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Identification of four differentially expressed genes associated with acute and chronic spinal cord injury based on bioinformatics data

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Neural Regeneration Research 2021年第5期16卷 865-870页

作者： Su-ping niu Ya-Jun Zhang Na Han Xiao-Feng Yin Dian-Ying Zhang Yu-Hui Kou Key Laboratory of Trauma and Neural Regeneration(Peking University) Ministry of EducationBeijingChina Department of Trauma and Orthopedics Peking University People’s HospitalBeijingChina Trauma Medicine Center Peking University People’s HospitalBeijingChina Office of Academic Research Peking University People’s HospitalBeijingChina

Complex pathological changes occur during the development of spinal cord injury(SCI),and determining the underlying molecular events that occur during SCI is necessary for the development of promising molecular targets and therapeutic *** study was designed to explore differentially expressed genes(DEGs)associated with the acute and chronic stages of SCI using bioinformatics *** expression profiles(GSE45006,GSE93249,and GSE45550)were downloaded from the Gene Expression Omnibus ***-associated DEGs from rat samples were identified,and Gene Ontology and the Kyoto Encyclopedia of Genes and Genomes pathway enrichment analyses were *** addition,a protein-protein interaction network was *** 66 DEGs were identified in GSE45550 between 3–14 days after SCI,whereas 2418 DEGs were identified in GSE450061–56 days after ***,1263,195,and 75 overlapping DEGs were identified between these two expression profiles,3,7/8,and 14 days after SCI,***,16 overlapping DEGs were obtained in GSE450061–14 days after SCI,including Pank1,Hn1,Tmem150c,Rgd1309676,Lpl,Mdh1,Nnt,Loc100912219,Large1,Baiap2,Slc24a2,Fundc2,Mrps14,Slc16a7,Obfc1,and ***,3882 overlapping DEGs were identified in GSE932491–6 months after SCI,including 3316 protein-coding genes and 567 long non-coding RNA genes.A comparative analysis between GSE93249 and GSE45006 resulted in the enrichment of 1135 overlapping *** significant functions of these 1135 genes were correlated with the response to the immune effector process,the innate immune response,and cytokine ***,the biological processes and KEGG pathways of the overlapping DEGs were significantly enriched in immune system-related pathways,osteoclast differentiation,the nuclear factor-κB signaling pathway,and the chemokine signaling ***,an analysis of the overlapping DEGs associated with both acute and chronic SCI,assessed using the expressio

关键词： bioinformatics differential expression factor gene immune response injury pathways protein spinal cord

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Constructing long-cycling crystalline C_(3)N_(4)-based carbonaceous anodes for sodium-ion battery via N configuration control

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Carbon Energy 2024年第1期6卷 159-171页

作者： Ying Wang Hongguan Li Shuanlong Di Boyin Zhai ping niu Antonios Kelarakis Shulan Wang Li Li School of Metallurgy Northeastern UniversityShenyangLiaoningChina State Key Laboratory of Rolling and Automation Northeastern UniversityShenyangLiaoningChina Department of Chemistry College of ScienceNortheastern UniversityShenyangLiaoningChina School of Natural Sciences UCLan Research Centre for Smart MaterialsUniversity of Central LancashirePrestonUK Foshan Graduate School of Innovation Northeastern UniversityFoshanGuangdongChina

Carbon nitrides with two-dimensional layered structures and high theoretical capacities are attractive as anode materials for sodium-ion batteries while their low crystallinity and insufficient structural stability strongly restrict their practical *** carbon nitrides with conductive carbon may relieve these ***,little is known about the influence of nitrogen(N)configurations on the interactions between carbon and C_(3)N_(4),which is fundamentally critical for guiding the precise design of advanced C_(3)N_(4)-related ***,highly crystalline C_(3)N_(4)(poly(triazine imide),PTI)based all-carbon composites were developed by molten salt *** importantly,the vital role of pyrrolic-N for enhancing charge transfer and boosting Na+storage of C_(3)N_(4)-based composites,which was confirmed by both theoretical and experimental evidence,was spot-highlighted for the first *** elaborately controlling the salt composition,the composite with high pyrrolic-N and minimized graphitic-N content was *** from the formation of highly crystalline PTI and electrochemically favorable pyrrolic-N configurations,the composite delivered an unusual reverse growth and record-level cycling stability even after 5000 cycles along with high reversible capacity and outstanding full-cell capacity *** work broadens the energy storage applications of C_(3)N_(4) and provides new prospects for the design of advanced all-carbon electrodes.

