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Combined ab-interno trabeculectomy and cataract surgery induces comparable intraocular pressure reduction in supine and sitting positions

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International Journal of Ophthalmology(English edition) 2021年第8期14卷 1192-1198页

作者： Caroline Gietzelt david Kiessling Randolf AWidder Ludwig MHeindl Claus Cursiefen Thomas Sdietlein philip Enders department of Ophthalmology University of CologneFaculty of Medicine and University Hospital CologneKerpener Straße 62Cologne 50924Germany Glaucoma Imaging Center University of Cologne(GICC) Faculty of Medicine and University Hospital CologneKerpener Straße 62Cologne 50924Germany department of Ophthalmology St Martinus-Krankenhaus DuesseldorfGladbacher Straße 26Düsseldorf 40219Germany

AIM:To analyze the therapeutic effect of combined abinterno trabeculectomy and cataract surgery on intraocular pressure(IOP)levels in supine and sitting postures during a 24-hour IOP ***:Twenty-six eyes of twenty-six patients receiving ab-interno trabeculectomy using electroablation of the trabecular meshwork combined with cataract surgery or stand-alone were included in this retrospective *** change during 24-hour IOP profiles within two years postoperatively were analyzed for eyes receiving surgery(“study eyes”)and compared to fellow eyes,which had not received *** data including mean sitting IOP(siIOP),mean supine IOP(su IOP)and the number of topical antiglaucomatous medications(TAM)were extracted from patients’***:Preoperatively,si IOP was 17.6±5.3 mm Hg in study and 17.1±4.7 mm Hg in fellow eyes(P=0.347).Patients were treated with an average of 2.8±1.0 *** corrected visual acuity(BCVA)was significantly worse in study eyes(Pd function was marginally not significantly dif ferent(P=0.057).Af ter surger y 9.6±6.8 mo,study eyes had a mean si IOP of 14.5±3.6 mm Hg(IOP reduction:-3.2 mm Hg,P=0.009),a mean su IOP of 18.0±3.5 mm Hg,and an average of 1.3±1.34 TAM(Pd mean su IOP was 20.5±5.1 mm ***,the relative IOP increase between sitting and supine postures was approximately 30%in both study and fellow eyes(P=0.99).CONCLUSION:IOP after ab-interno trabeculectomy shows a comparable relative reduction in both supine and sitting *** trabeculectomy is known to lower su IOP overproportionally.

关键词： glaucoma ab-interno trabeculectomy supine intraocular pressure posture-induced intraocular pressure increase intraocular pressure

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硒的化学形式对人血中含硒组分的影响

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营养学报 1993年第2期15卷 157-162页

作者：夏弈明赵新娥周燕朱莲珍 philip d.Whanger 中国预防医学科学院营养与食品卫生研究所北京100050 美国俄勒冈州立大学

在低膳食硒地区的农村,对健康男性受试者进行了为期一年的补硒干预试验。所有受试者每天服硒200μg,以硒酸钠或硒蛋氨酸形式供给。血样分析结果表明,这两种形式的硒均能有效地提高低硒人体的谷胱甘肽过氧化物酶(GPx)活力,因而在预防克... 详细信息

在低膳食硒地区的农村,对健康男性受试者进行了为期一年的补硒干预试验。所有受试者每天服硒200μg,以硒酸钠或硒蛋氨酸形式供给。血样分析结果表明,这两种形式的硒均能有效地提高低硒人体的谷胱甘肽过氧化物酶(GPx)活力,因而在预防克山病工作中可采用较为经济的硒酸钠;但补硒蛋氨酸后可见“富裕”硒进入了红细胞的Hb和血浆的白蛋白中,而补硒酸钠后未见“富裕”硒,因而为提高人体硒营养水平,以补充硒蛋氨酸形式的硒为宜。

关键词：硒酸钠硒谷胱甘肽过氧化物酶

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Essentials of family medicine 4th ed.

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2002年

作者： [edited by] philip d. Sloane ... [et al.]

