检索结果-南通市图书馆

Lenvatinib applicability in the therapeutic strategy of patients with hepatocellular carcinoma

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Hepatobiliary Surgery and Nutrition 2023年第2期12卷 248-251页

作者： philippe Merle Hepatology Unit University Croix-Rousse HospitalHospices Civils de LyonLyonFrance

The Expert Consensus on the management of lenvatinib tolerance in patients with hepatocellular carcinoma(HCC)was published(1).There,the authors discussed how possibly lenvatinib-related adverse events could be managed in aim to ensure continued lenvatinib therapy at the highest possible dose,and as a result to gain optimal benefit on survival of *** this editorial,the place of lenvatinib in HCC therapeutic strategies as well as its tolerance are reviewed and discussed.

关键词： Hepatocellular carcinoma(HCC) treatment lenvatinib

KINETIC FUNCTIONS IN MAGNETOHYDRODYNAMICS WITH RESISTIVITY AND HALL EFFECT

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Acta Mathematica Scientia 2009年第6期29卷 1684-1702页

作者： philippe G. Le Siddhartha Mishra FlochLaboratoire Jacques-Louis Lions Centre National de la Recherche ScientifiqueUniversit Pierre et Marie Curie (Paris 6) 4 Place Jussieu 75258 Paris France Seminar for Applied Mathematics D-Math ETH HG Raemistrasse Zürich-8092 Switzerland

We consider a nonlinear hyperbolic system of two conservation laws which arises in ideal magnetohydrodynamics and includes second-order terms accounting for magnetic resistivity and Hall effect. We show that the initial value problem for this model may lead to solutions exhibiting complex wave structures, including undercompressive nonclassical shock waves. We investigate numerically the subtle competition that takes place between the hyperbolic, diffusive, and dispersive parts of the system. Following Abeyratne, Knowles, LeFloch, and Truskinovsky, who studied similar questions arising in fluid and solid flows, we determine the associated kinetic function which characterizes the dynamics of undereompressive shocks driven by resistivity and Hall effect. To this end, we design a new class of ＂schemes with eontroled dissipation＂, following recent work by LeFloch and Mohammadian. It is now recognized that the equivalent equation associated with a scheme provides a guideline to design schemes that capture physically relevant, nonclassical shocks. We propose a new class of schemes based on high-order entropy conservative, finite differences for the hyperbolic flux, and high-order central differences for the resistivity and Hall terms. These schemes are tested for several regimes of （co-planar or not） initial data and parameter values, and allow us to analyze the properties of nonclassical shocks and establish the existence of monotone kinetic functions in magnetohydrodynamics.

关键词： hyperbolic conservation law magnetohydrodynamics magnetic resistivity Hall effect undercompressive shock kinetic function

在线全文

学校读者我要写书评

暂无评论

另一个

北京文学（中篇小说月报） 2024年第9期 191-201页

作者： [法国]菲利普·克洛代尔陈贝(译) 不详

欧仁·弗罗隆把妻子和三个女儿托付给圣母玛利亚后,踏上了通往南方的旅程。他留下的,不仅是安宁的生活和兴旺的绳索批发生意,还有那清白无瑕的名声。他能成为C专区最受尊崇的公民之一,靠的就是这份好声名。然而,几首题目怪异的诗歌,终... 详细信息

欧仁·弗罗隆把妻子和三个女儿托付给圣母玛利亚后,踏上了通往南方的旅程。他留下的,不仅是安宁的生活和兴旺的绳索批发生意,还有那清白无瑕的名声。他能成为C专区最受尊崇的公民之一,靠的就是这份好声名。然而,几首题目怪异的诗歌,终结了他平和安适的生活,引发了他的癫狂——大家事后都是这么说的——加速了他的巨变。

关键词：圣母玛利亚批发生意绳索

Conceptual design and implementation of spatial data warehouses integrating regular grids of points

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

International Journal of Digital Earth 2017年第9期10卷 901-922页

作者： Sandro Bimonte Mehdi Zaamoune philippe Beaune Technologies and information systems for agricultural systems Departement Institut national de recherche en sciences et technologies pour l’environnement et l’agricultureAubiereFrance Agaetis Clermont-FerrandFrance

Spatial online analytical processing(OLAP)and spatial data warehouse(SDW)systems are geo-business intelligence technologies that enable the analysis of huge volumes of geographic *** the last decade,the conceptual design and implementation of SDWs that integrate spatial data,which are represented using the vector model,have been extensively ***,the integration of field data(a continuous representation of spatial data)in SDWs is a recent unresolved research *** SDWs with field data improves the spatio-multidimensional analysis capabilities with continuity and *** by the need for a conceptual design tool and relational online analytical processing(ROLAP)implementation,we propose a UML profile for SDWs that integrates a regular grid of points and supports continuity and *** also propose an efficient implementation of a ROLAP architecture.

