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Contribution of Estrogen to Sex Dimorphic Expression of Cardiac Natriuretic Peptide and Nitric Oxide Synthase Systems in ANP Gene-Disrupted Mice

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Open j.urnal of Endocrine and Metabolic Diseases 2013年第4期3卷 1-11页

作者： philip G. Wong David W. j. Armstrong M. Yat Tse Nicole M. Ventura Stephen C. Pang Department of Biomedical and Molecular Sciences Queen’s University Kingston Canada

Background: Sex dimorphism in the prevalence, onset, development and progression of cardiovascular disease (CVD) is well recognized, but the mechanisms whereby sex hormones are believed to confer cardioprotection are still not fully understood. Obj.ctive: This study more closely delineates the effect of 17β-Estradiol (E2) on the expression and signaling of the cardiac NP and NOS systems, well-known cardioprotective modulators of the cardiac hypertrophy (CH) response, that both contribute to downstream production of cyclic guanosine 3’,5’-monophosphate (cGMP). Materials and Methods: Ovariectomized (OVX) female ANP+/+ and ANP-/- mice, 6 - 7 weeks old, were subj.cted to a five-week treatment with E2 (100 μg/100 μL/day) or vehicle (VEH). Left ventricle from these treatment groups, along with that from age-matched male ANP+/+ and ANP-/- mice was used to assess expression of these systems by real-time quantitative PCR (qPCR). Left ventricle tissue and plasma cGMP were measured by enzyme immunoassay to assess alterations in resultant downstream signaling. Results: NP system expression was unchanged across genotype, sex and E2 treatment. Sex-specific differences in NOS system expression were observed;female mice showed an increased expression of NOS system genes that were significantly elevated in all but one of the E2 treatment groups. Left ventricle tissue cGMP remained unchanged across genotype, sex and E2 treatment. Plasma cGMP levels were unchanged in ANP+/+ treatment groups. In ANP-/- treatment groups, plasma cGMP in the female OVX-E2 mice was significantly higher compared to male and female OVX-VEH mice. Conclusion: These findings demonstrate that in the absence of ANP, E2 upregulates cardiac NOS system expression to produce cGMP. This study confirms the importance of the cardiac NOS system in females;this particular system may be a promising future target for sex-specific treatments and therapies for CVD in women.

关键词： Estrogen Atrial Natriuretic Peptide Nitric Oxide Synthase Sex Dimorphism Heart

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Preoperative immunonutrition in patients undergoing liver resection:A prospective randomized trial

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World j.urnal of Hepatology 2019年第3期11卷 305-317页

作者： Kylie Russell Han-Guang Zhang Lyn K GillANDers Adam Sj. Bartlett Helena L Fisk philip C Calder Peter j.Swan Lindsay D Plank Nutrition Services Auckland City Hospital Department of Surgery University of Auckland New Zealand Liver Transplant Unit Auckland City Hospital Human Development and Health Faculty of Medicine University of Southampton NIHR Southampton Biomedical Research Centre University Hospital Southampton NHS Foundation Trust and University of Southampton

BACKGROUND Preoperative supplementation with immunonutrients, including arginine and n-3 fatty acids, has been shown in a number of systematic reviews to reduce infectious complications in patients who have undergone gastrointestinal surgery. Limited information, however, is available on the benefits of nutritional supplementation enriched with arginine and n-3 fatty acids in patients undergoing liver *** To evaluate the effects of preoperative nutritional supplementation enriched with arginine and n-3 fatty acids on inflammatory and immunologic markers and clinical outcome in patients undergoing liver *** Thirty-four patients undergoing liver resection were randomized to either five days of preoperative Impact? [1020 kcal/d, immunonutrition(IMN) group], or standard care [no supplementation, standard care(STD) group]. Nutritional status was measured at study entry by subj.ctive global assessment(SGA).Functional assessments(grip strength, fatigue and performance status) were carried out at study entry, on the day prior to surgery, and on postoperative day(POD) 7 and 30. Inflammatory and immune markers were measured at study entry, on the day prior to surgery, and POD 1, 3, 5, 7, 10 and 30. Postoperative complications were recorded prospectively until *** A total of 32 patients(17 IMN and 15 STD) were analysed. All except four patients were SGA class A. The plasma ratio of(eicosapentaenoic acid plus docosahexaenoic acid) to arachidonic acid was higher in IMN patients on the day prior to surgery and POD 1, 3, 5 and 7(P < 0.05). Plasma interleukin(IL)-6 concentrations were elevated in the IMN group(P = 0.017 for POD7). No treatment effect was detected for functional measures, immune response(white cell count and total lymphocytes) or markers of inflammation(C-reactive protein,tumour necrosis factor-α, IL-8, IL-10). There were 10 patients with infectious complications in the IMN group and 4 in the STD group(P = 0.087). Median hospital st