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ISBN: (纸本)078173391X

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关键词： Family medicine Family Practice

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Seasonal Rainfall Forecasts for the Yangtze River Basin of China in Summer 2019 from an Improved Climate Service

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Journal of Meteorological Research 2020年第5期34卷 904-916页

作者： philip E.BETT Nicola MARTIN Adam A.SCAIFE Nick dUNSTONE Gill M.MARTIN Nicola GOLdING Joanne CAMP Peiqun ZHANG Chris d.HEWITT Leon HERMANSON Chaofan LI Hong-Li REN Ying LIU Min LIU Met Office Hadley Centre Exeter EXI 3PBUK Plymouth Marine Laboratory Plymouth PL13DHUK College of Engineering Mathematics and Physical SciencesUniversity of ExeterDevon EX44QFUK Laboratory for Climate Studies National Climate CenterChina Meteorological AdministrationBeijing 100081China University of Southern Queensland Toowoomba QLD 4350Australia Center for Monsoon System Research Institute of Atmospheric PhysicsChinese Academy of SciencesBeijing 100029China Collaborative Innovation Center on Forecast and Evaluation of Meteorological disasters Nanjing University of Information Science&TechnologyNanjing 210044China Wuhan Regional Climate Center Wuhan 430074China

Rainfall forecasts for the summer monsoon season in the Yangtze River basin(YRB) allow decision-makers to plan for possible flooding, which can affect the lives and livelihoods of millions of people. A trial climate service was developed in 2016, producing a prototype seasonal forecast product for use by stakeholders in the region, based on rainfall forecasts directly from a dynamical model. Here, we describe an improved service based on a simple statistical downscaling approach. Through using dynamical forecast of an East Asian summer monsoon(EASM) index, seasonal mean rainfall for the upper and middle/lower reaches of YRB can be forecast separately by use of the statistical downscaling, with significant skills for lead times of up to at least three months. The skill in different sub-basin regions of YRB varies with the target season. The rainfall forecast skill in the middle/lower reaches of YRB is significant in May–June–July(MJJ), and the forecast skill for rainfall in the upper reaches of YRB is significant in June–July–August(JJA). The mean rainfall for the basin as a whole can be skillfully forecast in both MJJ and JJA. The forecasts issued in 2019 gave good guidance for the enhanced rainfall in the MJJ period and the near-average conditions in JJA. Initial feedback from users in the basin suggests that the improved forecasts better meet their needs and will enable more robust decision-making.

关键词： seasonal rainfall forecasts climate service Yangtze River basin(YRB) East Asian summer monsoon(EASM)

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BING: Binarized normed gradients for objectness estimation at 300fps

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Computational Visual Media 2019年第1期5卷 3-20页

作者： Ming-Ming Cheng Yun Liu Wen-Yan Lin Ziming Zhang Paul L.Rosin philip H.S.Torr CCS Nankai University Institute for Infocomm Research MERL Cambridge Cardiff University University of Oxford

Training a generic objectness measure to produce object proposals has recently become of significant interest. We observe that generic objects with well-defined closed boundaries can be detected by looking at the norm of gradients, with a suitable resizing of their corresponding image windows to a small fixed size. Based on this observation and computational reasons, we propose to resize the window to 8 × 8 and use the norm of the gradients as a simple 64 d feature to describe it, for explicitly training a generic objectness measure. We further show how the binarized version of this feature, namely binarized normed gradients(BING), can be used for efficient objectness estimation, which requires only a few atomic operations(e.g., add, bitwise shift, etc.). To improve localization quality of the proposals while maintaining efficiency, we propose a novel fast segmentation method and demonstrate its effectiveness for improving BING's localization performance, when used in multithresholding straddling expansion(MTSE) postprocessing. On the challenging PASCAL VOC2007 dataset, using 1000 proposals per image and intersectionover-union threshold of 0.5, our proposal method achieves a 95.6% object detection rate and 78.6% mean average best overlap in less than 0.005 second per image.

