检索结果-南通市图书馆

Making d.ug d.scovery More Efficient Applying Statistical Entropy to Biology

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Mod.rn Physics 2020年第12期11卷 1969-1976页

作者： philip d. houck d.partment of Med.cine (d.vision of Card.ology) Baylor Scott & White Health Temple TX USA

Biology without governing principle makes pred.cations impossible. Observations lead.to some successful therapies, and.to unexpected.failures. Erwin Schröd.nger attempted.to quantify biology with the concept of negative entropy. These insights lead.to fund.mental principles of biologic entropy. The quantification of negative entropy is d.fficult to calculate since the number of parts of the bod. and.the way these parts are arranged.is very large (atomistic d.sord.r). There can be approximations that answer questions such as why females live longer, and.why a lower bod. temperature pred.cts longevity. This concept can reveal the culprit of d.abetes II;und.rstand.ng the microbiome can red.ce its entropy by increasing the entropy of its host. The real ad.antage of statistical entropy is find.ng new d.ugs and.pred.cting viral mutations based.on energetics and.negative entropy. The misfold.ng of a protein will increase the entropy of an ind.vid.al with the result of early d.ath. The calculations of biologic entropy require the knowled.e of each d.velopmental step, and.the statistical possibilities of the next step. If the step is crucial to maintain low entropy, a carrier protein will assure the energetics of the step is favorable. This protein is the target of new therapies.

关键词： Negative Entropy Quantification of Biology Carrier Proteins d.ug d.velopment

MicroRNAs as potential d.agnostic biomarkers for bipolar d.sord.r

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第6期20卷 1681-1695页

作者： Brid.et Martinez philip V.Peplow d.partment of Pharmacology University of Nevada-RenoRenoNVUSA d.partment of Med.cine University of Nevada-RenoRenoNVUSA d.partment of Anatomy University of OtagoDunedinNew Zealand

Abnormal expression of microRNAs is connected.to brain d.velopment and.d.sease and.could.provid. novel biomarkers for the d.agnosis and.prognosis of bipolar d.sord.r. We performed.a PubMed.search for microRNA biomarkers in bipolar d.sord.r and.found.18 original research articles on stud.es performed.with human patients and.published.from January 2011 to June 2023. These stud.es includ.d.microRNA profiling in blood.nd.brain-based.materials. From the stud.es that had.valid.ted.the preliminary find.ngs,potential cand.d.te biomarkers for bipolar d.sord.r in ad.lts could.be miR-140-3p,-30d.5p,-330-5p,-378a-5p,-21-3p,-330-3p,-345-5p in whole blood. miR-19b-3p,-1180-3p,-125a-5p, let-7e-5p in blood.plasma, and.miR-7-5p,-23b-5p,-142-3p,-221-5p,-370-3p in the blood.serum. Two of the stud.es had.investigated.the changes in microRNA expression of patients with bipolar d.sord.r receiving treatment. One showed.a significant increase in plasma miR-134 compared.to baseline after 4 weeks of treatment which includ.d.typical antipsychotics, atypical antipsychotics, and.benzod.azepines. The other stud. had.assessed.the effects of prescribed.med.cations which includ.d.neurotransmitter receptorsite bind.rs(d.ug class B) and.sed.tives, hypnotics, anticonvulsants, and.analgesics(d.ug class C) on microRNA results. The combined.effects of the two d.ug classes increased.the significance of the results for miR-219 and.29c with miR-30e-3p and.526b* acquiring significance. MicroRNAs were tested.to see if they could.serve as biomarkers of bipolar d.sord.r at d.fferent clinical states of mania, d.pression, and.euthymia. One stud. showed.that upregulation in whole blood.of miR-9-5p,-29a-3p,-106a-5p,-106b-5p,-107,-125a-3p,-125b-5p and.of miR-107,-125a-3p occurred.in manic and.euthymic patients compared.to controls, respectively, and.that upregulation of miR-106a-5p,-107 was found.for manic compared.to euthymic patients. In two other stud.es using blood.plasma,d.wnregulation of miR-134 was observed.i

关键词： biomarker bipolar d.sord.r blood.leukocytes blood.plasma blood.plasma extracellular vesicles/exosomes blood.serum brain tissue brain tissue extracellular vesicles/exosomes lymphoblastoid.cell lines microRNA neural progenitor cells whole blood

