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Evolutionary ecology of chemosensation and its role in sensory drive

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Current Zoology 2018年第4期64卷 525-533页

作者： Laurel r. YOHE philipp BrAND Department of Ecology and Evolution Stony Brook University Stony Brook NY 11790 USA Department of Geology & Geophysics Yale University New Haven CT 06511 USA Department of Evolution and Ecology Center for Population Biology University of California Davis CA 95616 USA

All behaviors of an organism are rooted in sensory processing of signals from its environment, and nat ural selection shapes sensory adaptations to ensure successful detection of cues that maximize fitness. Sensory drive, or divergent selection for efficient signal transmission among heterogeneous environ ments, has been a useful hypothesis for describing sensory adaptations, but its current scope has pri marily focused on visual and acoustic sensory modalities. Chemosensation, the most widespread sensory modality in animals that includes the senses of smell and taste, is characterized by rapid evolu tion and has been linked to sensory adaptations to new environments in numerous lineages. Yet, olfac tion and gustation have been largely underappreciated in light of the sensory drive hypothesis. Here, we examine why chemosensory systems have been overlooked and discuss the potential of chemo sensation to shed new insight on the sensory drive hypothesis and vice versa. We provide suggestions for developing a framework to better incorporate studies of chemosensory adaptation that have the po tential to shape a more complete, coherent, and holistic interpretation of the sensory drive.

关键词： chemical signaling chemoreceptor chemosensation sensory drive olfaction

News on the physics potential of the reaction e^+e^-→ Zγ

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Science China(Physics,Mechanics & Astronomy) 2021年第2期64卷 27-28页

作者： philipp roloff CErN CH-1211Geneva 23Switzerland

The next large project in particle physics is widely expected to be a high-energy electron-positron *** a facility could be realised as a circular collider,like the Circular Electron Positron Collider(CEPC)and the Future e^+e^-Circular Collider(FCC-ee)[1],or as a linear collider,like the International Linear Collider(ILC)and the Compact Linear Collider(CLIC)[2].

关键词： circular positron potential

Plants against cancer:towards green Taxol production through pathway discovery and metabolic engineering

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aBIOTECH 2024年第3期5卷 394-402页

作者： philipp Zerbe Department of Plant Biology University of California DavisDavisCA 95616USA

The diversity of plant natural products presents a rich resource for accelerating drug discovery and addressing pressing human health ***,the challenges in accessing and cultivating source species,as well as metabolite structural complexity,and general low abundance present considerable hurdles in developing plant-derived *** in high-throughput sequencing,genome assembly,gene synthesis,analytical technologies,and synthetic biology approaches,now enable us to efficiently identify and engineer enzymes and metabolic pathways for producing natural and new-to-nature therapeutics and drug *** review highlights challenges and progress in plant natural product discovery and engineering by example of recent breakthroughs in identifying the missing enzymes involved in the biosynthesis of the anti-cancer agent Taxol^(®).These enzyme resources offer new avenues for the bio-manufacture and semi-synthesis of an old blockbuster drug.

关键词： Taxol Plant natural products Synthetic biology Pathway discovery Metabolic engineering

Calibration-free speckle matrix imaging

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Light(Science & Applications) 2022年第3期11卷 1-3页

作者： philipp del Hougne Univ rennes CNRSIETR-UMR 616435000RennesFrance

Unknown speckle patterns can be used to image targets embedded in complex scattering media 100 times faster than previous techniques based on carefully calibrated illuminations.

关键词： speckle illumination faster

Effect of nanoparticle concentration on zeta-potential measurement results and reproducibility

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Particuology 2010年第3期8卷 279-285页

作者： ratna Tantra philipp Schulze Paul Quincey National Physical Laboratory Hampton Road Teddington Middlesex TW11 0LW UK Department of Physics University of Bath Bath BA2 7AY UK. National Physical Laboratory Hampton Road Teddington Middlesex TW11 0LW

The effect of nanoparticle concentration on zeta-potential measurement results at dilute concentrations was evaluated. The values of the zeta-potential for four different types of nanoparticles, Ludox （silica）, multi-walled carbon nanotubes （bamboo-shaped and hollow nanotubes） and gold, at various concentrations, were obtained using a laser Doppler electrophoresis instrument. The size of the nanoparticles on dilution was measured using dynamic light scattering （DLS）. The results show that there is a concentration range within which the zeta-potential, and particle size, are not affected by nanoparticle concentration. The lower concentration limit for the system to produce consistent results was dependent on the nature of the sample under study and ranged between 10-2 and 10-4 wt%. Below this concentration, there was an apparent shift in zeta-potential values to less negative values, which was accompanied by an increase in the particle size. The shift in zeta-potential was attributed to an increase in contribution of the signal from extraneous particulate matter. The increase in particle size was attributed to the nature of the homodyne optical configuration of the instrument. The aim of this study was to elucidate the range in nanoparticle concentration that allows for accurate and reliable measurement of the zeta-potential and DLS data.

