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Oligodendroglial heterogeneity in health,disease,and recovery:deeper insights into myelin dynamics

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Neural Regeneration Research 2025年第11期20卷 3179-3192页

作者： pieter-Jan Serneels Julie D.De Schutter Lies De Groef Lieve Moons Steven Bergmans KU Leuven Leuven Brain InstituteDepartment of BiologyAnimal Physiology and Neurobiology DivisionNeural Circuit Development&Regeneration Research GroupLeuvenBelgium KU Leuven Leuven Brain InstituteDepartment of BiologyAnimal Physiology and Neurobiology DivisionCellular Communication&Neurodegeneration Research GroupLeuvenBelgium

Decades of research asserted that the oligodendroglial lineage comprises two cell types:oligodendrocyte precursor cells and ***,recent studies employing single-cell RNA sequencing techniques have uncovered novel cell states,prompting a revision of the existing *** forward,the oligodendroglial lineage should be delineated into five distinct cell states:oligodendrocyte precursor cells,committed oligodendrocyte precursor cells,newly formed oligodendrocytes,myelin-forming oligodendrocytes,and mature *** new classification system enables a deeper understanding of the oligodendroglia in both physiological and pathological *** this uniform terminology will facilitate comparison and integration of data across ***,including the consolidation of findings from various demyelinating models,is essential to better understand the pathogenesis of demyelinating ***,comparing injury models across species with varying regenerative capacities can provide insights that may lead to new therapeutic strategies to overcome remyelination ***,by standardizing terminology and synthesizing data from diverse studies across different animal models,we can enhance our understanding of myelin pathology in central nervous system disorders such as multiple sclerosis,Alzheimer's disease,and amyotrophic lateral sclerosis,all of which involve oligodendroglial and myelin dysfunction.

关键词： animal models demyelination fish mammals multiple sclerosis myelin neurodegeneration oligodendrocytes oligodendroglial lineage remyelination

Stem cells for cardiac repair: an introduction

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Journal of Geriatric cardiology 2013年第2期10卷 186-197页

作者： Bastiaan c du Pr(e) pieter A Doevendans Linda W van Laake Departments of cardiology and Medical Physiology Division of Heart and Lungs University Medical Center Utrecht P.O. box 85500 3508 GA Utrecht the Netherlands Departments of cardiology and Medical Physiology Division of Heart and Lungs University Medical Center Utrecht P.O. box 85500 3508 GA Utrecht the Netherlands Inter university Cardiology Institute of the Netherlands P.O. box 19258 2501 DG Utrecht the Netherlands Departments of cardiology and Medical Physiology Division of Heart and Lungs University Medical Center Utrecht P.O. box 85500 3508 GA Utrecht the Netherlands Hubrecht Institute P.O box 85164 3508 AD Utrecht the Netherlands

cardiovascular disease is a major cause of morbidity and mortality throughout the world. Most cardiovascular diseases, such as ischemic heart disease and cardiomyopathy, are associated with loss of functional cardiomyocytes. Unfortunately, the heart has a limited regenerative capacity and is not able to replace these cardiomyocytes once lost. In recent years, stem cells have been put forward as a potential source for cardiac regeneration. Pre-clinical studies that use stem cell-derived cardiac cells show promising results. The mechanisms,though, are not well understood, results have been variable, sometimes transient in the long term, and often without a mechanistic *** are still severalmajor hurdles to be taken. Stem cell-derived cardiac cells should resemble original cardiac cell types and be able to integrate in the damaged heart. Integration requires administration of stem cell-derived cardiac cells at the right time using the right mode of delivery. Once delivered, transplanted cells need vascularization, electrophysiological coupling with the injured heart, and prevention of immunological rejection. Finally, stem cell therapy needs to be safe, reproducible, and affordable. In this review, we will give an introduction to the principles of stem cell based cardiac repair.