Autism spectrum d.sord.r:d.fficulties in d.agnosis and.microRNA biomarkers

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第10期20卷 2776-2786页

We performed.a PubMed.search for microRNAs in autism spectrum d.sord.r that could.serve as d.agnostic biomarkers in patients and.selected.17 articles published.from January 2008 to d.cember 2023,of which 4 stud.es were performed.with whole blood.4 with blood.plasma,5 with blood.serum,1 with serum neural cell ad.esion molecule L1-captured.extracellular vesicles,1 with blood.cells,and.2 with peripheral blood.mononuclear *** of the stud.es involved.child.en and.the stud. cohorts were largely *** of the stud.es had.performed.microRNA sequencing or quantitative polymerase chain reaction assays to measure microRNA *** five stud.es had.used.real-time polymerase chain reaction assay to valid.te microRNA expression in autism spectrum d.sord.r subjects compared.to *** microRNAs that were valid.ted.in these stud.es may be consid.red.as potential cand.d.te biomarkers for autism spectrum d.sord.r and.includ. miR-500a-5p,-197-5p,-424-5p,-664a-3p,-365a-3p,-619-5p,-664a-3p,-3135a,-328-3p,and.500a-5p in blood.plasma and.miR-151a-3p,-181b-5p,-320a,-328,-433,-489,-572,-663a,-101-3p,-106b-5p,-19b-3p,-195-5p,and.130a-3p in blood.serum of child.en,and.miR-15b-5p and.6126 in whole blood.of *** important limitations were id.ntified.in the stud.es reviewed.and.need.to be taken into account in future *** stud.es are warranted.with child.en and.ad.lts having d.fferent levels of autism spectrum d.sord.r severity and.consid.ration should.be given to using animal mod.ls of autism spectrum d.sord.r to investigate the effects of suppressing or overexpressing specific microRNAs as a novel therapy.

关键词： autism spectrum d.sord.r biomarker blood.cells blood.plasma blood.serum d.agnosis microRNA peripheral blood.mononuclear cells serum neural cell ad.esion molecule L1-captured.extracellular vesicles whole blood

MicroRNAs as potential biomarkers for d.agnosis of post-traumatic stress d.sord.r

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第7期20卷 1957-1970页

Post-traumatic stress d.sord.r is a mental d.sord.r caused.by exposure to severe traumatic life ***,there are no valid.ted.biomarkers or laboratory tests that can d.stinguish between trauma survivors with and.without post-traumatic stress *** ad.ition,the heterogeneity of clinical presentations of post-traumatic stress d.sord.r and.the overlap of symptoms with other cond.tions can lead.to misd.agnosis and.inappropriate *** suggests that this cond.tion is a multisystem d.sord.r that affects many biological systems,raising the possibility that peripheral markers of d.sease may be used.to d.agnose post-traumatic stress *** performed.a PubMed.search for microRNAs(miRNAs)in post-traumatic stress d.sord.r(PTSd.that could.serve as d.agnostic biomarkers and.found.18 original research articles on stud.es performed.with human patients and.published.January 2012 to d.cember *** includ.d.four stud.es with whole blood.seven with peripheral blood.mononuclear cells,four with plasma extracellular vesicles/exosomes,and.one with serum *** of these stud.es had.also used.whole *** stud.es were exclud.d.as they d.d.not involve microRNA *** of the stud.es had.collected.samples from ad.lt male Veterans who had.returned.from d.ployment and.been exposed.to combat,and.only two were from recently traumatized.ad.lt *** measuring miRNA expression levels,many of the stud.es had.used.microarray miRNA analysis,miRNA Seq analysis,or NanoString *** six stud.es had.used.real time polymerase chain reaction assay to d.termine/valid.te miRNA expression in PTSd.subjects compared.to *** miRNAs that were found.valid.ted.in these stud.es may be consid.red.as potential cand.d.te biomarkers for PTSd.and.includ. miR-3130-5p in whole blood.miR-193a-5p,-7113-5p,-125a,-181c,and.671-5p in peripheral blood.mononuclear cells;miR-10b-5p,-203a-3p,-4488,-502-3p,-874-3p,-5100,and.7641 in plasma extracellular vesicles/

关键词： biomarker d.agnosis microRNA peripheral blood.mononuclear cells plasma extracellular vesicles/exosomes post-traumatic stress d.sord.r serum exosomes whole blood whole plasma

Array processing-a new method.to d.tect and.correct errors on array resistivity logging tool measurements

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of Oceanology and.Limnology 2007年第1期25卷 51-58页

作者： philip d. RABINOWITZ Zhiqiang ZHOU d.partment of Geology and.Geophysics Texas A＆M University College Station Texas USA

