检索结果-南通市图书馆

The importance of depression and alcohol use in coronary artery bypass graft surgery patients：risk factors for delirium and poorer quality of life

引用

Journal of Geriatric Cardiology 2016年第1期13卷 51-57页

作者： Joanne M Humphreys Linley A Denson Robert A Baker phillip J Tully School of Psychology Faculty of Health Sciences University of Adelaide Australia Cardiac Surgery Research Department of Surgery School of Medicine Flinders University of South Australia Australia University of Bordeaux Department of Neuroepidemiology Bordeaux France INSERM Department of Neuroepidemiology Bordeaux France Freemasons Foundation Centre for Men's Health Discipline of Medicine School of Medicine University of Adelaide Australia

ObjectiveToinvestigate whether depression, anxiety and stress increase the risk for delirium and poor quality of life （QOL） after co-ronary artery bypass （CABG） *** total of 180 CABG patients （mean age of 63.5 ± 10.1 years, 82.2% males） completed baseline and postoperative self-report questionnaires to assess distress and QOL. Incident delirium was diagnosed postoperatively with a structured clinical interview and patients were monitored every day post-operatively for confusion and disturbance in *** Delirium developed in 63 persons （35% of sample）. After adjustment for covariates, delirium was significantly associated with depression [odds ratio （OR）： 1.08; 95% confidence interval （CI）： 1.03-1.13,P = 0.003], anxiety （OR： 1.07; 95% CI： 1.02-1.13,P= 0.01） and stress （OR： 1.05; 95% CI： 1.00-1.09,P= 0.03）. Preoperative depression scores were associated with poorer QOL including bodily pain （β =-0.39,P = 0.013）, vitality （β=-0.32,P = 0.020）, social functioning （β=-0.51,P≤0.001）, emotional role function （β=-0.44,P = 0.003） and general health （β=-0.33,P = 0.038）. Among the covariates, harmful levels of alcohol use was consistently associated with poorer *** Depression and harmful levels of alcohol use were consistently associated with poorer QOL whereas depression, anxiety and stress were associated with delirium risk. These findings point to further research examining depression and harmful levels of alcohol use in coronary heart disease populations undergoing coronary revascularization.

关键词： Coronary artery bypass grafts Coronary heart disease Delirium Depression Quality of life

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Mouse models of colorectal cancer

引用

Chinese Journal of Cancer 2011年第7期30卷 450-462页

作者： Yunguang Tong Wancai Yang H. phillip Koeffler Department of Medicine Cedars-Sinai Medical Center Los Angeles CA 90048 USA Department of Pathology University of Illinois at Chicago Chicago IL 62269 USA National Cancer Institute and Cancer Institute of Singapore Singapore 119074 Singapore.

Colorectal cancer is one of the most common malignancies in the world. Many mouse models have been developed to evaluate features of colorectal cancer in humans. These can be grouped into genetically-engineered, chemically-induced, and inoculated models. However, none recapitulates all of the characteristics of human colorectal cancer. It is critical to use a specific mouse model to address a particular research question. Here, we review commonly used mouse models for human colorectal cancer.

关键词：小鼠模型大肠癌恶性肿瘤基因工程化学诱导人类

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Hydrophobic Effect in a Continuum Model of the Lipid Bilayer

引用

Communications in Computational Physics 2009年第8期6卷 655-672页

作者： phillip L.Wilson Huaxiong Huang Shu Takagi Department of Mathematics and Statistics University of CanterburyPrivate Bag 4800Christchurch 8140New Zealand Department of Mathematics and Statistics York UniversityTorontoM3J 1P3Canada Department of Mechanical Engineering The University of TokyoTokyoJapan

We study a continuum paradigm of the lipid bilayer based on minimizing the free energy of a mixture of water and lipid *** paper extends previous work of Blom and Peletier[European ***.,15(2004),pp.487-508]in the following ways.(a)It formulates a more general model of the hydrophobic effect to facilitate connections with microscale simulations and first-principles analysis.(b)It clarifies the meaning and role of the model parameters.(c)It outlines a method for determining parameter values so that physically-realistic bilayer density profiles can be obtained,for example for use in macroscale ***(a)-(c)suggest that the model has potential to robustly connect some micro-and macroscale levels of multiscale blood flow *** mathematical modelling in point(a)is based upon a consideration of the underlying physics of inter-molecular *** governing equations thus obtained are minimized by gradient flows via a novel numerical approach;this enables point(b).The numerical results are shown to behave physically in terms of the effect of background concentration,in contrast to the earlier model which is shown here to not display the expected behaviour.A“short-tail”approximation of the lipid molecules also gives an analytical tool which yields critical values of some parameters under certain ***(c)involves the first quantitative comparison of the numerical data with physical experimental results.

