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Secondary acute promyelocytic leukemia following chemotherapy for gastric cancer: A case report

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World Journal of Gastroenterology 2015年第14期21卷 4402-4407页

作者： Ying-Cheng Zhang Yu-Qi Zhou Bing Yan Jun Shi Li-Juan Xiu Yu-wei Sun Xuan Liu Zhi-Feng Qin pin-kang wei Yong-Jin Li Department of Traditional Chinese Medicine Changzheng HospitalSecond Military Medical University Department of Oncology Hainan branch of PLA General Hospital

Therapy-related acute myeloid leukemia(t-AML) refers to a heterogeneous group of myeloid neoplasms that develop in patients following extensive exposure to either cytotoxic agents or *** development of t-AML has been reported following treatment of cancers ranging from hematological malignancies to solid tumors; however, to our knowledge, t-AML has never been reported following treatment of gastric *** this study, we report the development of t-acute promyelocytic leukemia in a cT 4N1M0 gastric cancer patient after an approximate 44 mo latency period following treatment with 4 cycles of oxaliplatin(OXP)(85 mg/m2 on day 1) plus capecitabine(1250 mg/m2 orally twice daily on days 1-14) in combination with recombinant human granulocyte-colony stimulating factor *** analysis of the patient revealed 46,XY,t(15;17)(q22;q21)[15]/46,idem,-9,+add(9)(p22)[2]/46,XY[3], which, according to previous studies, includes some "favorable" genetic *** patient was then treated with all-trans retinoic acid(ATRA, 25 mg/m2/d) plus arsenic trioxide(ATO, 10 mg/d) and attained complete *** case illuminated the role of certain cytotoxic agents in the induction of t-AML following gastric cancer *** recommend instituting a mandatory additional evaluation for patients undergoing these therapies in the future.

关键词： Gastric cancer Acute promyelocytic leukemia Oxalip

Syndrome differentiation in traditional Chinese medicine and E-cadherin/ICAM-1 gene protein expression in gastric carcinoma

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World Journal of Gastroenterology 2007年第32期13卷 4321-4327页

作者： Da-Zhi Sun Ling Xu pin-kang wei Long Liu Jin He Department of Traditional Chinese Medicine Second Affiliated Hospital to Second Military Medical University Shanghai 200003 China Department of Pathology Second Affiliated Hospital to Second Military Medical University Shanghai 200003 China

AIM： To explore the syndrome differentiation in traditional Chinese medicine （TCM） and gene protein expression in gastric carcinoma METHODS： Preoperative data of gastric cancer cases were collected from the General Surgery Department and classified according to the criteria for syndrome differentiation in TCM. E-cadherin （E-cad） and ICAM-1 gene protein expressions were detected in postoperative specimens from these cases by the immunohistochemical EnVision two-step method. RESULTS： The E-cad positive expression rate was 90% in 100 cases of gastric carcinoma. The difference in E-cad expression was significant between the different syndrome differentiation types in TCM （P 〈 0.01）. Further group-group comparison showed that there was a significant difference in E-cad expression between the stagnation of phlegm-damp type and the deficiency in both qi and blood and the deficiency-cold of stomach and spleen types, where E-cad expression was high. There was no significant difference between the internal obstruction of stagnant toxin type and the in-coordination between liver and stomach type, where E-cad expression was relatively low. The ICAM-1 positive expression rate was 58%, and there was no statistically significant difference between the two groups （x^2= 8.999, P 〉 0.05）. CONCLUSION： E-cad expression is relatively low in the internal obstruction of stagnant toxin type and the incoordination between liver and stomach type, where tumor development and metastasis may be associated with low E-cad expression, or with low homogeneous adhesiveness between tumor cells.

