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经腋窝腔镜辅助保留乳头乳晕皮下腺体切除术+Ⅰ期胸肌前假体乳房重建术

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中华普外科手术学杂志（电子版） 2024年第4期18卷 419-422页

作者：刘虹王品王彬任杰超张文杰吴剑刘莹成都市第三人民医院普外科乳腺甲状腺疾病中心西南交通大学附属医院&重庆医科大学附属成都第二临床医学院成都610031

目的探讨经腋窝腔镜辅助保留乳头乳晕皮下腺体切除术+Ⅰ期胸肌前假体乳房重建术的可行性及临床应用价值。方法回顾性分析2022年1月至12月接受经腋窝腔镜辅助保留乳头乳晕皮下腺体切除术+I期胸肌前假体乳房重建术的32例女性乳腺癌患者的... 详细信息

目的探讨经腋窝腔镜辅助保留乳头乳晕皮下腺体切除术+Ⅰ期胸肌前假体乳房重建术的可行性及临床应用价值。方法回顾性分析2022年1月至12月接受经腋窝腔镜辅助保留乳头乳晕皮下腺体切除术+I期胸肌前假体乳房重建术的32例女性乳腺癌患者的临床资料。数据应用SPSS22.0统计学软件分析。围手术期各项指标、Breast-Q量表、Scar-Q量表等计量资料以(x±s)表示,组内比较采用配对样本t检验;术后并发症等计数资料以[例(%)]表示,采用X检验。P<0.05为差异有统计学意义。结果32例患者均顺利完成经腋窝腔镜辅助保留乳头乳晕皮下腺体切除术+I期胸肌前假体乳房重建术,手术时间为(138.5±20.7)min,术中失血量为(49.6±24.3)ml,前哨淋巴结数为(3.0±1.0)枚,术区引流时间为(7.3±1.5)d,术区总引流量为(504.8±19.6)ml,术后住院时间为(6.3±1.2)d,且所有患者术后病理标本的切缘均为阴性。术后美容效果评价优良率为93.8%(30/32),Breast-Q评分结果显示,术后1个月及3个月胸壁状态、性生活、社会心理状态的评分与术前比较,差异有统计学意义(P<0.05);Scar-Q评分结果显示,术后疤痕外观满意度随时间逐渐升高,术后6个月评分升高至(66.1±6.2)分。术后出现假体移位1例(3.1%),皮下积液2例(6.3%),皮瓣局部性坏死2例(6.3%),但无切口感染、切口裂开、术后出血、胸壁疼痛、包膜挛缩等并发症的发生,且随访期间内所有患者均未出现局部复发、远处转移及死亡等事件。结论经腋窝腔镜辅助保留乳头乳晕皮下腺体切除术+Ⅰ期胸肌前假体乳房重建术安全可行,并获得了较好的根治效果、美容效果和满意度,可于临床广泛推广应用.

关键词：乳腺肿瘤腔镜乳房切除术,改良根治性乳房植入乳房成形术

不同还原剂处理电镀含铬废水的效果分析与比较

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山西化工 2024年第7期44卷 238-240页

作者：易玉龙刘果实吴财松高宝钗谢品林毅赛恩斯环保股份有限公司湖南长沙410000

化学沉淀法是处理电镀行业含铬废水的常用方法,通常采用还原剂加水解的方式,使铬最终以氢氧化铬的形式实现固液分离。研究了几种不同类型的还原剂在处理含铬废水的过程中表现出的效果和特性,并从处理效果、表观现象、药剂成本、产生渣... 详细信息

化学沉淀法是处理电镀行业含铬废水的常用方法,通常采用还原剂加水解的方式,使铬最终以氢氧化铬的形式实现固液分离。研究了几种不同类型的还原剂在处理含铬废水的过程中表现出的效果和特性,并从处理效果、表观现象、药剂成本、产生渣量等方面展开对比分析。研究表明:在原水铬质量浓度为500 mg/L的情况下,硫酸亚铁、亚硫酸氢钠和焦亚硫酸钠均能使六价铬处理至满足《电镀污染物排放标准》(GB 21900—2008)中六价铬的排放要求(<0.2 mg/L),但是从氢氧化钠消耗量、絮凝沉淀后的表观现象、产生渣量、总药剂成本等方面进行全方位对比后综合考虑,亚硫酸氢钠的消耗量和水解过程中所需的氢氧化钠量最少,因此总药剂成本最低,且产生渣量最少,出水表观无色澄清,是最适合的还原剂。

