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Constructing multifunctional deep-blue emitters with weak charge transfer excited state for high-performance non-doped blue OLEDs and single-emissive-layer hybrid white OLEDs

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Chinese Chemical Letters 2024年第10期35卷 175-179页

作者： Hui Liu Xiangyang Tang zhuang Cheng Yin Hu Yan Yan Yangze Xu Zihan Su Futong Liu ping Lu State Key Laboratory of Supramolecular Structure and Materials Department of Chemistry Jilin UniversityChangchun 130012China Sichuan Province Key Laboratory of Information Materials and Devices Application College of Optoelectronic EngineeringChengdu University of Information TechnologyChengdu 610225China

Deep-blue emitter with high photoluminescence efficiency(PLQY)is highly desirable in ultra-high definition displays and white solid-state *** this work,two deep-blue phenanthro[9,10]imidazole derivatives,PPIS and PPPIS,with hot exciton property are successfully *** to PPIS,the embedded phenyl bridge in PPPIS is able to effectively increase the overlap of frontier molecular *** consequence,PPPIS shows higher oscillator strength and significantly enhanced *** also achieves better electroluminescence performance in non-doped device,showing deep-blue emission with Commission International de l’Eclairage(CIE)coordinates of(0.153,0.087)and the maximum external quantum efficiency(EQEmax)of 8.5%with minuscule efficiency ***,when PPPIS serves as the host for phosphor PO-01,high-efficiency orange phosphorescent device is obtained with high EQEmax of 29.8%and negligible efficiency roll-off at 1000 cd/m^(2).Further,efficient single-emissive-layer white device is assembled via utilizing PPPIS as a blue emitter as well as the host for PO-01 simultaneously,providing warm-white emission with CIE coordinates of(0.429,0.433)at 1000 cd/m^(2),the forward-viewing EQEmaxof 27.2%and maximum power efficiency(PEmax)of 80.1 lm/W,*** studies can establish a viable design strategy for deep-blue emitters in high-performance non-doped blue OLEDs and hybrid WOLEDs.

关键词： Deep-blue emitters Phenanthroimidazole Hot exciton Host Single-emissive-layer white device

Engineered extracellular vesicles: A new approach for targeted therapy of tumors and overcoming drug resistance

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Cancer Communications 2024年第2期44卷 205-225页

作者： Chen Ming-Kun Chen Zi-Xian Cai Mao-ping Chen Hong Chen zhuang-Fei Zhao Shan-Chao Department of Urology The Third Affiliated Hospital of Southern Medical UniversityGuangzhouGuangdongP.R.China The Third Clinical College Southern Medical UniversityGuangzhouGuangdongP.R.China Luoyang Key Laboratory of Organic Functional Molecules College of Food and DrugLuoyang Normal UniversityLuoyangHenanP.R.China Department of Urology Nanfang HospitalSouthern Medical UniversityGuangzhouGuangdongP.R.China

Targeted delivery of anti-tumor drugs and overcoming drug resistance in malig-nant tumor cells remain significant clinical ***,there are only few effective methods to address these *** vesicles(EVs),actively secreted by cells,play a crucial role in intercellular information transmis-sion and cargo *** studies have demonstrated that engineered EVs can serve as drug delivery carriers and showed promising application ***,there is an urgent need for further improvements in the isolation and purification of EVs,surface modification techniques,drug assem-bly processes,and precise recognition of tumor cells for targeted drug delivery *** this review,we summarize the applications of engineered EVs in cancer treatment and overcoming drug resistance,and current challenges asso-ciated with engineered EVs are also *** review aims to provide new insights and potential directions for utilizing engineered EVs as targeted delivery systems for anti-tumor drugs and overcoming drug resistance in the near future.