关键词： Gastric carcinoma Syndrome differentiationin traditional Chinese medicine Metastasis E-cadherin ICAM-1

Anticancer effect of Jinlongshe granules on in situ-transplanted human MKN-45 gastric cancer in nude mice and xenografted sarcoma 180 in Kunming mice and its mechanism

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World Journal of Gastroenterology 2006年第18期12卷 2890-2894页

作者： Zhi-Hong Yu pin-kang wei Ling Xu Zhi-Feng Qin Jun Shi Department of Traditional Chinese Medicine Changzheng Hospital Second Military Medical University Shanghai 200003 China

AIM： To study the antitumor effect of Chinese compound Jinlongshe （JLS） granules on sarcoma 180 and MKN-45 human gastric cancer cell lines in vivo and its mechanism. METHODS： After establishment of S180 sarcoma （S180） and MKN-45 gastric cancer model of nude mice, the tumor-bearing mice were divided into 5 groups at random. Three experimental groups were respectively given the aqueous extract of JLS granules at doses of 120 g, 60 g and 20 g/（kg per 6/wk,i.g） for 3 wk in S180 and 6 wk in nude mice model. Positive control was given cyclophosphamide （Cy） at a dose of 50 mg/（kg per 3/wk, i.g） for 3 wk in S180 models and 5-Fluorouracil （5-FU） 20 mg/（kg per 3/wk, i.g） for 3 wk in nude mice model. Negative control was given normal saline （NS） at a dose of 0.18 g/（kg per 6/wk, i.g） respectively. After 3 wk in mice bearing S180 tumor and 6 wk in nude mice model, the experimental animals were sacrificed and the masses of tumor were weighed, and the rates of tumor inhibition of each treated group were calculated respectively. To determine the antitumor mechanisms, the morphological changes, cell cycle and apoptosis were observed in MKN-45 nude mice model. Annexin V-FITC/PI double staining FCM assay was used to further determine the live cells, apoptotic cells, necrotic cells and debris. RESULTS： The inhibitory rates of JLS granules at the doses of 20 g/kg, 60 g/kg and 120 g/kg were 50.31%, 55.94% and 68.13% （P 〈 0.01） in nude mice models and 40.90%, 50.32% and 58.46% （P 〈 0.01） in S180 model. The inhibitory rate of Cy was 85.22% in S180 models and the inhibitory rate of 5-FU was 53.43% in nude mice model （P 〈 0.01）. Nuclear chromatin and margination were observed under a transmission electron microscope （TEM）. The G0/G1 phase was arrested, typical apoptotic peak appeared, the apoptotic rate was 22.81%-38.54% in three JLS granule-treated groups. Annexin V-FITC/PI double staining FCM assay showed that the apoptotic cells were 4.36%, 3.08% and 7.08% in three dosages, most cell

关键词： Jinlongshe granules Sarcoma 180 Human MKN-45 gastric cancer lines Traditional Chinese medicine

Xiaotan Tongfu granules contribute to the prevention of stress ulcers

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World Journal of Gastroenterology 2013年第33期19卷 5473-5484页

作者： Bing Yan Jun Shi Li-Juan Xiu Xuan Liu Yu-Qi Zhou Shou-Han Feng Can Lv Xiu-Xia Yuan Yin-Cheng Zhang Yong-Jin Li pin-kang wei Zhi-Feng Qin Department of Traditional Chinese Medicine Changzheng HospitalSecond Military Medical University

AIM:To investigate the efficacy and potential mechanism of Xiaotan Tongfu granules(XTTF)in stress ***:One hundred sixty rats were randomly divided into 4 groups(n=10)as follows:the model group(MP group),the control group(CP group),the ranitidine group(RP group)and the XTTF granule group(XP group).Rats in the MP group received no drugs,rats in the CP group received 0.2 mL of a 0.9%sodium chloride solution via oral gavage,and rats in the RP and XP groups received the same volume of ranitidine(50 mg/kg)or XTTF granule(4.9 g/kg).The cold-restraint stress model was applied to induce stress ulcers after 7 consecutive days of drug ***,rats were sacrificed at 0,3,6 and24 *** pH was measured by a precise pH meter;gastric emptying rate(GER)was measured by using a methylcellulose test meal;myeloperoxidase activity(MPO),macrophage migration inhibitory factor(MIF),proliferating cell nuclear antigen(PCNA),and heat shock protein 70(HSP70)were measured by immunohistochemical staining;and mucosal cell apoptosis was measured by transferase dUTP nick end ***:In the cold-restraint stress model,the development of stress ulcers peaked at 3 h and basically regressed after 24 *** lesions were significantly different in the RP and XP groups at each time ***,although this index was much lower in the RP group than in the XP group immediately following stress induction(7.00±1.10 vs 10.00±1.79,P<*** gastric pH,between the RP and XP groups,we detected a statistically significant difference immediately after stress induction(0 h:4.56±0.47 vs 3.34±0.28,P<0.05)but not at any of the subsequent time *** GER,compared to the RP group,GER was remarkably elevated in the XP group because a statistically significant difference was detected(3 h:46.84±2.70 vs 61.16±5.12,P<0.05;6 h:60.96±6.71 vs 73.41±6.16,P<0.05;24 h:77.47±3.17 vs 91.31±4.34,P<0.05).With respect to MPO and MIF,comparisons between the RP and XP groups