关键词： cardiomyocytes Heart Regeneration Stem cell

Investigating the use cases of a novel heat battery in Dutch residential buildings

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Building Simulation 2023年第9期16卷 1675-1689页

作者： Shuwei Wang pieter-Jan Hoes Jan L.M.Hensen Olaf c.G.Adan Pim A.J.Donkers Department of the Built Environment Eindhoven University of TechnologyEindhovenP.O.Box 5135600 MB Eindhoventhe Netherlands Department of Applied Physics Eindhoven University of TechnologyEindhovenP.O.Box 5135600 MB Eindhoventhe Netherlands TNO Materials Solutions P.O.Box 62355600 HE Eindhoventhe Netherlands cellcius BV Horsten 15612 AXEindhoventhe Netherlands

Recent advances in thermochemical storage technology have introduced a novel closed-loop thermal energy storage(TES)system,known as the heat battery(HB),which is believed to have great potential for aiding the energy transition in the built environment because of its higher energy density and neglectable storage loss compared to conventional TES *** order to investigate the potential use cases of the HB and provide practical feedback for its further development,this research employs a simulation-based approach to analyze its influence on building performance in various use cases within Dutch residential *** including the homeowner,distribution system operator,and district heating system operator are identified,and a preliminary list of use cases is defined based on relevant literature and input from the HB *** simulation approach is conducted to predict key performance indicators for each *** Kruskal-Wallis test was employed to sort and scrutinize the simulation outcomes and discern the significance of each use case *** findings demonstrated that the HB holds the potential to diminish both the operational energy cost by up to 30%for the homeowners and the peak heating load transmitted from the building to the district heating system.

关键词： thermochemical storage building performance simulation use case solar energy demand-side management

Laboratory vs. Field calibration of HydraScOUT Probes for Soil Water Measurement

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Pedosphere 2019年第1期29卷 132-136页

作者： cinisani M.TFWALA Leon D.van RENSBURG Zaid A.BELLO pieter c.ZIETSMAN Department of Soil Crop & Climate Sciences University of the Free State Department of Botany National Museum(South Africa) centre for Environmental Management University of the Free State

Dear Editor,Accurate measurement of volumetric soil water content(θ_v)is essential for efficient soil water ***(HS)probes are capacitance-type probes forθ_v measurement with high accuracy,but require calibration for... 详细信息

关键词： Field calibration of HydraScOUT Probes for Soil Water Measurement Laboratory vs

Magnetic resonance imaging under isoflurane anesthesia alters cortical cyclooxygenase-2 expression and glial cell morphology during sepsis-associated neurological dysfunction in rats

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Animal Models and Experimental Medicine 2021年第3期4卷 249-260页

作者： Ibtihel Dhaya Marion Griton Jan pieter Konsman INcIA Institut de Neurosciences Cognitives et Intégratives d'AquitaineCNRS UMR 5287BordeauxFrance Univ.Bordeaux INCIAUMR 5287BordeauxFrance Laboratoire de Neurophysiologie Fonctionnelle et Pathologies UR/11ES09Facultédes Sciences MathématiquesPhysiques et NaturellesUniversitéde Tunis El ManarTunisTunisie Service de Réanimation Anesthésie Neurochirurgicale Centre Hospitalier Universitaire(CHU)de BordeauxBordeauxFrance

Background:Magnetic resonance imaging(MRI)of rodents combined with histol-ogy allows to determine what mechanisms underlie functional and structural brain changes during sepsis-associated ***,the effects of MRI per-formed in isoflurane-anesthetized rodents on modifications of the blood-brain bar-rier and the production of vasoactive prostaglandins and glia cells,which have been proposed to mediate sepsis-associated brain dysfunction,are ***:This study addressed the effect of MRI under isoflurane anesthesia on blood-brain barrier integrity,cyclooxygenase-2 expression,and glial cell activation during cecal ligature and puncture-induced sepsis-associated brain dysfunction in ***:cecal ligature and puncture reduced food intake and the righting *** under isoflurane anesthesia reduced blood-brain barrier breakdown,decreased cir-cularity of white matter astrocytes,and increased neuronal cyclooxygenase-2 immu-noreactivity in the cortex 24 hours after *** addition,it annihilated cecal ligature and puncture-induced increased circularity of white matter *** under isoflurane anesthesia,however,did not alter sepsis-associated perivascular cyclooxygenase-2 ***:These findings indicate that MRI under isoflurane anesthesia of rodents can modify neurovascular and glial responses and should,therefore,be interpreted with caution.

