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升降散改善MNNG诱导的胃黏膜损伤及其机制

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中国药理学通报 2025年第1期41卷 178-185页

作者：刘轶璜张思佳刘菲陈苹苹河北中医药大学药学院河北石家庄050091 河北省离子通道功能与创新中药国际联合研究中心河北石家庄050091 河北中医药大学中西医结合学院河北石家庄050091

目的确定升降散对胃黏膜损伤的改善作用并探讨其机制。方法通过文献计量学研究了解升降散的研究现状。采用液质联用技术获取升降散主要药效成分,通过网络药理学分析预测机制。对胃黏膜损伤大鼠灌胃给予阳性药及不同剂量升降散,通过HE染... 详细信息

目的确定升降散对胃黏膜损伤的改善作用并探讨其机制。方法通过文献计量学研究了解升降散的研究现状。采用液质联用技术获取升降散主要药效成分,通过网络药理学分析预测机制。对胃黏膜损伤大鼠灌胃给予阳性药及不同剂量升降散,通过HE染色,观察胃组织形态。ELISA实验检测血清中TNF-α、IL-1β的水平。IHC实验评价胃黏膜MUC5AC、MUC6的表达。结果文献计量学分析表明,升降散在内外伤杂病治疗方面应用广泛。根据升降散主要药效成分中浓度前20位的化合物得到的作用靶点525个,与胃炎相关靶点相交集的129个;GO分析得条目数2127条,KEGG分析得通路140条;说明升降散具有多靶点多通路改善胃黏膜损伤的可能性。HE染色结果显示,升降散确能改善大鼠胃黏膜炎症。ELISA实验结果显示,升降散可有效下调大鼠血清中的TNF-α和IL-1β。IHC实验结果表明,升降散有效下调MUC5AC的表达、上调MUC6的表达。结论升降散能以缓解炎症、调节表面黏液屏障的方式改善胃黏膜损伤。

关键词：升降散慢性胃炎文献计量学网络药理学胃组织结构炎症因子免疫组织化学

脑源性神经营养因子介导帕金森病的运动防治:作用与机制

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中国组织工程研究 2025年第25期29卷 5454-5468页

作者：雷森林谌晓安陈平王兆锋吉首大学体育科学学院湖南省吉首市416000 北部湾大学体育学院广西壮族自治区钦州市535000

背景:运动干预作为经济有效的非物理疗法,可有效上调脑源性神经营养因子表达进而防治帕金森病发生发展,但目前关于靶向脑源性神经营养因子的运动治疗策略在延缓帕金森病发生发展的潜在作用机制尚不明晰。目的:以脑源性神经营养因子和帕... 详细信息

背景:运动干预作为经济有效的非物理疗法,可有效上调脑源性神经营养因子表达进而防治帕金森病发生发展,但目前关于靶向脑源性神经营养因子的运动治疗策略在延缓帕金森病发生发展的潜在作用机制尚不明晰。目的:以脑源性神经营养因子和帕金森病的关系为切入点,分析帕金森病病理状态下运动对脑源性神经营养因子表达的特异性调控作用及机制,梳理脑源性神经营养因子介导下不同运动方式对帕金森病的改善效果,并阐明靶向脑源性神经营养因子的运动治疗策略在防治帕金森病的潜在作用机制,旨在为运动防治帕金森病提供新的理论依据。方法:以“帕金森病,脑源性神经营养因子,神经保护,多巴胺,神经元异常凋亡,神经炎症反应,突触可塑性,运动”等为中文检索词;以“Parkinson’s disease,BDNF,Neuroprotection,neuroinflammation,synaptic plasticity”等为英文检索词,分别检索中国知网、万方数据库、PubMed和Web of Science数据库,搜寻各数据库建库至2024年2月发表的所有研究文献,根据纳排标准共获得核心相关文献98篇。结果与结论:①在帕金森病理背景下,运动可通过促进肌因子鸢尾素大量分泌,并降低色氨酸-犬尿氨酸代谢途径紊乱特异性调控脑源性神经营养因子表达。②有氧运动,尤其是特殊有氧运动(动物:旋转杆步行/人类:北欧健走)以及多模式运动可显著上调脑源性神经营养因子表达,进而改善帕金森病的运动症状,此外脑源性神经营养因子还介导身心运动(太极拳)对帕金森病患者认知障碍和睡眠障碍等非运动症状的有效调节。③运动诱导的高表达脑源性神经营养因子可能通过上调抗炎因子白细胞介素10、神经生长因子β和转化生长因子β表达,下调促炎因子肿瘤坏死因子α及白细胞介素1β表达,并抑制核转录因子κB信号通路表达降低小胶质细胞活性减轻神经炎症反应;增加酪氨酸羟化酶活性以促进多巴胺合成释放,并通过下调基质金属蛋白酶3及糖原合成酶激酶3β表达抑制α-突触核蛋白在丝氨酸129位点的磷酸化修饰,以防止神经异常凋亡;诱导突触效能的长时程增强发生,促进突触后致密区蛋白95及突触素大量表达以改善突触可塑性,发挥神经保护作。④鉴于脑源性神经营养因子在帕金森病发病进程及治疗中发挥重要作用,靶向脑源性神经营养因子的运动治疗策略将有助于推动帕金森病疾病“运动+药物”精准医疗的发展。但由于目前研究采用的运动处方较为单一,且研究焦点主要围绕运动症状而缺乏对非运动症状的考察,因此亟待学者采用更加统一和系统的运动处方,围绕非有氧运动类型对同一批帕金森病患者进行长期纵向跟踪研究,以此完善帕金森病运动防治领域研究的不足。

