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Foundations and implications of Human Aging Omics:A framework for identifying cumulative health risks from embryo to senescence

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Science Bulletin 2024年第20期69卷 3184-3187页

作者： Xiaoying Zheng Binbin Su Yihao Zhao Chen Chen Bruno Vellas Jean-pierre michel Ruitai Shao School of Population Medicine and Public Health Chinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100730China APEC Health Science Academy(HeSAY) Peking UniversityBeijing 100871China Department of Geriatric Health Sciences School of Population Medicine and Public HealthChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100730China Gérontopôle&Department of Geriatric Internal Medicine Toulouse University HospitalToulouse 31000France Geneva University Medical School Geneva 1205Switzerland

We are witnessing a global demographic shift towards an aging society,driven by significant improvements in life *** the past two decades,the average life expectancy has increased by more than 6 years from 66.8 years ... 详细信息

关键词： life aging identifying

The beginnings of plasmomechanics： towards plasmonic strain sensors

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Frontiers of Materials Science 2015年第2期9卷 170-177页

作者： Thomas MAURER Joseph MARAE-DJOUDA Ugo CATALDI Arthur GONTIER Guillaume MONTAY Yazid MADI Benoit PANICAUD Demetrio MACIAS pierre-michel ADAM Gaetan LEVEQUE Thomas BURGI Roberto CAPUTO Laboratory of Nanotechnology and Instrumentation in Optics (LNIO) ICD CNRS UMR 6281 University of Technology of Troyes CS 42060 10004 Troyes France The Laboratory of Mechanical Systems and Concurrent Engineeringl ICD CNRS UMR 6281 University of Technology of Troyes CS 42060 10004 Troyes France Ermess EPF Sceaux France Center of Materials Mines ParisTech UMR CNRS 7633 BP 87 91003 Evry Cedex France Institute of Electronics Microelectronics and Nanotechnology (IEMN CNRS-8520) Cite Scientifique Avenue Poincare 59652 Villeneuve d'Ascq France Department of Physical Chemistry University of Geneva 30 Quai Ernest-Ansermet 1211 Geneva 4 Switzerland Department of Physics and CNR-NANOTEC University of Calabria 87036 Rende Italy

This article exposes the beginnings of a new field which could be named as ＂plasmomechanics＂. Plasmomechanics comes from the convergence between mechanics and plasmonics. Here we discuss a relatively recent topic whose technolo- gical aim is the development of plasmonic strain sensors, The idea is based on the ability to deduce Au nanoparticles （NPs） distance distributions from polarized optical extinction spectroscopy which could thus give access to material strains. Variations of interparticle distances distributions can indeed lead to variations of plasmonic coupling and thus to material color change as shown here experimentally and numerically for random Au NP assemblies deposited onto elastomer films,

关键词： localized surface plasmon resonance (LSPR) metallic nanoparticle strain composite material elastomeric film

社交网红影响者的可信度对消费者购买意向的影响——中国和法国之间的比较

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社交网红影响者的可信度对消费者购买意向的影响——中国和法国之...

作者： GONNET MAXIME pierre michel 华东师范大学

学位级别：硕士

社交媒体已经成为品牌的基本推广工具,其面对的是联系越来越紧密、对传统媒体消费越来越少的新世代。因此,品牌现在正利用社交媒体来锁定这批新的受众,并调整了其营销策略。利用名人代言,品牌利用社交媒体明星推广其产品,即社交媒体影... 详细信息

