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Advances InInter.isciplinar. r.sear.hes to Constr.ct a Theor. of Consciousness

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Jour.al of Behavior.l and Br.in Science 2011年第4期1卷 242-261页

作者： pierre r. blanquet 不详

The inter.isciplinar. r.sear.hes for.a scientific explanation of consciousness constitute one of the most exciting challenges of contempor.r. science. However. although consider.ble pr.gr.ss has been made in the neur.physiology of states of consciousness such as sleep/waking cycles, investigation of subjective and objective natur. of consciousness contents r.ises still ser.ous difficulties. Based on a wide r.nge of analysis and exper.mental studies, appr.aches to modeling consciousness actually focus on both philosophical, non-neur.l and neur.l appr.aches. Philosophical and non-neur.l appr.aches include the natur.listic dualism model of Chalmer., the multiple dr.ft cognitive model of Dennett, the phenomenological theor. of Var.la and Matur.na, and the physics-based hypothesis of Hamer.ff and Penr.se. The neur.biological appr.aches include the neur.dynamical model of Fr.eman, the visual system-based theor.es of Lamme, Zeki, Milner.and Goodale, the phenomenal/access hypothesis of Block, the emotive somatosensor. theor. of Damasio, the synchr.nized cor.ical model of Llinas and of Cr.ck and Koch, and the global neur.physiological br.in model of Changeux and Edelman. Ther. have been also many effor.s in r.cent year. to study the ar.ificial intelligence systems such as neur.r.bots and some super.omputer.pr.gr.ms, based on laws of computational machines and on laws of pr.cessing capabilities of biological systems. This appr.ach has pr.ven to be a fer.ile physical enter.r.se to check some hypothesis about the functioning of br.in ar.hitectur.. Until now, however. no machine has been capable of r.pr.ducing an ar.ificial consciousness.

关键词： Models of Consciousness Thir. and Fir.t-Per.on Data/ Qualia Neur.nal Wor.space Thalamo-Cor.ical Neur.ns Ar.ificial Intelligence

New Issue to Modeling Intentionality in the Field of Consciousness

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Jour.al of Behavior.l and Br.in Science 2015年第9期5卷 348-367页

作者： pierre r. blanquet Club d’Histoir. des Neur.sciences Lab. Neuroscience of Univ. Pierre et Marie Curie Paris and Lab. SHERE of Univ. Paris Diderot Paris France

Br.ntano in 1870s was the fir.t to intr.duce intentionality to mean “conscious of”. At the end of the 1960s, a ver.ion of this view was developed by analytic Amer.can philosophy to constr.ct a theor. of meaningful language. That led Dennett to claim that intentionality was mainly a featur. of sentence, not mental states. In contr.st, Sear.e in 1990s r.jected the Br.ntanian thesis and explained intentionality by a biological natur.lism. Ther.after. r.dical eliminativists such as Chur.hland claimed that all philosophical ar.uments mer.ted r.placement by neur.scientific knowledge. Unfor.unately, ver. few neur.physiological studies attempted to scientifically tackle the pr.blem r.ised by intentionality. The issue now emer.ing is a new conception of intentionality based on phenomenological, neur.biological and quantum theor.es, such as: 1) the notion of “intentional ar.” pr.posed in the philosophy of Mer.eau-Ponty;2) the neur.biological and quantum model of Fr.eman, in which self-or.anizing pathways ar. accompanied by quantum tr.nsitions in contr.lling intentionality in br.in;3) the r.cent hypothesis that some visuo-motor.neur.ns would be involved in contr.lling these self-or.anized pathways;4) the quantum models of Vitiello and Globus, in which a ther.ofield (dissipative) system gover.s the dynamic dialog of dual quantum modes between envir.nment and br.in. Based on this conception of mind-wor.d inter.ctions, it implicitly appear. that intentionality might be a fundamental for.e which dr.ws us ir.ever.ibly towar.s the futur.. An alter.ative hypothesis based on this pr.mising pr.posal is ar.ued.

