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FtsH4 protease controls biogenesis of the PSII complex by dual regulation of high light-inducible proteins

Plant Communications 2023年第1期4卷 272-286页

作者： Vendula Krynická Petra Skotnicová philip j.j.ckson Samuel Barnett j.anfeng Yu Anna Wysocka Radek Kaña Mark j.Dickman Peter j.Nixon C.Neil Hunter j.sef Komenda The Czech Academy of Sciences Institute of MicrobiologyCentre AlgatechNovohradská 23737901 TreboñCzech Republic Plants Photosynthesis and SoilSchool of BiosciencesUniversity of SheffieldSheffield S102TNUK Department of Chemical and Biological Engineering University of SheffieldSheffield S13JDUK Sir Ernst Chain Building-Wolfson Laboratories Department of Life SciencesSouth Kensington CampusImperial College LondonLondon SW72AZUK Faculty of Science University of South Bohemia37005 Ceské BudějoviceCzech Republic

FtsH proteases are membrane-embedded proteolytic complexes important for protein quality control and regulation of various physiological processes in bacteria,mitochondria,and *** most cyanobacteria,the model species Synechocystis *** 6803 contains four FtsH homologs,FtsH1–***1–FtsH3 form two hetero-oligomeric complexes,FtsH1/3 and FtsH2/3,which play a pivotal role in acclimation to nutrient deficiency and photosystem Ⅱ quality control,***4 differs from the other three homologs by the formation of a homo-oligomeric complex,and together with Arabidopsis thaliana AtFtsH7/9 orthologs,it has been assigned to another phylogenetic group of unknown *** results exclude the possibility that Synechocystis FtsH4 structurally or functionally substitutes for the missing or non-functional FtsH2 subunit in the FtsH2/3 ***,we demonstrate that FtsH4 is involved in the biogenesis of photosystem Ⅱ by dual regulation of high light-inducible proteins(Hlips).FtsH4 positively regulates expression of Hlips shortly after high light exposure but is also responsible for Hlip removal under conditions when their elevated levels are no longer *** provide experimental support for Hlips as proteolytic substrates of *** labeling of FtsH4 enabled us to assess its localization using advanced microscopic *** show that FtsH4 complexes are concentrated in well-defined membrane regions at the inner and outer periphery of the thylakoid *** on the identification of proteins that co-purified with the tagged FtsH4,we speculate that FtsH4 concentrates in special compartments in which the biogenesis of photosynthetic complexes takes place.

关键词： thylakoid photosystemⅡbiogenesis FtsH4 high light-inducible protein proteolysis

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Cystathionine-γ-lyase ameliorates the histone demethylase j.j.3-mediated autoimmune response in rheumatoid arthritis

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Cellular & Molecular Immunology 2019年第8期16卷 694-705页

作者： Weij.n Wu Ming Qin Wanwan j.a Zheng Huang Zhongzheng Li Di Yang Mengwei Huang Chenxi Xiao Fen Long j.anchun Mao philip K.Moore Xinhua Liu Yi Zhun Zhu Department of Pharmacology Shanghai Key Laboratory of Bioactive Small MoleculesSchool of PharmacyFudan UniversityShanghai 201203China State Key Laboratory of Quality Research in Chinese Medicine and School of Pharmacy Macao University of Science and TechnologyMacaoChina Institute of Arthritis Research Shanghai Academy of Chinese Medical SciencesGuanghua Integrative Medicine Hospital/Shanghai University of T.C.MShanghaiChina Ningbo The 9th Hospital Ningbo 315000China Department of Rheumatology Shanghai Longhua HospitalShanghaiChina Department of Pharmacology National University of SingaporeSingaporeSingapore

Cystathionine-γ-lyase(CSE),an enzyme associated with hydrogen sulfide(H2S)production,is an important endogenous regulator of *** domain-containing protein 3(j.j.3)is implicated in the immune response and ***,we investigated the potential contribution of j.j.3 to endogenous CSE-mediated inflammation in rheumatoid arthritis(RA).Upregulated CSE and j.j.3 were identified in synovial fibroblasts(SFs)from RA patients as well as in the j.ints of arthritic *** down CSE augmented inflammation in IL-1β-induced SFs by increasing j.j.3 *** addition,CSE−/−mice with collagen-induced arthritis(CIA)developed severe j.int inflammation and bone ***,overexpressing CSE inhibited j.j.3 expression by the transcription factor Sp-1 and was accompanied by reduced inflammation in IL-1β-treated ***,j.j.3 silencing or the administration of the j.j.3 inhibitor GSK-j. significantly decreased the inflammatory response in IL-1β-treated SFs,mainly by controlling the methylation status of H3K27me3 at the promoter of its target ***-j. markedly attenuated the severity of arthritis in CIA *** conclusion,suppressing j.j.3 expression by the transcription factor Sp-1 is likely responsible for the ability of CSE to negatively modulate the inflammatory response and reduce the progression of RA.