关键词： anesthesia astrocyte blood-brain barrier magnetic resonance imaging microglia sepsis

The measurement of proprioceptive accuracy:A systematic literature review

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Journal of Sport and Health Science 2023年第2期12卷 219-225页

作者： Àron Horváth Eszter Ferentzi Kristóf Schwartz Nina Jacobs pieter Meyns Ferenc Köteles Doctoral School of Psychology ELTE Eötvös Loránd UniversityKazinczy street 23-27Budapest 1075Hungary Institute of Health Promotion and Sport Sciences ELTE Eötvös Loránd UniversityPrielle Kornélia Street 47-49Budapest 1117Hungary Rehabilitation Research(REVAL) Faculty of Rehabilitation SciencesUniversity of HasseltMartelarenlaan 42Hasselt 3500Belgium

Background:Proprioceptive accuracy refers to the individual’s ability to perceive proprioceptive information,that is,the information referring to the actual state of the locomotor system,which originates from mechanoreceptors located in various parts of the locomotor system and from tactile receptors located in the *** accuracy appears to be an important aspect in the evaluation of sensorimotor functioning;however,no widely accepted standard assessment *** this systematic review,our goal was to identify and categorize different methods that are used to assess different aspects of proprioceptive ***:A literature search was conducted in 5 different databases(PubMed,SPORTDiscus,PsycINFO,ScienceDirect,and SpringerLink).Results:Overall,1139 scientific papers reporting 1346 methods were included in this *** methods assess 8 different aspects of proprioception:(a)the perception of joint position,(b)movement and movement extent,(c)trajectory,(d)velocity,and the sense of(e)force,(f)muscle tension,(g)weight,and(h)*** apply various paradigms of psychophysics(i.e.,the method of adjustment,constant stimuli,and limits).conclusion:As the outcomes of different tasks with respect to various body parts show no associations(i.e.,proprioceptive accuracy is characterized by site-specificity and method-specificity),the appropriate measurement method for the task needs to be chosen based on theoretical considerations and/or ecological validity.

关键词： Assessment Kinesthesia Motor control Proprioception Proprioceptive accuracy

Improvement on the Mechanical Performance and Resistance Towards Hydrolysis of Poly(glycolic acid)via Solid-state Drawing

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chinese Journal of Polymer Science 2023年第1期41卷 14-23页

作者： Jia-Xuan Li De-Yu Niu Bo Liu Peng-Wu Xu Wei-Jun Yang pieter Jan Lemstra Pi-Ming Ma The Key Laboratory of Synthetic and Biological colloids Ministry of EducationJiangnan UniversityWuxi214122China PlemPolco B.V. Roek 245508 KEVeldhoventhe Netherlands

Poly(glycolic acid)is a biocompatible as well as biocomposable polymer with superior mechanical and barrier properties and,consequently,has found important applications in both medical and packaging ***,the high hydrolysis rate in a high humidity environment restricts its *** this work,a solid-state drawing process after melt extrusion is applied in order to produce fibrous PGA with enhanced mechanical properties and a much better resistance towards *** crystal structure of PGA gradually transformed from spherulites into oriented fibrous crystals in the stretching direction upon solid-state ***,both the length of microfibril and the size of lamellae increased initially with the drawing ratio(DR),while the chain-folded lamellae transformed into extended-chain fibrils at high(er)*** oriented structures lead to an overall improvement of the mechanical properties of PGA,e.g.,the tensile strength increased from 62.0±1.4 MPa to 910±54 MPa and the elongation at break increased from around 7%to 50%.Meanwhile,the heat capacity of totally mobile amorphous PGA(∆c_(p)^(0)=0.64 J·g^(−1)·℃^(−1))was reported for the first time,which was used to analyze the content of mobile amorphous fraction(XMAF)and rigid amorphous fraction(XRAF).Both the oriented chain-folded lamellae crystals and the tightly arranged RAF are beneficial to prevent water molecules from penetrating the matrix,thus improving the resistance towards *** a consequence,the fibrous PGA with a DR of 5 showed a tensile strength retention rate of 17.3%higher in comparison with the undrawn sample after 7-days accelerated ***,this work provides a feasible method to improve the mechanical and resistance towards hydrolysis performance of PGA,which may broaden its application and prolong the shelf-life of PGA products.