关键词： Liver cancer Partial hepatectomy Fish oil Arginine Nutritional status Inflammation

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Priority areas at the frontiers of ecology and energy

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Ecosystem Health and Sustainability 2018年第10期4卷 2-5页

作者： S.K.Chou Robert Costanza philip Earis Klaus Hubacek B.Larry Li Yonglong Lu Roland Span Hao Wang j.anping Wu Yegang Wu j.rry j.Yan Department of Mechanical Engineering National University of SingaporeSingaporeSingapore Crawford School of Public Policy The Australian National UniversityCanberraAustralia j.ule Publication Department CellPressCambridgeMAUSA Geography Department University of MarylandCollege ParkMDUSA Department of Botany and Plant Sciences University of California RiversideRiversideCAUSA State Key Laboratory of Urban and Regional Ecology Research Center for Eco-Environmental SciencesChinese Academy of SciencesBeijingChina Thermodynamics Faculty of Mechanical EngineeringRuhr University BochumBochumGermany j.ule Publication Department China Institute of Hydraulic and Hydropower ResearchBeijingChina School of Civil Engineering Tsinghua UniversityBeijingChina j.ule Publication Department Beijing Bold Institute of Eco-City Planning&DesignBeijingChina j.ule Publication Department Royal Institute of Technology(KTH)StockholmSweden

The complexity of economic development and humanitarian crisesmeans that energy science and technology should be involved in actions that address almost everymaj.r challenges of ecosystem health and *** is the engine of the world economy and the key to ecosystems’functioning,which also has a great impact on global *** energy crisis,environmental pollution,overuse of natural resources,water supply shortages,global climate disruption,and deteriorating ecosystems are maj.r challenges to address in order to achieve the United Nations Sustainable Development Goals(SDGs).In light of the frontiers in energy sciences and disruptive innovation in eco-tech,we recognize the need to review and establish working mechanisms that identify and examine issues that are critical to future sustainable development,to offer advice to decision-makers in different social sectors(public and private),to secure a shared future for mankind,and to achieve shared prosperity and common interests through international communications and collaborations.

关键词： Energy ecology sustainability United Nations Goals

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前十字韧带（ACL）重建术的材料选择

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中国纤检 2010年第6期 84-86页

作者： Kristofer D. Sinclair philip j. Brown

将纤维和纺织材料应用到受损膝关节韧带的修复治疗中已经有30多年了。如今，这个领域中最新的研究工作是利用纤维支架材料在根本上使受损组织重新生长。

关键词：材料选择韧带纺织材料支架材料膝关节纤维

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为什么我是（温和的）社会构建主义者

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数学译林 2016年第1期35卷 77-79页

作者： philip j. Davis 李乔赵振江

引用了Vico后，我本当就此搁笔：还能再说些什么呢？但数学的整体历经一代接一代不断出现的真正的新概念以及各种各样的交融诠释已发展得如此博大和如此丰富多彩，使得我们必须再多说一些．然而，单单一句或一段话、乃至一本书又怎能从... 详细信息