关键词： cystathionine-γ-lyase rheumatoid arthritis j.monj. domain-containing protein 3 Sp-1 Toll like receptor 2

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采用GC/MSD DRS对残留农药进行全面筛查

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现代科学仪器 2006年第1期23卷 13-17页

作者： philip L. Wylie Michael j. Szelewski Chin-Kai Meng Christopher P. Sandy Agilent Technologies Inc.2850Centerville Road WilmingtonDE 19808-1610 USA Agilent

1引言根据农药手册,目前世界上正在使用的农药有700多种[1].大约600种农药是过去使用的,但现在已经禁用或不再销售.有一些农药早已不再使用,但它们仍然存在于环境中,还可能在植物和动物体内生物富集.在食品和饮料、在土壤、水和大气、... 详细信息

1引言根据农药手册,目前世界上正在使用的农药有700多种[1].大约600种农药是过去使用的,但现在已经禁用或不再销售.有一些农药早已不再使用,但它们仍然存在于环境中,还可能在植物和动物体内生物富集.在食品和饮料、在土壤、水和大气、在水生和陆生的动植物、在人类血液、脂肪组织和乳汁中,都能检测到痕量的农药或它们的代谢物.

关键词：残留农药世界卫生组织筛查 GC 急性毒性生物富集动物体内脂肪组织正常使用动植物

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用GC/MSD DRS对残留农药进行全面筛查的应用

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农业质量标准 2006年第1期 19-23页

作者： philip L. Wylie Michael j. Szelewski Chin-Kai Meng Christopher P. Sandy Agilent Technologies Inc.WilmingtonDE 19808-1610 USA 不详

世界卫生组织根据农药对人的急性毒性将农药分成5类[1],其类别从'有急性毒性'到'正常使用时没有急性毒性',一些农药被归之为持久性有机污染物(POP),致癌、致畸或内分泌干扰物.分析食品和环境样品中的农药,跟踪它们在环境中的分布以保证... 详细信息

世界卫生组织根据农药对人的急性毒性将农药分成5类[1],其类别从'有急性毒性'到'正常使用时没有急性毒性',一些农药被归之为持久性有机污染物(POP),致癌、致畸或内分泌干扰物.分析食品和环境样品中的农药,跟踪它们在环境中的分布以保证食品安全,是一项经常工作.目前,很多分析方法仅针对一部分可能存在的化合物,然而无论是食品还是环境样品,由于其中一些天然产物能够被一起提取出来,致使分析工作变得复杂起来.因此,在分析之前需要进行若干样品净化步骤[2],但即便如此,在残余基质存在的情况下检测痕量的污染物也很困难.

关键词：残留农药持久性有机污染物 DRS 应用筛查急性毒性世界卫生组织内分泌干扰物食品安全环境样品

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腰果组织培养中的器官发生和小植株形成

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热带作物译丛 1987年第3期 31-32页

作者： V.j.philip 崔元方

本文报道从成熟种子的子叶切片直接诱导增殖小植株的快速组织培养方法。

关键词：器官发生小植株子叶胚子叶外植体腰果

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腹主动脉瘤病因新探讨

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北京医学 2000年第6期22卷 360-363页

作者：徐东王京生万峰 M j.West Kim Summers philip Walker 北京大学人民医院心外科邮政编码100044 Prince Charles Hospital

目的　证实家族性因素和遗传性因素在腹主动脉瘤 ( abdominal aortic aneurysm,AAA)发病中的作用。方法　 30 8例澳大利亚欧洲腹主动脉瘤病人和 110例健康对照组以及男女各 4 0例的新生儿对照组。对动脉壁四种重要结构蛋白基因进行等位... 详细信息

目的　证实家族性因素和遗传性因素在腹主动脉瘤 ( abdominal aortic aneurysm,AAA)发病中的作用。方法　 30 8例澳大利亚欧洲腹主动脉瘤病人和 110例健康对照组以及男女各 4 0例的新生儿对照组。对动脉壁四种重要结构蛋白基因进行等位基因分析。等位基因频率分析采用 Sham and Curtis方法。结果　 50例 AAA病人至少有一例直系亲属患有 AAA。在 539例存活的同代亲属中 ,14例查出 AAA,其中 12例已施行了手术治疗。对 74例同代亲属筛选发现 4例患有轻度主动脉扩张 ,6例患有中到重度主动脉扩张。女性病人与对照组之间及女性病人与男性病人之间 ,COL 1A2基因的等位基因频率具有统计学差别。结论　在本组病例中遗传性因素在 AAA发病中起着重要作用。 COL 1A2在男女 AAA发病中作用不同 ,其详细机制有待进一步探讨。