关键词： Poly(glycolic acid) Solid-state drawing Fibrous crystal Mechanical property Hydrolysis resistance

Single nucleotide polymorphism in the tumor necrosis factor-alpha gene affects inflammatory bowel diseases risk

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World Journal of Gastroenterology 2008年第29期14卷 4652-4661页

作者： Lynnette R Ferguson claudia Huebner Ivonne Petermann Richard B Gearry Murray L Barclay pieter Demmers Alan Mcculloch Dug Yeo Han Discipline of Nutrition the University of AucklandPrivate Bag 92019 Auckland 1142 New Zealand Department of Gastroenterology Christchurch HospitalChristchurch 8140 New Zealand crop and Food Research Mosgiel 9053 New Zealand AgResearch Limited Mosgiel 9053 New Zealand

AIM: To investigate the role that single nucleotide polymorphisms (SNPs) in the promoter of the tumour necrosis factor-alpha (TNF-α) gene play in the risk of inflammatory bowel diseases (IBDs) in a New Zealand population, in the context of international studies. METHODS: DNA samples from 388 patients with crohn's disease (cD), 405 ulcerative colitis (Uc), 27 indeterminate colitis (Ic) and 201 randomly selected controls, from canterbury, New Zealand were screened for 3 common polymorphisms in the TNF-α receptor: -238 G→A, -308 G→A and -857c→T, using a TaqmanR assay. A meta-analysis was performed on the data obtained on these polymorphisms combined with that from other published studies. RESULTS: Individuals carrying the -308 G/A allele had a significantly (OR = 1.91, χ2 = 17.36, P creased risk of pancolitis, and a 1.57-fold increased risk (OR = 1.57, χ2 = 4.34, P = 0.037) of requiring a bowel resection in Uc. carrying the -857 c/T variant decreased the risk of ileocolonic cD (OR = 0.56, χ2 =4.32, P = 0.037), and the need for a bowel resection (OR = 0.59, χ2 = 4.85, P = 0.028). The risk of Uc was reduced in individuals who were smokers at diagnosis, (OR = 0.48, χ2 = 4.86, P = 0.028). cONcLUSION: TNF-α is a key cytokine known to play a role in inflammatory response, and the locus for the gene is found in the IBD3 region on chromosome 6p21, known to be associated with an increased risk for IBD. The -308 G/A SNP in the TNF-α promoter is functional, and may account in part for the increased Uc risk associated with the IBD3 genomic region. The -857 c/T SNP may decrease IBD risk in certain groups. Pharmaco- or nutrigenomic approaches may be desir- able for individuals with such affected genotypes.

关键词： Tumour necrosis factor alpha Singlenucleotide polymorphisms Inflammatory boweldiseases crohn's disease Ulcerative colitis

A nanoparticle platform for combined mucosal healing and immunomodulation in inflammatory bowel disease treatment

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Bioactive Materials 2024年第2期32卷 206-221页

作者： Valentina Marotti Yining Xu cécilia Bohns Michalowski Wunan Zhang Inês Domingues Hafsa Ameraoui Tom G.Moreels pieter Baatsen Matthias Van Hul Giulio G.Muccioli Patrice D.cani Mireille Alhouayek Alessio Malfanti Ana Beloqui UcLouvain Universit´e catholique de LouvainLouvain Drug Research InstituteAdvanced Drug Delivery and Biomaterials1200 BrusselsBelgium UcLouvain Universit´e catholique de LouvainLouvain Drug Research InstituteBioanalysis and Pharmacology of Bioactive Lipids1200 BrusselsBelgium UcLouvain Universit´e catholique de LouvainInstitute of Experimental and Clinical ResearchLaboratory of Hepato-Gastroenterology1200 BrusselsBelgium cliniques universitaires Saint-Luc Department of Hepato-GastroenterologyBrusselsBelgium EM-platform VIB Bio Imaging CoreKU LeuvenCampus GasthuisbergHerestraat 493000 LeuvenBelgium UcLouvain Universit´e catholique de LouvainLouvain Drug Research InstituteMetabolism and Nutrition Group1200 BrusselsBelgium UcLouvain Institute of Experimental and Clinical Research1200 BrusselsBelgium WEL Research Institute Avenue Pasteur61300 WavreBelgium

current treatments for inflammatory bowel disease(IBD)treatment consist of anti-inflammatory *** this study,we sought to induce the physiological secretion of glucagon-like peptide 2,a peptide with intestinal growth-promoting activity,via nanoparticles while simultaneously providing with immunomodulation by tailoring the nanoparticle *** this end,we developed hybrid lipid hyaluronate-KPV conjugated nanoparticles loaded with teduglutide for combination therapy in *** nanocarriers induced(or did not induce)immunosuppression depending on the presence(or absence)of a hyaluronan-KPV *** strategy holds promise as a nanoparticle platform for combined mucosal healing and immunomodulation in IBD treatment.

关键词： Nanocarrier GLP-2 Teduglutide KPV Inflammatory bowel disease