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Ascophyllum nodosum and Fucus vesiculosus ameliorate restenosis via improving inflammation and regulating the PTEN/PI3K/AKT signaling pathway

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Food Science and Human Wellness 2024年第3期13卷 1711-1728页

作者： Crystal Ngofi Zumbi Chun-Hsu Pan Hui-Yu Huang chieh-Hsi wu Program in Clinical Drug Development from Herbal Medicine College of PharmacyTaipei Medical UniversityTaipei 11031China Program in Drug Discovery and Development Industry College of PharmacyTaipei Medical UniversityTaipei 11031China School of Pharmacy Taipei Medical UniversityTaipei 11031China Graduate Institute of Metabolism and Obesity Sciences Taipei Medical UniversityTaipei 11031China

Restenosis is a common complication following coronary *** traditional use of seaweeds for health benefits has increasingly been explored,however few studies exist reporting its protective effects on the development of restenosis and gut *** aim of this study was to investigate the potential of seaweed extracts(SE) of Ascophyllum nodosum and Fucus vesiculosus in inhibiting intimal hyperplasia in a rat model of restenosis and its underlying mechanisms in macrophages and vascular smooth muscle cells(vSMCs).16S rRNA sequencing was done to investigate the regulatory effect of SE on the gut microbiome of injured *** indicated by the results,SE significantly inhibited the progression of intimal hyperplasia in vivo,attenuated inflammation in macrophages and could inhibit the proliferation,dedifferentiation and migration of *** was observed through immunoblotting assays that treatment with SE significantly upregulated PTEN expression in macrophages and inhibited the upregulation of PI3K and AKT expression in ***,according to the 16S rRNA gene sequencing analysis,supplementation with SE modulated gut microbiota composition in injured *** conclusion,SE could ameliorate intimal hyperplasia by inhibiting inflammation and vSMCs proliferation through the regulation of the PTEN/PI3K/AKT pathway and modulating the gut microbiome.

关键词： Ascophyllum nodosum Fucus vesiculosus PTEN/PI3K/AKT Restenosis Macrophage Vascular smooth muscle cells Gut microbiota

Low Surface Brightness Galaxies Selected by Different Model Fitting

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Research in Astronomy and Astrophysics 2024年第1期24卷 223-236页

作者： Bing-Qing Zhang Hong wu Wei Du pin-Song Zhao Min He Feng-Jie Lei Key Laboratory of Optical Astronomy National Astronomical ObservatoriesChinese Academy of SciencesBeijing 100101China School of Astronomy and Space Science University of Chinese Academy of SciencesBeijing 100049China

We present a study of low surface brightness galaxies(LSBGs) selected by fitting the images for all the galaxies inα.40 SDSS DR7 sample with two kinds of single-component models and two kinds of two-component models(disk+bulge):single exponential,single sersic,exponential+deVaucular(exp+deV),and exponential+sérsic(exp+ser).Under the criteria of the B band disk central surface brightness μ_(0,disk)(B)≥22.5 mag arcsec^(-2) and the axis ratio b/a> 0.3,we selected four none-edge-on LSBG samples from each of the models which contain 1105,1038,207,and 75 galaxies,*** are 756 galaxies in common between LSBGs selected by exponential and sersic models,corresponding to 68.42% of LSBGs selected by the exponential model and 72.83% of LSBGs selected by the sersic model,the rest of the discrepancy is due to the difference in obtaining μ_(0) between the exponential and sersic *** on the fitting,in the range of 0.5≤n≤1.5,the relation of μ_(0) from two models can be written as μ_(0,sérsic)-μ_(0,exp)=-1.34(n-1).The LSBGs selected by disk+bulge models(LSBG_(2)comps) are more massive than LSBGs selected by single-component models(LSBG_1comp),and also show a larger disk *** the bulges in the majority of our LSBG_(2)comps are not prominent,more than 60% of our LSBG_(2)comps will not be selected if we adopt a single-component model *** also identified 31 giant low surface brightness galaxies(gLSBGs) from LSBG_(2)*** are located at the same region in the color-magnitude diagram as other *** we compared different criteria of gLSBGs selection,we find that for gas-rich LSBGs,M_(*)> 10^(10)M_⊙ is the best to distinguish between gLSBGs and normal LSBGs with bulge.

