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Prevalence and predictors of nonalcoholic fatty liver disease in South Asian women with polycystic ovary syndrome

World j.urnal of Gastroenterology 2020年第44期26卷 7046-7060页

作者： Mohamed Shengir Srinivasan Krishnamurthy Peter Ghali Marc Deschenes philip Wong Tianyan Chen Giada Sebastiani Department of Experimental Medicine McGill UniversityMontreal H4A3J1Canada Department of Obstetrics and Gynecology McGill University Health CentreMontreal H4A3J1Canada Department of Medicine McGill University Health CentreMontreal H4A3J1Canada

BACKGROUND Polycystic ovary disease(PCOS)may be a risk factor for nonalcoholic fatty liver disease(NAFLD)due to common pathogenetic pathways,including insulin resistance and *** PCOS and NAFLD are more severe in South Asian *** on NAFLD in South Asian women with PCOS are *** To investigate prevalence and predictors of NAFLD and liver fibrosis in PCOS patients from South *** We conducted an observational routine screening program by means of transient elastography(TE)with associated controlled attenuation parameter(CAP).NAFLD was defined as CAP≥288 decibels per *** liver fibrosis(stage 2 and higher out of 4)was defined as TE measurement≥8.0 *** alanine aminotransferase(ALT)was defined as ALT>24 IU/L,as per upper limit of normal reported in South Asian *** hyperandrogenism was defined as free androgen index>*** of NAFLD were determined by logistic regression *** 101 PCOS patients(mean age 36.3 years)with no significant alcohol intake or viral hepatitis were *** of NAFLD and significant liver fibrosis was 39.6% and 6.9%,*** ALT was observed in 40%and 11.5%of patients with and without NAFLD,*** adj.sting for duration of PCOS and insulin resistance measured by homeostasis model for assessment of insulin resistance,independent predictors of NAFLD were higher body mass index[adj.sted odds ratio(aOR)1.30,95% confidence interval(CI):1.13-1.52],hyperandrogenism(aOR:5.32,95%CI:1.56-18.17)and elevated ALT(aOR:3.54,95%CI:1.10-11.47).Lifetime cardiovascular risk was higher in patients with NAFLD compared to those without NAFLD(0.31±0.11 vs 0.26±0.13).CONCLUSION Despite their young age,NAFLD diagnosed by TE with CAP is a frequent comorbidity in South Asian women with PCOS and is strongly associated with higher body mass index and ***-invasive screening strategies could help early diagnosis and initiation of interventi

关键词： Body mass index Transient elastography Controlled attenuation parameter Hyperadrogenism Alanine aminotransferase Lifetime cardiovascular risk

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中国西藏恐龙足迹的首次记录(英文)

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地质通报 2011年第1期31卷 173-178页

作者：邢立达杰瑞德D．哈里斯菲利普j.柯里阿尔伯塔大学生物科学系加拿大埃德蒙顿T6G 2E9 脊椎动物进化系统学开放实验室中国科学院北京100044 迪克西州立学院自然科学系美国犹他84770

记述了中国西藏昌都地区莫荣化石点的三道蜥脚类恐龙行迹,共8个足迹,这些足迹被归入雷龙足迹(Brontopodus)。这些具有宽或亚宽的行迹表明,早—中侏罗世的昌都地区可能生活有大型的巨龙形类。该发现还表明,西藏昌都地区的蜥脚类恐龙动物... 详细信息

记述了中国西藏昌都地区莫荣化石点的三道蜥脚类恐龙行迹,共8个足迹,这些足迹被归入雷龙足迹(Brontopodus)。这些具有宽或亚宽的行迹表明,早—中侏罗世的昌都地区可能生活有大型的巨龙形类。该发现还表明,西藏昌都地区的蜥脚类恐龙动物群不仅具有与四川盆地蜥脚类动物群相同的要素,还可能具有更多样化的动物区系成分。

关键词：早—中侏罗世蜥脚类足迹巨龙形类雷龙足迹西藏昌都地区

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A cluster-randomized trial comparing two SWITCH implementation support strategies for school wellness intervention effectiveness

