Molecular Optoelectronic Sciences Department of Chemistry School of Sciences Tianjin University & Collaborative Innovation Center of Chemical Science and Engineering (Tianjin)

As a quite ubiquitous phenomenon,crystal polymorph is one of the key issues in the field of organic *** review gives a brief summary to the advances on polymorph control of thin film and single crystal of representative organic semiconductors towards high-performance field-effect ***,the relationship between crystal polymporh and charge transport behaviour has been discussed to shed light on the rational preparation of outstanding organic semiconducting materials with desired crystal polymorph.

关键词： Organic semiconductors Crystal polymorphs Crystal engineering Charge transport Field-effect transistors