关键词： Nanoparticles Zeta-potential Dynamic light scattering reproducibility

Entropy‑Conservative Discontinuous Galerkin Methods for the Shallow Water Equations with Uncertainty

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Communications on Applied Mathematics and Computation 2024年第3期6卷 1978-2010页

作者： Janina Bender philipp Öffner Institute of Mathematics University KasselMonchebergstraße 1934127 KasselGermany Institute of Mathematics Johannes Gutenberg UniversityStaudingerweg 955099 MainzGermany Mathematical Institute Technical University ClausthalErzstraße 138678 Clausthal ZellerfeldGermany

In this paper,we develop an entropy-conservative discontinuous Galerkin(DG)method for the shallow water(SW)equation with random *** of the most popular methods for uncertainty quantifcation is the generalized Polynomial Chaos(gPC)approach which we consider in the following *** apply the stochastic Galerkin(SG)method to the stochastic SW *** the SG approach in the stochastic hyperbolic SW system yields a purely deterministic system that is not necessarily hyperbolic *** lack of the hyperbolicity leads to ill-posedness and stability issues in numerical *** transforming the system using roe variables,the hyperbolicity can be ensured and an entropy-entropy fux pair is known from a recent investigation by Gerster and Herty(***.27(3):639–671,2020).We use this pair and determine a corresponding entropy fux ***,we construct entropy conservative numerical twopoint fuxes for this augmented *** applying these new numerical fuxes in a nodal DG spectral element method(DGSEM)with fux diferencing ansatz,we obtain a provable entropy conservative(dissipative)*** numerical experiments,we validate our theoretical fndings.

关键词： Shallow water(SW)equations Entropy conservation/dissipation Uncertainty quantification Discontinuous Galerkin(DG) Generalized Polynomial Chaos(gPC)

Mode structure symmetry breaking of reversed shear Alfvén eigenmodes and its impact on the generation of parallel velocity asymmetries in energetic particle distribution

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Plasma Science and Technology 2022年第2期24卷 17-27页

作者： Guo MENG philipp LAUBEr Xin WANG Zhixin LU Max-Planck-Institut fiir Plasmaphysik D-85748 GarchingGermany

In this work,the gyrokinetic eigenvalue code LIGKA,the drift-kinetic/MHD hybrid code HMGC and the gyrokinetic full-f code TrIMEG-GKX are employed to study the mode structure details of reversed shear Alfvén eigenmodes(rSAEs).Using the parameters from an ASDEXUpgrade plasma,a benchmark with the three different physical models for rSAE without and with energetic particles(EPs)is carried *** agreement has been found for the mode frequency and the growth *** structure symmetry breaking(MSSB)is observed when EPs are included,due to the EPs’non-perturbative *** is found that the MSSB properties are featured by a finite radial wave phase velocity,and the linear mode structure can be well described by an analytical complex Gaussian expressionФ(s)=e^(-σ(s-s_(0))^(2))with complex parametersσand s_(0),where s is the normalized radial *** mode structure is distorted in opposite manners when the EP drive shifted from one side of qminto the other side,and specifically,a non-zero average radial wave number with opposite signs is *** initial EP density profiles and the corresponding mode structures have been used as the input of HAGIS code to study the EP *** parallel velocity of EPs is generated in opposite directions,due to different values of the average radial wave number,corresponding to different initial EP density profiles with EP drive shifted away from the qmin.

关键词： reversed shear Alfvén eigenmode symmetry breaking energetic particles non-perturbative effects

realising Data-Centric Scientific Workflows with Provenance-Capturing on Data Lakes

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Data Intelligence 2022年第2期4卷 426-438页

作者： Hendrik Noltet philipp Wieder Gesellschaft fur wissenschaftliche Datenverarbeitung mbH Gottingen Gottingen Gottingen 37077Germany

Since their introduction by James Dixon in 2010,data lakes get more and more attention,driven by the promise of high reusability of the stored data due to the schema-on-read *** on this idea,several additional requirements were discussed in literature to improve the general usability of the concept,like a central metadata catalog including all provenance information,an overarching data governance,or the integration with(high-performance)processing *** the necessity for a logical and a physical organisation of data lakes in order to meet those requirements is widely recognized,no concrete guidelines are yet *** most common architecture implementing this conceptual organisation is the zone architecture,where data is assigned to a certain zone depending on the degree of *** paper discusses how FAIr Digital Objects can be used in a novel approach to organize a data lake based on data types instead of zones,how they can be used to abstract the physical implementation,and how they empower generic and portable processing capabilities based on a provenance-based approach.

关键词： Data lake Provenance Workflows FAIrDigital Objects CWFr

Novel treatment options for portal hypertension

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Gastroenterology report 2017年第2期5卷 90-103,I0001页

作者： philipp Schwabl Wim Laleman Division of Gastroenterology and Hepatology Department of Internal Medicine IIIMedical University of ViennaViennaAustria Department of Gastroenterology and Hepatology University Hospitals LeuvenKU LeuvenLeuvenBelgium

Portal hypertension is most frequently associated with cirrhosis and is a major driver for associated complications,such as variceal bleeding,ascites or hepatic *** such,clinically significant portal hypertension forms the prelude to decompensation and impacts significantly on the prognosis of patients with liver *** present,non-selective bblockers,vasopressin analogues and somatostatin analogues are the mainstay of treatment but these strategies are far from satisfactory and only target splanchnic *** contrast,safe and reliable strategies to reduce the increased intrahepatic resistance in cirrhotic patients still represent a pending *** recent years,several preclinical and clinical trials have focused on this latter component and other therapeutic *** this review,we highlight novel data in this context and address potentially interesting therapeutic options for the future.

关键词： portal hypertension hepatic venous pressure gradient non-selective b-blockers nitric oxide angiogenesis statins farnesoid X receptor renin-angiotensin-aldosterone