关键词： Lipid bilayer free energy continuum model numerical minimization

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Evaluation of different models to describe egg and pupal development of Xyleborus fornicatus Eichh, （Coleoptera： Scolytidae）, the shot-hole borer of tea in Sri Lanka

引用

Insect Science 2006年第2期13卷 109-118页

作者： RAVINDRA SAMPATH WALGAMA MYRON phillip ZALUCKI School of Integrative Biology University of Queensland Queensland Australia Division of Entomology Tea Research Institute Talawakelle Sri Lanka

Development data of eggs and pupae ofXyleborusfornicatus Eichh. （Coleoptera： Scolytidae）, the shot-hole borer of tea in Sri Lanka, at constant temperatures were used to evaluate a linear and seven nonlinear models for insect development. Model evaluation was based on fit to data （residual sum of squares and coefficient of determination or coefficient of nonlinear regression）, number of measurable parameters, the biological value of the fitted coefficients and accuracy in the estimation of thresholds. Of the nonlinear models, the Lactin model fitted experimental data well and along with the linear model, can be used to describe the temperature-dependent development of this species.

关键词： linear model nonlinear model insect development evaluation Xyleborus

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Deep learning for visualization and novelty detection in large X-ray diffraction datasets

引用

npj Computational Materials 2021年第1期7卷 942-947页

作者： Lars Banko phillip M.Maffettone Dennis Naujoks Daniel Olds Alfred Ludwig Materials Discovery and Interfaces Institute for MaterialsRuhr University BochumBochumGermany National Synchrotron Light Source II Brookhaven National LaboratoryUptonNYUSA ZGH Center for Interface-Dominated High Performance MaterialsRuhr University BochumBochumGermany

We apply variational autoencoders(VAE)to X-ray diffraction(XRD)data analysis on both simulated and experimental thin-film *** show that crystal structure representations learned by a VAE reveal latent information,such as the structural similarity of textured diffraction *** other artificial intelligence(AI)agents are effective at classifying XRD data into known phases,a similarly conditioned VAE is uniquely effective at knowing what it doesn’t know:it can rapidly identify data outside the distribution it was trained on,such as novel phases and *** capabilities demonstrate that a VAE is a valuable AI agent for aiding materials discovery and understanding XRD measurements both‘on-the-fly’and during post hoc analysis.

关键词： VAE uniquely latent

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Congenital coronary artery anomalies:what about the young?

引用

Journal of Geriatric Cardiology 2004年第1期1卷 15-16页

作者： phillip Moore Division of Pediatric Cardiology University of California San FranciscoUSA

Drs. Rigatem, Rigatelli, and Trivellato present a complete retrospective review of the prevalence of congenital coronary abnormalities in a cohort of consecutive adult patients catheterized at their institution and compare them to younger patients ＜ 65 years of *** review in detail the clinical implications of these findings and then offer an algorithm for management. This article is particularly timely and significant as we move into an era of non-invasive coronary imaging with CT,MRI, and improved echo that will allow ns to make these diagnoses more often and with greater accuracy in younger patients. This will have a significant impact on the nanagement of symptomatic patients diagnosed at catheterization but also on asymptomatic patients diagnosed on screening evaluations.

关键词： retrospective young prevalence cohort fistula 曲加 abnormal tonic 玄石 sinus

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Towards Transgenic Primates:What can we learn from mouse genetics?

