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Application of neutrophil-lymphocyte ratio and red blood cell distribution width in diabetes mellitus complicated with heart failure

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World Journal of Diabetes 2024年第6期15卷 1226-1233页

作者： Jie Pang Lin-Yan Qian ping lv Xiao-Ru Che Heart Center Department of Cardiovascular MedicineZhejiang Provincial People’s Hospital(The Affiliated People’s Hospital)Hangzhou Medical CollegeHangzhou 310014Zhejiang ProvinceChina

BACKGROUND Accumulating clinical evidence has shown that diabetes mellitus(DM)is a serious risk factor for cardiovascular disorders and an important factor for adverse cardiovascular *** To explore the value of the combined determination of the neutrophil-lymphocyte ratio(NLR)and red blood cell distribution width(RDW)in the early diagnosis and prognosis evaluation of DM complicated with heart failure(HF).METHODS We retrospectively analyzed clinical data on 65 patients with type 2 DM(T2DM)complicated with HF(research group,Res)and 60 concurrent patients with uncomplicated T2DM(control group,Con)diagnosed at Zhejiang Provincial People’s Hospital between January 2019 and December *** NLR and RDW values were determined and comparatively analyzed,and their levels in T2DM+HF patients with different cardiac function grades were *** receiver operating characteristic(ROC)curves were plotted to determine the NLR and RDW values(alone and in combination)for the early diagnosis of *** correlation between NLR and RDW with the presence or absence of cardiac events was also *** Higher NLR and RDW levels were identified in the Res vs the Con groups(P<0.05).The NLR and RDW increased gradually and synchronously with the deterioration of cardiac function in the Res group,with marked differences in their levels among patients with grade II,III,and IV HF(P<0.05).ROC curve analysis revealed that NLR combined with RDW detection had an area under the curve of 0.915,a sensitivity of 76.9%,and a specificity of 100%for the early diagnosis of ***,HF patients with cardiac events showed higher NLR and RDW values compared with HF patients without cardiac *** NLR and RDW were useful laboratory indicators for the early diagnosis of DM complicated with HF,and their joint detection was beneficial for improving diagnostic ***,NLR and RDW values were directly proportional to patient outcomes.

关键词： Neutrophil-lymphocyte ratio Red blood cell distribution width Type 2 diabetes Heart failure Early diagnosis

Micromechanism and mathematical model of stress sensitivity in tight reservoirs of binary granular medium

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Petroleum Science 2024年第3期21卷 1780-1795页

作者： Jian-Bang Wu Sheng-Lai Yang Qiang Li Kun Yang Can Huang Dao-ping lv Wei Zhou State Key Laboratory of Petroleum Resources and Engineering China University of Petroleum(Beijing)Beijing2249China Laboratoire de G eologie Ecole Normale Sup erieure/CNRS UMR8538PSL Research UniversityParis75005France Research Institute of Exploration and Development Xinjiang Oilfield CompanyKaramay834000XinjiangChina

Research on reservoir rock stress sensitivity has traditionally focused on unary granular structures,neglecting the binary nature of real reservoirs,especially tight *** the stresssensitive behavior and mathematical characterization of binary granular media remains a challenging *** this study,we conducted online-NMR experiments to investigate the permeability and porosity evolution as well as stress-sensitive control mechanisms in tight sandy conglomerate *** results revealed stress sensitivity coefficients between 0.042 and 0.098 and permeability damage rates ranging from 65.6%to 90.9%,with an average pore compression coefficient of 0.0168—0.0208 MPa ***-scale compression occurred in three stages:filling,compression,and compaction,with matrix pores playing a dominant role in pore *** stress sensitivity of binary granular media was found to be influenced by the support structure and particle *** stress sensitivity was associated with small fine particle size,high fines content,high uniformity coefficient of particle size,high plastic deformation,and low Young's ***-supported samples exhibited a high irreversible permeability damage rate(average=74.2%)and stress sensitivity coefficients(average=0.089),with pore spaces more *** contrast,grain-supported samples showed low stress sensitivity coefficients(average=0.021)at high stress *** on the experiments,we developed a mathematical model for stress sensitivity in binary granular media,considering binary granular properties and nested interactions using Hertz contact deformation and Poiseuille *** describing the change in activity content of fines under stress,we characterized the non-stationary state of compressive deformation in the binary granular structure and classified the reservoir into three *** model was applied for production prediction using actual data from the Mahu reservoir in China,showing that the e