关键词：运动帕金森病脑源性神经营养因子神经保护神经炎症多巴胺 α-突触核蛋白突触可塑性神经元凋亡非运动症状

Evolution of surface morphologies of CaMoO_(4)films and their luminescent properties

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Rare Metals 2022年第8期41卷 2789-2793页

作者： Lian-ping chen School of Materials Science and Engineering Jiangxi University of Science and TechnologyGanzhou341000China

Alkaline earth molybdate and tungstate thin films are widely prepared by electrochemical *** solutions,these crystals often grow into large ***,it is difficult to obtain nanomolybdate and tungstate thin films via *** morphologies of CaMoO_(4)thin films synthesized by galvanic cell route at different stages were compared and *** electron microscope(SEM)observations reveal that CaMoO_(4)thin films consist of two layers,sub-layer and top *** force microscope(AFM)examination confirms that the roughness of sub-layer is within several *** AFM analysis and the calculation based on XRD results favor that the average size of CaMoO_(4)crystallites is approximately several tens of *** top layer is usually rough due to large crystals in shapes of *** study shows that the luminescence intensities of samples only with smooth layers are about four times of those filled with micrometer-sized CaMoO_(4)*** reason accounting for the improvement of luminescent properties may lie in that there are much less lateral scattering for smooth samples.

关键词： Morphology CaMoO_(4) Thin films Electrochemical

Nonparametric Estimation for the Diffusion Coefficient of Multidimensional Time-Varying Diffusion Processes

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Journal of Systems Science & Complexity 2020年第5期33卷 1602-1631页

作者： WANG Jun chen ping Department of Science Nanjing University of Science andTechnologyNanjing 210000China

This paper proposes a kernel estimator for the coefficient of multidimensional time-varying diffusion processes as an extension of the estimation model for one dimensional diffusion coefficient to the multidimensional *** using"time division",the authors overcome the problem of sample observation in time varying *** addition,the authors prove the strong consistency and limit distribution of the ***,the authors test the performance of the estimator through a simulation experiment and an empirical application.

关键词： Asymptotic properties kernel function multidimensional model nonparametric estimation time-inhomogeneous

Principal Value and Its Applications for One Type of Cauchy–FantappièIntegral and the System of Equations

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Acta Mathematica Sinica,English Series 2022年第9期38卷 1537-1550页

作者： Lüping chen School of Mathematical Sciences Xiamen UniversityXiamen 361005P.R.China

It is known that principal value plays vital roles in the study of singular *** this paper,one type of Cauchy–Fantappièintegral with multiple indexes is *** the structure of the kernel is complexity,the Jacobian determinant included in the kernel is expanded for making clearly the expression of the ***,one differential operator is utilized for setting up relations between integrals with higher and usual *** work also concerns the convergent properties of the *** order to study Hadamard principal value and composite formula of this integral,finite and divergent parts will be estimated and *** an application,solvability of the system of integral equations with higher order singularity kernel is discussed.