关键词： anode highly crystalline C_(3)N_(4) N configuration sodium-ion batteries ultra-long cyclic stability

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Genetic variation in the triosephosphate isomerase gene of the fall armyworm and its distribution across China

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Insect Science 2024年第6期31卷 1984-1997页

作者： Xin-Yue Liang Lei Zhang Hong-Ran Li Xiao-ping niu Yu-Tao Xiao Shenzhen Branch Guangdong Laboratory for Lingnan Modern AgricultureKey Laboratory of Gene Editing Technologies(Hainan)Ministry of Agriculture and Rural AffairsAgricultural Genomics Institute at ShenzhenChinese Academy of Agricultural SciencesShenzhenGuangdongChina College of Life Sciences South China Agricultural UniversityGuangzhouChina Xingping Plant Protection and Plant Quarantine Station XianChina

The fall armyworm(FAW),Spodoptera frugiperda,has colonized and caused consistent damage in the Eastern *** identification of various FAW strains is essential for developing precise prevention and control *** triosephosphate isomerase(Tpi)gene is recognized as an effective marker closely linked to FAW ***,most current studies primarily focus on the comparison of variations in specific gene sites of this *** this study,we conducted full-length sequencing of the Tpi genes from 5 representative FAW *** findings revealed that the Tpi genes varied in length from 1220 to 1420 bp,with the primary variation occurring within 4 ***,the exon lengths remained consistent,at 747 bp,with 37 observed base variations;however,no amino acid variations were *** sequence alignment,we identified 8 stable variation sites that can be used to distinguish FAW strains in the Eastern ***,we performed strain identification on 1569 FAW samples collected from 19 provinces in China between 2020 and *** extensive analysis indicated the absence of the rice strain in the ***,we only detected the presence of the corn strain and the Zambia strain,with the Zambia strain being distributed in a very low proportion(3.44%).Furthermore,the corn strain could be further categorized into 2 *** comprehensive study provides a valuable reference for enhancing our understanding of FAW population differentiation and for improving monitoring and early warning efforts.

关键词： corn strain molecular marker rice strain Spodoptera frugiperda Tpi Zambia strain

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Photocatalytic overall water splitting by graphitic carbon nitride

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InfoMat 2021年第9期3卷 931-961页

作者： ping niu Junjing Dai Xiaojuan Zhi Zhonghui Xia Shulan Wang Li Li School of Metallurgy Northeastern UniversityShenyangPeople's Republic of China State Key Laboratory of Rolling and Automation Northeastern UniversityShenyangLiaoningChina Department of Chemistry College of ScienceNortheastern UniversityShenyangLiaoningChina

Photocatalytic overall water splitting(OWS)without using any sacrificial reagent to realize H_(2)and O_(2)production in the stoichiometric ratio of 2:1 is viewed as the“holy grail”in the field of solar fuel *** stable,low cost,and nontoxic photocatalysts that have satisfactory solar-tohydrogen conversion efficiency is of significance but challenging for realizing the large-scale use of this sustainable *** various photocatalysts,graphitic carbon nitride(GCN)has shown great potential as an ideal candidate to fulfill the breakthrough in this dynamic research field due to its attractive physicochemical ***,for the first time,the state-ofthe-art research progress of GCN for photocatalytic OWS is *** first summarize the basic principle of photocatalytic OWS along with the advantages/challenges of GCN *** strategies that have been used to modulate the OWS activity of GCN are then reviewed,including cocatalyst investigation,morphology modulation,atomic structure modification,crystallinity engineering,and heterostructure *** the end of the review,the concluding remarks and perspectives for the future development are presented,with our expectation to provide some new ideas for the design of advanced OWS photocatalysts.