引用了Vico后，我本当就此搁笔：还能再说些什么呢？但数学的整体历经一代接一代不断出现的真正的新概念以及各种各样的交融诠释已发展得如此博大和如此丰富多彩，使得我们必须再多说一些．然而，单单一句或一段话、乃至一本书又怎能从特征上对如此浩瀚的整体提出一种确定而又令人信服或最终的哲学上的刻画呢？即便是睿智渊博如Vico的一句话也不能够，但我仍想一试．

关键词：社会构建主义者数学哲学数学概念数系元素

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强制性运动疗法对卒中后3～9个月上肢功能恢复的效果：EXCITE随机临床试验

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国际内科双语杂志（中英文） 2007年第1期7卷 68-70页

作者： Steven L. Wolf Carolee j. Winstein j. philip Miller

单中心研究显示，对于卒中后超过1年而保存部分手、腕运动功能的患者，为期2周的强制性运动疗法（CIMT）能够促进上肢功能，其效果至少可达1年。

关键词：强制性运动疗法上肢功能恢复随机临床试验卒中后单中心研究运动功能

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儒家伦理哲学的新旧基础——以伊藤仁斋、戴震和丁若镛为例

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社会科学战线 2019年第2期 1-17,281页

作者：艾文贺张黛英刘昊王韵婷香港城市大学公共政策学系复旦大学哲学学院清华大学哲学系

伊藤仁斋、戴震和丁若镛三位儒家学者基于以人为本的伦理学说,将人们的情感、欲望、需求以及广义上的幸福置于他们思想的核心地位。伊藤仁斋、戴震和丁若镛等对宋明理学伦理学之形上学进行批判,明确反对宋明理学的形上学,特别是对程朱... 详细信息

伊藤仁斋、戴震和丁若镛三位儒家学者基于以人为本的伦理学说,将人们的情感、欲望、需求以及广义上的幸福置于他们思想的核心地位。伊藤仁斋、戴震和丁若镛等对宋明理学伦理学之形上学进行批判,明确反对宋明理学的形上学,特别是对程朱理学的"理气"世界观有深刻的剖析,这对于理解儒学传统在当代的丰富性、多样性以及发展潜力具有重要意义。19世纪40年代以来,曾对儒家思想造成影响的佛道思想似乎被西方哲学取代,在梳理西方哲学与儒家伦理思想关系时,当代学者深受伊藤仁斋、戴震和丁若镛的影响。此外,三位思想家关于"恕"的思想的阐释也十分深刻。

关键词：情绪同情的考虑(恕) 伦理哲学伦理关怀伊藤仁斋戴震茶山

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制作和发表系统评价的伦理问题

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中国循证医学杂志 2011年第7期11卷 721-725页

作者： Elizabeth Wager philip j.Wien 王应强李幼平 Sideview PrincesRisborough UKCochraneCentre

1引言医学证据基础或＂文献＂形成了临床选择和决策的基础,因此,生产（医学）证据的人有责任尽可能确保证据准确且无偏倚。由于发表文章既可用于评定个人和部门的产出能力又可用于遴选学术职位的候选人,因而这对发表文章的人获得公平信... 详细信息

1引言医学证据基础或＂文献＂形成了临床选择和决策的基础,因此,生产（医学）证据的人有责任尽可能确保证据准确且无偏倚。由于发表文章既可用于评定个人和部门的产出能力又可用于遴选学术职位的候选人,因而这对发表文章的人获得公平信誉很重要。系统评价是研究的一种形式，应以一种负责任的态度来确保其完整性，避免因选择性发表引起的误导。

关键词：伦理问题系统医学证据制作临床选择候选人责任

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INTERNATIONAL COLLABORATION TO CONTROL ALKALI-AGGREGATE REACTION:THE SUCCESSFUL PROGRESS OF RILEM TC 106 AND TC 191-ARP.

INTERNATIONAL COLLABORATION TO CONTROL ALKALI-AGGREGATE REAC...