关键词：电镀含铬废水还原剂效果分析成本与渣量

Hypoxia signaling in human health and diseases:implications and prospects for therapeutics

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Signal Transduction and Targeted Therapy 2022年第8期7卷 2787-2816页

作者： Zhen Luo Mingfu Tian Ge Yang Qiaoru Tan Yubing Chen Geng Li Qiwei Zhang Yongkui Li pin Wan Jianguo wu Guangdong Provincial Key Laboratory of Virology Institute of Medical MicrobiologyJinan UniversityGuangzhou 510632China Foshan Institute of Medical Microbiology Foshan 528315China The First Affiliated Hospital of Jinan University Guangzhou 510632China The Affiliated Shunde Hospital of Jinan University Foshan 528303China

Molecular oxygen(O2)is essential for most biological reactions in mammalian *** the intracellular oxygen content decreases,it is called *** process of hypoxia is linked to several biological processes,including pathogenic microbe infection,metabolic adaptation,cancer,acute and chronic diseases,and other stress *** mechanism underlying cells respond to oxygen changes to mediate subsequent signal response is the central question during ***-inducible factors(HIFs)sense hypoxia to regulate the expressions of a series of downstream genes expression,which participate in multiple processes including cell metabolism,cell growth/death,cell proliferation,glycolysis,immune response,microbe infection,tumorigenesis,and ***,hypoxia signaling also interacts with other cellular pathways,such as phosphoinositide 3-kinase(PI3K)-mammalian target of rapamycin(mTOR)signaling,nuclear factor kappa-B(NF-κB)pathway,extracellular signal-regulated kinases(ERK)signaling,and endoplasmic reticulum(ER)*** paper systematically reviews the mechanisms of hypoxia signaling activation,the control of HIF signaling,and the function of HIF signaling in human health and *** addition,the therapeutic targets involved in HIF signaling to balance health and diseases are summarized and highlighted,which would provide novel strategies for the design and development of therapeutic drugs.

关键词： diseases metabolism drugs

Acupuncture and Moxibustion Inhibited Intestinal Epithelial-Mesenchymal Transition in Patients with Crohn's Disease Induced by TGF-β1/Smad3/Snail Pathway:A Clinical Trial Study

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Chinese Journal of Integrative Medicine 2022年第9期28卷 823-832页

作者： GUO Sen ZHOU Jing ZHANG Liang BAO Chun-hui ZHAO Ji-meng GAO Yan-ling wu pin WENG Zhijun SHI Yin Graduate School Shanghai University of Traditional Chinese MedicineShanghai201203China Department of Acupuncture and Moxibustion Shanghai Shanghai Traditional Chinese Medicine Integrated HospitalShanghai University of Traditional Chinese MedicineShanghai200082China Department of Acupuncture and Moxibustion Yueyang Hospital of Integrated Traditional Chinese and Western Medicine Affiliated to Shanghai University of Traditional Chinese MedicineShanghai200437China Key Laboratory of Acupuncture and Immunological Effects Shanghai Research Institute of Acupuncture and MeridianShanghai200030China Outpatient Department Shanghai Research Institute of Acupuncture and MeridianShanghai200030China

Objective:To explore whether acupuncture combined with moxibustion could inhibit epithelialmesenchymal transition in Crohn’s disease by affecting the transforming growth factorβ1(TGF-β1)/Smad3/Snail ***:Sixty-three patients with Crohn’s disease were randomly divided into an observation group(31 cases)receiving moxibustion at 43℃ combined with acupuncture,and a control group(32 cases)receiving moxibustion at 37℃combined with sham acupuncture using a random number *** were treated for12 ***’s Disease Activity Index(CDAI)was used to evaluate disease ***-eosin staining and transmission electron microscopy were utilized to observe the morphological and ultrastructural *** was used to detect the expression of transforming growth factorβ1(TGF-β1),TβR1,TβR2,Smad3,Snail,E-cadherin and fibronectin in intestinal mucosal ***:The decrease of the CDAI score,morphological and ultrastructural changes were more significant in observation *** expression levels of TGF-β1,TβR2,Smad3,and Snail in the observation group were significantly lower than those before the treatment(P<0.05 or P<0.01).After treatment,the expression levels of TGF-β1,TβR2,and Snail in the observation group were significantly lower than those in the control group(all P<0.05);compared with the control group,the expression of fibronectin in the observation group was significantly decreased,and the expression of E-cadherin was significantly increased(all P<0.05).Conclusions:Moxibustion at 43℃combined with acupuncture may suppress TGF-β1/Smad3/Snail pathway-mediated epithelial-mesenchymal transition of intestinal epithelial cells in Crohn’s disease patients by inhibiting the expression levels of TGF-β1,TβR2,Smad3,and Snail.(Registration ***-IIR-16007751).