关键词： Geoinformatics spatial OLAP geospatial data integration spatial data infrastructure

Machine learning applied to road safety modeling:A systematic literature review

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Traffic and Transportation Engineering(English Edition) 2020年第6期7卷 775-790页

作者： philippe Barbosa Silva Michelle Andrade Sara Ferreira Department of Civil Engineering Goiano Federal Institute-Rio Verde CampusRio Verde 75901-970Brazil Department of Civil and Environmental Engineering University of BrasiliaBrasilia 70910-900Brazil Research Centre for Territory Transports and EnvironmentUniversity of PortoPorto 4200-465Portugal

Road safety modeling is a valuable strategy for promoting safe mobility,enabling the development of crash prediction models(CPM)and the investigation of factors contributing to crash *** modeling has traditionally used statistical techniques despite acknowledging the limitations of this kind of approach(specific assumptions and prior definition of the link functions),which provides an opportunity to explore alternatives such as the use of machine learning(ML)*** study reviews papers that used ML techniques for the development of CPM.A systematic literature review protocol was conducted,that resulted in the analysis of papers and their *** types of models were identified:crash frequency,crash classification by severity,and crash frequency and *** first is a regression problem,the second,a classificatory one and the third can be approached either as a combination of the preceding two or as a regression model for the expected number of crashes by severity *** main groups of techniques used for these purposes are nearest neighbor classification,decision trees,evolutionary algorithms,support-vector machine,and artificial neural *** last one is used in many kinds of approaches given the ability to deal with both regression and classification problems,and also multivariate response *** paper also presents the main performance metrics used to evaluate the models and compares the results,showing the clear superiority of the ML-based models over the statistical *** addition,it identifies the main explanatory variables used in the models,which shows the predominance of road-environmental aspects as the most important factors contributing to crash *** review fulfilled its objective,identifying the various approaches and the main research characteristics,limitations,and opportunities,and also highlighting the potential of the usage of ML in crash analyses.

关键词： Transportation engineering Road safety modeling Crash prediction Crash injury severity Machine learning Systematic literature review

Radical-mediated hydroalkylation of 2-vinylpyrrolidine derivatives: a versatile entry into indolizidine alkaloids

在线全文

学校读者我要写书评

暂无评论

Science China Chemistry 2019年第11期62卷 1504-1506页

作者： Sankar Rao Suravarapu Bettina Peter philippe Renaud Department of Chemistry and Biochemistry University of Bern

A concise route for the preparation of two simple optically pure indolizidin-5-ones has been *** key chain elongation process was achieved using a triethylborane/catechol mediated hydroalkylation of Boc-protected *** using complementary strategies,these two bicyclic lactams can be alkylated with complete control of the stereochemistry at C(5)and their conversion to a variety of indolizidine alkaloids such as coniceine,indolizidine 209D and 167B,5-epi-indolizidine 249A and monomorine has been reported in the literature.

关键词： alkenes carbohydrogenation radical reaction catechol triethylborane α-iodoesters allylamine

Genetic Enhancement of Indigenous Cowpea with Gamma-Ray Induced Trait Variation

在线全文

学校读者我要写书评

暂无评论

American Journal of Plant Sciences 2024年第8期15卷 651-676页

作者： Mathurin Tiergnin Dabiré Minimassom philippe Nikiéma Djibril Yonli Safiatou Sanna Wossoguim Josué Gouba Siébou Palé Hamidou Traoré Joseph T. B. Batieno Varra Prasad Zacharia Stewart Jan B. Middendorf Abhishek Rathore Anupama J. Hingane Unit de Formation et de Recherches en Sciences et Technologies Dpartement des Sciences de la Vie et de la Terre Universit Norbert ZONGO Koudougou Burkina Faso Institut de lEnvironnement et de Recherches Agricoles (INERA) Ouagadougou Burkina Faso Department of Agronomy Kansas State University Manhattan USA Center for Agriculture-Led Growth Bureau for Resilience and Food Security United States Agency for International Development United States Agency for International Development Washington DC USA International Maize and Wheat Improvement Center (CIMMYT) ICRISAT Campus Patancheru India Joint FAO/IAEA Division of Nuclear Techniques in Food and Agriculture Department of Nuclear Sciences and Applications Plant Breeding and Genetics Laboratory International Atomic Energy Agency (IAEA) Seibersdorf Vienna Austria

