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The immunological roles in acute-on-chronic liver failure:An update

Hepatobiliary & Pancreatic Diseases International 2019年第5期18卷 403-411页

作者： ping chen Yun-Yun Wang Chao chen Jun Guan Hai-Hong Zhu Zhi chen State Key Laboratory for Diagnosis and Treatment of Infectious Diseases Collaborative Innovation Center for Diagnosis and Treatment of Infectious DiseasesThe First Affiliated Hospital Zhejiang University School of Medicine

Background: Acute-on-chronic liver failure (ACLF) refers to the acute deterioration of liver function that occurs in patients with chronic liver disease. ACLF is characterized by acute decompensation, organ failure and high short-term mortality. Numerous studies have been conducted and remarkable progress has been made regarding the pathophysiology and pathogenesis of this disease in the last decade. The present review was to summarize the advances in this field. Data sources: A comprehensive search in PubMed and EMBASE was conducted using the medical subject words “acute-on-chronic liver failure”,“ACLF”,“pathogenesis”,“predictors”, and “immunotherapy” combined with free text terms such as “systemic inflammation” and “immune paralysis”. Relevant papers published before October 31, 2018, were included. Results: ACLF has two marked pathophysiological features, namely, excessive systemic inflammation and susceptibility to infection. The systemic inflammation is mainly manifested by a significant increase in the levels of plasma pro-inflammatory factors, leukocyte count and C-reactive protein. The underlying mechanisms are unclear and may be associated with decreased immune inhibitory cells, abnormal expression of cell surface molecules and intracellular regulatory pathways in immune cells and increased damageassociated molecular patterns in circulation. However, the main cause of susceptibility to infection is immune paralysis. Immunological paralysis is characterized by an attenuated activity of immune cells. The mechanisms are related to elevations of immune inhibitory cells and the concentration of plasma antiinflammatory molecules. Some immune biological indicators, such as soluble CD163, are used to explore the pathogenesis and prognosis of the disease, and some immunotherapies, such as glucocorticoids and granulocyte colony-stimulating factor, are effective on ACLF. Conclusions: Overwhelming systemic inflammation and susceptibility to infection are two key featur

关键词： Acute-on-chronic liver failure Pathogenesis Predictors Immunotherapy

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Synthesis of Hydroxystilbene Derivatives and their Antioxidant Activity by DPPH Method

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Chemical Research in Chinese Universities 2006年第6期22卷 742-746页

作者： LI Yue-qing SONG Qi-ling chen ping-ping ZHAO Wei-jie WANG Shi-sheng State Key Laboratory of Fine Chemicals Dalian University of Technology Dalian 116012 P. R. China

Five hydroxystilbene derivatives were synthesized and their structures were determined using high-resolution mass spectrometry, ^1H NMB, and IR. In this study, the antioxidant activities of eight hydroxystilbenes （five synthesized hydroxystilbene derivatives and three other compounds） were evaluated with the free radiced scavenging model 1,1-diphenyl-2-picrylhydraxyl. It was observed that there exists a very significant linear rehtionship between the reciprocal of the EC50 value of each of the compounds and the maximum wavelength of the ultraviolet absorption peaks, It is believed that this result will be helpful for the further synthesis of such antioxidants.

关键词： Polyhydroxystilbene Antioxidant activity 1,1-Diphenyl-2-picrylhydrazyl (DPPH)

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Matrix Image Method for Ranking Nonregular Fractional Factorial Designs

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Acta Mathematicae Applicatae Sinica 2018年第4期34卷 742-751页

作者： Xue-ping chen Jin-guan LIN Xuan-qing chen Xiao-di WANG Department of Statistics Jiangsu University of Technology Changzhou 213001 China Department of Statistics Nanjing Audit University Nanjing 211815 China School of Statistics and Mathematics Central University of Finance and Economics Beijing 100081 China

Nonregular fractional factorial designs such as Plackett-Burman designs and other orthogonal arrays are widely used in various screening experiments for their run size economy and flexibility. In this paper,we study matrix image theory and present a new method for distinguishing and assessing nonregular designs with complex alias structure, which works for all symmetrical and asymmetrical, regular and nonregular orthogonal arrays. Based on the matrix image theory, our proposed method captures orthogonality and projection properties. Empirical studies show that the proposed method has a more precise differentiation capacity when comparing with some other criteria.