关键词： object proposals objectness visual attention category agnostic proposals

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Use of Synteny Conversion in Identification of Candidate Genes for Somitogenesis in Humans

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Open Journal of Orthopedics 2012年第2期2卷 62-68页

作者： philip F. Giampietro Cathy L. Raggio Robert d. Blank Hospital for Special Surgery New York USA University of Wisconsin Madison USA

Understanding the genetic component of scoliosis in humans has relied on the assumption that spine development is conserved across species. Since evolutionary conserved genes tend to lie within synteny blocks (HSBs) and genes which are not conserved lie within evolutionary breakpoint regions (EBRs), HSB analysis may be used to determine if spine development is conserved across species. We hypothesized that vertebral patterning genes are conserved in amniotes and their location is within stable or “syntenic” regions of chromosomes. Seventy seven patterning genes involved in Fgf, Wnt and Notch signaling pathways were analyzed to determine their location within HSBs or EBRs in the genomes of several amniotic species. The human genome was divided into 1 Mbp intervals and a comparison was made to determine whether these genes were preferentially localized within HSBs or EBRs associated with rapid evolution. The results indicate that genes associated with somite development in humans are preferentially located away from the EBRs: 0.014 genes in EBRs on genome average vs. 0.030 on average in other parts of the genome (p-value = 0.01). The concentration of vertebral patterning genes in HSBs, provides evidence that developmental pathways involved in vertebral morphogenesis are likely conserved across amniotes, consistent with their known function. These data support prior observations indicating that gene networks associated with major developmental processes such as neuronal, central nervous system, bone and blood vessel development, some mediated by Wnt and Notch signaling pathways, were less likely to be localized at EBRs.

关键词： Synteny Candidate Genes Vertebral Patterning Genes Congenital Scoliosis Idiopathic Scoliosis

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直接数码喷墨印花T恤衫的色牢度探讨

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纺织导报 2007年第11期 83-86页

作者： philip d.Age Jean K.dilworth Eastern Illinois大学

本项目的研究目的是比较5个服饰直接数码喷墨印花机制造商印制产品的色牢度。研究数据有助于帮助印花机制造商对其产品质量进行评估，在这之前还未有利用直接喷墨印花产品家用水洗色牢度来评价印花性能的研究。

关键词：数码喷墨印花色牢度 T恤衫喷墨印花机产品质量印花性能制造商印制

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Litter cover of the invasive tree <i>Melaleuca quinquenervia</i>influences seedling emergence and survival

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Open Journal of Ecology 2012年第3期2卷 131-140页

作者： Min B. Rayamajhi Paul d. Pratt philip W. Tipping Ted d. Center United States department of Agriculture Invasive Plant Research Laboratory Fort Lauderdale USA

Exotic tree Melaleuca quinquenervia (melaleuca) deposits large quantities of slowly decomposing litter biomass that accumulates over time and covers forest floors in its adventive habitats in Florida (USA). Herein, we assessed the influence of melaleuca litter cover, seed addition, and seeding date on seedling emergence and survival. The assessment was conducted by ma-nipulating litter cover and seed inputs of melaleuca and two native species at different dates in two soil types. Litter cover was either removed or left in place in organic and arenaceous soils within melaleuca stands. Each of the three treatment plots were seeded with melaleuca, wax myrtle or sawgrass, while the fourth plot was not seeded and served as the control. Seedlings were counted at 2-wk intervals to determine cumulative seedling emergence and survival during the experimental period. The experiment was repeated four times within a year. Soil type did not influence seedling emergence of all three species but influenced survival of wax myrtle. Litter removal increased the emergence of melaleuca, sawgrass, and wax myrtle and increased the survival of melaleuca. Seed addition increased the emergence and survival of sawgrass and wax myrtle but made no difference for melaleuca. Seeding during the periods of high soil moisture content had positive effects on the emergence and survival of melaleuca, wax myrtle, and sawgrass seedlings. These findings are deemed useful in planning active restoration for melaleuca invaded sites.