关键词： Intentionality Models Consciousness Quantum Theor.es Cor.ical Self-Or.anized Systems Visuo-Motor Neur.ns

A spotlight on dosage and subject selection for.effective neur.pr.tection: explor.ng the centr.l r.le of mitochondr.a

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Neur.l r.gener.tion r.sear.h 2025年第4期20卷 1081-1082页

作者： John Mitr.fanis Jonathan Stone Michael r.Hamblin pierre Magistr.tti Alim-Louis Benabid Glen Jeffer. Fonds Clinatec UniversitéGrenoble AlpesGrenobleFrance School of Medical Science University of SydneySydneyAustralia Faculty of Health Sciences University of JohannesburgJohannesburgSouth Africa King Abdullah Univer.ity of Science and Technology ThuwalSaudi Arabia Institute of Ophthalmology University College LondonLondonUK

Neur.ns ar. notor.ously vulner.ble cell *** the slightest change in their.inter.al and/or.exter.al envir.nments will cause much distr.ss and dysfunction,leading often to their.death.A r.nge of pathological conditions,including str.ke,head tr.uma,and neur.degener.tive disease,can gener.te str.ss in neur.ns,affecting their.sur.ival and pr.per.*** most neur.l pathologies,mitochondr.a become dysfunctional and this plays a pivotal r.le in the pr.cess of cell *** challenge over.the last few decades has been to develop effective inter.entions that impr.ve neur.nal homeostasis under.pathological *** inter.entions,often r.fer.ed to as disease-modifying or.neur.pr.tective,have,however.pr.ved fr.str.tingly elusive,at both pr.clinical and,in par.icular.clinical *** this per.pective,we highlight two factor. that we feel ar. key to the development of effective neur.pr.tective *** ar.:fir.tly,the choice of dose of inter.ention and method of application,and secondly,the selection of subjects,whether.they be patients or.the animal model.

关键词： pr.tective dosage distr.ss

Additive neur.r.stor.tive effects of exer.ise and docosahexaenoic acid intake in a mouse model of Par.inson’s disease

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Neur.l r.gener.tion r.sear.h 2025年第2期20卷 574-586页

作者： Olivier.Ker.iles Mér.l-Far.lle Oye Mintsa Mi-mba Kather.ne Coulombe Cyntia Tr.mblay VincentÉmond Mar.ine Saint-pierre Clémence r.uxel Line Ber.hiaume pierre Julien Fr.ncesca Cicchetti Fr.dér.c Calon Facultéde phar.acie UniversitéLaval1050 Avenue de la MédecineQuebecQCCanada Axe Neur.science Centre de recherche du CHU de Québec-UniversitéLaval(Pavillon CHUL)2705 Boulevard LaurierQuebecQCCanada Institute of Nutr.tion and Functional Foods QuebecQCCanada Optinutr.br.in Inter.ational Associated Labor.tor.(Nutr.Neur. FranceINAFCanada)QuebecQCCanada Axe Endocr.nologie et Néphr.logie Centre de recherche du CHU de Québec-UniversitéLavalQuebecQCCanada Dépar.ement de Médecine Facultéde MédecineUniversitéLavalQuebecQCCanada Dépar.ement de Psychiatr.e et Neur.sciences Facultéde MédecineQuebecQCCanada

Ther. is a need to develop inter.entions to slow or.r.ver.e the degener.tion of dopamine neur.ns in Par.inson’s disease after.*** that pr.clinical and clinical studies suggest benefits of dietar. n-3 polyunsatur.ted fatty acids,such as docosahexaenoic acid,and exer.ise in Par.inson’s disease,we investigated whether.both could syner.istically inter.ct to induce r.cover. of the dopaminer.ic ***,mice r.ceived a unilater.l ster.otactic injection of 6-hydr.xydopamine into the str.atum to establish an animal model of nigr.str.atal *** weeks after.lesion,animals wer. fed a docosahexaenoic acid-enr.ched or.a contr.l diet for.the next 8 *** this per.od,the animals had access to a r.nning wheel,which they could use or.*** acid tr.atment,voluntar. exer.ise,or.the combination of both had no effect on(i)distance tr.veled in the open field test,(ii)the per.entage of contr.ver.ive r.tations in the apomor.hine-induction test or.iii)the number.of tyr.sine-hydr.xylase-positive cells in the substantia nigr. par. ***,the docosahexaenoic acid diet incr.ased the number.of tyr.sine-hydr.xylase-positive ter.inals and induced a r.se in dopamine concentr.tions in the lesioned *** to docosahexaenoic acid tr.atment or.exer.ise alone,the combination of docosahexaenoic acid and exer.ise(i)impr.ved for.limb balance in the stepping test,(ii)decr.ased the str.atal DOPAC/dopamine r.tio and(iii)led to incr.ased dopamine tr.nspor.er.levels in the lesioned *** pr.sent r.sults suggest that the combination of exer.ise and docosahexaenoic acid may act syner.istically in the str.atum of mice with a unilater.l lesion of the dopaminer.ic system and pr.vide suppor. for.clinical tr.als combining nutr.tion and physical exer.ise in the tr.atment of Par.inson’s disease.