Production of cowpea (Vigna unguiculata (L.) Walp.), a staple legume crop in Sub-Saharan Africa, faces challenges due to biotic and abiotic constraints. Induced mutagenesis was deployed to create genetic variation in two cowpea varieties (KVX396-4-5-2D and Moussa local). The radio-sensitivity tests led to determe the lethal dose 50 (LD50) corresponding to 230 Gy and 220 Gy for KVX396-4-5-2D and Moussa local varieties, respectively. Dried seeds (M0) of each variety were gamma-ray irradiated with LD50 − 50, LD50 and LD50 + 50. M1 seeds were advanced to generate M2, M3 and M4 mutants using the single-seed-descent method. M4 mutant lines were evaluated in rain-fed conditions using a randomized complete block design to assess phenotypic differences. Data on seven qualitative and eleven quantitative traits were collected. The results indicated that the mutation induced variability in three qualitative traits: in KVX 396-4-5-2D mutant lines, with flower and seed color frequencies at 2.61% and 0.56% respectively, and pod dehiscence at a frequency of 0.24%. While in Moussa local mutants, a pod color changed at a frequency of 17%. ANOVA results revealed significant differences between mutants of both varieties for all quantitative traits, including photosynthetic parameters. Positive correlations were observed between leaf diameter and 100-seed weight, and between branch number and 100-seed weight. Hierarchical clustering revealed three clusters among KVX 396-4-5-2D mutants and six clusters among Moussa local mutants. Early maturity and high foliage were induced traits in Cluster 3 of KVX 396-4-5-2D mutants while high hundred-seed weight was induced in Cluster 6 of Moussa local mutants.

关键词： Cowpea Mutagenesis Gamma Rays Radio-Sensitivity Phenotyping

SECOND-ORDER CONVERGENCE PROPERTIES OF TRUST-REGION METHODS USING INCOMPLETE CURVATURE INFORMATION, WITH AN APPLICATION TO MULTIGRID OPTIMIZATION

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Computational Mathematics 2006年第6期24卷 676-692页

作者： Serge Gratton Annick Sartenaer philippe L. Toint CERFACS av. G. Coriolis Toulouse France Department of Mathematics University of Namur 61 rue de Bruxelles B-5000 Namur Belgium

Convergence properties of trust-region methods for unconstrained nonconvex optimization is considered in the case where information on the objective function＇s local curvature is incomplete, in the sense that it may be restricted to a fixed set of ＂test directions＂ and may not be available at every iteration. It is shown that convergence to local ＂weak＂ minimizers can still be obtained under some additional but algorithmically realistic conditions. These theoretical results are then applied to recursive multigrid trust-region methods, which suggests a new class of algorithms with guaranteed second-order convergence properties.

关键词： Nonlinear optimization Convergence to local minimizers Multilevel problems.

Using experimental data to reduce the single-building sigma of fragility curves:case study of the BRD tower in Bucharest,Romania

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Earthquake Engineering and Engineering Vibration 2013年第4期12卷 643-658页

作者： Matthieu Perrault philippe Gueguen Alexandru Aldea Sorin Demetriu Institut des Sciences de la Terre Université Joseph Fourier Grenoble ICNRS/IFSTTAR Technical University of Civil Engineering

The lack of knowledge concerning modelling existing buildings leads to significant variability in fragility curves for single or grouped existing buildings. This study aims to investigate the uncertainties of fragility curves, with special consideration of the single-building sigma. Experimental data and simplified models are applied to the BRD tower in Bucharest, Romania, a RC building with permanent instrumentation. A three-step methodology is applied：（1） adjustment of a linear MDOF model for experimental modal analysis using a Timoshenko beam model and based on Anderson＇s criteria, （2） computation of the structure＇s response to a large set of accelerograms simulated by SIMQKE software, considering twelve ground motion parameters as intensity measurements （IM）, and （3） construction of the fragility curves by comparing numerical interstory drift with the threshold criteria provided by the Hazus methodology for the slight damage state. By introducing experimental data into the model, uncertainty is reduced to 0.02 considering Sd ） as seismic intensity IM and uncertainty related to the model is assessed at 0.03. These values must be compared with the total uncertainty value of around 0.7 provided by the Hazus methodology.

关键词： vulnerability fragility curves uncertainty slight damage Timoshenko model Bucharest