关键词： Principal value Cauchy–Fantappièintegral piecewise smooth manifold differential operator system of singular integral equation

Boundedness of the Commutator of Marcinkiewicz Integral with Rough Variable Kernel

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Acta Mathematica Sinica,English Series 2009年第6期25卷 983-1000页

作者： Yan ping chen Department of Mathematics and Mechanics Applied Science School University of Science and Technology of Beijing Beijing 100083 P. R. China

In this paper the author proves that the commutator of the Marcinkiewicz integral operator with rough variable kernel is bounded from the homogeneous Sobolev space Lγ^2（R^n） to the Lebesgue space L^2（R^n）, which ... 详细信息

关键词： commutator Marcinkiewicz integral variable kernel BMO Sobolev space spherical harmonic function

KeJia:towards an autonomous service robot with tolerance of unexpected environmental changes

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Frontiers of Information Technology & Electronic Engineering 2019年第3期20卷 307-317页

作者： Wei SHUAI Xiao-ping chen Department of Computer Science and Technology University of Science and Technology of China

KeJia is a domestic service robot, consisting of a mobile base, an arm, two cameras, and a set of software components for perception, manipulation, natural language understanding, motion and task planning, and decision making. With on-line running of these functions, a robot can adapt to dynamic environments which may have unexpected changes. In this paper, we propose a novel hierarchical method which combines motion planning with a neural network, so that the robot can tolerate errors from sensors, wear of parts, and human disturbances during motion execution. We evaluate our work on KeJia that cooks popcorn using a microwave oven, where humans try to disturb KeJia during the operation.

关键词： Robot Task planning Manipulation

Analytical solutions to the Navier-Stokes equations for non-Newtonian fluid

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Applied Mathematics(A Journal of Chinese Universities) 2009年第4期24卷 483-489页

作者： chen ping ZHANG Ting Department of Mathematics Zhejiang University Hangzhou 310027 China Center of Mathematical Sciences Zhejiang University Hangzhou 310027 China

The pressureless Navier-Stokes equations for non-Newtonian fluid are studied. The analytical solutions with arbitrary time blowup, in radial symmetry, are constructed in this paper. With the previous results for the analytical blowup solutions of the N-dimensional （N ≥ 2） Navier-Stokes equations, we extend the similar structure to construct an analytical family of solutions for the pressureless Navier-Stokes equations with a normal viscosity term （μ（ρ）｜ u｜^α u）.

关键词： blowup solution pressureless Navier-Stokes equation non-Newtonian fluid

An Improved Treatment on the Apparent Contact Angle of a Single-Bubble in Consideration of Microlayer for Simulations of Nucleate Pool Boiling

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Journal of Thermal Science 2021年第6期30卷 1951-1959页

作者： chen Zhihao WU Feifei UTAKA Yoshio chen ping LIANG chen School of Mechanical Engineering Tianjin UniversityTianjin 300350China Key Laboratory of Efficient Utilization of Low and Medium Grade Energy(Tianjin University) Ministry of EducationTianjin 300350China Department of Mechanical Engineering Graduate School of EngineeringKyushu UniversityFukuoka 819-0395Japan National New Energy Vehicle Technology Innovation Center Beijing 100176China Beijing Automotive Technology Center BAIC GroupBeijing 101300China

Numerical simulation of single-bubble growth behavior during nucleate pool boiling was developed based on the volume of fluid method considering the thin liquid layer under the bubble(microlayer).However,the experimental values of apparent contact angle(the small region connecting the microlayer and bulk liquid)are crucial for the *** on experimental results limited the further application of such numerical *** this study,a new method calculating the force balance,used to determine the interface shape near the apparent contact angle,was proposed instead of using the experimental values of the apparent contact *** a result,the good agreement was shown between the simulation results obtained based on the new and previous numerical *** simulation results were also in consistent with the experimental *** can be concluded that the single-bubble behavior,including the heat transfer characteristics,during nucleate pool boiling can be simulated based on the proposed method.

关键词： numerical simulation nucleate pool boiling bubble growth microlayer surface tension VOF method