关键词： graphitic carbon nitride overall water splitting photocatalyst solar energy conversion

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Selective flotation separation of andalusite and quartz and its mechanism

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International Journal of Minerals,Metallurgy and Materials 2019年第9期26卷 1059-1068页

作者： Yan-ping niu Chuan-yao Sun Wan-zhong Yin Xing-rong Zhang Hong-feng Xu Xu Zhang College of Resources and Civil Engineering Northeastern UniversityShenyang 110000China State Key Laboratory of Mineral Processing BGRIMM Technology GroupBeijing 100160China The Research Center of Experimental Testing for Geology and Minerals in Heilongjiang Province Harbin 150000China Heilongjiang Mining Group Co. Ltd. Harbin 150000China

The separation of andalusite and quartz was investigated in the sodium oleate flotation system, and its mechanism was studied by solution chemical calculation, zeta-potential tests, Fourier transform infrared spectroscopic(FTIR), and X-ray photoelectron spectroscopic(XPS). The flotation tests results show that FeCl3·6H2O has a strong activation effect on andalusite and quartz and citric acid has a strong inhibitory effect on activated quartz, thus increasing the floatability difference between quartz and andalusite when the pulp p H is approximately 8. The FTIR, Zeta potential, and XPS analyses combined with the chemical calculation of flotation reagent solutions demonstrate that Fe forms hydroxide precipitates on the surface of andalusite and quartz and that oleate anions and metal ions adsorb onto the surface of the minerals. The elements Al and Fe can be chemically reacted. The anions in citric acid have different degrees of dissolution of Fe on the andalusite and quartz surfaces, thereby selectively eliminating the activation of the elemental Fe on andalusite and quartz and increasing the floatability of andalusite, leading to a better separation effect between andalusite and quartz.

关键词： andalusite quartz flotation mechanism zeta potential Fourier infrared spectrum analysis X-ray photoelectron energy spectrum analysis

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Oxygen content of high ferrotitanium prepared by thermite method with different melt separation temperatures

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Rare Metals 2019年第9期38卷 892-898页

作者： Chu Cheng Zhi-He Dou Ting-An Zhang Jian-Ming Su Hui-Jie Zhang Yan Liu Li-ping niu School of Metallurgy Northeastern UniversityShenyang 110819China Key Laboratory of Ecological Utilization of Multi-metal Intergrown Ores of Ministry of Education Shenyang 110819China

High ferrotitanium prepared directly by the thermite method has a disadvantageously high O content(≥10 wt%)because of the short slag-metal separation *** this study,CaO and CaF2 are added to the melt to improve the basicity of the slag and melt separation under heat preservation is performed to strengthen slag-metal *** thermodynamics of the step-by-step reduction process of TiO2 in the Ti-Al-Fe-Si-O system whose composition is close to the alloy after melt separation were *** of alloys and slags before and after melt separation were systematically *** result indicates that the reaction that TiO is reduced by Al to Ti is the limited step in the reduction process of *** O content of the alloys slightly decreases with temperature from 1873 to 2023 K,which agrees with the changes in the law of deoxidation *** is mainly attributed to the movement of chemical reactions in the alloy melt at different temperatures and slag-metal interfacial *** addition of Al2 O3-CaO-CaF2 slag and high temperature promote the removal of Al2 O3 and titanium *** minimum contents of O and Al in the alloy reach 1.84 wt% and 3.26 wt%,respectively.