关键词： Stress ulcer Xiaotan Tongfu granule Inflammation Heat shock protein 70 Proliferation and apoptosis Gastric emptying rate

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胃癌从痰论治理论体系

中西医结合学报 2011年第6期9卷 581-587页

作者：施俊魏品康解放军总医院学员队北京100853 第二军医大学长征医院中医科上海200003

魏品康教授在古代文献研究和多年临床实践与基础研究的基础上,采用取象比类和以方测证的方法,从胃癌病因、病位、症状、病势、转移、治疗等角度分析认为痰与胃癌密切相关。其建立的胃癌从痰论治理论体系,以痰作为胃癌发生发展的根本病... 详细信息

魏品康教授在古代文献研究和多年临床实践与基础研究的基础上,采用取象比类和以方测证的方法,从胃癌病因、病位、症状、病势、转移、治疗等角度分析认为痰与胃癌密切相关。其建立的胃癌从痰论治理论体系,以痰作为胃癌发生发展的根本病因病机,将胃癌这一痰结分为痰核、痰络、痰浊三部分,以痰浊污染作为核心来阐述胃癌发生、复发和转移的机制,以消痰散结作为胃癌治疗的根本治法。

关键词：胃癌痰中医治法

Xiaotan Sanjie decoction attenuates tumor angiogenesis by manipulating Notch-1-regulated proliferation of gastric cancer stem-like cells

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World Journal of Gastroenterology 2014年第36期20卷 13105-13118页

作者： Bing Yan Long Liu Ying Zhao Li-Juan Xiu Da-Zhi Sun Xuan Liu Ye Lu Jun Shi Yin-Cheng Zhang Yong-Jin Li Xiao-wei Wang Yu-Qi Zhou Shou-Han Feng Can Lv pin-kang wei Zhi-Feng Qin Department of Traditional Chinese Medicine Changzheng Hospital the Second Military Medical University Department of Traditional Chinese Medicine Changhai Hospital the Second Military Medical University

AIM: To determine the underlying mechanisms of action and influence of Xiaotan Sanjie (XTSJ) decoction on gastric cancer stem-like cells (GCSCs).

关键词： Gastric cancer stem-like cells Xiaotan Sanjie decoction Tumor angiogenesis Notch-1 Vascular endothelial growth factor

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胃癌细胞增殖相关基因研究进展

世界华人消化杂志 2007年第9期15卷 975-979页

作者：李春杰魏品康中国人民解放军第二军医大学长征医院中医科上海市200003

恶性肿瘤治疗困难和预后不良的主要原因,就在于其易复发转移,而恶性肿瘤细胞转移扩散与其细胞增殖活性密切相关.因此抑制肿瘤细胞的恶性增殖,是治疗恶性肿瘤的关键所在.本文着重阐述了与胃癌细胞增殖过程密切相关的端粒酶、核转录因子... 详细信息

恶性肿瘤治疗困难和预后不良的主要原因,就在于其易复发转移,而恶性肿瘤细胞转移扩散与其细胞增殖活性密切相关.因此抑制肿瘤细胞的恶性增殖,是治疗恶性肿瘤的关键所在.本文着重阐述了与胃癌细胞增殖过程密切相关的端粒酶、核转录因子、环氧化酶等基因以及参与细胞周期调控的原癌基因、抑癌基因的异常表达及临床意义,这些基因或单独作用,或相互协同,参与胃癌细胞的增殖,使肿瘤细胞生长以增殖过多、凋亡过少的失控性生长为特征.