关键词：腹主动脉瘤遗传因素病因

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Spontaneous Imbibition of Water and Determination of Effective Contact Angles in the Eagle Ford Shale Formation Using Neutron Imaging

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j.urnal of Earth Science 2017年第5期28卷 874-887页

作者： Victoria H.DiStefano Michael C.Cheshire j.anna McFarlane Lindsay M.Kolbus Richard E.Hale Edmund Perfect Hassina Z.Bilheux Louis j.Santodonato Daniel S.Hussey David L.j.cobson j.cob M.LaManna philip R.Bingham Vitaliy Starchenko Lawrence M.Anovitz Physical Sciences Directorate Chemical Sciences Division Oak Ridge National Laboratory Bredesen Center University of Tennessee Energy & Environmental Sciences Directorate Energy & Transportation Sciences Division Oak Ridge National Laboratory Neutron Sciences Directorate Chemical and Engineering Materials Division Oak Ridge National Laboratory Nuclear Science & Engineering Directorate Reactor & Nuclear Systems Division Oak Ridge National Laboratory Department of Earth and Planetary Science University of Tennessee Neutron Sciences Directorate Instrument and Source Division Oak Ridge National Laboratory Physical Measurement Laboratory National Institute of Standards and Technology Energy & Environmental Sciences Directorate Electrical & Electronics Systems Research DivisionOak Ridge National Laboratory

Understanding of fundamental processes and prediction of optimal parameters during the horizontal drilling and hydraulic fracturing process results in economically effective improvement of oil and natural gas extraction. Although modern analytical and computational models can capture fracture growth, there is a lack of experimental data on spontaneous imbibition and wettability in oil and gas reservoirs for the validation of further model development. In this work, we used neutron im- aging to measure the spontaneous imbibition of water into fractures of Eagle Ford shale with known geometries and fracture orientations. An analytical solution for a set of nonlinear second-order diffe- rential equations was applied to the measured imbibition data to determine effective contact angles. The analytical solution fit the measured imbibition data reasonably well and determined effective con- tact angles that were slightly higher than static contact angles due to effects of in-situ changes in veloci- ty, surface roughness, and heterogeneity of mineral surfaces on the fracture surface. Additionally, small fracture widths may have retarded imbibition and affected model fits, which suggests that aver- age fracture widths are not satisfactory for modeling imbibition in natural systems.

关键词： spontaneous imbibition effective contact angle neutron imaging Eagle Ford shale rock fractures.

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Photoluminescence of Ag-In-S/ZnS quantum dots: Excitation energy dependence and low-energy electronic structure

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Nano Research 2019年第7期12卷 1595-1603页

作者： Irina V. Martynenko Anvar S. Baimuratov Florian Weigert j.se X. Soares Lorena Dhamo philip Nickl Ilona Doerfel j.tta Pauli Ivan D. Rukhlenko Alexander V. Baranov Ute Resch-Genger Federal Institute for Materials Research and Testing (BAM) Unter den Eichen 8712205 BerlinGermany ITMO University 49 Kronverksky Pr.St. Petersburg197101Russia University of Porto Rua de Jorge Viterbo Ferreira2284050-313 PortoPortugal Institute of Photonics and Optical Sciences (IPOS) School of PhysicsThe University of SydneyCamperdown 2006NSWAustralia

Cd-free Ⅰ-Ⅲ-Ⅵ group semiconductor quantum dots (QDs) like Ag-ln-S and Cu-ln-S show unstructured absorption spectra with a pronounced Urbach tail,rendering the determination of their band gap energy (Eg) and the energy structure of the exciton ***,the origin of the broad photoluminescence (PL) band with lifetimes of several hundred nanoseconds is still *** encouraged us to study the excitation energy dependence (EED) of the PL maxima,PL spectral band widths,quantum yields (QYs),and decay kinetics of AlS/ZnS QDs of j.different size,composition,and surface capping *** results were then correlated with the second derivatives of the corresponding absorption *** excellent match between the onset of changes in PL band position and spectral width with the minima found for the second derivatives of the absorption spectra underlines the potential of the EED approach for deriving Eg values of these ternary QDs from PL *** PL QY is,however,independent of excitation energy in the energy range *** the EED of the PL features of the AlS/ZnS QDs we could also derive a mechanism of the formation of the low-energy electronic *** was additionally confirmed by a comparison of the EED of PL data of as-synthesized and size-selected QD ensembles and the comparison of these PL data with PL spectra of single *** results indicate a strong contribution of intrinsic inhomogeneous PL broadening to the overall emission features of AlS/ZnS QDs originating from radiative transitions from a set of energy states of defects localized at different positions within the quantum dot volume,in addition to contributions from dimensional and chemical *** mechanism was confirmed by numerically modelling the absorption and PL energies with a simple mass approximation for spherical QDs and a modified donor-acceptor model,thereby utilizing the advantages of previously proposed PL mechanisms of ternary *** findings will

