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HIV Compartmentalization in Male Genital Tract:Relevance for Viral Eradication

Infectious Diseases & Immunity 2021年第2期1卷 86-92页

作者： Xiaorong Peng Stéphane Isnard John Lin Brandon Fombuena Lena Royston Jean-pierre Routy Infectious Diseases and Immunity in Global Health Program Research InstituteMcGill University Health CentreMontréalQCCanada Chronic Viral Illness Service McGill University Health CentreMontréalQCCanada State Key Laboratory for Diagnosis and Treatment of Infectious Diseases National Clinical Research Center for Infectious DiseasesCollaborative Innovation Center for Diagnosis and Treatment of Infectious Diseasesthe First Affiliated HospitalCollege of MedicineZhejiang UniversityHangzhouZhejiang 310006China CIHR Canadian HIV Trials Network VancouverBCCanada Division of Hematology McGill University Health CentreMontréalQCCanada

Human immunodeficiency virus(HIV)has been shown to evolve independently in different anatomical *** HIV genetic evolution in different tissues and cells provides insights into the mechanisms that maintain the viral *** compartmentalization has been well documented in the semen but rarely in male genital tract(MGT)*** precise mechanisms that result in the development of HIV compartmentalization in multiple genitourinary sites have been poorly explored due to the difficulty in accessing these *** on evidence from lymph nodes and gut tissues,mechanisms that may influence compartmentalization include immune pressures,local concentrations of antiviral drugs,clonal expansion of different cell types and inflammation that alters the cellular *** reviewed phylogenetic evidences supporting viral compartmentalization between the blood and multiple genitourinary sites in HIV-infected *** distinct viral subpopulations enhances our overall understanding of the HIV reservoir inMGTand could ultimately lead to the development of novel therapies to eradicate the virus in tissues.

关键词： HIV Compartmentalization Male genital tract Reservoir Testes

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Heart‘omicsin’AGEing (HOMAGE):design,research objectives and characteristics of the common database

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The Journal of Biomedical Research 2014年第5期28卷 349-359页

作者： Lotte Jacobs Lutgarde Thijs Yu Jin Faiez Zannad Alexandre Mebazaa Philippe Rouet Florence Pinet Christophe Bauters Burkert Pieske Andreas Tomaschitz Mamas Mamas Javier Diez Kenneth McDonald John G F Cleland Hans-Peter Brunner-La Rocca stephane Heymans Roberto Latini Serge Masson Peter Sever Christian Delles Stuart Pocock Timothy Collier Tatiana Kuznetsova Jan A Staessen Studies Coordinating Centre Research Unit Hypertension and Cardiovascular EpidemiologyKU Leuven Department of Cardiovascular Sciences University of Leuven Centre d'Investigation Clinique pierre Drouin and U 961 Hypertension and Heart Failure UnitInstitut Lourrain du Coeur etdes VaisseauxInsermNancyFrance Department of Anesthesiology and Critical Care Medicine InsermUMR-S942Hopital LariboisiereUniversite Paris Diderot Equipe obesite et insuffisance cardiaque Universite UPSInserm I2MCUMR 1048ToulouseFrance Inserm U744CHRULilleFrance Department of Cardiology Medical University Graz Cardiovascular Institute University of ManchesterManchesterUK Division of Cardiovascular Sciences Foundation for Applied Medical ResearchUniversity of Navarra Heart Failure Unit St Vincent's University Hospital University College Dublin Department of Cardiology University of HullUK Department of Cardiology Maastricht University Medical CentreNetherlands Center for Heart Failure Research Department of CardiologyMaastricht UniversityNetherlands Department of Cardiovascular Research IRCCS - Istituto di Ricerche Farmacologiche "Mario Negri" International Center for Circulatory Health Imperial College Institute of Cardiovascular and Medical Sciences BHF Glasgow Cardiovascular Research CenterUniversity of Glasgow London School of Hygiene and Tropical Medicine

Heart failure is common in older people and its prevalence is *** Heart ＇omics＇ in AGEing（HOMAGE） project aims to provide a biomarker approach that will improve the early diagnosis of heart failure.A large clinical database,based on（1） prospective population studies or（2） cross-sectional,prospective studies or randomized controlled trials（RCTs） of patients at risk for or with overt cardiovascular disease will be constructed to determine most promising ＇omics＇-based biomarkers to identify the risk of developing heart failure and/or *** studies,patient cohorts and RCTs are eligible for inclusion in the common database,if they received ethical approval to obtain and share data and have baseline information on cardiovascular risk ***,the HOMAGE database includes 43,065 subjects,from 20 studies in eight European countries,including healthy subjects from three population studies in France,Belgium and Italy（n = 7,124）,patients with heart failure（n = 4,312） from four cohorts in the UK,Spain and Switzerland and patients at high risk for cardiovascular disease（n = 31,629） in 13 *** is anticipated that more partners will join the consortium and enlarge the pooled *** large merged database will be a useful resource with which to identify candidate biomarkers that play a role in the mechanism underlying the onset and progression of heart failure.