关键词： generalized minimum aberration Bayes matrix image partial aliasing

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Celastrol inhibits migration, proliferation and transforming growth factor-β2-induced epithelial-mesenchymal transition in lens epithelial cells

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International Journal of Ophthalmology(English edition) 2019年第10期12卷 1517-1523页

作者： Li-ping Wang Bao-Xin chen Yan Sun Jie-ping chen Shan Huang Yi-Zhi Liu State Key Laboratory of Ophthalmology Zhongshan Ophthalmic Center Sun Yat-sen University

AIM: To investigate the mechanism of celastrol in inhibiting lens epithelial cells(LECs) fibrosis, which is the pathological basis of ***: Human LEC line SRA01/04 was treated with celastrol and transforming growth factor-β2(TGF-β2). Wound-healing assay, proliferation assay, flow cytometry, real-time polymerase chain reaction(PCR), Western blot and immunocytochemical staining were used to detect the pathological changes of celastrol on LECs. Then, we cultured Sprague-Dawley rat lens in medium as a semi-in vivo model to find the function of celastrol ***: We found that celastrol inhibited the migration of LECs, as well as proliferation(P<0.05). In addition, it induced the G2/M phase arrest by cell cyclerelated proteins(P<0.01). Moreover, celastrol inhibited epithelial-mesenchymal transition(EMT) by the blockade of TGF-β/Smad and Jagged/Notch signaling ***: Our study demonstrates that celastrol could inhibit TGF-β2-induced lens fibrosis and raises the possibility that celastrol could be a potential novel drug in prevention and treatment of fibrotic cataract.

关键词： lens cataract fibrosis transforming growth factor-β2 celastrol

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Experimental Research of Concrete with Steel Slag Powder and Zeolite Powder

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Journal of Renewable Materials 2020年第12期8卷 1647-1655页

作者： Yang Ming ping chen Yuanhao Wang Ling Li Xuandong chen Pengliang Sun Guangxi Key Laboratory of New Energy and Building Energy Saving Guilin541004China College of Civil and Architecture Engineering Guilin University of TechnologyGuilin541004China Guangxi Beibu Gulf Engineering Research Center for Green Marine Materials Guilin541004China School of Chemical Science and Technology Yunnan UniversityKunming650091China

In order to increase use ratio of steel slag solid waste,the concrete containing steel slag powder and zeolite powder as admixtures was prepared by using the orthogonal test *** effects of water-binder ratio,sand ratio,steel slag powder content and zeolite powder on working properties,mechanical strength and chloride ion permeability of the concrete was *** was found that the early strength of the concrete had a decrease with the mixing of steel slag and zeolite powders,but its later strength approached to pure ***,the physical filling and pozzolanic activity of the admixtures increased the density of the concrete,resulting in the improvement of the durability of the concrete by the migration speed of Cl−*** optimum mix ratio of C40 steel slag powder-zeolite powder concrete is obtained,and which had the slump of 220 mm,the 3 d,7 d and 28 d compressive strengths of 27.8 MPa,37.5 MPa and 48.4 MPa,the 6 h electric flux of 950 C and the diffusion coefficient of 1.65×10−12 m2/s.

关键词： Concrete steel slag powder zeolite powder compressive strength chloride ion permeability

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A Transfusion Monitor According to Fuzzy Neural Network

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微计算机信息 2007年第34期23卷 107-108,142页

作者： chen ping Science and Technology College Shandong University of Technology Shandong 255049 China

With the MSP430 MCU as the core of control, the monitor combines the transfusion sensor, the electric apparatus, the LCDscreen and the keyboard to realize automatic monitor for transfusion process. Because transfusion system is nonlinear and complex,which changes now and then and lags behind hour, conventional control method can hardly obtain benign real time monitor *** article introduced a control method according to fuzzy neural network, which integrates the excellences of fuzzy logical controland neural network. The method uses neural network to remember fuzzy rule and achieve fuzzy control and uses error back propaga-tion to realize online self- learning when the control object parameter has changed. So it can colligate, analysis and dispose dataquickly and exactly to achieve intelligent control. Through examination, this monitor manages accurately, runs credibility, and itssmall bulk, low cost and convenient manipulation makes it worth popularizing and applying.

关键词：输液监控模糊神经网络 MSP430单片机步进电机系统设计

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Controller Design for Electric Power Steering System Using T-S Fuzzy Model Approach

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International Journal of Automation and computing 2009年第2期6卷 198-203页

作者： Xin Li Xue-ping Zhao Jie chen School of Mechanical Engineering Shanghai Jiao Tong University Shanghai 200240 PRC

Pressure ripples in electric power steering （EPS） systems can be caused by the phase lag between the driver s steering torque and steer angle, the nonlinear frictions, and the disturbances from road and sensor noise especially during high-frequency maneuvers. This paper investigates the use of the robust fuzzy control method for actively reducing pressure ripples for EPS systems. Remarkable progress on steering maneuverability is achieved. The EPS dynamics is described with an eight-order nonlinear state-space model and approximated by a Takagi-Sugeno （T-S） fuzzy model with time-varying delays and external disturbances. A stabilization approach is then presented for nonlinear time-delay systems through fuzzy state feedback controller in parallel distributed compensation （PDC） structure. The closed-loop stability conditions of EPS system with the fuzzy controller are parameterized in terms of the linear matrix inequality （LMI） problem. Simulations and experiments using the proposed robust fuzzy controller and traditional PID controller have been carried out for EPS systems. Both the simulation and experiment results show that the proposed fuzzy controller can reduce the torque ripples and allow us to have a good steering feeling and stable driving.