关键词： core/shell quantum dot silver indium sulfide defect photoluminescence photoluminescence quantum yield single-dot spectroscopy

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DTC-SVM-based Matrix Converter for a PMSM in a Vessel Electric Propulsion System

DTC-SVM-based Matrix Converter for a PMSM in a Vessel Electr...

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2009中国控制与决策会议

作者： C.L.philip Chen College of Engineering the University of Texas at San AntonioTX 78249USA MemberIEEE

＜正＞This paper addresses the control technology of Matrix Converter for a Permanent Synchronous Motor（PMSM） in a vessel electric propulsion *** paper provides an algorithm based on flux linkage reference model,double space vector modulation（DSVM）,and Direct Torque Control（DTC） *** PMSM is controlled by the DTC theory with double space vector *** experiment result has shown that the drives control system has fast and stabilized performance under sudden load varying and four-quadrant running *** the energy in the design system can flow in both directions,the compound control strategy is effective and feasible.

关键词： Paper Instruction Chinese Control Conference

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急性缺血性卒中血管内治疗质量改进的多学会共识

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国际脑血管病杂志 2013年第11期21卷 807-820页

作者： David Sacks Carl M. Black Christophe Cognard j.hn j. Connors Donald Frei Rishi Gupta Tudor G. j.vin Bryan Kluck philip M. Meyers Kieran j. Murphy Stephen Ramee Daniel A. Rufenacht M.j. Bernadette Stallmeyer Dierk Vorwerk 皮燕(译) 张莉莉(译) 李敬诚(译) Department of Interventional Radiology Reading Hospital and Medical Center West Reading Center for Neuroendovascular Therapy University of Pittsburgh Medical Center Stroke Institute Pittsburgh The Heart Care Group Allentown Pennsylvania Department of Radiology Utah Valley Regional Medical Center Provo Utah Departments of Radiology Neurological Surgery and Neurology Vanderbilt University Medical Center Nashville Tennessee Department of Neurointerventional Surgery Radiology Imaging Associates and Swedish Medical Center Denver Colorado Department of Neurology Emory Clinic Atlanta Georgia Department of Neurological Surgery Columbia University College of Physicians and Surgeons New York New York Department of Interventional Cardiology Ochsner Medical Center New Orleans Louisiana Diagnostic and Therapeutic Neuroradiology Service Centre Hospitalier Universitaire de Toulouse Hopital Purpan Toulouse France Department of Medical Imaging University of Toronto Toronto Ontario Canada Neuroradiology Division Swiss Neurolnstitute Clinic Hirslanden Zurich Switzerland Institute for Diagnostic and Interventional Radiology Klinikum Ingolstadt Ingolstadt Germany 重庆第三军医大学第三附属医院野战外科研究所神经内科 400042

目的这份国际性多学科共识文件将对急性缺血性卒中诊治过程和临床转归的质量标准进行定义，并希望在质量保证程序中使用这些标准，从而评估和改善急性卒中血运重建的过程和转归。材料和方法写作组成员由美国神经放射学学会、加拿大介入... 详细信息

目的这份国际性多学科共识文件将对急性缺血性卒中诊治过程和临床转归的质量标准进行定义，并希望在质量保证程序中使用这些标准，从而评估和改善急性卒中血运重建的过程和转归。材料和方法写作组成员由美国神经放射学学会、加拿大介入放射学协会、欧洲心血管和介入放射学学会、心血管造影和介入学会、介入放射学学会、神经介入外科学会、欧洲微创神经病学治疗学会以及血管和介入神经病学学会认命。写作组回顾了1986年至2012年2月期间的相关文献，对急性缺血性卒中的诊疗过程和转归进行总结形成一份证据表，然后通过共识设立性能指标和阈值。本指南得到发起学会的批准，并计划在3年后进行全面更新。结果这份国际性多学科共识文件对诊治过程和临床转归的质量标准进行了定义，包括从入院到进行影像学检查、动脉穿刺和血运重建的时间间隔以及90d时的临床转归评估标准。结论本文件为急性缺血性卒中血管内血运重建程序提供了质量改进指南。

关键词：急性缺血性卒中血管内治疗质量改进学会介入放射学临床转归心血管造影质量标准

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