关键词： Stress sensitivity Binary granular medium Tight reservoir Online-NMR Reservoir energy retention rate

Enhanced activation of peroxymonosulfate on layered molybdenum disulfide loaded with Co–La bimetallic oxide for efficient degradation of chloramphenicol

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Rare Metals 2024年第9期43卷 4628-4635页

作者： Yu-Ning Fan Yun-Qiu Zhang San-Shuang Gao Zeng-Hui Bi Yin Wang Shu-Xing Zhou Qian Liu Tian-ping lv Guang-Zhi Hu Institute for Ecological Research and Pollution Control of Plateau Lakes School of Ecology and Environmental ScienceYunnan University Hubei Key Laboratory of Low Dimensional Optoelectronic Materials and Devices Hubei University of Arts and Science Institute for Advanced Study Chengdu University

The use of transition metal-activated peroxymonosulfate（PMS） as an advanced oxidation technology has gained recognition. This study developed a catalyst using cobaltDlanthanum bimetallic oxide supported on layered molybdenum disulfide （Mo S2） as a carrier. The CoDLa/Mo S2catalyst was synthesised through coprecipitation, followed by calcination with an optimised metal ratio of Co:La=2:1 to activate PMS and degrade trace chloramphenicol（CAP） in water. The chemical composition of the catalyst was confirmed using X-ray diffraction （XRD） and X-ray photoelectron spectroscopy （XPS）. At catalyst and PMS dosages of 0.1 and 0.5 g·L-1, respectively, the degradation rate of CAP was 95% with in 30 min. The catalyst exhibitedstrong resistance to most interfering anions and maintained a high degradation rate at p H 3D11. Liquid chromatographyDmass spectrometry analysis revealed the potential degradation pathways of CAP in the CoDLa/Mo S2（2:1）/PMS system. For other pollutants, such as oxytetracycline,complete degradation was achieved within 20 min,demonstrating the broad applicability of the CoDLa/Mo S2（2:1）/PMS system for the degradation and removal of antibiotic organic contaminants. This study offers a feasible approach for the degradation of antibiotic organic pollutants, including CAP, in natural water bodies.

关键词： Catalysts

Caveolin‑1 is critical for hepatic iron storage capacity in the development of nonalcoholic fatty liver disease

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Military Medical Research 2024年第2期11卷 206-227页

作者： Guang-Hui Deng Chao-Feng Wu Yun-Jia Li Hao Shi Wei-Chao Zhong Mu-Keng Hong Jun-Jie Li Jia-Min Zhao Chang Liu Meng-Chen Qin Zhi-Yun Zeng Wei-Min Zhang Ken Kin Lam Yung Zhi-ping lv Lei Gao Department of Gastroenterology Integrated Hospital of Traditional Chinese MedicineSouthern Medical UniversityGuangzhou 510315China School of Traditional Chinese Medicine Southern Medical UniversityGuangzhou 510515China Department of Hepatology Cancer CenterIntegrated Hospital of Traditional Chinese MedicineSouthern Medical UniversityGuangzhou 510315China Shenzhen Traditional Chinese Medicine Hospital Shenzhen 518033GuangdongChina Department of Biology Hong Kong Baptist UniversityKowloon TongKowloonHong Kong SAR 999077China

Background:Nonalcoholic fatty liver disease(NAFLD)is associated with disordered lipid and iron *** previous study has substantiated the pivotal role of Caveolin-1(Cav-1)in protecting hepatocytes and mediating iron metabolism in the *** study aimed to explore the specific mechanisms underlying the regulation of iron metabolism by Cav-1 in ***:Hepatocyte-specific Cav-1 overexpression mice and knockout mice were used in this ***-1-knockdown of RAW264.7 cells and mouse primary hepatocytes were performed to verify the changes in ***,a high-fat diet and palmitic acid plus oleic acid treatment were utilized to construct a NAFLD model in vivo and in vitro,respectively,while a high-iron diet was used to construct an in vivo iron overload ***,iron concentration,the expression of Cav-1 and iron metabolism-related proteins in liver tissue or serum were detected using iron assay kit,Prussian blue staining,Western blotting,immunofluorescence staining,immunohistochemical staining and *** related indicators of lipid metabolism and oxidative stress were evaluated by the corresponding reagent kit and ***:Significant disorder of lipid and iron metabolism occurred in *** expression of Cav-1 was decreased in NAFLD hepatocytes(P<0.05),accompanied by iron metabolism ***-1 enhanced the iron storage capacity of hepatocytes by activating the ferritin light chain/ferritin heavy chain pathway in NAFLD,subsequently alleviating the oxidative stress induced by excess ferrous ions in the ***,CD68^(+) CD163^(+) macrophages expressing Cav-1 were found to accelerate iron accumulation in the liver,which was contrary to the effect of Cav-1 in *** correlations were also observed between the serum Cav-1 concentration and the serum iron-related protein levels in NAFLD patients and healthy volunteers(P<0.05).Conclusions:These findings confirm that Cav-1 is an essential target protein that reg

