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Protecting the delivery of heart failure: Regenerative Medicine/Stem Cell Therapeutics:Potential protections afforded by the Department of Health and Human Services and Health Resources Service Administration’s Bureau of Special Programs

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Journal of Geriatric Cardiology 2006年第3期3卷 171-180页

作者： Gary S Friedman John S. Tomicki Neil Cohen Robert Marshal philip lowry Jeffrey Warsh New Jersey Stem Cell Research & Education Foundation International Regenerative Medicine Incorporated New Jersey State Legislature Virginia State Legislature New Jersey Stem Cell Research & Education Foundation University of Massachusetts Stem Cell Transplant Program

Advances in stem cell science and potential clinical applications have brought clinical medicine closer to the actualization of Regenerative Medicine—an extension of transplantation of organs and cells and implantation of bioprosthetics and biodevices. The goal of such therapeutics will be intervention prior to onset of severe individual disability, enhance organ function and enhance patient performance status without incurring the economic impacts of standard organ transplantation. Regenerative Medicine is already demonstrating proof of principle or efficacy in restora- tion of myocardial contractility, joint mobility and function, immune competence, pulmonary function, immunologic self- tolerance, motor function and normal hemoglobin production with the next targets—diabetes mellitus (type I and type II), neurologic injury, hepatic dysfunction preparing to enter trials. Expenditures on health care needs of an aging U.S. citizenry approximate 20-25% ($3 trillion) of U.S. GDP currently and may to grow to 40% of U.S. GDP by 2025. As the potential of Regenerative Medicine is clinically realized, the societal impact and economic benefits will be disproportionately magnified in the economies of industrialized nations. The experi- ence of the Department of Health and Human Services (HHS), United Network for Organ Sharing (UNOS), the National Bone Marrow Donor Registry (NBMDR), and the National Vaccine Injury Compensation Programs (NVICP) can help ensure that as Regenerative Medicine strives to achieve clinical benefits while avoiding decimation of therapeutic options by product liability and medical malpractice concerns—concerns that crippled the U.S. vaccine manufacturing industry until the creation of the NVICP. The first 50 years of organ/cell/tissue transplantation demonstrates that clinical reality of allogeneic and autologous transplantation can antedate complete understanding of the basic science underlying successful transplantation. Product liability and medical

关键词： regenerative medicine stem cell heart failureAcknowledgements

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Intraspecific variation in precipitation responses of a widespread C_(4) grass depends on site water limitation

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Journal of Plant Ecology 2017年第2期10卷 310-321页

作者： Michael J.Aspinwall philip A.Fay Christine V.Hawkes David B.lowry Albina Khasanova Jason Bonnette Briana K.Whitaker Nicholas Johnson Thomas E.Juenger Hawkesbury Institute for the Environment Western Sydney UniversityHawkesbury CampusLocked Bag 1797PenrithNew South Wales 2751Australia USDA-ARS Grassland Soil and Water Research Laboratory 808 East Blackland RdTempleTX 76502USA Department of Integrative Biology University of Texas at Austin1 University StationAustinTX 78712USA Department of Plant Biology Michigan State University612 Wilson RoadEast LansingMI 48824USA

Aims Variation in precipitation strongly influences plant growth,species distributions and genetic *** variation in pheno-typic plasticity,the ability of a genotype to alter its growth,morphol-ogy or physiology in response to the environment,could influence species responses to changing precipitation and climate *** this,the patterns and mechanisms of intraspecific varia-tion in plasticity to variable precipitation,and the degree to which genotype responses to precipitation are influenced by variation in edaphic conditions,remain poorly ***,we determined whether genotypes of a widespread C_(4) grass(Panicum virgatum L.,switchgrass)varied in aboveground productivity in response to changes in precipitation,and if site edaphic conditions modified genotype aboveground productivity responses to *** also determined if genotype productivity responses to precipitation are related to plasticity in underlying growth and phenological *** Nine *** genotypes originating from an aridity gradient were grown under four treatments spanning the 10th to the 90th percentiles of annual precipitation at two sites in central Texas:one site with deep,fine-textured soils and another site with shallow,coarse-textured *** measured volumetric soil water content(VWC),aboveground net primary productivity(ANPP),tiller pro-duction(tiller number),average tiller mass,canopy height,leaf area index(LAi)and flowering time on all plants at both sites and examined genotype responses to changes in *** Findings Across precipitation treatments,VWC was 39%lower and more variable at the site with shallow,coarse-textured soils compared to the site with deep,fine-textured *** averaged across genotypes and precipita-tion treatments was also 103%higher at the site with deep,fine-textured soils relative to the site with shallow,coarse-textured soils,indicating substantial differences in site water limitation.W

关键词： climate change Panicum virgatum phenology phenotypic plasticity precipitation

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主厨级烹饪神器

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商业周刊（中文版） 2017年第10期 83-85页

作者： Matthew Kronsberg Ryan lowry

在芝加哥西环地区的Aviary鸡尾酒吧，60岁的菲利普·普雷斯顿（philip Preston）靠在厨房墙上，在他周围，几个穿黑衣的调酒师正聚精会神地制作全美最新颖的几款鸡尾酒，他们头顶上的灯把房间照得和手术室一样明亮。

关键词：神器烹饪鸡尾酒芝加哥菲利普调酒师手术室酒吧

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