关键词： catalogs galaxies:spiral galaxies:bulges methods:data analysis methods:statistical

General anesthetic agents induce neurotoxicity through astrocytes

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Neural Regeneration Research 2024年第6期19卷 1299-1307页

作者： Yanchang Yang Tiantian Liu Jun Li Dandan Yan Yuhan Hu pin wu Fuquan Fang Patrick M.McQuillan Wenxin Hang Jianhang Leng Zhiyong Hu Department of Anesthesiology The First Affiliated Hospital Zhejiang University School of Medicine Department of Anesthesiology Ningbo Women and Children's Hospital 3. Department of Anesthesiology Shulan (Hangzhou) Hospital Affiliated to Zhejiang Shuren University Shulan International Medical College 4. Cell Biology Department Yale University 5. Department of Anesthesiology Penn State Hershey Medical Centre Penn State College of Medicine 6. Department of Central Laboratory Affiliated Hangzhou First People's Hospital Zhejiang University School of Medicine

Neuroscientists have recognized the importance of astrocytes in regulating neurological function and their influence on the release of glial transmitters. Few studies, however, have focused on the effects of general anesthetic agents on neuroglia or astrocytes. Astrocytes can also be an important target of general anesthetic agents as they exert not only sedative, analgesic, and amnesic effects but also mediate general anesthetic-induced neurotoxicity and postoperative cognitive dysfunction. Here, we analyzed recent advances in understanding the mechanism of general anesthetic agents on astrocytes, and found that exposure to general anesthetic agents will destroy the morphology and proliferation of astrocytes, in addition to acting on the receptors on their surface, which not only affect Ca2+signaling, inhibit the release of brain-derived neurotrophic factor and lactate from astrocytes, but are even involved in the regulation of the pro-and anti-inflammatory processes of astrocytes. These would obviously affect the communication between astrocytes as well as between astrocytes and neighboring neurons, other neuroglia, and vascular cells. In this review, we summarize how general anesthetic agents act on neurons via astrocytes, and explore potential mechanisms of action of general anesthetic agents on the nervous system. We hope that this review will provide a new direction for mitigating the neurotoxicity of general anesthetic agents.

关键词： astrocytes brain-derived neurotrophic factor general anesthetic agents neuron neurotoxicity N-methyl-D-aspartate receptor perioperative neurocognition Toll-like receptor γ-aminobutyric acid receptor

上海市浦东新区小学女生血脂水平状况及其与青春期发育关联的研究

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现代预防医学 2024年第13期51卷 2387-2392页

作者：任亚萍秦存胡卉邬天凤柏品清上海市浦东新区疾病预防控制中心学校卫生与营养食品科复旦大学浦东预防医学研究院

目的探索上海市浦东新区小学女生血脂水平与青春期发育的关系，为青春期血脂异常的研究提供依据。方法采用分层整群随机抽样方法，于2020年在浦东新区抽取一年级女生作为研究对象，进行问卷调查和体格检查，并抽取静脉血检测胆固醇（T... 详细信息

目的探索上海市浦东新区小学女生血脂水平与青春期发育的关系，为青春期血脂异常的研究提供依据。方法采用分层整群随机抽样方法，于2020年在浦东新区抽取一年级女生作为研究对象，进行问卷调查和体格检查，并抽取静脉血检测胆固醇（TC）、甘油三酯（TG）、高密度脂蛋白胆固醇（HDL-C）、低密度脂蛋白胆固醇（LDL-C）。2年后对该人群进行随访调查和体格检查，并抽取空腹静脉血，检测项目同基线。采用多重线性回归模型分析血脂水平和不同青春发育分期的关系。结果共纳入符合要求女生932人，其中6～7岁血脂水平TC、TG、HDL-C、LDL-C分别为4.15、1.02、1.52和2.17mmol/L。2年后随访时（8～9岁）四项指标分别为4.57、0.76、1.66和2.64mmol/L。基线时受检对象血脂异常检出率19.96%，随访时为19.42%。基线和随访调查均显示，女生TG和HDL-C水平在不同青春期发育分期之间的差异均有统计学意义（均P<0.05）。结论上海市浦东新区女生血脂异常检出率较高，应引起高度重视。青春期女生血脂水平在不同青春期发育会有不同，在评估青春期女生血脂水平时应考虑不同青春发育分期的影响。