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j.urnal of Sport and Health Science 2023年第1期12卷 87-96页

作者： Richard R.Rosenkranz philip M.Dixon David A.Dzewaltowski Gabriella M.McLoughlin j.ey A.Lee Senlin Chen Spyridoula Vazou Lorraine M.Lanningham-Foster Doug A.Gentile Gregory j.Welk Department of Food NutritionDietetics&HealthKansas State UniversityManhattanKS 66506USA Department of Statistics Snedecor HallIowa State UniversityAmesIA 50011-1210USA Department of Health Promotion University of NebraskaOmahaNE 68198-4365USA Implementation Science Center for Cancer Control and Prevention Research Center Brown SchoolWashington University in St.LouisSt.LouisMO 63130USA Division of Public Health Sciences(Department of Surgery) Washington University School of MedicineWashington University in St.LouisSt.LouisMO 63130USA Department of Health Sciences University of Colorado Colorado SpringsColorado SpringsCO 80918USA Department of Kinesiology Iowa State UniversityAmesIA 50011-4008USA Department of Food Science&Human Nutrition Iowa State UniversityAmesIA 50011USA Department of Psychology Iowa State UniversityAmesIA 50011-1041USA

Background:The School Wellness Integration Targeting Child Health(SWITCH)intervention has demonstrated feasibility as an implementation approach to help schools facilitate changes in students’physical activity(PA),sedentary screen time(SST),and dietary intake(DI).This study evaluated the comparative effectiveness of enhanced(individualized)implementation and standard(group-based)***:Twenty-two Iowa elementary schools participated,with each receiving standardized training(wellness conference and webinars).Schools were matched within region and randomized to receive either individualized or group implementation *** PA,SST,and DI outcomes of 1097 students were assessed at pre-and post-intervention periods using the Youth Activity *** mixed models evaluated differential change in outcomes by condition,for comparative effectiveness,and by ***:Both implementation conditions led to significant improvements in PA and SST over time(p<0.01),but DI did not improve commensurately(p value range:0.02‒0.05).There were no differential changes between the group and individualized conditions for PA(p=0.51),SST(p=0.19),or DI(p=0.73).There were no differential effects by gender(i.e.,non-significant condition-by-gender interactions)for PA(p_(for interaction)=0.86),SST(p_(for interaction)=0.46),or DI(p_(for interaction)=0.15).Effect sizes for both conditions equated to approximately 6 min more PA per day and approximately 3 min less sedentary ***:The observed lack of difference in outcomes suggests that group implementation of SWITCH is equally effective as individualized implementation for building capacity in school wellness ***,the lack of interaction by gender suggests that SWITCH can be beneficial for both boys and *** research is needed to understand the school-level factors that influence implementation(and outcomes)of SWITCH.

关键词： Children Implementation science Obesity prevention Physical activity School health

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Polycomb response element-binding sites in the MDR of CLL: Potential tumor suppressor regulation

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Advances in Bioscience and Biotechnology 2013年第1期4卷 129-135页

作者： Christine E. Cutucache j.veed Iqbal philip j. Bierman Robert Gregory Bociek Dennis D. Weisenburger Shantaram S. j.shi Department of Biology University of Nebraska at Omaha Omaha USA Department of Genetics Cell Biology and Anatomy University of Nebraska Medical Center Omaha USA Department of Internal Medicine Oncology/Hematology University of Nebraska Medical Center Omaha USA Department of Pathology and Microbiology University of Nebraska Medical Center Omaha USA