引用

Science China(Life Sciences) 2009年第6期52卷 506-514页

作者： WANG phillip L. TSIEN Joe Z. Brain and Behavior Discovery Institute School of MedicineMedical College of Georgia Yunnan Banna Primate Disease Model Research Center and Shanghai Institute of Brain Functional GenomicsKey Laboratory of Brain Functional GenomicsMOE & STCSMEast China Normal University

Considering the great physiological and behavioral similarities with humans,monkeys represent the ideal models not only for the study of complex cognitive behavior but also for the preclinical research and development of novel therapeutics for treating human *** powerful genetic tech-nologies initially developed for making mouse models are being explored for generating transgenic primate *** review the latest genetic engineering technologies and discuss the potentials and limitations for systematic production of transgenic primates.

关键词： Non-human primate Mouse Transgene Genetics Learning Memory disease model

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Bile acids and sphingosine-1-phosphate receptor 2 in hepatic lipid metabolism

引用

Acta Pharmaceutica Sinica B 2015年第2期5卷 151-157页

作者： Eric Kwong Yunzhou Li phillip B.Hylemon Huiping Zhou Department of Microbiology and Immunology Virginia Commonwealth University Medical College of Virginia Campus McGuire VA Medical Center

The liver is the central organ involved in lipid metabolism. Dyslipidemia and its related disorders, including non-alcoholic fatty liver disease(NAFLD), obesity and other metabolic diseases, are of increasing public health concern due to their increasing prevalence in the population. Besides their well-characterized functions in cholesterol homoeostasis and nutrient absorption, bile acids are also important metabolic regulators and function as signaling hormones by activating specific nuclear receptors, G-protein coupled receptors, and multiple signaling pathways. Recent studies identified a new signaling pathway by which conjugated bile acids(CBA) activate the extracellular regulated protein kinases(ERK1/2) and protein kinase B(AKT) signaling pathway via sphingosine-1-phosphate receptor 2(S1PR2). CBA-induced activation of S1PR2 is a key regulator of sphingosine kinase 2(Sph K2) andhepatic gene expression. This review focuses on recent findings related to the role of bile acids/S1PR2-mediated signaling pathways in regulating hepatic lipid metabolism.

关键词： Bile acid Sphingosine-1 phosphate receptor Heptic lipid metabolism

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

The opportunity cost of androgen suppression in locally advanced prostate cancer

引用

Asian Journal of Andrology 2013年第3期15卷 356-357页

作者： phillip J Gray Jason A Efstathiou William U Shipley Harvard Radiation Oncology Program Boston MA 02114 USA Department of Radiation Oncology Massachusetts General Hospital Boston MA 02114 USA

The use of androgen suppression ther- apy （AST） and radiotherapy for locallyadvanced prostate cancer has become the standard of care worldwide. At the same time, it has become clear that AST carries significant risk for side effects. Recently, Denham and colleagues have reported ini- tial quality of life （QoL） results from the TROG 03.04 RADAR trial. The authors identify clinically meaningful decrements in patient-reported QoL for those treated with 18 months of AST vs. 6 months but only marginal differences at 36 months. Once survival data becomes available, these data will help to frame any benefits seen for longer courses of AST.

关键词： PHASE-III TRIAL QUALITY-OF-LIFE DEPRIVATION THERAPY CARDIOVASCULAR MORTALITY RADIATION-THERAPY RANDOMIZED-TRIAL RADIOTHERAPY DURATION

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Thymic carcinoma:review and update

引用

Journal of Cancer Metastasis and Treatment 2022年第1期8卷 476-487页

作者： Kirill Karlin phillip D.Michaels Department of Pathology Beth Israel Deaconess Medical CenterBostonMA 02115USA

Thymic carcinoma(TC)is a rare thymic epithelial neoplasm with an aggressive clinical *** are many recognized histologic subtypes as described by the fifth edition of the World Health Organization(WHO)Classification of Thoracic Tumors;however,given the rarity of this tumor group,diagnosis remains a challenge,especially on limited tissue ***,rare variants of TC are continuing to be established,particularly in the era of molecular ***,histologic subtypes are described as the rare subtypes of TC in the context of their immunoprofile,cytogenetic or molecular features,clinical presentation,and ensuing challenges.

关键词： Thymic carcinoma NUT carcinoma thymus KIT thymoma

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：