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A<i>β</i>-Like Peptide Displayed on Bacteriophage T7 Catalyzes Chromate and Uranyl Reduction

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j.urnal of Environmental Protection 2013年第8期4卷 857-868页

作者： Hongj.n j.n Chiann-Tso Lin j.anying Shang Michael j. Wilkins Yingbin Liu Wei Gong Weiping Xu Thomas C. Squier philip E. Long 1Fundamental & Computational Sciences Directorate Pacific Northwest National Laboratory Richland USA 2Department of Radi-ological Science Washington University School of Medicine St. Louis USA Earth Sciences Division Lawrence Berkeley National Laboratory Berkeley USA Fundamental & Computational Sciences Directorate Pacific Northwest National Laboratory Richland USA Xinhua Hospital Affiliated to Shanghai j.aotong University Shanghai China

In order to discover genes capable of catalyzing the reductive immobilization of toxic chromate and uranyl ions, we have created a T7 bacteriophage library containing cDNA from environmental microbes (i.e., Geobacter sulfurreducens and Shewanella oneidensis MR-1) that are known to mediate the reduction of chromate and uranyl ions. After three rounds of screening, ten bacteriophage mutants were found to mediate the NADH-dependent reduction of chromate and uranyl ions whose cDNA encodes polypeptide chains ranging 14 to 73 amino acids in length. All identified sequences contain disordered structural motifs similar to the β-amyloid peptide (Aβ) known to promote aggregation and formation of high-affinity metal binding sites. Confirmation of this structural similarity involved phage display of the 42 amino-acid Aβ-peptides that have been found to catalyze the NADH-dependent reduction of both chromate and uranyl ions. Transmission electron microscopy (TEM) and X-ray absorption near edge structure (XANES) measurements confirm that reduced uranium is present on the surface of bacteriophage expressing the Aβ-peptide. The surface-displayed Aβ-like peptide on bacteriophage has the potential to couple naturally occurring electron transfer shuttles present in soils to promote economically viable remediation of contaminated sites containing toxic chromate and uranyl ions.

关键词： Chromate Uranyl Bioremediation Bacteriophage

CONSIDERATIONS WHEN SPECIFYING LITHIUM ADMIXTURES TO MITIGATE THE RISK OF ASR

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CONSIDERATIONS WHEN SPECIFYING LITHIUM ADMIXTURES TO MITIGAT...

A Placebo-Controlled Trial of Subcutaneous Semaglutide in Nonalcoholic Steatohepatitis

第十二届国际混凝土碱集料反应会议

作者： Rebecca L Hooper philip j.Nixon Michael D A Thomas Scott Wilson Pavement Engineering 9/10 Faraday BuildingNottingham Science and Technology ParkUniversity BoulevardNottinghamNG7 2QPUK. Building Research Establishment Garston WatfordWD25 9XXUK. Department of Civil Engineering Head HallUniversity of New BrunswickFrederictonNBE3B 5A3Canada.

＜正＞ Based on research conducted at the Building Research Establishment （BRE） and work from across the globe, theUK has established recommended addition levels of lithium admixtures as one method to minimize the risk ofdeleterious alkali-silica reaction （ASR）.These addition levels allow increases in the permitted alkali content of concrete mixtures beyond that previouslyrecommended in the UK, and allow for combinations of lithium admixtures with pulverized-fuel ash （pfa） alsoknown as fly ash, a supplementary cementitious material or Type Ⅱ*** the impossibility of testing every lithium admixture addition level in combination with every alkali contentconcrete mixture, the recommendations are based on a pragmatic approach to safe specification. Thisspecification process includes interpolation of threshold levels and determination of an appropriate margin ofsafety based on concrete batching practices in the UK and embodied in European *** paper provides an overview of the use of lithium salts to mitigate deleterious ASR and provides furtherresearch evidence to validate the findings of previous authors. The paper explains the research basis for the UKrecommendations and describes the approach to the safe specification of lithium admixtures. Theserecommendations were published in BRE Information paper IP 1/02, and are now included in the 2004 edition ofBRE Digest 330, and referenced in the British Standard, BS 8500.

关键词： Lithium Specification Pulverized-fuel ash Fly ash.

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四川生理科学杂志 2020年第4期42卷 472-472页

作者： philip N Newsome From the National Institute for Health Research Biomedical Research Centre at University Hospitals Birmingham NHS Foundation Trust and the Centre for Liver and Gastrointestinal Research Institute of Immunology and Immunotherapy University of Birmingham and the Liver Unit University Hospitals Birmingham NHS Foundation Trust Birmingham (P.N.N.) and the Radcliffe Department of Medicine University of Oxford Oxford (S.A.H.) — all in the United Kingdom Novo Nordisk Søborg Denmark (K.B. M.L. A.-S.S.) the Division of Endocrinology Diabetes and Metabolism University of Florida Gainesville (K.C.) the Department of Gastroenterology and Hepatology Kyoto Prefectural University of Medicine Kyoto Japan (T.O.) the Institute of Cardiometabolism and Nutrition Sorbonne Université Hôpital Pitié–Salpêtrière Assistance Publique–Hôpitaux de Paris INSERM Unité Mixte de Recherche Scientifique 1138 Centre de Recherche des Cordeliers Paris (V.R.) and the Division of Gastroenterology Hepatology and Nutrition Virginia Commonwealth University School of Medicine Richmond (A.J.S.).