关键词： drug delivery drug resistance extracellular vesicles nanoparticles

Clinicopathological study on TTV infection in hepatitis of unknown etiology

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World Journal of Gastroenterology 2002年第2期8卷 288-293页

作者： Zhong-Jie Hu Zhen-Wei Lang Yu-Sen Zhou Hui-ping Yan De-zhuang Huang Wan-Rong Chen Zhao-Xia Luo,Department of Pathology,Beijing You’an Hospital,Beijing 100054,China Department of Pathology Beijing You'an Hospital 8 You'an Men Wai Beijing 100054 China. huzhong-jie@***

AIM: To investigate the state of infection, replication site, pathogenicity and clinical significance of transfusion transmitted virus (TTV) in patients with hepatitis, especially in patients of unknown etiology. METHODS: Liver tissues taken from 136 cases of non-A non-G hepatitis were tested for TT virus antigen and nucleic acid by in situ hybridization (ISH) and nested-polymerase chain reaction (PCR). Among them, TT virus genome and its complemental strand were also detected in 24 cases of autopsy liver and extrahepatic tissues with ISH. Meanwhile, TTV DNA was detected in the sera of 187 hepatitis patients by nested-PCR. The pathological and clinical data of the cases infected with TTV only were analyzed. RESULTS: In liver, the total positive rate of TTV DNA was 32.4% and the positive signals were located in the nuclei of hepatocytes. In serus, TTV DNA was detected in 21.4% cases of hepatitis A-G, 34.4% of non-A non-G hepatitis and 15% of healthy donors. The correspondence rate of TTV DNA detection between liver tissue with ISH and sera with PCR was 63.2% and 89.3% in the same liver tissues by ISH and by PCR, *** double-strand probes and single-strand probes designed to detect TTV genome, the correspondence rate of TTV DNA detected in liver and extrahepatic tissues was 85.7%. Using single-strand probes, TTV genome could be detected in liver and extrahepatic tissues by PCR, but its complemental strands (replication strands) could be observed only in livers. The liver function of most cases infected with TTV alone was abnormal and the liver tissues had different pathological damage such as ballooning, acidophilia degeneration, formation of apoptosis bodies and focus of necrosis, but the inflammation in the lobule and portal area was mild. CONCLUSION: The positive rate of TTV DNA among cases of hepatitis was higher than that of donors, especially in patients with non-A non-G hepatitis, but most of them were coinfected with other hepatitis viruses. TTV

关键词： Adolescent Adult Aged DNA Virus Infections Female Hepatitis, Viral, Human Humans In Situ Hybridization Liver Male Middle Aged Research Support, Non-U.S. Gov't Torque teno virus purification

Reading Shakespeare’s Sonnets on The Relationship of Love and Time as A Drama

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海外英语 2019年第21期 230-231页

作者：庄平贤 Faculty of English Language and Culture Guangdong University of Foreign Studies

There is special intertextuality between Shakespeare’s sonnet 115&116,each of which contributes to make up a complete mosaic of the speaker’s passionate but philosophical process of rumination on the relationship between love and *** juxtaposing these two sonnets,we can find an organic entirety very similar to“a drama”under the same theme,and each sonnet,like a scene for the drama,is indispensable in constructing a process of pondering on the relationship between love and time.

关键词： sonnet Shakespeare intertextuality stylistics comparative study

Juxtaposing the Road Taken and Not Taken: An Intertextual Study on Two of Robert Frost’s Poems

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海外英语 2019年第20期 237-238页

作者：庄平贤 Faculty of English Language and Culture Guangdong University of Foreign Studies

By juxtaposing two of Robert Frost's poems—"The Road Not Taken"and"Stopping by Woods on a Snowy Evening"and using stylistic analysis method,this essay tries to make a comparative study on the poems from the perspective of intertextuality,so as to find out a trajectory of Robert Frost's meditations on life and the consistency and connectivity in the crafts and style of his poems,and thus acquire a deeper and multi-angle interpretation on the poems.