关键词： Crohn’s disease moxibustion acupuncture transforming growth factorβ1/Smad3/Snail pathway intestinal epithelial-mesenchymal transition

Ⅱ类射线装置审批权限下放及管理可行性研究——以广西为例

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辐射防护通讯 2024年第4期44卷 38-43页

作者：李丽红刘静西吴易超易鹞徐聘石伟力广西壮族自治区辐射环境监督管理站南宁530222

党的十八大明确提出:“深化行政审批制度改革,继续简政放权,推动政府职能向创造良好发展环境、提供优质公共服务、维护社会公平正义转变。”为进一步深化生态环境领域简政放权改革,推动辐射环境领域“放管服”改革,服务广西社会经济高... 详细信息

党的十八大明确提出:“深化行政审批制度改革,继续简政放权,推动政府职能向创造良好发展环境、提供优质公共服务、维护社会公平正义转变。”为进一步深化生态环境领域简政放权改革,推动辐射环境领域“放管服”改革,服务广西社会经济高质量发展,广西拟将Ⅱ类射线装置核技术利用项目的审批权限下放至各设区市。本文通过调查、分析广西各设区市审批、监管能力,确定该项目审批权限下放的可行性。

关键词：射线装置审批可行性对策研究

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不同中医证型Wilson病患者肝脏纤维化差异及其与弹性硬度值的关系

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中西医结合肝病杂志 2024年第6期34卷 495-499页

作者：吴晓倩唐露露王金萍李冰王艺星安徽中医药大学第一附属医院超声医学科安徽合肥230031 安徽中医药大学第一附属医院脑病一科

目的:探讨不同中医证型Wilson病(WD)患者肝脏硬度值(LSM)及纤维化指标差异及两者的关系。方法:回顾性收集2021年2月至2023年4月住院确诊的110例WD患者的临床资料,中医证型采用指标聚类分析,绘制聚类图。采用简单对应分析中医证型与ADL... 详细信息

目的:探讨不同中医证型Wilson病(WD)患者肝脏硬度值(LSM)及纤维化指标差异及两者的关系。方法:回顾性收集2021年2月至2023年4月住院确诊的110例WD患者的临床资料,中医证型采用指标聚类分析,绘制聚类图。采用简单对应分析中医证型与ADL分级的相关性。比较不同中医证型的一般临床资料、LSM及肝纤维化相关指标,从而探讨LSM与肝纤维化及中医证型分布的关系。结果:WD患者中医证型以湿热内蕴证(59例,53.64%)居多,痰瘀互结证(43例,39.09%)次之,肝肾阴虚证(5例,4.54%)、脾肾阳虚证(3例,2.73%)较少;痰瘀互结证偏向0~Ⅰ级,湿热内蕴证偏向Ⅱ级,肝肾阴虚证偏向Ⅲ~Ⅳ级,脾肾阳虚证在二维投影图中间,并未偏向WD病变程度某一分级;痰瘀互结证、肝肾阴虚证、脾肾阳虚证患者肝脏LSM均高于湿热内蕴证(P0.05)。湿热内蕴证、痰瘀互结证、肝肾阴虚证中LSM与HA、Ⅳ-C均呈不同程度的正相关。结论:LSM联合血清学指标能更好地评估不同证型WD患者肝纤维化程度。

关键词： Wilson病中医证型肝脏硬度值肝纤维化

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基于CFD数值模拟优化汽油机燃烧系统

内燃机与配件 2024年第14期 16-18页

作者：吴胡胜李强李红洲颜平涛王时光宁波吉利罗佑发动机零部件有限公司浙江宁波315336

对现有某款2.0L GDI发动机的进气道进行改进,应用AVL-FIRE软件进行CFD仿真分析,结果表明,优化后的进气道平均流量系数较之前提高了4.73%,平均滚流比提高了7.93%。应用Star—CD软件对改进前后的燃烧系统进行缸内流动瞬态CFD分析,结果表明... 详细信息

对现有某款2.0L GDI发动机的进气道进行改进,应用AVL-FIRE软件进行CFD仿真分析,结果表明,优化后的进气道平均流量系数较之前提高了4.73%,平均滚流比提高了7.93%。应用Star—CD软件对改进前后的燃烧系统进行缸内流动瞬态CFD分析,结果表明,改进后的燃烧系统能在缸内形成更大更强的涡流,瞬态滚流比和湍动能都要明显好于原燃烧系统。台架试验表明,改进后的燃烧系统在不同转速和额定功率点油耗也是低于原燃烧系统。