Background:Nonalcoholic steatohepatitis(NASH)is a common disease that is associated with increased morbidity and mortality,but treatment options are *** efficacy and safety of the glucagon-like peptide-1 receptor agon... 详细信息

关键词： mortality hepatitis morbidity

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无先前已知心脏病儿童的电轴左偏

中国循证儿科杂志 2019年第4期14卷 319-320页

作者： Andrew E. Schneider Bryan C. Cannon j.nathan N. j.hnson Michael j. Ackerman philip L. Wackel 赵趣鸣(译) 刘芳(校) Division of Pediatric Cardiology Department of Pediatric and Adolescent MedicineMayo ClinicRochesterMinnesota Division of Heart Rhythm Services Department of Cardiovascular DiseasesMayo ClinicRochesterMinnesota Department of Molecular Pharmacology and Experimental Therapeutics and Windland Smith Rice Sudden Death Genomics Laboratory Mayo ClinicRochesterMinnesota 不详

研究背景在儿童中,电轴左偏与一些特殊类型的心脏病理有关,许多患儿在婴儿期得到确诊;但目前尚不清楚无症状的电轴左偏儿童的心脏病发生率,也不清楚这类儿童需要做哪些其他检查。研究新知本研究确认,无先前已知心脏病的电轴左偏儿童可... 详细信息

研究背景在儿童中,电轴左偏与一些特殊类型的心脏病理有关,许多患儿在婴儿期得到确诊;但目前尚不清楚无症状的电轴左偏儿童的心脏病发生率,也不清楚这类儿童需要做哪些其他检查。研究新知本研究确认,无先前已知心脏病的电轴左偏儿童可能存在合并心脏病的危险因素,这些危险因素可以帮助临床医师在偶然发现电轴左偏时,决定哪些患儿应做进一步的检查。

关键词：电轴左偏心脏病理儿童危险因素临床医师婴儿期发生率无症状

Factor analysis identifies subgroups of constipation

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World j.urnal of Gastroenterology 2011年第11期17卷 1468-1474页

作者： philip G Dinning Mike j.nes Linda Hunt Sergio E Fuentealba j.mshid Kalanter Denis W King David Z Lubowski Nicholas j.Talley Ian j.Cook Department of Gastroenterology St.George HospitalUniversity of New South WalesKogarahNSW 2217Australia Department of Psychology Macquarie UniversityNSW 2109Australia Gastroenterology Research Unit Nepean HospitalUniversity of SydneySydneyNSW 2050Australia Department of Colorecta Surgery St.George HospitalKogarahNSW 2217Australia Gastroenterology and Hepatology Mayo ClinicJacksonvilleFL 32224United States

AIM:To determine whether distinct symptom groupings exist in a constipated population and whether such grouping might correlate with quantifiable pathophysiological measures of colonic ***:One hundred and ninety-one patients presenting to a Gastroenterology clinic with constipation and 32 constipated patients responding to a newspaper advertisement completed a 53-item,wide-ranging selfreport *** hundred of these patients had colonic transit measured *** analysis determined whether constipation-related symptoms grouped into distinct aspects of *** analysis was used to determine whether indi-vidual patients naturally group into distinct ***:Cluster analysis yielded a 4 cluster solution with the presence or absence of pain and laxative unresponsiveness providing the main *** all clusters there was a considerable proportion of patients with demonstrable delayed colon transit,irritable bowel syndrome positive criteria and regular stool *** maj.rity of patients with these characteristics also reported regular laxative ***:Factor analysis identified four constipation subgroups,based on severity and laxative unresponsiveness,in a constipated ***,clear stratification into clinically identifiable groups remains imprecise.

关键词： Factor analysis Constipation Symptoms Clusters Laxatives

Thrombotic Thrombocytopenic Purpura in a Parturient Leading to Life-Threatening Thrombocytopenia and Neonatal Demise—A Case Report

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Maternal-Fetal Medicine 2023年第2期5卷 119-122页

作者： Amnon A.Berger j.hn j.Kowalczyk philip E.Hess Yunping Li Department of Anesthesia Critical Care and Pain MedicineBeth Israel Deaconess Medical CenterHarvard Medical SchoolBostonMA 02215USA