社交媒体已经成为品牌的基本推广工具,其面对的是联系越来越紧密、对传统媒体消费越来越少的新世代。因此,品牌现在正利用社交媒体来锁定这批新的受众,并调整了其营销策略。利用名人代言,品牌利用社交媒体明星推广其产品,即社交媒体影响者营销。然而,品牌必须知道所选择的影响者是否会对其追随者的购买意向产生积极的影响。在Zietek(2016)看来,可信度会影响说服效果,而缺乏可信度则会导致说服力的丧失。因此,影响者的可信度是衡量其对购买意向影响的重要因素。Ohanian(1990)提出,名人的可信度可以通过三个主要维度来衡量:吸引力、可信度和专业性。通过确定一个来源的可信度,我们可以确定它对其信息接收者的购买意向的影响。本研究论文的目的是确定哪些因素塑造了社交媒体影响者的可信度,并使用Ohanian来源可信度模型研究其如何影响消费者的购买意向。此外,本研究还分析了法国和中国的消费者,以确定这些因素在这两个国家是否相同或不同。共有245名法国和中国的社交媒体用户回答了关于他们使用社交媒体以及与影响者的关系的问卷调查。经过统计分析,本论文确定了Ohanian模型中建立的三个因素也适用于社交媒体影响者营销。然而,这些因素对法国和中国消费者的影响并不一样:吸引力和可信度对中国消费者的购买意向有积极影响,但对法国人的影响不大。专业性对法国消费者的购买意向有正向影响,但对中国消费者的购买意向没有影响。因此,Ohanian模型的三个因素的影响会因国家或市场的不同而不同。一个品牌必须确立考虑的标准,在其社交媒体影响者营销中为目标消费者选择最相关的影响者

关键词：社会网络影响者购买意向可信度说服力来源可信度的Ohanian模型中国法国

利用互联网技术为中国中小企业传统工艺创造价值的策略研究

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利用互联网技术为中国中小企业传统工艺创造价值的策略研究

作者： Faineant pierre-Louis michel André 北京外国语大学

学位级别：硕士

本文聚焦传统工艺产业,通过定量和理论的研究方法,提出价值定位模型并将互联网技术与传统中小企业相结合,以期提升其在中国电子市场中的价值创造力。本文更多关注在价值主导的商业模型下,如何通过中国电子商务市场的种种机遇实现并增强... 详细信息

本文聚焦传统工艺产业,通过定量和理论的研究方法,提出价值定位模型并将互联网技术与传统中小企业相结合,以期提升其在中国电子市场中的价值创造力。本文更多关注在价值主导的商业模型下,如何通过中国电子商务市场的种种机遇实现并增强工匠技艺的力量。然而中国的工匠及地方小型工艺企业并没有做好迎接相应竞争的准备,因此错失了中国乃至世界电子市场的各种机遇。事实上,在“十三五计划”中“振兴传统工艺,弘扬工匠精神”的号召下即使政治、法律和社会环境都在逐渐大力支持手工艺,无论传统还是创新的地方工艺仍发展迟缓。本文指出已有文献中的两大空缺:一是缺少对工艺生产商战略性创新的的研究;二是缺少对网络市场中工艺的链接和机遇的研究,更广泛地说,即缺少传统工艺生产商大量利用网络的商业模型。因此,本文旨在促进提出一个以工艺为核心的有效且原创的工艺品价值创造策略.本文观点来自丰富的文献阅读及自上而下的分析,认为电子市场蕴含独特的机遇——社区建设、高速通行能力、有效分销渠道,如电子平台、定制开发工具和第三方繁荣市场。为利用这些机遇,工艺制造商应接纳新型互联网技术以便分享、创造和加强其在更广阔市场中的价值定位。一味追求低成本不但会折损工艺品的内在价值,更会破环其品牌形象。电子市场竞争激烈,要想保证工艺品在中国的竞争力、活力和繁荣发展,关键不能缺失价值创造策略的革新。

关键词：工艺中国电子商务价值创造互联网技术

AGRI-ENVIRONMENTAL ASSESSMENT OF CONVENTIONAL AND ALTERNATIVE BIOENERGY CROPPING SYSTEMS PROMOTING BIOMASS PRODUCTIVITY

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Frontiers of Agricultural Science and Engineering 2022年第2期9卷 284-294页

作者： Léa KERVROEDAN David HOUBEN Julien GUIDET Julia DENIER Anne-Maimiti DULAURENT Elisa MARRACCINI Amandine DELIGEY Charlotte JOURNEL Justine LAMERRE michel-pierre FAUCON UniLaSalle Polytechnic Institute AGHYLE(SFR Condorcet FR CNRS 3417)19 rue Pierre Waguet60026 BeauvaisFrance UniLaSalle Polytechnic Institute InTerACT(UP 2018.C102)19 rue Pierre Waguet60026 BeauvaisFrance Department of Agricultural FoodEnvironmental and Animal SciencesUniversity of UdineVia delle Scienze 20633100UdineItaly Agro-Transfert Ressources et Territoires 2 Chaussée de Brunehaut80200 Estrées MonsFrance