关键词： disturbance Exotic Tree Invasive Plant Leaf Litter Melaleuca Quinquenervia Seedling Emergence Seedling Survival

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Feasibility study of large-scale mass customization 3d printing framework system with a case study on Nanjing Happy Valley East Gate

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Frontiers of Architectural Research 2022年第4期11卷 670-680页

作者： philip F.Yuan Hooi Shan Beh Xuezhou Yang Liming Zhang Tianyi Gao College of Architecture and Urban Planning Tongji UniversityShanghaiChina Fab-Union Technology Co. LTDShanghaiChina

At present, the development and implementation of digital transformation are the keys to promoting high-quality industry development. The new digital fabrication method of robotic 3d printing is a research area being studied by many to tackle the issue of the declining productivity of traditional construction methods. Although many studies have been done, most of the current 3d printing projects are facing limitations in terms of scale. In order to bridge the gap, this article proposed a mass customization 3d printing framework system for large-scale projects. This article discusses how mass customization is made possible through the joint operation of the FUROBOT software and 3d printing hardware. By taking the east gate of Nanjing Happy Valley Plaza as a case study, the article demonstrates and studies the feasibility of the large-scale mass customization 3d printing framework system.

关键词： Mass customization 3d printing Hardware-software integration Human-machine collaboration digital fabrication

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Critically Ill COVId-19 Patient with Chronic Liver disease-Insights into a Comprehensive Liver Intensive Care

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Journal of Clinical and Translational Hepatology 2021年第4期9卷 576-586页

作者： Cyriac Abby philips Kamna Kakkar Moby Joseph Praveen Kumar Yerol Rizwan Ahamed Sasidharan Rajesh philip Augustine department of Clinical Hepatology The Liver InstituteCenter of Excellence in GI SciencesRajagiri HospitalChunangamvelyAluvaErnakulamKeralaIndia department of Pulmonary and Critical Care Medicine Pt.B.D.Sharma Post Graduate Institute of Medical SciencesRohtakHaryanaIndia Great Western Hospitals NHS Foundation TrustSwindonUnited Kingdom department of Gastroenterology State Government Medicine College and HospitalThrissurKeralaIndia Gastroenterology and Advanced G.I Endoscopy Center of Excellence in GI SciencesRajagiri HospitalChunangamvelyAluvaErnakulamKeralaIndia Interventional Hepatobiliary Radiology The Liver InstituteCenter of Excellence in GI SciencesRajagiri HospitalChunangamvelyAluvaErnakulamKeralaIndia

The novel coronavirus-related coronavirus disease 2019(COVId-19)pandemic has been relentless in disrupting and overwhelming healthcare the world *** outcomes of COVId-19 in patients with chronic comorbidities,especially in those with metabolic syndrome,are well *** liver disease and cirrhosis patients are a special subgroup,among whom the management of COVId-19 is *** the pathophysiology of COVId-19 in patients with cirrhosis and portal hypertension improves our identification of at-risk patients for disease progression that will further help compartmentalize generalized and specialized treatment options in this special patient *** this exhaustive review,we critically review the impact of COVId-19 on the liver and in chronic liver disease and cirrhosis *** further discuss common features associated with the pathophysiology of COVId-19 and cirrhosis,based on the renin-angiotensin system and deliberate current literature on guidelines for the treatment of COVId-19 and extrapolate the same to the cirrhosis population to provide a concise and stepwise,evidence-based management for cirrhosis patients with severe and critical *** are no specific management guidelines for cirrhosis patients with COVId-19 and current recommendations for treatment are as per guidelines for general ***,specific issues like avoiding corticosteroids in decompensated patients with variceal bleeding,suspected sepsis,high grade hepatic encephalopathy and acute kidney injury,use of early mechanical ventilation strategies in those with severe ascites and hepatopulmonary syndrome,avoidance of remdesivir in advanced liver disease,and application of liver-specific severity scores for prognostication and identification of futility need to be highlighted.

关键词： SARS-CoV-2 Coronavirus Pandemic ACLF decompensation Portal hypertension Sepsis

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