关键词：胃癌细胞增殖基因研究进展

消痰散结方对人胃癌MKN-45裸鼠移植瘤生长及细胞增殖相关蛋白表达的影响

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中西医结合学报 2007年第4期5卷 432-436页

作者：郭晓冬魏品康上海中医药大学岳阳中西医结合医院肿瘤科上海200437 第二军医大学长征医院中医科上海200003

目的:观察消痰散结方对裸鼠胃腺癌体内生长的抑制作用及其对胃癌组织中增殖细胞核抗原(proliferatingcell nuclear antigen,PCNA)和表皮生长因子受体(epidermal growth factor receptor,EGFR)表达的影响,探讨消痰散结方抑制胃癌细胞增... 详细信息

目的:观察消痰散结方对裸鼠胃腺癌体内生长的抑制作用及其对胃癌组织中增殖细胞核抗原(proliferatingcell nuclear antigen,PCNA)和表皮生长因子受体(epidermal growth factor receptor,EGFR)表达的影响,探讨消痰散结方抑制胃癌细胞增殖的作用机制。方法:建立人胃腺癌MKN-45裸鼠原位种植模型,将45只模型鼠随机分为荷瘤对照组、中药组及化疗组,接种后次日分别给予生理盐水、中药灌胃及5-氟尿嘧啶(fluorouracil,5-FU)腹腔注射,6周实验结束后,观察移植瘤生长情况,免疫组化抗生物素蛋白链菌素-过氧化物酶(streptavidin peroxidase,SP)连接法检测胃癌组织PCNA及EGFR的阳性表达率,同时观察各组瘤组织的重量及病理学变化。结果:与对照组相比,消痰散结方可明显抑制裸鼠MKN-45胃腺癌移植瘤生长,下调裸鼠胃癌组织中PCNA和EGFR表达(P<0.05)。结论:消痰散结方可通过抑制胃癌细胞核中PCNA表达,干扰DNA合成并影响细胞表面生长因子受体表达,降低细胞增殖活性,抑制移植瘤生长。

关键词：胃肿瘤中药增殖细胞核抗原表皮生长因子受体裸小鼠

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中药治疗癌痛临床文献41篇的分析

世界华人消化杂志 2007年第35期15卷 3764-3769页

作者：许玲魏品康孙大志 LixingLao 中国人民解放军第二军医大学长征医院美国马里兰大学医学院结合医学中心访问学者上海市200003 中国人民解放军第二军医大学长征医院上海市200003 美国马里兰大学医学院结合医学中心美国马里兰州21207-6697

目的:本文通过对41篇中药治疗癌痛的临床研究文献进行分析,讨论提高中医论文质量的重要性和必要性.方法:检索《中国生物医学文献数据库》(CBM),《中国生物医学期刊文献数据库》(Chinese Medical Current Contents,CMCC)和维普中文数据... 详细信息

目的:本文通过对41篇中药治疗癌痛的临床研究文献进行分析,讨论提高中医论文质量的重要性和必要性.方法:检索《中国生物医学文献数据库》(CBM),《中国生物医学期刊文献数据库》(Chinese Medical Current Contents,CMCC)和维普中文数据库以及PubMed和荷兰医学文摘数据库(Excerpta Medical Datebase,EMBASE)英文数据库在1986年至2006年中医药治疗癌痛的文献.根据the National Cancer Institute(NCI)"补充和替代医学领域中癌症临床研究循证医学的强度等级"筛选出属于随机对照临床研究的论文41篇,并以Gagnier et al的"中药治疗随机对照试验的报道质量"一文为参考,进行论文质量分析.结果:41篇论文中一些必要信息如随机方法,纳入和排除标准,研究结果测定,盲法应用,中药制剂的质量控制和评价.以及药物的不良反应等表述不足.结论:科研论文报告的信息量是影响论文质量的因素,也是阻碍中医药在癌痛治疗领域被广泛接受的原因之一.

关键词：中医癌痛文献质量