关键词： High ferrotitanium Oxygen content Melt separation Slag-metal separation Thermite method

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Sulfur distribution in preparation of high titanium ferroalloy by thermite method with different CaO additions

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Rare Metals 2019年第8期38卷 793-799页

作者： Chu Cheng Zhi-He Dou Ting-An Zhang Jian-Ming Su Hui-Jie Zhang Yan Liu Li-ping niu School of Metallurgy Northeastern University Shenyang 110819 China Key Laboratory of Ecological Utilization of Multi-Metal Intergrown Ores of Ministry of Education Northeastern University Shenyang 110819 China

Ferrotitanium is used as a deoxidizer and alloying agent during steelmaking process,which has a high demand for sulfur *** was introduced from raw materials in the process of producing ferrotitanium by thermite method,where CaO was used as fluxing *** the same time,CaO has a great desulfurization *** of CaO addition on the distribution of sulfur in high titanium ferroalloy prepared by thermite method were studied in this *** equilibrium diagram of Ti-AlFe-S system was calculated by FactSage 6.4 software package with FactPS and FTmisc *** alloy and slag samples were characterized by X-ray diffraction(XRD),scanning electron microscopy(SEM),inductively coupled plasma atomic emission spectrometer(ICP-AES),X-ray fluorescence(XRF)and high-frequency infrared ray carbon sulfur *** result indicates that the sulfur in the alloy firstly exists in the form of liquid FeS,thereafter TiS(s)and eventually Ti2 S(s)during *** sulfur is mainly distributed in the alloy,and only a small amount of sulfur remains in the ***,it is noted that the sulfur in the alloy does not distribute homogeneously,and it exists in the form of solid solution phase,(Ti,Al,Fe)S.S content in the slag,the sulfur capacity of the slag and the sulfur distribution ratio(LS)all increase with the increment of CaO addition,while S content in alloys decreases.

关键词： Desulfurization Sulfur partition ratio Optical basicity High titanium ferroalloy Thermite method

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Pollution tracks of r-process material in[Sr/Ba]vs.[Ba/Fe]space for the early Galaxy

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Research in Astronomy and Astrophysics 2021年第5期21卷 91-100页

作者： Wan-Qiang Han Guo-Chao Yang Lu Zhang Wen-Yuan Cui ping niu Fang Wen Bo Zhang Department of Physics Hebei Normal UniversityShijiazhuang 050024China Department of Physics Shijiazhuang UniversityShijiazhuang 050035China School of Sciences Hebei University of Science and TechnologyShijiazhuang 050018China College of Mathematics and Information Science Hebei Normal UniversityShijiazhuang 050024China

In the early Galaxy,elemental abundances of the extremely metal-poor(EMP)stars contain abundant information about the neutron-capture nucleosynthesis and the chemical enrichment *** this work,we study the abundance characteristics of Sr and Ba for the EMP stars in the[Sr/Ba]vs.[Ba/Fe]*** find that there are three boundaries for the distribution region of the EMP *** weak rprocess star CS 22897-008 lies on the upper end and the main r-process stars lie on the right end of the *** the right boundary of the distribution region,there is an Fe-normal *** the EMP stars in the belt,element Fe dominantly originates from the normal massive *** low-Sr stars([Sr/Fe]6−0.3)distribute in the region of the lower left of the Fe-normal belt and their Fe should originate partly from the prompt *** find that the formation of the lower boundary of the distribution region is due to the pollution of the main r-process material and the formation of the right boundary could be explained by the combination of the weak r-and main r-process ***,the formation of the left boundary is due to the pollution of the weak r-process *** the[Sr/Ba]ratios are related to the relative importance of the weak r-process material,the scatter of[Sr/Ba]ratios for the EMP stars mainly depends on the abundance ratio of the weak r-process.