Chronic lymphocytic leukemia [CLL] is the most common adult leukemia and is heterogeneous in clinical presentation. CLL cases present with various chromosomal aberrations, including 11q23, 14q32, 17p, and trisomy 12, with the most common abnormality being deletion of 13q14 [1]. Although monoallelic deletion of 13q14 is common, there is a subset of patients who have complete nullisomy at 13q14, a locus that has been hypothesized to contribute to CLL pa thogenesis [2] due to loss of tumor suppressors [DLEU and miR-15a/16-1]. We hypothesized that deletion of both copies of 13q14 would lead to uncontrollable proliferation of CLL cells and a poor prognosis. We examined our 13q14 nullisomy for survival, treatment-free survival, lymphocyte doubling time, and the presence of lymphadenopathy. Furthermore, we compared the gene expression profiles between patients with 13q14 monosomy, nullisomy, or normal karyotype. Our results suggest that patients with 13q nullisomy have a higher incidence of bulky lymphadenopathy [16.6% compared to 10% of monosomy patients], a higher frequency of lymphocyte doubling time [27.7% compared to 7.4% of monosomy patients], and a higher rate of needing treatment [50% compared to 18.5% of monosomy patients]. We observed deletion of DLEU1 and HTR2A, consistent with a gene dosage effect, and observed PRE-binding sites on DLEU1. Patients with homozygous deletion of 13q14 had a worse prognosis compared to heterozygotes. Lastly, the DLEU1 locus is a possible “second hit” loss for CLL progression.

关键词： Chronic Lymphocytic Leukemia Gene Expression 13q14 Nullisomy DLEU Tolerogenic

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Impaired CTLA-4 responses in COPD are associated with systemic inflammation

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Cellular & Molecular Immunology 2014年第6期11卷 606-608页

作者： Dino BA Tan Sonia Fernandez PatriciaPrice Martyn A French philip j.Thompson Yuben P Moodley Centre for Asthma Allergy and Respiratory Research Lung Institute of Western Australia Nedlands Australia School of Medicine and Pharmacology Nedlands Australia School of Pathology and Laboratory Medicine University of Western Australia Nedlands Australia Department of Clinical Immunology Perth Australia Department of Respiratory and Sleep Medicine Royal Perth Hospital Perth Australia

Systemic inflammation is a feature of chronic obstructive pulmo- nary disease （COPD）. Defects in T cell-mediated anti-inflamma- tory pathways such as cytotoxic T lymphocyte antigen-4 （CTLA- 4） may promote damaging inflammation. This study provides novel data implicating the impaired induction of an anti-inflam- matory molecule, CTLA-4 in the elevated inflammation observed in COPD patients. Low induction of CTLA-4 in COPD patients paralleled increased markers of systemic inflammation ex vivo and increased T-cell responses to a bacterial superantigen, staphylo- coccal enterotoxin-B （SEB） in vitro. This mechanism may explain the increased inflammation in COPD patients.

关键词： T淋巴细胞肠毒素类肺疾病慢性阻塞性抗原分化炎症胰岛素体外研究

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Intraspecific variation in precipitation responses of a widespread C_(4) grass depends on site water limitation

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j.urnal of Plant Ecology 2017年第2期10卷 310-321页

作者： Michael j.Aspinwall philip A.Fay Christine V.Hawkes David B.Lowry Albina Khasanova j.son Bonnette Briana K.Whitaker Nicholas j.hnson Thomas E.j.enger Hawkesbury Institute for the Environment Western Sydney UniversityHawkesbury CampusLocked Bag 1797PenrithNew South Wales 2751Australia USDA-ARS Grassland Soil and Water Research Laboratory 808 East Blackland RdTempleTX 76502USA Department of Integrative Biology University of Texas at Austin1 University StationAustinTX 78712USA Department of Plant Biology Michigan State University612 Wilson RoadEast LansingMI 48824USA

Aims Variation in precipitation strongly influences plant growth,species distributions and genetic *** variation in pheno-typic plasticity,the ability of a genotype to alter its growth,morphol-ogy or physiology in response to the environment,could influence species responses to changing precipitation and climate *** this,the patterns and mechanisms of intraspecific varia-tion in plasticity to variable precipitation,and the degree to which genotype responses to precipitation are influenced by variation in edaphic conditions,remain poorly ***,we determined whether genotypes of a widespread C_(4) grass(Panicum virgatum L.,switchgrass)varied in aboveground productivity in response to changes in precipitation,and if site edaphic conditions modified genotype aboveground productivity responses to *** also determined if genotype productivity responses to precipitation are related to plasticity in underlying growth and phenological *** Nine *** genotypes originating from an aridity gradient were grown under four treatments spanning the 10th to the 90th percentiles of annual precipitation at two sites in central Texas:one site with deep,fine-textured soils and another site with shallow,coarse-textured *** measured volumetric soil water content(VWC),aboveground net primary productivity(ANPP),tiller pro-duction(tiller number),average tiller mass,canopy height,leaf area index(LAi)and flowering time on all plants at both sites and examined genotype responses to changes in *** Findings Across precipitation treatments,VWC was 39%lower and more variable at the site with shallow,coarse-textured soils compared to the site with deep,fine-textured *** averaged across genotypes and precipita-tion treatments was also 103%higher at the site with deep,fine-textured soils relative to the site with shallow,coarse-textured soils,indicating substantial differences in site water limitation.W