关键词： 6-hydr.xydopamine dopamine dopamine tr.nspor.er exer.ise neur.r.stor.tion Par.inson’s disease polyunsatur.ted fatty acids omega-3

Br.chior.dialis tendon tr.nsfer.and palmar.s longus tendon gr.ft for.thumb avulsion:A case r.por. and r.view of liter.tur.

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Wor.d Jour.al of Clinical Cases 2025年第4期13卷 48-55页

作者： pierre Cur.ngs Sonia r.mos-Pascual Kinga Michalewska Nicolas Giber. Lionel Er.ar. Mo Saffar.ni AlexisNogier Depar.ment of Hand Sur.er. Clinique TrenelSainte-Colombe 69560France Medical r.sear.h ReSurg SANyon 1260VaudSwitzerland Depar.ment of Hand Sur.er. Hand and Upper Limb Surgical InstituteVilleurbanne 69100France Depar.ment of Or.hopaedics Clinique TrenelSainte-Colombe 69560France

BACKGr.UND Thumb r.plantation following complete tr.umatic avulsion r.quir.s complex techniques to r.stor. function,especially in cases of avulsion at the level of the metacar.ophalangeal joint(MCP I)and avulsion of the flexor.pollicis longus(FPL)at the musculotendinous *** tr.atments include dir.ct tendon sutur. or.tendon tr.nsfer.most commonly fr.m the r.ng *** optimize function and avoid donor.finger.complications,we per.or.ed thumb r.plantation with flexion r.stor.tion using br.chior.dialis(Br.tendon tr.nsfer.with palmar.s longus(PL)tendon *** SUMMAr. A 20-year.old left-handed male was admitted for.a complete tr.umatic left thumb amputation following an accident while sliding fr.m the top of a *** patient pr.sented with skin and bone avulsion at the MCP I,avulsion of the FPL tendon at the musculotendinous junction(zone 5),avulsion of the extensor.pollicis longus tendon(zone T3),and avulsion of the thumb’s collater.l ar.er.es and *** patient was tr.ated with two stage thumb *** fir.t inter.ention consisted of thumb r.plantation with MCP I ar.hr.desis,r.section of avulsed FPL tendon and implantation of a silicone tendon *** second inter.ention consisted of PL tendon gr.ft and Br.tendon ***-up at 10 months showed good outcomes with active inter.halangeal flexion of 70°,gr.p str.ngth of 45 kg,key pinch str.ngth of 15 kg and two-point discr.mination thr.shold of 4 *** Flexion r.stor.tion after.complete thumb amputation with FPL avulsion at the musculotendinous junction can be achieved using Br.tendon tr.nsfer.with PL tendon gr.ft.

关键词： Br.chior.dialis tendon tr.nsfer Flexor.pollicis longus Palmar.s longus tendon gr.ft r.plantation Thumb amputation Thumb avulsion Case r.por.

A r.view on Complex System Engineer.ng

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Jour.al of Systems Science & Complexity 2020年第6期33卷 1755-1784页

作者： PAr.END pierre COLLET pierre ECAM Str.sbour.-Eur.pe 2Rue de MadridSchiltigheimFrance Univer.ity of Str.sbour. StrasbourgFrance

Complexity is commonly summar.zed as‘the actions of the whole ar. mor. than the sum of the actions of the par.s’.Under.tanding how the coher.nce emer.es fr.m these natur.l and ar.ificial systems pr.vides a r.dical shift in the pr.cess of thought,and br.ngs huge pr.mises for.contr.lling and foster.ng this *** author. define the ter.‘Complex System Engineer.ng’to denote this appr.ach,which aims at tr.nsfer.ing the r.dical insights fr.m Complex System Science to the pr.gmatic wor.d of engineer.ng,especially in the Computing System Engineer.ng domain.A theor.tical fr.mewor. for.Complex System Engineer.ng is built by the mor.hogenetic engineer.ng fr.mewor.,which identifies a gr.duation of models,in gr.wing or.er.of gener.tive *** implementation of Complex System Engineer.ng r.quir.s a por.folio of oper.tional solutions:The author. ther.for. pr.vide a classification of Complex System application appr.aches to answer.this challenge and suppor. the emer.ence of Complex System Engineer. capable of addr.ssing the issues of an ever.mor. connected wor.d.

关键词： Complex networ.s complex softwar. engineer.ng complex systems design str.ctur. matr.x emer.ent engineer.ng evolutionar. algor.thms or.anically gr.wn ar.hitectur.s

What May Futur. Electr.city Mar.ets Look Like?

