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Long-term complete response in metastatic poorly-differentiated neuroendocrine rectal carcinoma with a multimodal approach: A case report

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World Journal of Clinical Oncology 2021年第6期12卷 500-506页

作者： Silvia Della torre Germana de Nucci pietro Maria Lombardi Samuele Grandi Gianpiero Manes Roberto Bollina Oncology Unit ASST RhodenseRho 20017Italy Department of Gastroenterology Garbagnate Milanese HospitalASST RhodenseGarbagnate Milanese 20024Italy Minimally Invasive Surgery Division Niguarda HospitalMilan 20110Italy Robotic and Emergency Surgery General Surgery DivisionManzoni HospitalLecco 23900Italy Gastroenterology Unit ASST Rhodense-Garbagnate MilaneseGarbagnate Milanese 20054Italy

BACKGROUND Neuroendocrine gastrointestinal tumors(NETs)are rare and have different natural *** is the gold standard treatment for local disease while radiotherapy has been demonstrated to be *** differentiated neuroendocrine carcinomas(NECs)represent only 5%-10%of digestive *** to aggressive growth and rapid metastatic diffusion,early diagnosis and a multidisciplinary approach are *** role of surgery and radiotherapy in this setting is still debated,and chemotherapy remains the treatment of *** SUMMARY A 42-year-old male with an ulcerated bleeding rectal lesion was diagnosed with a NEC G3(Ki67 index>90%)on May 2015 and initially treated with 3 cycles of first-line chemotherapy,but showed early local progressive disease at 3 mo and underwent sphincter-sparing open anterior low rectal *** September 2015,the first post-surgery total-body computed tomography(CT)scan showed an early pelvic disease ***,systemic chemotherapy with FOLFIRI was started and the patient obtained only a partial *** was followed by pelvic radiotherapy(50 Gy).On April 2016,a CT scan and 18F-fluorodeoxy-glucose positron emission tomography imaging showed a complete response(CR)of the pelvic lesion,but pathological abdominal inter-aortocaval lymph nodes were *** to disease progression of abdominal malignant nodes,the patient received radiotherapy at 45 Gy,and finally obtained a *** of January 2021,the patient has no symptoms of relapse and no late toxicity after chemotherapy or *** This case demonstrates how a multimodal approach can be successful in obtaining long-term CR in metastatic sites in patients with high grade digestive NECs.

关键词： Neuroendocrine tumor Multimodal therapy Rectal carcinoma Surgery Radiotherapy Case report

Ebola:a review on the state of the art on prevention and treatment

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Asian Pacific Journal of Tropical Biomedicine 2014年第12期4卷 925-927页

作者： Giuseppe La torre Vincenzo Nicosia Maurizio Cardi Department of Public Health and Infectious Diseases.Sapienza University of Rome SIMVIM-Italian Society of Travel and Migration Medicine Department of Surgery "pietro Valdoni" Azienda Policlinico Umberto ISapienza University of Rome Emergency NGO Surgical Division

The aim of this paper is to highlight the current development in the research field for helping people just exposed to Ebola virus survive(treatment) and to prevent the disease when given at various times after exposure(vaccine).Concerning the treatment,recombinant anti-Ebola monoclonal antibodies and small interfering RNAs that block the expression of essential viral proteins,are the most promising way in stopping the disease when it has already reached the *** far as concerns the prevention field,two candidate vaccines have clinical-grade vials available for phase 1 pre-licensure clinical trials,and demonstrated to have a 100%efficacy in studies on non human ***-informed communities can reduce the main ways of spread the infection,by avoiding unprotected home-based care of people who are infected and also by completely modifying traditional burial practices that are way of diffusion of the contagion.

关键词： Ebola virus Treatment Vaccine Prevention

Clinical characteristics and prognostic impact of atrial fibrillation in patients with chronic heart failure

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World Journal of Cardiology 2016年第11期8卷 647-656页

作者： Lorenzo Gigli pietro Ameri Gianmarco Secco Gabriele De Blasi Roberta Miceli Alessandra Lorenzoni Francesco torre Francesco Chiarella Claudio Brunelli Marco Canepa Cardiovascular Disease Unit Department of Internal MedicineUniversity of Genova and IRCCS Azienda Ospedaliera Universitaria San Martino-IST Istituto Nazionale per la Ricerca sul Cancro Cardiology Unit IRCCS Azienda Ospedaliera Universitaria San Martino-IST Istituto Nazionale per la Ricerca sul Cancro