关键词： Caveolin-1 Nonalcoholic fatty liver disease Iron metabolism Ferritin Oxidative stress

我国产业结构优化升级对全球价值链嵌入的影响——基于对外开放的调节效应分析

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商业经济研究 2024年第6期 139-142页

作者：刘思锐吕萍哈尔滨商业大学经济学院黑龙江哈尔滨150028 黑龙江科技大学黑龙江哈尔滨150027

优化产业结构升级是提升我国在全球产业发展中竞争力的重要基础。本文从产业结构合理化和产业结构高级化两个维度研究了产业结构优化升级对我国全球价值链嵌入的影响,并进一步考察了对外开放的调节效应。研究发现,产业结构优化升级对我... 详细信息

优化产业结构升级是提升我国在全球产业发展中竞争力的重要基础。本文从产业结构合理化和产业结构高级化两个维度研究了产业结构优化升级对我国全球价值链嵌入的影响,并进一步考察了对外开放的调节效应。研究发现,产业结构优化升级对我国全球价值链嵌入会产生显著的正向赋能作用,但不同类型的产业结构优化升级对我国全球价值链嵌入的边际赋能效应存在一定的差异。相比较而言,产业结构高级化对我国全球价值链嵌入的边际赋能效应更强;进一步地发现,对外开放的调节效应存在,对外开放能够提升我国产业结构优化升级对全球价值链嵌入的边际赋能作用,但同样在不同类型产业结构优化升级对全球价值链嵌入的影响中表现出差异化的调节效应,在产业结构高级化对我国全球价值链嵌入影响中的调节效应更强。最后,本文从政策引领支持产业结构优化升级、走出去拓展国际市场、进一步深化对外开放三个层面提出了针对性的建议。

关键词：产业结构优化升级全球价值链价值链嵌入对外开放调节效应

基于西南雷达拼图的航路叠加绘制系统关键技术及其实现

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气象水文海洋仪器 2024年第4期41卷 134-137页

作者：吕萍中国民用航空西南地区空中交通管理局气象中心成都610202

为了满足空管部门提出的将天气信息与航路信息融合的需求,减轻强对流天气发生时管制运行人员的资料查询负担,文章利用C#图像处理技术,搭建了一套叠加西南地区重要航路数据及西南雷达拼图生成融合雷达图形产品的系统,并阐明了航路提取、... 详细信息

为了满足空管部门提出的将天气信息与航路信息融合的需求,减轻强对流天气发生时管制运行人员的资料查询负担,文章利用C#图像处理技术,搭建了一套叠加西南地区重要航路数据及西南雷达拼图生成融合雷达图形产品的系统,并阐明了航路提取、图像叠加绘制、实时监控西南雷达拼图更新情况、用户界面实现等关键技术。

关键词：西南雷达拼图航路信息提取航路叠加图像处理软件设计

贸易自由化与中国出口农产品质量:基于双边贸易成本的研究

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南京理工大学学报（社会科学版） 2024年第1期37卷 26-37页

作者：林大燕吕娉南京理工大学经济管理学院江苏南京210094 南京理工大学国际经贸问题研究中心江苏南京210094 江苏产业集群决策咨询研究基地江苏南京210094 浙江财经大学人事处浙江杭州310018

出口农产品质量直接关系农产品出口的长远发展。基于双边贸易成本的视角,利用中国与127个贸易伙伴847种农产品的数据,运用回归反推法测算了中国出口农产品的质量水平,并从理论和实证两个方面分析了贸易自由化对中国出口农产品质量的影... 详细信息