关键词： climate change Panicum virgatum phenology phenotypic plasticity precipitation

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Separation,detection and quantification of hydroperoxides formed at side-chain and backbone sites on amino acids,peptides and proteins

Separation,detection and quantification of hydroperoxides fo...

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第14届国际自由基学术大会

作者： philip E. Morgan David I. Pattison Clare L. Hawkins Michael j. Davies Faculty of Medicine University of Sydney Sydney NSW 2006 Australia

＜正＞Hydroperoxides are maj.r reaction products of radicals and singlet oxygen with amino acids, peptides and proteins. However there are few data on the distribution of hydroperoxides in biological samples, and their sites of formation on peptides and proteins. In this study we show that normal- or reversed-phase gradient HPLC can be employed

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The double helium-white dwarf channel for the formation of AM CVn binaries

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Research in Astronomy and Astrophysics 2018年第1期18卷 101-112页

作者： Xian-Fei Zhang j.n-Zhong Liu C.Simon j.ffery philip D.Hall Shao-Lan Bi Department of Astronomy Beijing Normal University Xinj.ang Astronomical Observatory Chinese Academy of Sciences Armagh Observatory and Planetarium College Hill School of Physics Trinity College Dublin

Most close double helium white dwarfs will merge within a Hubble time due to orbital decay by gravitational wave ***,a significant fraction with low mass ratios will survive for a long time as a consequence of stable mass *** stable mass transfer between two helium white dwarfs（He WDs） provides one channel for the production of AM CVn binary *** previous calculations of double He WD progenitors,the accreting He WD was treated as a point *** have computed the evolution of 16 double He WD models in order to investigate the consequences of treating the evolution of both components in *** find that the boundary between binaries having stable and unstable mass transfer is slightly modified by this *** comparing with observed periods and mass ratios,we redetermine masses of eight known AM CVn stars by our double He WDs channel,*** Cnc,AM CVn,V406 Hya,j.926,j.240,GP Com,Gaia14 aae and V396 *** propose that central spikes in the triple-peaked emission spectra of j.240,GP Com and V396 Hya and the surface abundance ratios of N/C/O in GP Com can be explained by the stable double He WD *** mass estimates derived from our calculations are used to discuss the predicted gravitational wave signal in the context of the Laser Interferometer Space Antenna（LISA） proj.ct.

关键词： stars:peculiar(helium) stars:white dwarfs binaries:close gravitational waves

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Relationship between nitrate headache and outcome in patients with acute stroke: results from the efficacy of nitric oxide in stroke (ENOS) trial

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Stroke & Vascular Neurology 2021年第2期6卷 180-186页

作者： Lucy Beishon Lisa j.Woodhouse Daniel Bereczki Hanne K Christensen Ronan Collins j.hn Gommans Christina Kruuse George Ntaios Serefnur Ozturk Stephen Phillips Stuart Pocock Szabolcs Szatmari j.anna Wardlaw Nikola Sprigg philip M Bath Stroke Trials Unit Division of Clinical NeuroscienceUniversity of NottinghamNottinghamUK Department of Neurology Semmelweis UniversityBudapestHungary Bispebj.rg Hospital and University of Copenhagen University of CopenhagenCopenhagenDenmark Department of Geriatric and Stroke Medicine Adelaide and Meath HospitalDublinIreland Department of Medicine Hawke's Bay HospitalCamberleyNew Zealand Department of Neurology Herlev Gentofte HospitalUniversity of CopenhagenCopenhagenDenmark Department of Medicine Larissa University HospitalUniversity of ThessalyVolosGreece Department of Neurology Selcuk University Medical FacultyKonyaTurkey Department of Neurology Queen Elizabeth II Health Sciences CentreHalifaxNova ScotiaCanada Medical Statistics Unit London School of Hygiene&Tropical MedicineLondonUK Department of Neurology George Emil Palade University of MedicinePharmacyScience and Technology of Târgu MureșTargu MuresRomania Centre for Clinical Brain Sciences University of EdinburghEdinburghUK Stroke Nottingham University Hospitals NHS TrustNottinghamUK