Bioenergy,currently the largest renewable energy source in the EU(64%of the total renewable energy consumption),has sparked great interest to meet the32%renewable resources for the 2030 bioeconomy *** design of innovative cropping systems informed by bioeconomy imperatives requires the evaluate of the effects of introducing crops for bioenergy into conventional crop *** study aimed to assess the impacts of changes in conventional cropping systems in mixed dairy cattle farms redesigned to introduce bioenergy crops either by increasing the biomass production through an increase of cover crops,while keeping main feed/food crops,or by substituting food crops with an increase of the crop rotation *** assessment is based on the comparison between conventional and innovative systems oriented to feed and biogas production,with and without tillage,to evaluate their agri-environmental performances(biomass production,nitrogen fertilization autonomy,greenhouse gas emissions and biogas production).The result showed higher values in the biogas cropping system than in the conventional and feed ones for all indicators,biomass productivity(27%and20%higher,respectively),nitrogen fertilization autonomy(26%and 73%higher,respectively),methanogenic potential(77%and 41%higher,respectively)and greenhouse gas emissions(15%and 3%higher,respectively).There were no negative impacts of no-till compared to the tillage practice,for all tested *** biogas cropping system showed a better potential in terms of agri-environmental performance,although its greenhouse gas emissions were ***,it would be appropriate to undertake a multicriteria assessment integrating agri-environmental,economic and social performances.

关键词： alternative cropping systems bioeconomy biogas biomass production fertilization autonomy greenhouse gas assessment

人肺泡上皮细胞株A549和脐静脉内皮细胞中的内皮素-1通路(英文)

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Acta Pharmacologica Sinica 2000年第6期21卷 21-28页

作者： Isabelle DEPREZ-ROY,Francis COGE,Lydia BERTRY,Jean-pierre GALIZZI,michel FELETOU,Paul MVANHOUTTE,Emmanuel CANET Institut de Recherches Servier 11 rue des Moulineaux 92150 Suresnes France Institut de Recherches Servier 11 rue des Moulineaux 92150 Suresnes France Institut de Recherches Servier 11 rue des Moulineaux 92150 Suresnes France Institut de Recherches Servier 11 rue des Moulineaux 92150 Suresnes France Institut de Recherches Servier 11 rue des Moulineaux 92150 Suresnes France Institut de Recherches Servier 11 rue des Moulineaux 92150 Suresnes France Institut de Recherches Servier 11 rue des Moulineaux 92150 Suresnes France Departement de Dibetologie Institut de Recherches Servier II rue des Moulineaux 92150 Suresnes France.

AIM: This study was designed to characterize the en-dothelin pathway in an immortalized human adenocarcino-ma-derived alveolar epithelial cell line (A549) and human umbilical vein endothelial cell line (HUVEC). METHODS: The release of BT-1 and big-ET-1 was measured in the incubation medium of both cell lines. The expression of mRNAs coding for the endothelin iso-forms (hppET-1, -2, -3), the endothelin converting enzymes (hECE-la, b, c, and d) and the hETA and hETB receptors was investigated using RT-PCR. The expression of ECE-1 mRNA in various human tissues and in A549 cells was investigated by Northern blot analysis and the subcellular localization of ECE-1 in A549 cells was investigated by immunoblotting using a polyclonal antibody. RESULTS: Under control conditions, HUVEC release both ET-1 and big-ET-1 (ratio 5 to 1) while in A549 cells the big-ET-1 levels were below the threshold of detection. The release of these two peptides was minimally affected by various inhibitors of peptidases. However, in b

关键词：内皮素-1 分泌内皮素受体

Predictive factors of survival in patients treated with definitive chemoradiotherapy for squamous cell esophageal carcinoma

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World Journal of Gastroenterology 2006年第26期12卷 4185-4190页