关键词：血脂水平血脂异常青春期发育

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小众体育运动进校园的实践经验与推进策略

体育文化导刊 2024年第4期 98-104页

作者：查庆蘋吴开霖池州学院学生工作处安徽池州247100 吉首大学体育科学学院湖南吉首416000 湖南水利水电职业技术学院基础课部长沙410131

运用文献资料、逻辑分析等方法,阐述小众体育运动进校园的价值,探究实践经验,并提出推进策略。价值:满足学生多元体育需求、丰富学校体育育人内涵、培养小众体育后备人才。实践经验:推动多元主体联动,构建特色育人模式;制定配套政策举措... 详细信息

运用文献资料、逻辑分析等方法,阐述小众体育运动进校园的价值,探究实践经验,并提出推进策略。价值:满足学生多元体育需求、丰富学校体育育人内涵、培养小众体育后备人才。实践经验:推动多元主体联动,构建特色育人模式;制定配套政策举措,建设体育特色学校;打破体制机制壁垒,共建人才培养体系。推进策略:发挥政府统筹作用,健全制度保障体系;汇聚多元主体合力,促进深度融合发展;明确主体权责关系,完善人才培养体系;整合各方体育资源,创新资源要素配置。

关键词：体育教育小众体育运动校园学校体育

中华民族共同体文化理念的建构--吴仕民长篇小说的创作特色

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中南民族大学学报（人文社会科学版） 2024年第5期44卷 190-198,224页

作者：任现品烟台大学文学与新闻传播学院山东烟台264005

吴仕民的五部长篇小说虽题材内容各不相同,却有着共同的核心要素,即通过描绘特定地域的生活场景,在多重交错的历史纵深感中,彰显中华民族共同体的文化理念。其中,富有地域色彩的风土人情为故事发展提供了真实可感的特定场景,个人史、类... 详细信息

吴仕民的五部长篇小说虽题材内容各不相同,却有着共同的核心要素,即通过描绘特定地域的生活场景,在多重交错的历史纵深感中,彰显中华民族共同体的文化理念。其中,富有地域色彩的风土人情为故事发展提供了真实可感的特定场景,个人史、类别史与民族史的三重奏拓展了文本的历史纵深感,对瓷器、宗法制等文化层面的观照则建构了中华民族多元一体、差异互融的文化理念,最终达到地域性、历史感和民族文化理念的多维统一。这种统一,反映了吴仕民将自身创作立场、学术研究成果融入小说创作的自觉意识。

关键词：吴仕民长篇小说创作特色中华民族共同体文化理念

不同规模玉米种植技术效率差异分析——基于随机前沿生产函数与农户微观数据的研究

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玉米科学 2024年第2期32卷 168-175页

作者：瞿若频吴永常张琳中国农业科学院农业经济与发展研究所北京100000

基于黑龙江、辽宁、河北和山东4个省的372组调研数据,运用倾向得分匹配法和随机前沿模型得到玉米种植农户生产效率模型,依据最大似然检测判断不同规模玉米种植户的生产效率模型,分别估算农户生产效率模型和生产效率水平。结果表明,匹配... 详细信息