Introduction Nitrate-induced headache is common and may signify responsive cerebral *** assessed the relationship between nitrate headache and outcome in patients with acute *** and methods Patients were those randomised to glyceryl trinitrate(GTN)versus no GTN in the efficacy of nitric oxide in stroke *** of headache by end of treatment(day 7),and functional outcome(modified Rankin Scale,primary outcome)at day 90,were *** are adj.sted for baseline prognostic factors and give OR and mean difference(MD)with 95%*** In 4011 patients,headache was more common in GTN than control(360,18.0% vs 170,8.5%;p<0.001).Nitrate-related headache was associated with:younger age,female sex,higher diastolic blood pressure,non-total anterior circulation syndrome,milder stroke and absence of dysphasia(p<0.05).Nitrate headache was not associated with improved functional outcome(OR 0.90,95% CI 0.73 to 1.10,p=0.30)or death(day 90)(HR 0.64,95% CI 0.40 to 1.02,p=0.062),but reduced death or deterioration(day 7)(OR 0.45,95% CI 0.25 to 0.82),death in hospital(OR 0.44,95% CI 0.22 to 0.88)and improved activities of daily living(Barthel index,MD 3.7,95% CI 0.3 to 7.1)and cognition(telephone interview cognitive screen,MD 2.0,95% CI 0.7 to 3.3)(day 90).Non-nitrate headache was not associated with death,disability or *** and conclusion Development of a nitrate headache by day 7 after stroke may be associated with improved activities of daily living and cognitive impairment at day 90,which was not seen with non-nitrate headache.

关键词： headache patients nitrate

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Production systems and important antimicrobial resistant-pathogenic bacteria in poultry:a review

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j.urnal of Animal Science and Biotechnology 2023年第2期14卷 481-500页

作者： philip H.W.Mak Muhammad Attiq Rehman Elij.h G.Kiarie Edward Topp Moussa S.Diarra Guelph Research and Development Centre Agriculture and Agri-Food Canada(AAFC)GuelphONCanada Department of Animal Biosciences University of GuelphGuelphONCanada London Research and Development Center AAFCLondonONCanada.

Economic losses and market constraints caused by bacterial diseases such as colibacillosis due to avian pathogenic Escherichia coli and necrotic enteritis due to Clostridium perfringens remain maj.r problems for poultry producers,despite substantial efforts in prevention and *** have been used not only for the treatment and prevention of such diseases,but also for growth ***,these practices have been linked to the selection and spread of antimicrobial resistant bacteria which constitute a significant global threat to humans,ani-mals,and the *** break down the antimicrobial resistance(AMR),poultry producers are restricting the antimicrobial use(AMU)while adopting the antibiotic-free(ABF)and organic production practices to satisfy consum-ers’***,it is not well understood how ABF and organic poultry production practices influence AMR profiles in the poultry gut *** Gram-negative(Salmonella enterica serovars,Campylobacter j.j.ni/coli,***)and Gram-positive(Enterococcus spp.,Staphylococcus *** ***)bacteria harboring multiple AMR determinants have been reported in poultry including organically-and ABF-raised *** this review,we discussed maj.r poultry production systems(conventional,ABF and organic)and their impacts on AMR in some potential pathogenic Gram-negative and Gram-positive bacteria which could allow identifying issues and opportuni-ties to develop efficient and safe production practices in controlling pathogens.

关键词： Antibiotic-free Antimicrobial resistance Conventional feeding Organic Poultry

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