Thrombocytopenia is common (up to 12%) in pregnancy;thrombotic thrombocytopenia is a rare cause of thrombocytopenia;however,it is immediately life-threatening to both mother and fetus and requires immediate *** is compounded by the need to act on a presumptive diagnosis with high level of suspicion given the relatively long laboratory confirmation time.A 31-year-old gravida 3,para 1 parturient at 26 weeks of gestation presented to outside hospital with recent onset of easy bruising and blurry vision.A blood count was drawn and showed a platelet count of 19,000/μ*** was transferred to our institution for management where an initial diagnosis of preeclampsia with severe features was made based on thrombocytopenia and fetal growth restriction (<1%).Platelet count nadired at 14,000/μL and a blood smear showed schistocytes,suggesting microangiopathic hemolysis,prompting discussion of urgent cesarean delivery and anesthesia *** urgent hematology consult led to presumptively diagnosing thrombotic thrombocytopenic purpura and cesarean delivery was deferred after discussion with the patient and *** exchange and steroid therapy were started promptly,and her platelet count improved within 12 ***,the patient experienced neonatal *** ADAMTS13 levels confirmed diagnosis of thrombotic *** was transitioned to rituximab,platelets recovered to baseline,and she continues to do *** thrombocytopenia is a rare,life-threatening cause of thrombocytopenia in *** grim fetal prognosis,especially in early pregnancy,low threshold of suspicion,early anesthesia involvement,and multi-disciplinary approach can facilitate diagnosis and timely *** our case,it was likely lifesaving.

关键词： Thrombocytopenia Pregnancy Plasma exchange Preeclampsia Fetal death von Willebrand factor Purpura thrombocytopenic idiopathic HELLP syndrome.

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大麦生理成熟的外观指标

麦类作物学报 1987年第1期 42-44页

作者： philip j. Copeland ,R. Kent Crookston ,杨竹平

谷类作物籽粒干重达最大值时称为生理成熟.对于研究籽粒灌浆生理学或把籽粒灌浆持续期作为选择指标的研究者以及采用摊晒的种植者来说,了解作物生理成熟的时间都是很重要的.

关键词：大麦品种旗叶生理成熟期籽粒灌浆失绿褪绿植物生理性病颖片籽粒含水量穗颈

Stimulated Brillouin scattering in chiral photonic crystal fiber

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Photonics Research 2022年第3期10卷 711-718页

作者： Xinglin Zeng Wenbin He Michael HFrosz Andreas Geilen Paul Roth Gordon K.L.Wong philip St.j.Russell Birgit Stiller Max-Planck Institute for the Science of Light 91058 ErlangenGermany Department of Physics Friedrich-Alexander-Universität91058 ErlangenGermany

Stimulated Brillouin scattering(SBS)has many applications;for example,in sensing,microwave photonics,and signal ***,we report the first experimental study of SBS in chiral photonic crystal fiber(PCF),which displays optical activity and robustly maintains circular polarization states against external *** a result,circularly polarized pump light is cleanly backscattered into a Stokes signal with the orthogonal circular polarization state,as is required by angular momentum *** comparison,untwisted PCF generates a Stokes signal with an unpredictable polarization state,owing to its high sensitivity to external *** use chiral PCF to realize a circularly polarized continuous-wave Brillouin *** results pave the way for a new generation of stable circularly polarized SBS systems with applications in quantum manipulation,optical tweezers,optical gyroscopes,and fiber sensors.

关键词： polarization fiber scattering

一例难治性脊髓损伤痛患者的处理：病例报道及文献综述

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麻醉与镇痛 2008年第5期4卷 63-74页

作者： j.celyn C. Que philip j. Siddall Michael j. Cousins 张瑞林(译) 郭政(校) Pain Management Unit University of Santo Tomas Faculty of Medicine and SurgeryUniversity of Santo Tomas Hospital Manila Philippines Pain Management Research Institute University of Sydney Royal North Shore Hospital Sydney Australia 不详

慢性疼痛是脊髓损伤众多后遗症之一，它会妨碍患者的基本活动、功能恢复及生活质量。脊髓损伤患者的疼痛常常难以治疗。有限的治疗选择，包括药物治疗和非药物治疗使疼痛的治疗更加困难。我们用检索词“脊髓损伤”或“脊髓损伤和疼痛”... 详细信息

慢性疼痛是脊髓损伤众多后遗症之一，它会妨碍患者的基本活动、功能恢复及生活质量。脊髓损伤患者的疼痛常常难以治疗。有限的治疗选择，包括药物治疗和非药物治疗使疼痛的治疗更加困难。我们用检索词“脊髓损伤”或“脊髓损伤和疼痛”或“僵直”或“肌僵直”从Medline数据库查阅1975～2005年的关于脊髓损伤后疼痛的相关文章。我们也手工查阅了国际疼痛研究协会最近出版的关于脊髓损伤痛的书籍以及综述，同时检出参考文献中的相关文章。文中我们报道了一例难治性脊髓损伤痛患者，该患者通过采用综合性治疗措施成功治愈。同时对治疗方式的循证医学证据也进行了回顾。

关键词：脊髓损伤患者文献综述难治性病例报道伤痛 Medline数据库非药物治疗慢性疼痛