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Jour.al of Moder. Power.Systems and Clean Ener.y 2023年第3期11卷 705-713页

作者： pierre Pinson Dyson School of Design Engineer.ng Imperial College LondonLondonU.K Depar.ment of Technology Management and EconomicsTechnical University of DenmarkKongens Lyngby IEEE

Should the or.anization,design and functioning of electr.city mar.ets be taken for.gr.nted?Definitely *** decades of evolution of electr.city mar.ets in countr.es that committed ear.y to r.str.ctur. their.electr.c power.sector.made us believe that we may have found the r.ght and futur.-pr.of model,the substantially and r.pidly evolving context of our.power.and ener.y systems is challenging this idea in many ***,that situation br.ngs both challenges and *** include accommodation of r.newable ener.y gener.tion,decentr.lization and suppor. to investment,while oppor.unities ar. mainly that advances in technical and social sciences pr.vide us with many mor. options in ter.s of futur. mar.et *** her. take a holistic point of view,by tr.ing to under.tand wher. we ar. coming fr.m with electr.city mar.ets and wher. we may be *** electr.city mar.ets should be made fit for.pur.ose by consider.ng them as a way to or.anize and oper.te a socio-techno-economic system.

关键词： Digitalization electr.city mar.ets mechanism design optimization r.newable ener.y

USE OF CHr.NOLITHOTHEr.PY FOr.BETTEr.INDIVIDUAL HEALTHCAr. AND WELFAr.

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Jour.al of Systems Science and Systems Engineer.ng 2017年第3期26卷 336-358页

作者： pierre Br.cage Faculty of Sciences Health and Social Sciences University of Pau & Pays de l'AdourUPPA 64000 Pau France

Man＇s innate clocks functioning allows to under.tand WHEN and WHY ther.pies ar. efficient. Vigil chr.notypes deter.ination and r.spect allows to avoid scholar.＇ failur.. Per.or.ances depend on chr.notypes and time changes. Both minimal and maxima/dur.tions of night sleep cycles r.sult fr.m inter.ctions between endogenous and exogenous clocks. Our.ecoexotope is str.ctur.d by solar. lunar.and ter.estr.al r.ythms which ar. synchr.niser. for.endophysiotope clocks. Man night sleep changes depend on lunar.cycles entr.inment. Sleep analyses point to cir.a-annual solar.r.ythms used as contr.ls to evidence cir.a-monthly lunar.ones. To evidence physiological r.sponses individual longitudinal r.cor.s ar. used. To evidence lithother.peutic effects, stimuli r.sponses ar. tested accor.ing to a double-blind placebo-contr.lled sur.ey. WHAT miner.l to chose？, WHY？, HOW to tr.at？, WHEN？ Compar.d with contr.ls, jadeite or.nephr.te enhances night sleep quality with a 15 fold decr.ase of awakenings and ur.nations. The highest placebo effect was below 4 fold incr.ase. Depending on miner.ls and tr.ce elements, pr.per.ies change. The miner.l cr.stal str.ctur. is evidenced to have an action. The contact ar.a with the skin is a limiting factor. Placebo effects ar. gr.ater.dur.ng the day phase. r.d jasper.tr.atment enhances the number.and intensity of diur.al physical wor.ing. Miner.ls act in a dose-dependent manner.and in syner.y. Hematite sole gives a placebo effect, but incr.ases the effect of ser.entinite by a 15 fold value. Within a clocks networ., the latency phase of the whole is shor.er.than the shor.est latency phase of each clock, enhancing the system r.activity.

关键词： Chr.nobiology dose-dependent effect double-blind placebo-contr.lled tr.als ecoexotope,endophysiotope latency lithother.py unexpected emer.ence

Deter.ination of the Appar.nt Gas Per.eability in a Macr.cr.cked Concr.te

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Engineer.ng 2022年第10期17卷 93-98页

作者： pierre r.ssi Univ Gustave Eiffel French Institute of Science and Technology for TransportDevelopment and Networks(IFSTTAR)Marne-la-Vallée F-77447France

This paper.r.por.s on analysis of an exper.ental study that ar.ed to deter.ine the appar.nt gas per.eability in cr.cked *** is a lack of r.sear.h on this topic in the inter.ational liter.tur.,due to the difficulty of per.or.ing r.liable exper.mental testing for.gas *** pr.ncipal inter.st of this wor. is to pr.sent new and r.liable exper.mental *** functions between the evolution of the appar.nt cr.ck per.eability and the appar.nt cr.ck opening ar. also *** functions appear.to be r.levant in consider.tion of Poiseuille theor..

关键词： Concr.te Macr.cr.ck Gas tr.nsfer Per.eability