AIM To assess the prevalence, clinical characteristics and independent prognostic impact of atrial fibrillation(AF) in chronic heart failure(CHF) patients, and the potential protective effect of disease-modifying medications, particularly beta-blockers(BB). METHODS We retrospectively reviewed the charts of patients referred to our center since January 2004, and collected all clinical information available at their first visit. We assessed mortality to the end of June 2015. We compared patients with and without AF, and assessed the association between AF and all-cause mortality by multivariate Cox regression and Kaplan-Meyer analysis, particularly accounting for ongoing treatment with *** A total of 903 patients were evaluated(mean age 68 ± 12 years, 73% male). Prevalence of AF was 19%, ranging from 10% to 28% in patients ≤ 60 and ≥ 77 years, respectively. Besides the older age, patients with AF had more symptoms(New York Heart Association II-III 60% vs 44%), lower prevalence of dyslipidemia(23% vs 37%), coronary artery disease(28% vs 52%) and left bundle branch block(9% vs 16%). On the contrary, they more frequently presented with an idiopathic etiology(50% vs 24%), a history of valve surgery(13% vs 4%) and received overall more devices implantation(31% vs 21%). The use of disease-modifying medications(i.e., BB and ACE inhibitors/angiotensin receptor blockers) was lower in patients with AF(72% vs 80% and 71% vs 79%, respectively), who on the contrary were more frequently treated with symptomatic and antiarrhythmic drugs including diuretics(87% vs 69%) and digoxin(51% vs 11%). At a mean follow-up of about 5 years, all-cause mortality was significantly higher in patients with AF as compared to those in sinus rhythm(SR)(45% vs 34%, P value < 0.05 for all previous comparisons). However, in a multivariate analysis including the main significant predictors of allcause mortality, the univariate relationship between AF and death(HR = 1.49, 95%CI: 1.15-1.92) became no

关键词： Atrial fibrillation Chronic heart failure Beta-blockers Digoxin Prognosis

A novel ABHD5 mutation in two Chanarin Dorfman siblings with severe and heterogeneous clinical phenotype

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Genes & Diseases 2023年第3期10卷 690-693页

作者： Solaf Mohamed Elsayed Enza torre Daniela Tavian Laura Moro Corrado Angelini Tawhida Y.Abdel Ghaffar Khalid Zalata Enas Ezzeldein Fahmy Sara Missaglia Medical Genetics Department Faculty of MedicineAin Shams UniversityCairoEgypt Yassin Abdel Ghaffar Center for Liver Disease and Research CairoEgypt Laboratory of Cellular Biochemistry and Molecular Biology CRIBENSCatholic University of the Sacred HeartMilan 20145Italy Department of Psychology Catholic University of the Sacred HeartMilan 20123Italy Department of Pharmaceutical Sciences University of Piemonte OrientaleNovara 28100Italy Neuromuscular Lab Department of NeurosciencesUniversity of PadovaCampus Biomedico Pietro D'AbanoPadova 35131Italy

Chanarin Dorfman Syndrome(CDS;MIM:275630)is a rare autosomal recessive disorder,characterized by triacylglycerol(TG)accumulation in lipid droplets(LDs)within different tissues including skin,liver,skeletal muscle,bone marrow,eyes,ears,and central nervous system.1 In CDS,the prevalent and always observed clinical feature is a non-bullous congenital ichthyosiform erythroderma(NCIE).

关键词： clinical congenital skeletal

CEPC Technical Design Report

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Radiation Detection Technology and Methods 2024年第1期8卷 I0003-I0016,1-1091页