出口农产品质量直接关系农产品出口的长远发展。基于双边贸易成本的视角,利用中国与127个贸易伙伴847种农产品的数据,运用回归反推法测算了中国出口农产品的质量水平,并从理论和实证两个方面分析了贸易自由化对中国出口农产品质量的影响。研究发现,样本期间,中国出口农产品质量呈波动上升趋势,且贸易自由化总体上可显著促进中国出口农产品质量的提高,但对出口到不同收入组国家农产品质量的影响存在显著差异。具体而言,贸易自由化对中国出口到埃塞俄比亚等低收入组国家农产品质量的促进作用最为显著,对出口到孟加拉等中等偏低收入组和日本高收入组国家农产品质量的促进作用次之,对出口到印度尼西亚等中等偏高收入组国家的农产品质量反而具有阻碍作用。

关键词：农产品质量贸易自由化贸易成本出口回归反推法

腾格里沙漠湖泊群小气候特征及其对气候变化的响应

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中国沙漠 2024年第2期44卷 231-238页

作者：陈阳吕萍曹敏夏子书马芳余军林陕西师范大学地理科学与旅游学院陕西西安710119

沙漠湖泊对气候变化的响应相较其他湖泊更敏感,同时湖泊也对局地气候有一定的反馈。当前国内对沙漠湖泊的研究主要在巴丹吉林沙漠,腾格里沙漠也存在诸多沙漠湖泊,然而相关研究较少。基于全球地表水体数据集分析腾格里沙漠湖泊区2001—2... 详细信息

沙漠湖泊对气候变化的响应相较其他湖泊更敏感,同时湖泊也对局地气候有一定的反馈。当前国内对沙漠湖泊的研究主要在巴丹吉林沙漠,腾格里沙漠也存在诸多沙漠湖泊,然而相关研究较少。基于全球地表水体数据集分析腾格里沙漠湖泊区2001—2020年水体面积变化,结合该区域气温、风速、降水量、蒸发量等数据,利用趋势分析、灰色关联分析、皮尔逊相关性分析等方法,探究腾格里沙漠湖泊群对气候变化的响应机制及湖泊对局地气候的反馈作用。结果表明:(1)在2001—2020年,湖泊群面积处于波动状态,相对变率为10.05%~13.66%。(2)湖泊区年均气温和风速波动较小,年降水量和年蒸发量呈波动上升趋势。(3)湖泊对气候变化的响应表现为湖泊群面积与气温呈负相关,与降水量呈正相关;湖泊对局地气候的反馈表现为沙漠湖泊区的气温和降水量高于非湖泊区。

关键词：沙漠湖泊 Google Earth Engine 响应与反馈腾格里沙漠气候变化

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基于标准化降水蒸散指数分析湖南各气候区干旱事件重现期

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中国农业气象 2024年第8期45卷 913-923页

作者：先建春周青云吕平安韩信蒋磊天津农学院水利工程学院/天津农学院−中国农业大学智慧水利研究中心天津300392

湖南省气候条件复杂,干旱发生概率高,为揭示湖南省各气候区(湘中、湘东北、湘西北、湘西和湘南)干旱事件的概率特征,基于湖南省97个气象站点1961−2020年的气象资料,采用标准化降水蒸散指数(SPEI)和Copula函数等方法,提取干旱事件的历时... 详细信息

湖南省气候条件复杂,干旱发生概率高,为揭示湖南省各气候区(湘中、湘东北、湘西北、湘西和湘南)干旱事件的概率特征,基于湖南省97个气象站点1961−2020年的气象资料,采用标准化降水蒸散指数(SPEI)和Copula函数等方法,提取干旱事件的历时及烈度,研究湖南省各气候区干旱历时与烈度的同现重现期。结果表明:(1)沿湘南、湘中、湘东北、湘西北、湘西的方向上,气候区的干旱事件数由多到少,干旱事件历时及烈度的数值范围由小到大。(2)干旱历时与烈度分别进行最优边际分布函数的拟合时,GEV函数拟合的站点数均超过60%,且干旱烈度的最优边际分布函数拟合效果优于干旱历时。建立干旱历时与烈度最优边际分布的联合函数时,Frank Copula函数应用超过50%的站点。(3)湘南地区易发生干旱历时较短且烈度较大的干旱事件,湘西地区、湘西北地区及湘东北部分地区易发生干旱历时较长且烈度大的干旱事件。湘中地区易发生干旱历时较长且烈度大的干旱事件,湘中偏南地区易发生干旱历时较短且烈度较大的干旱事件。湖南省各气候区干旱事件的概率特征存在差异,需针对其概率特征采取措施,减轻干旱的危害。

关键词：湖南省 SPEI Copula函数干旱事件干旱重现期