关键词： poem Robert Frost intertextuality stylistics comparative study

Comparison of Nutritional Components in the Muscle of Juvenile Siganus guttatus Fed with Enteromorpha prolifera and Artificial Feed

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Animal Husbandry and Feed Science 2017年第6期9卷 373-378页

作者： Song Chao Zhao Feng Liu Jianyi Wang Yu Huang Xiaorong zhuang ping Key Laboratory of East China Sea Fishery Resources Exploitation Ministry of Agriculture East China Sea Fisheries Research Institute Chinese Academy of Fishery Sciences

[ Objective] This experiment was conducted to analyze and compare the nutritional components in the muscle of juvenile Siganus guttatus fed with Enteromorpha prolifera and artificial feed. [ Method] A total of 180 healthy S. guttatus juveniles with similar body size were assigned into two groups： one fed with E. prolifera, and the other fed with artificial feed, respectively. There were three replicates in each group, and 30 fish in each replicate. And the experiment lasted for 90 d. [ Result] The results showed that the weight gain rate, specific growth rate and relative growth rate of E. prolifera-fed group were significantly lower than those of artificial feed-fed group （P 〈0.05） ; the contents of crude protein and crude ash of E. prolifera-fed group were significantly higher than those of artificial feed-fed group （P 〈 0.05 ）. However, the content of crude fat of E. prolifera-fed group was significantly lower than that of artificial feed-fed group （P 〈 0.05 ）. The moisture content had no significant difference between the two groups （P 〉 0.05 ）. The amino acid composition was similar between the two groups. Seventeen amino acids were found in both groups, and the essential amino acid index （EAAI） was 76.71 in E. prolifera-fed group and 70.05 in artificial feed-fed group, both of which met the criteria set by the Food and Agriculture Organization of the United Nations （FAO）/World Health Organization （WHO）. The content of eicosapentaenoic acid （EPA）＋ docosahexaenoic acid （DHA） and the content of to-3 polyunsaturated fatty acids （ to-3 PUFAs） of E. prolifera-fed group were significantly higher than those of artificial feed-fed group （ P 〈 0.05 ）. [ Conclusion ] In conclusion, the juvenile S. guttatus in both groups contains a variety of nutritional components. S. guttatus fed with E. prolifera has higher levels of essential amino acids, more balanced composition of polyunsaturated fatty acids, higher nutritive val- ue and better taste than that fed with artificial

关键词： Siganus guttatus Nutritional components Amino acids Fatty acids Enteromorpha prolifera Artificial feed

清华大学图书馆业务统计工作模式的创新与实践

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大学图书馆学报 2009年第4期27卷 24-28页

作者：王平庄玫赵熊清华大学图书馆北京100084

业务统计历来是图书馆管理规范化的一项重要基础工作,统计信息是掌握图书馆各项工作情况的重要依据。统计工作中最重要的因素是统计制度、统计系统、统计指标和统计方法。该文以国外及港台图书馆的统计工作为参照,详细介绍了清华大学图... 详细信息

业务统计历来是图书馆管理规范化的一项重要基础工作,统计信息是掌握图书馆各项工作情况的重要依据。统计工作中最重要的因素是统计制度、统计系统、统计指标和统计方法。该文以国外及港台图书馆的统计工作为参照,详细介绍了清华大学图书馆2005年起由主管馆长负责尝试在全馆范围组织开展的业务统计工作的过程、进展情况和发展方向。

关键词：高校图书馆统计模式 i@report 统计系统

Subthalamic deep brain stimulation for Parkinson＇s disease： correlation of active contacts and electrophysiologically mapped subthalamic nucleus

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Chinese Medical Journal 2009年第20期122卷 2419-2422页

作者： ZHENG Zhe ZHANG Yu-qing LI Jian-yu ZHANG Xiao-hua zhuang ping LI Yong-jie Beijing Institute of Functional Neurosurgery Xuanwu Hospital Capital Medical University Beijing 100053 China Key Laboratory of Neurodegenerative Diseases Capital Medical University Ministry of Education Beijing 100053 China