关键词： left ventricle heart failure heart failure with reduced ejection fraction heart failure with preserved ejection fraction population science morbidity mortality

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A demonstration project of Global Alliance against Chronic Respiratory Diseases:Prediction of interactions between air pollution and allergen exposure—the Mobile Airways Sentinel NetworK-Impact of air POLLution on Asthma and Rhinitis approach

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Chinese Medical Journal 2020年第13期133卷 1561-1567页

作者： Mikhail Sofiev Yuliia Palamarchuk Annabelle Bedard Xavier Basagana Josep M.Anto Rostislav Kouznetsov Rodrigo Delgado Urzua Karl Christian Bergmann Joao A.Fonseca Govert De Vries Michiel Van Erd Isabella Annesi-Maesano Daniel Laune Jean Louis Pepin Ingrid Jullian-Desayes stephane Zeng Wienczyslawa Czarlewski Jean Bousquet Finnish Meteorological Institute(FMI) Helsinki 00560Finland Barcelona Institute for Global Health Centre for Research in Environmental Epidemiology(CREAL)Barcelona 08003Spain Centro de Investigacion Biomedica en Red de Epidemiologia y Salud Publica(CIBER)Epidemiologia y Salud Publica(CIBERESP) Barcelona 08003Spain Universitat Pompeu Fabra(UPF) Barcelona 08003Spain Institut Hospital del Mar d'lnvestigacions Mediques(IMIM) Barcelona 08003Spain Charite-Universitatsmedizin Berlin Corporate Member of Freie Universitat BerlinHumboldt-Uniersitat zu Berlin and Berlin Institute of HealthComprehensive Allergy-CentreDepartment of Dermatology and AllergyBerlin 10117Germany Center for Health Technology and Services Research(CINTESIS) Center for Research in Health Technology and Information SystemsFaculdade de Medicina da Universidade do Portoand MedidaLda Porto s/n 4200-450Portugal Peercode BV Geldermalsen 4191 NWThe Netherlands Epidemiology of Allergic and Respiratory Diseases Department Institute Pierre Louis of Epidemiology and Public HealthINSERM and Sorbonne UniversiteMedical School Saint AntoineParis 75571France KYomed Innovation Montpellier 34184France Universite Grenoble Alpes Laboratoire HP2GrenobleINSERMU1042 and CHU de GrenobleGrenoble 38000France Bull DSAS Echirolles 38130France Medical Consulting Czarlewski Levalloisand MASK-airMontpellier 92300France University Hospital Montpellier Montpellier 34000France Contre les Maladies Chroniques pour un Vieillissement Actif en Languedoc Roussillon-France MontpellierFrance Charite Universitatsmedizin BerlinHumboldt-Universitat zu Berlinand Berlin Institute of HealthComprehensive Allergy CenterDepartment of Dermatology and AllergyBerlin 10117Germany

This review analyzes the state and recent progress in the field of information support for pollen allergy *** decades,information available for the patients and allergologists consisted of pollen counts,which are vital but *** technology paves the way to substantial increase in amount and diversity of the *** paper reviews old and newly suggested methods to predict pollen and air pollutant concentrations in the air and proposes an allergy risk concept,which combines the pollen and pollution information and transforms it into a qualitative risk *** new index is available in an app(Mobile Airways Sentinel NetworK-air)that was developed in the frame of the European Union grant Impact of Air POLLution on sleep,Asthma and Rhinitis(a project of European Institute of Innovation and Technology-Health).On-going transformation of the pollen allergy information support is based on new technological solutions for pollen and air quality monitoring and *** new information-technology and artificial-intelligence-based solutions help to convert this information into easy-to-use services for both medical practitioners and allergy sufferers.

关键词： Pollen allergy Pollen season Google trends Pollen dispersion modeling System for Integrated modeLling of Atmospheric coMposition model Pollen index Air quality index

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