关键词： GDI发动机优化流量系数滚流比油耗

SARS-CoV-2 Nsp8 induces mitophagy by damaging mitochondria

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Virologica Sinica 2023年第4期38卷 520-530页

作者： Shan Zong Yan wu Weiling Li Qiang You Qian Peng Chenghai Wang pin Wan Tao Bai Yanling Ma Binlian Sun Jialu Qiao wuhan Institute of Biomedical Sciences School of MedicineJianghan UniversityWuhan430056China State Key Laboratory of Virology Wuhan Institute of VirologyCenter for Biosafety Mega-ScienceChinese Academy of SciencesWuhan430071China Hubei Key Laboratory of wudang Local Chinese Medicine Research Hubei University of MedicineShiyan442000China Division of Gastroenterology Tongji Medical CollegeHua Zhong University of Science and TechnologyWuhan430030China Department of Respiratory and Critical Care Medicine Hubei Province Clinical Research Center for Major Respiratory DiseasesNHC Key Laboratory of Pulmonary DiseasesUnion HospitalTongji Medical CollegeHua Zhong University of Science and TechnologyWuhan430030China

Autophagy plays an important role in the interaction between viruses and host ***-CoV-2 infection can disrupt the autophagy process in target ***,the precise molecular mechanism is still *** this study,we discovered that the Nsp8 of SARS-CoV-2 could cause an increasing accumulation of autophagosomes by preventing the fusion of autophagosomes and *** further investigation,we found that Nsp8 was present on mitochondria and can damage mitochondria to initiate *** results of experiments with immunofluorescence revealed that Nsp8 induced incomplete ***,both domains of Nsp8 orchestrated their function during Nsp8-induced mitophagy,in which the N-terminal domain colocalized with mitochondria and the C-terminal domain induced auto/*** novel finding expands our understanding of the function of Nsp8 in promoting mitochondrial damage and inducing incomplete mitophagy,which helps us to understand the etiology of COVID-19 as well as open up new pathways for creating SARS-CoV-2 treatment methods.

关键词： SARS-CoV-2 Nsp8 Autophagy Mitophagy Mitochondrial damage

基于文献及计量学方法研究脾阴学说古今发展及参苓白术散滋补脾阴作用阐释

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中华中医药学刊 2024年第3期42卷 210-214,I0035页

作者：臧凝子王世文李品王清华战丽彬辽宁中医药大学辽宁沈阳110847 辽宁中医药大学附属医院辽宁沈阳110032

脾乃后天之本、气血生化之源,脾之阳气为脾脏功能的发挥提供了“动力”,而脾阴则提供了“物质基础”。脾阴学说成说较晚、论说较少,基于文献研究系统梳理了脾阴理论内涵及历史发展源流,认为“辅运化”“主滋养”和“和胃阳”是脾阴主要... 详细信息

脾乃后天之本、气血生化之源,脾之阳气为脾脏功能的发挥提供了“动力”,而脾阴则提供了“物质基础”。脾阴学说成说较晚、论说较少,基于文献研究系统梳理了脾阴理论内涵及历史发展源流,认为“辅运化”“主滋养”和“和胃阳”是脾阴主要的生理功能;脾阴理论的发展主要经历了《黄帝内经》构建脏腑阴阳理论体系、《伤寒论》初识脾阴方证、“丹溪学派”首开滋阴法先河、缪希雍系统建立脾阴理论体系、吴澄引申“芳香甘平”治法5个历史时期。此外,通过文献计量学Citespace分析脾阴学说现代整体发展应用情况,对比古今常用11个滋补脾阴类中药复方发现:现代研究中对脾阴学说的认识主要传承自唐容川、叶天士、吴澄、李东垣、缪希雍、张锡纯几位医家;其理论主要应用在消渴(糖尿病)、泄泻、便秘、肉痿等疾病治疗中;用药偏以甘淡,兼顾养胃阴为特色;局方参苓白术散成方早,充分体现了“甘淡”补脾之滋补脾阴用药的基本法则,具有健脾气、滋脾阴、渗脾湿之功效,全方升降相因、散收并用、补行兼施,尤宜于脾气阴虚夹湿的患者,乃滋补脾阴理论应用的基础方。

关键词：脾阴参苓白术散文献研究文献计量学滋补脾阴

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