作者： Waleed Abdallah Tiago Carlos Adorno de Freitas Konstantin Afanaciev Shakeel Ahmad Ijaz Ahmed Xiaocong Ai Abid Aleem Wolfgang Altmannshofer Fabio Alves Weiming An Rui An Daniele Paolo Anderle Stefan Antusch Yasuo Arai Andrej Arbuzov Abdesslam Arhrib Mustafa Ashry Sha Bai Yu Bai Yang Bai Vipul Bairathi Csaba Balazs Philip Bambade Yong Ban Tripamo Bandyopadhyay Shou-Shan Bao Desmond P.Barber Ayse Bat Varvara Batozskaya Subash Chandra Behera Alexander Belyaev Michele Bertucci Xiao-Jun Bi Yuanjie Bi Tianjian Bian Fabrizio Bianchi Thomas Biekotter Michela Biglietti Shalva Bilanishvili Deng Binglin Denis Bodrov Anton Bogomyagkov Serge Bondarenko Stewart Boogert Maarten Boonekamp Marcello Borri Angelo Bosotti Vincent Boudry Mohammed Boukidi Igor Boyko Ivanka Bozovic Giuseppe Bozzi Jean-Claude Brient Anastasiia Budzinskaya Masroor Bukhari Vladimir Bytev Giacomo Cacciapaglia Hua Cai Wenyong Cai Wujun Cai Yijian Cai Yizhou Cai Yuchen Cai Haiying Cai Huacheng Cai Lorenzo Calibbi Junsong Cang Guofu Cao Jianshe Cao Antoine Chance Xuejun Chang Yue Chang Zhe Chang Xinyuan Chang Wei Chao Auttakit Chatrabhuti Yimin Che Yuzhi Che Bin Chen Danping Chen Fuqing Chen Fusan Chen Gang Chen Guoming Chen Hua-Xing Chen Huirun Chen Jinhui Chen Ji-Yuan Chen Kai Chen Mali Chen Mingjun Chen Mingshui Chen Ning Chen Shanhong Chen Shanzhen Chen Shao-Long Chen Shaomin Chen Shiqiang Chen Tianlu Chen Wei Chen Xiang Chen Xiaoyu Chen Xin Chen Xun Chen Xurong Chen Ye Chen Ying Chen Yukai Chen Zelin Chen Zilin Chen Gang Chen Boping Chen Chunhui Chen Hok Chuen Cheng Huajie Cheng Shan Cheng Tongguang Cheng Yunlong Chi pietro Chimenti Wen Han Chiu Guk Cho Ming-Chung Chu Xiaotong Chu Ziliang Chu Guglielmo Coloretti Andreas Crivellin Hanhua Cui Xiaohao Cui Zhaoyuan Cui Brunella D'Anzi Ling-Yun Dai Xinchen Dai Xuwen Dai Antonio De Maria Nicola De Filippis Christophe De La Taille Francesca De Mori Chiara De Sio Elisa Del Core Shuangxue Deng Wei-Tian Deng Zhi Deng Ziyan Deng Bhupal Dev Tang Dewen Biagio Di Micco Ran Ding Siqin Dingl Yadong Ding Haiyi Dong Jianin AGH University of Science and Technology Faculty of Physics and Applied Computer ScienceKrakow Anhui University HefeiAnhui Applied Physics Department Federal Urdu University of ArtsScience and TechnologyIslamabad Banaras Hindu University Institute of ScienceVaranasi Bandirma Onyedi Eylul University Bandirma Beihang University Beijing Beijing Computational Science Research Center Beijing Beijing Conveyi LTD Beijing Beijing Glass Research Institute Co. LtdBeijing Beijing Institute of Technology Beijing Beijing Normal University Beijing Brown University ProvidenceRI Budker Institute of Nuclear Physics Novosibirsk Cadi Ayyad University Laboratory of Fundamental and Applied PhysicsPolydisciplinary FacultyMarrakech Cairo University Giza Center for Theory and Computation National Tsing Hua UniversityHsinchu Central China Normal University WuhanHubei Central South University ChangshaHunan Centro de Fisica Teorica de Particulas Universidade Tecnica de LisboaLisboa Chengdu KaitengSifang Digital Radio&TV Equipment Co. LtdChengduSichuan China academy of engineering physics MianyangSichuan China building materials academy Beijing China Center of Advanced Science and Technology Beijing China Institute of Atomic Energy Beijing China Jiliang University HangzhouZhejiang China Nuclear Instrument CO. LTDBeijing China University of Geosciences Beijing China University of Geosciences WuhanHubei China University of Mining and Technology XuzhouJiangsu China West Normal University NanchongSichuan Chongqing University Department of PhysicsChongqing Chulalongkorn University Bangkok City University of Hong Kong Department of PhysicsHong Kong Cockcroft Institute Daresbury Cornell University IthacaNY CPPM(AMU/IPhU&CNRS/INP) Marseille Dalian Minzu University DalianLiaoning Dalian University of Technology Department of PhysicsDalian Deutsches Elektronen-Synchrotron DESY Hamburg Dzhelepov Laboratory of Nuclear Problems of Joint Institute for Nuclear Research(DLNP JINR) Dubna East China University Of Science And Technol

The Circular Electron Positron Collider(CEPC)is a large scientific project initiated and hosted by China,fostered through extensive collaboration with international *** complex comprises four accelerators:a 30 GeV Linac,a 1.1 GeV Damping Ring,a Booster capable of achieving energies up to 180 GeV,and a Collider operating at varying energy modes(Z,W,H,and tt).The Linac and Damping Ring are situated on the surface,while the subterranean Booster and Collider are housed in a 100 km circumference underground tunnel,strategically accommodating future expansion with provisions for a potential Super Proton Proton Collider(SPPC).The CEPC primarily serves as a Higgs *** its baseline design with synchrotron radiation(SR)power of 30 MW per beam,it can achieve a luminosity of 5×10^(34)cm^(-2)s^(-1)per interaction point(IP),resulting in an integrated luminosity of 13 ab^(-1)for two IPs over a decade,producing 2.6 million Higgs *** the SR power to 50 MW per beam expands the CEPC's capability to generate 4.3 million Higgs bosons,facilitating precise measurements of Higgs coupling at sub-percent levels,exceeding the precision expected from the HL-LHC by an order of *** Technical Design Report(TDR)follows the Preliminary Conceptual Design Report(Pre-CDR,2015)and the Conceptual Design Report(CDR,2018),comprehensively detailing the machine's layout,performance metrics,physical design and analysis,technical systems design,R&D and prototyping efforts,and associated civil engineering ***,it includes a cost estimate and a preliminary construction timeline,establishing a framework for forthcoming engineering design phase and site selection *** is anticipated to begin around 2027-2028,pending government approval,with an estimated duration of 8 *** commencement of experiments and data collection could potentially be initiated in the mid-2030s.

关键词： initiated exceeding precise