基于黑龙江、辽宁、河北和山东4个省的372组调研数据,运用倾向得分匹配法和随机前沿模型得到玉米种植农户生产效率模型,依据最大似然检测判断不同规模玉米种植户的生产效率模型,分别估算农户生产效率模型和生产效率水平。结果表明,匹配前的大规模农户效率高于小规模农户,匹配后结果相反。以研究结论为基础,本文为难以改变或不愿意改变玉米种植面积的农户提供效率水平提升的参考依据和建议。

关键词：玉米技术效率随机前沿模型倾向得分匹配

臭氧污染对杨树地上和地下生物量降低的直接和间接效应

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生态学报 2024年第15期44卷 6684-6695页

作者：吴贤杰李品闫香如侯霄帆北京林业大学林木资源高效生产全国重点实验室森林培育与保护教育部重点实验室干旱半干旱地区森林培育及生态系统研究国家林草局重点实验室北京100083

目前尚不清楚地表臭氧(O_(3))污染下植物、土壤和微生物之间的直接或间接相互作用对森林地上和地下固碳功能的影响。采用开顶式气室装置和结构方程模型,研究4种O_(3)浓度下欧美杨107(Populus euramericana cv.‘74/76’)的光合性状、叶... 详细信息

目前尚不清楚地表臭氧(O_(3))污染下植物、土壤和微生物之间的直接或间接相互作用对森林地上和地下固碳功能的影响。采用开顶式气室装置和结构方程模型,研究4种O_(3)浓度下欧美杨107(Populus euramericana cv.‘74/76’)的光合性状、叶和细根生化性状、土壤理化因子和土壤微生物群落特征对地上和地下生物量降低的直接和间接效应。结果表明,O_(3)浓度升高(86 nmol/mol)分别导致杨树地上、地下和总生物量相比对照分别下降16%、11%和15%,对地上生物量降低的影响大于地下生物量。结构方程模型发现光合速率、叶淀粉和叶非结构性碳水化合物对地上生物量有直接的影响;表明O_(3)主要通过影响植物的光合生理代谢过程对地上生物量积累产生直接作用。O_(3)对地下生物量的影响是通过直接影响叶氮和土壤总碳,叶氮再影响叶淀粉从而间接影响地下生物量。土壤pH、总碳和土壤微生物(细菌和真菌群落)对地上产生直接效应,且O_(3)对真菌群落的影响效应大于细菌群落,表明植物通过地下过程对O_(3)的响应可直接反馈作用于生物量的积累和分配过程。本研究通过解析植物、土壤和微生物之间的直接或间接相互作用为评估O_(3)污染对杨树人工林地上和地下固碳功能的影响提供科学依据。

关键词：臭氧结构方程模型生物量效应土壤微生物

Gibberellin promotes cambium reestablishment during secondary vascular tissue regeneration after girdling in an auxin-dependent manner in Populus

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Journal of Integrative Plant Biology 2024年第1期66卷 86-102页

作者： Yufei Zhang Lingyan Wang Yuexin wu Donghui Wang Xin‐Qiang He State Key Laboratory of Protein and Plant Gene Research School of Life SciencesPeking UniversityBeijing 100871China

Secondary vascular tissue(SVT)development and regeneration are regulated by *** this study,we used an in vitro SVT regeneration system to demonstrate that gibberellin(GA)treatment significantly promotes auxin-induced cambium *** GA content by overexpressing or knocking down ent-kaurene synthase(KS)affected secondary growth and SVT regeneration in *** poplar DELLA gene GIBBERELLIC ACID INSENSITIVE(PtoGAI)is expressed in a specific pattern during secondary growth and cambium regeneration after *** of PtoGAI disrupted poplar growth and inhibited cambium regeneration,and the inhibition of cambium regeneration could be partially restored by GA *** analysis of the PtaDR5:GUS transgenic plants,the localization of pin-FORMED 1(pin1)and the expression of auxin-related genes found that an additional GA treatment could enhance the auxin response as well as the expression of pin1,which mediates auxin transport during SVT *** together,these findings suggest that GA promotes cambium regeneration by stimulating auxin signal transduction.

关键词： auxin cambium gibberellin Populus secondary vascular tissue regeneration