关键词： stars:abundances stars:formation stars:massive

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Changes in proteins related to early nerve repair in a rat model of sciatic nerve injury

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Neural Regeneration Research 2021年第8期16卷 1622-1627页

作者： Yu-Song Yuan Fei Yu Ya-Jun Zhang Su-ping niu Hai-Lin Xu Yu-Hui Kou Department of Trauma and Orthopedics Peking University People’s HospitalBeijingChina Key Laboratory of Trauma and Neural Regeneration(Peking University) Ministry of EducationBeijingChina National&Local Joint Engineering Research Center of Orthopedic Biomaterials Department of Bone&Joint SurgeryPeking University Shenzhen HospitalShenzhenGuangdong ProvinceChina National Center for Trauma Medicine BeijingChina Office of Academic Research Peking University People’s HospitalBeijingChina Diabetic Foot Treatment Center Peking University People’s HospitalBeijingChina

Peripheral nerves have a limited capacity for self-repair and those that are severely damaged or have significant defects are challenging to repair. Investigating the pathophysiology of peripheral nerve repair is important for the clinical treatment of peripheral nerve repair and regeneration. In this study, rat models of right sciatic nerve injury were established by a clamping method. Protein chip assay was performed to quantify the levels of neurotrophic, inflammation-related, chemotaxis-related and cell generation-related factors in the sciatic nerve within 7 days after injury. The results revealed that the expression levels of neurotrophic factors(ciliary neurotrophic factor) and inflammationrelated factors(intercellular cell adhesion molecule-1, interferon γ, interleukin-1α, interleukin-2, interleukin-4, interleukin-6, monocyte chemoattractant protein-1, prolactin R, receptor of advanced glycation end products and tumor necrosis factor-α), chemotaxis-related factors(cytokine-induced neutrophil chemoattractant-1, L-selectin and platelet-derived growth factor-AA) and cell generation-related factors(granulocyte-macrophage colony-stimulating factor) followed different trajectories. These findings will help clarify the pathophysiology of sciatic nerve injury repair and develop clinical treatments of peripheral nerve injury. This study was approved by the Ethics Committee of Peking University People's Hospital of China(approval No. 2015-50) on December 9, 2015.

关键词： animal model cell generation chemotaxis clamp injury inflammation injury neurotrophic factor peripheral nerve protein array repair sciatic nerve Wallerian degeneration

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Constructing CdSe QDs modified porous g-C_(3)N_(4)heterostructures for visible light photocatalytic hydrogen production

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Journal of Materials Science & Technology 2021年第36期95卷 167-171页

作者： Zheng Zhang Yuyang Kang Li-Chang Yin ping niu Chao Zhen Runze Chen Xiangdong Kang Fayu Wu Gang Liu School of Material and Metallurgy University of Science and Technology LiaoningAnshan 114051China Shenyang National Laboratory for Materials Science Institute of Metal ResearchChinese Academy of SciencesShenyang 110016China School of Materials Science and Engineering University of Science and Technology of ChinaShenyang 110016China School of Metallurgy Northeastern UniversityShenyang 110819China Key Laboratory for Anisotropy and Texture of Materials(Ministry of Education) Northeastern UniversityShenyang 110819China

Constructing heterostructures with narrow-band-gap semiconductors is a promising strategy to extend light absorption range of graphitic carbon nitride(g-C_(3)N_(4))and simultaneously promote charge separation for its photocatalytic activity ***,its highly localized electronic states of g-C_(3)N_(4)hinder photo-carrier migration through bulk towards heterostructure interfaces,resulting in low charge carrier separation efficiency of solid bulk g-C_(3)N_(4)-based ***,porous g-C_(3)N_(4)(PCN)material with greatly shortened migration distance of photo-carriers from bulk to surface was used as an effective substrate to host Cd Se quantum dots to construct type II heterostructure of Cd Se/PCN for photocatalytic hydrogen *** homogeneous modification of the Cd Se quantum dots throughout the whole bulk of PCN together with proper band alignments between Cd Se and PCN enables the effective separation of photo-generated charge carriers in the ***,the Cd Se/PCN heterostructure photocatalyst gives the greatly enhanced photocatalytic hydrogen production activity of192.3μmol h^(-1),which is 4.4 and 8.1 times that of Cd Se and PCN,*** work provides a feasible strategy to construct carbon nitride-based heterostructure photocatalysts for boosting visible light driven water splitting performance.

关键词： Porous g-C_(3)N_(4) CdSe QDs Heterostructure Photocatalytic water splitting

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