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第十二届国际混凝土碱集料反应会议

作者： Ian Sims philip j.Nixon Anne-Marie Marion STATS Limited St AlbansAL3 6PQUnited Kingdom Building Research Establishment GarstonWatfordWD25 9XXUnited Kingdom CRIC BrusselsB-1050Belgium

＜正＞ Since 1988, RILEM has been seeking to establish universally applicable test methods for assessing the alkali-reactivity potential of aggregates. Technical committee TC 106 （1988-2000） published two expansion tests （AAR-2 ＆ AAR-3）, following international trials, and started to develop two further procedures, for petrographic examination （AAR-1） and an ultra-accelerated concrete method （AAR-4）, together with an integrated assessment scheme （AAR-0）. Successor committee TC 191-ARP （formed in 2000）, comprising members from all parts of the world, has now finalised and published procedures AAR-0 and AAR-1 and has carried out international trials on AAR-4 and a method for assessing carbonate aggregates （AAR-5）. It also has a widened scope to seek international consistency in approaches to diagnosis （AAR-6） and specification （AAR-7） and in the assessment of alkali release from aggregates （AAR-8）. This paper reviews the overall progress of TC 191-ARP;three other papers presented at the conference describe the detailed progress on particular aspects of the work.. The authors are respectively Secretary and Chairman of TC 191-ARP （and previously of TC 106） and the leader of the TC 191-ARP team developing AAR-4.

关键词： RILEM International Tests Diagnosis Specification Alkali-aggregate Reaction Carbonates Releasable Alkalis.

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Symbiosome-like intracellular colonization of cereals and other crop plants by nitrogen-fixing bacteria for reduced inputs of synthetic nitrogen fertilizers

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Science China(Life Sciences) 2005年第Z2期48卷 888-896页

作者： Edward C.Cocking philip j.Stone Michael R.Davey Centre for Crop Nitrogen Fixation School of Biology University of NottinghamUniversity ParkNottingham NG7 2RDU.K. Plant Sciences Division School of BiosciencesUniversity of NottinghamSutton BoningtonLoughborough LE12 5RDU.K. Plant Sciences Division School of Biosciences University of NottinghamSutton BoningtonLoughborough LE12 5RDU.K.

It has been forecast that the challenge of meeting increased food demand and protecting environmental quality will be won or lost in maize, rice and wheat cropping systems, and that the problem of environmental nitrogen enrichment is most likely to be solved by substituting synthetic nitrogen fertilizers by the creation of cereal crops that are able to fix nitrogen symbiotically as legumes do. In legumes, rhizobia present intracellularly in membrane-bound vesicular compartments in the cytoplasm of nodule cells fix nitrogen endosymbiotically. Within these symbiosomes, membrane-bound vesicular compartments, rhizobia are supplied with energy derived from plant photosynthates and in return supply the plant with biologically fixed nitrogen, usually as ammonia. This minimizes or eliminates the need for inputs of synthetic nitrogen fertilizers. Recently we have demonstrated, using novel inoculation conditions with very low numbers of bacteria, that cells of root meristems of maize, rice, wheat and other maj.r non-legume crops, such as oilseed rape and tomato, can be intracellularly colonized by the non-rhizobial, non-nodulating, nitrogen fixing bacterium, Gluconacetobacter diazotrophicus that naturally occurs in sugarcane. G. diazotrophicus expressing nitrogen fixing (nifH) genes is present in symbiosome-like compartments in the cytoplasm of cells of the root meristems of the target cereals and non-legume crop species, somewhat similar to the intracellular symbiosome colonization of legume nodule cells by rhizobia. To obtain an indication of the likelihood of adequate growth and yield, of maize for example, with reduced inputs of synthetic nitrogen fertilizers, we are currently determining the extent to which nitrogen fixation, as assessed using various methods, is correlated with the extent of systemic intracellular colonization by G. diazotrophicus, with minimal or zero inputs.

关键词： cereals, endosymbiotic nitrogen fixation, Gluconacetobacter diazotrophicus, intracellular colonization,legumes, synthetic nitrogen fertilizers.

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