作者： Frédéric Di Fiore Stéphane Lecleire Olivier Rigal Marie-pierre Galais Emmanuel Ben Soussan Isabelle David Bernard Paillot Jacques-Henri Jacob pierre michel Digestive Oncology Unit Hepatogastroenterology Department Rouen University HospitalFrance Digestive Oncology unit Francois Baclesse Centre CaenFrance Radiotherapy Department Henri Becquerel Centre RouenFrance

AIM： The aim of the study was to evaluate the predictive factors of survival in patients with locally advanced squamous cell esophageal carcinoma （LASCOC） treated with definitive chemoradiotherapy （CRT） regimen based on the 5FU/CDDP combination. METHODS： All patients with LASCOC treated with a definitive CRT using the 5FU/CDDP combination between 1994 and 2000 were retrospectively included. Clinical complete response （CCR） to CRT was assessed by esophageal endoscopy and C-F-scan 2 mo after CRT completion. Prognostic factors of survival were assessed using univariate and multivariate analysis by the Cox regression model. RESULTS： A total of 116 patients were included in the study. A CCR to CRT was observed in 86/116 （74.1%）. The median survival was 20 mo （range 2-114） and the 5-year survival was 9.4%. Median survival of responder patients to CRT was 25 mo （range 3-114） as compared to 9 mo （range 2-81） in non-responder patients （P 〈 0.001）. In univariate analysis, survival was associated with CCR （P 〈 0.001）, WHO performance status 〈 2 （P = 0.01）, tumour length 〈 6 cm （P = 0.045） and weight loss 〈 10% was in limit of significance （P = 0.053）. In multivariate analysis, survival was dependant to CCR （P 〈 0.0001）, weight loss 〈 10% （P = 0.034） and WHO performance 〈 2 （P = 0.046）. CONCLUSION： Our results suggest that survival in patients with LASCOC b＇eated with definitive CRT was correlated to CCR, weight loss and WHO performance status.

关键词： Definitive chemoradiotherapy Esophageal squamous cell carcinoma Predictive factors

Antioxidant and Antifungal Activities of the Essential Oils of Ocimum gratissimum from Yaounde and Dschang （Cameroon）

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Journal of Pharmacy and Pharmacology 2014年第4期2卷 257-268页

作者： Jean Baptiste Hzounda Fokou pierre michel Jazet Dongmo Fabrice Fekam Boyom Elizabeth Zeuko'o Menkem Issakou Bakargna-Via Ide Flavie Kenfack Tsague Marguerite Simo Kamdem Paul Henri Amvam Zollo Chantal Menut Department of Biochemistry University of Yaounde L Yaounde Cameroon Department of Biochemistry University of Douala Douala Cameroon Department of Food Science and Nutrition National Advanced School of Agro-industrial Sciences Ngaoundere Cameroon Institute of Biomolecules Max Mousseron Faculty of Pharmacy Montpellier 999019 France

Due to the harmful effect of free radical on physiological and pathological state of our body on one hand, and the increase of the fungal infection on the other hand, drug that can reduce free radical and inhibit fungal growth is needed. This work aims to evaluate the antioxidant and antifungal activities of the Ocimum gratissimum L. essential oils from center and west region of Cameroon. Essential oil was analyzed by GC （gas chromatography） and GC coupled with MS （mass spectrometry）. The antioxidant activities of essential oils were studied by the Diphenylpicrylhydrazyl method and the β-carotene bleaching test. The antifungal activities were assessed using micro-dilution technique for yeasts and agar dilution method for Aspergillus. Thymol and γ-terpinene, eugenol and thymol were the major compounds for Yaounde and Dschang, respectively. The scavenging capacity of sample from Dschang was higher than that of Yaounde. Also, the β-carotene bleaching tests of the sample from Dschang were better than that from Yaounde. The antifungal activity of the sample from Yaounde was higher than that from Dschang on yeasts and Aspergillus isolates, respectively. This work presents and compares the chemical composition, antioxidant and antifungal activity of Ocimum gratissimum essential oil from center and west region of Cameroon.

关键词： Ocimum gratissimum L. antioxidant antifungal gas chromatography gas chromatography coupled with mass spectrometry.

左撇子的历史 “与众不同的人” “Des gens a l'envers”

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