关键词： Electric power steering (EPS) fuzzy control Takagi-Sugeno (T-S) model parallel distributed compensation (PDC) timedelay linear matrix inequality (LMI).

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Death decoy receptor overexpression and increased malignancy risk in colorectal cancer

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World Journal of Gastroenterology 2014年第15期20卷 4440-4445页

作者： Liang Zong ping chen Da-Xin Wang Department of Gastrointestinal Surgery Su Bei People’s Hospital of Jiangsu ProvinceYangzhou University Department of Gastrointestinal Surgery Graduate School of MedicineUniversity of TokyoTokyo 113-8655Japan Institute of Biomedical Engineering Yangzhou University

AIM: To evaluate human epidermal growth factor receptor 2 (HER2) and death decoy receptor (DcR3) as colorectal cancer prognostic indicators.

关键词： Colorectal carcinoma Human epidermal growth factor receptor 2 Death decoy receptor Immunohistochemistry Prognosis

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LPE Growth of InAsPSb on InAs:Melt Composition,Lattice Mismatch and Surface Morphology

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Rare Metals 1990年第1期10卷 46-51页

作者： Zhang, Yonggang Zhou, ping chen, Huiying Pan, Huizhen Shanghai Inst of Metallurgy China

The LPE growth of quaternary InAs11-x-yPxSby with x = 0.2 and y = 0.09 on InAs substrate has been studied. This composition is very suitable for the laser and detector applications at about 2.5 μm. We show that in InAsPSb/InAs system there is a determinate relation between the surface morphology and the lattice mismatch of the epi-wafers, by which we can easily control the melt composition to grow high quality hetero-structures. The reason has been discussed. The p-n junctions with fairly good carrier profile have been prepared in this system.

关键词： Indiumarsenic Phosphorus Antimony Alloys Surface Properties Laser Pulses Applications Optical Fibers Optical Properties Optics Nonlinear Semiconducting Antimony Compounds Energy Gap

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Effect of salvia miltiorrhiza pretreatment on the CCK and VIP expression in hepatic ischemia-reperfusion-induced digestive tract congestion

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Frontiers of Medicine 2010年第3期4卷 317-322页

作者： Zhi-Yong ZHANG Xiao-ping chen Qi-ping LU Hepatic Surgery Center Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China Department of General Surgery Wuhan General Hospital of PLAWuhan 430070China

The inhibitory effect of different reperfusion periods 45 min following hepatic ischemia on the expression of cholecystokinin(CCK)and vasoactive intestinal peptide(VIP)in the jejunum and the effect of salvia miltiorrhiza pretreatment were investigated,and the possible mechanism and implications were *** rats were randomly divided into four groups:normal control group(CO group),sham-operated group(SO group),ischemia/reperfusion(I/R)injury group(IR group)and salvia miltiorrhiza pretreatment group(SM group).The rat model of I/R was established by using a non-invasive artery clamp to clip(45 min)or relax the hepatic *** the SM group,saline(40 mL/kg)and salvia miltiorrhiza injection(6 g/kg)were injected via the tail vein 30 min before clipping the hepatic *** the SO group only the porta hepatis was dissected after laparotomy without clamping the hepatic *** 0,3,12,24 and 72 h post-reperfusion,respectively,upper jejunum samples were taken for immunohistochemistry of CCK and *** was found that 0 h after I/R,the expression of CCK and VIP in the upper jejunum was *** prolongation of the reperfusion period,the expression of CCK and VIP was also increased,reached the peak at the 24th h,and gradually returned to the normal level at the 72nd h after *** levels of both CCK and VIP in the SM group were lower than those in the IR *** is suggested that the digestive tract congestion injury caused by liver ischemia can upregulate the expression of CCK and VIP in the jejunum following *** pretreatment can partly reduce the increased expression of CCK and VIP in the jejunum in the same period,which might contribute to the early recovery of gastrointestinal motility.

关键词： hepatic ischemia-reperfusion digestive tract congestion cholecystokinin vasoactive intestinal peptide salvia miltiorrhiza

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