Background Subthalamic deep brain stimulation （STN-DBS） has been shown to be effective in the treatment of Parkinson＇s disease. The site for permanent stimulation is still in debate. This study aimed to assess the position of active contacts in relation to the subthalamic nucleus. Methods We reviewed the location of 40 electrodes in 34 patients who underwent STN-DBS. The position of electrode was evaluated by postoperative magnetic resonance imaging （MRI）. The position of active contacts was compared with the subthalamic nucleus （STN） determined by intraoperative electrophysiological mapping and postoperative MRI. Results The average position of the 40 active contacts was （11.7±1.2） mm lateral, （0.6±1.3） mm anterior, and （0.7±1.4） mm vertical to the midcommissural point. The dorsal margin of the STN was （11.6±1.1） mm lateral, （0.2±1.1） mm anterior, and （1.3±1.1） mm vertical to the midcommissural point. When compared with the dorsal margin of the STN, the active contacts were located more dorsally （P=0.033） and anteriorly （P=-0.012）, no significant difference was found in the lateral direction （P=0.107）. When compared with the position of the STN, 26 （65%） of active contacts were located in the region dorsal to the STN, only 13 （32.5%） were located in the upper two-thirds portion of STN. Conclusions The site for permanent stimulation appears to be in the subthalamic region dorsal to the STN, close to the dorsal margin of the STN. Besides the dorsal portion of the STN, other structures such as fields of Forel H and zona incerta may also be involved in the therapeutic benefit of deep brain stimulation.

关键词： subthalamic nucleus deep brain stimulation Parkinson's disease active contact

Neuronal firing in the ventrolateral thalamus of patients with Parkinson＇s disease differs from that with essential tremor

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Chinese Medical Journal 2010年第6期123卷 695-701页

作者： CHEN Hai zhuang ping MIAO Su-hua YUAN Gao ZHANG Yu-qing LI Jian-yu LI Yong-jie Beijing Institute of Functional Neurosurgery Department of NeurologyXuanwu HospitalCapital Medical UniversityKey Laboratory of Neurodegenerative DiseasesMinistry of EducationBeijing 100053China

Background Although thalamotomy could dramatically improve both parkinsonian resting tremor and essential tremor （ET）, the mechanisms are obviously different. This study aimed to investigate the neuronal activities in the ventrolateral thalamus of Parkinson＇s disease （PD） and ET. Methods Thirty-six patients （PD： 20, ET： 16） were studied. Microelectrode recordings in the ventral oral posterior （Vop）and the ventral intermediate nucleus （Vim） of thalamus was performed on these patients who underwent *** （EMG） was recorded simultaneously on the contralateral limbs to surgery. Single unit analysis and the interspike intervals （ISIs） were measured for each neuronal type. ISI histogram and auto-correlograms were constructed to estimate the pattern of neuronal firing. Mann-Whitney test and Kruskal-Wallis （K-W） test were used to compare the mean spontaneous firing rate （MSFR） of neurons of PD and ET patients. Results Three hundred and twenty-three neurons were obtained from 20 PD trajectories, including 151 （46.7%） tremor related neuronal activity, 74 neurons （22.9%） with tonic firing, and 98 （30.4%） neurons with irregular discharge. One hundred and eighty-seven neurons were identified from 16 ET trajectories including 46 （24.6%） tremor-related neuronal activity, 77 （41.2%） neurons with tonic firing, and 64 neurons （34.2%） with irregular discharge. The analysis of MSFR of neurons with tonic firing was 26.7 （3.4-68.3） Hz （n=74） and that of neurons with irregular discharge （n=98） was 13.9 （3.0-58.1） Hz in PD; whereas MSFR of neurons with tonic firing （n=77） was 48.8 （19.0-135.5） Hz and that of neurons with irregular discharge （n=64） was 26.3 （8.7-84.7） Hz in ET. There were significant differences in the MSFR of two types of neuron for PD and ET （K-W test, both P〈0.05）. Significant differences in the MSFR of neuron were also obtained from Vop and Vim of PD and ET （16.3 Hz vs. 34.8 Hz, 28.0 Hz vs. 49.9 Hz）（K-W test, both P 〈0.05）, respectively. Conclusi

关键词： Parkinson disease essential tremor ventrolateral thalamic nucleus microelectrodes