In recent years more and.more multi-array logging tools, such as the array ind.ction and.the array lateralog, are applied.in place of conventional logging tools resulting in increased.resolution, better rad.al and.vertical sound.ng capability and.other features. Multi-array logging tools acquire several times more ind.vid.al measurements than conventional logging tools. In ad.ition to new information contained.in these d.ta, there is a certain red.nd.ncy among the measurements. The sum of the measurements actually composes a large matrix. Provid.ng the measurements are error-free, the elements of this matrix show certain consistencies. Taking ad.antage of these consistencies, an innovative method.is d.veloped.to d.tect and.correct errors in the array resistivity logging tool raw measurements, and.evaluate the quality of the d.ta. The method.can be d.scribed.in several steps. First, d.ta consistency patterns are id.ntified.based.on the physics of the measurements. Second. the measurements are compared.against the consistency patterns for error and.bad.d.ta d.tection. Third. the erroneous d.ta are eliminated.and.the measurements are re-constructed.accord.ng to the consistency patterns. Finally, the d.ta quality is evaluated.by comparing the raw measurements with the re-constructed.measurements. The method.can be applied.to all array type logging tools, such as array ind.ction tool and.array resistivity tool. This paper d.scribes the method.and.illustrates its application with the High d.finition Lateral Log （Hd.L, Baker Atlas） instrument. To d.monstrate the efficiency of the method. several field.examples are shown and.d.scussed.

关键词： array processing array resistivity logging tool error

Pand.mic Policymaking

在线全文

学校读者我要写书评

暂无评论

Journal of Social Computing 2021年第1期2卷 14-26页

作者： philip d.Waggoner niversity of Chicago ChicagoIL 60637USAand also with Columbia UniversityNew YorkNY 10027USA.

This stud. leverages a high d.mensional manifold.learning d.sign to explore the latent structure of the pand.mic policymaking space only based.on bill-level characteristics of pand.mic-focused.bills from 1973 to *** ind.cate the COVId.19 era of policymaking maps extremely closely onto prior period. of related.*** suggests that there is striking uniformity in Congressional policymaking related.to these types of large-scale crises over time,d.spite currently operating in a unique era of hyperpolarization,d.vision,and.ineffective governance.

关键词： manifold.learning computational social science congress policymaking COVId.19

Verification of the 2019 GloSea5 Seasonal Tropical Cyclone Land.all Forecast for East China

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Meteorological Research 2020年第5期34卷 917-925页

作者： Joanne CAMP philip E.BETT Nicola GOLd.NG Chris d.HEWITT Timothy d.MITCHELL Ad.m A.SCAIFE Met Office Had.ey Centre Exeter EX 13PBUK University of Southern Queensland Toowoomba QLD 4350Australia College of Engineering Mathematics and Physical SciencesUniversity of ExeterDevon EX44QFUK

A prototype climate service was d.veloped.and.trialled.in early 2019 to provid. seasonal forecast of the June–July–August(JJA) tropical cyclone(TC) land.all risk for the East China region ahead.of the forthcoming typhoon *** forecasts were prod.ced.in both March and.April 2019 and.a final forecast was released.to the China Meteorological Ad.inistration(CMA) on 1 May 2019. The trial service was prod.ced.by using the Met Office Global Seasonal forecast system(GloSea5), and.a forecast of the western Pacific subtropical high(WPSH) ind.x was used.to infer the TC land.all risk based.on a simple linear regression between historical mod.l WPSH ind.ces and.observed.TC land.alls in East China. The forecast method.shows significant skill for forecasting the JJA TC land.all risk in East China with up to three-month lead.time, with the greatest skill for pred.ctions initialized.in May. The 2019 forecast provid.d.good.guid.nce of the near-average TC activity observed.in East China in JJA 2019. Success of the forecast ad.s confid.nce to an improved.climate service ahead.of the 2020 typhoon season.

关键词： seasonal forecasting typhoons tropical cyclones(TCs) land.all risk East China western Pacific subtropical high(WPSH)

d.agnosis and.treatment of d.abetes mellitus in chronic pancreatitis

在线全文

学校读者我要写书评

暂无评论

World.Journal of Gastroenterology 2013年第42期19卷 7276-7281页

作者： Nils Ewald.philip d.Hard. Justus-Liebig-University Giessen 35392 GiessenGermany d.partment of Internal Med.cine General Hospital Luebbecke-Rahden32312 LuebbeckeGermany

d.abetes second.ry to pancreatic d.seases is commonly referred.to as pancreatogenic d.abetes or type 3c d.abetes *** is a clinically relevant cond.tion with a prevalence of 5%-10%among all d.abetic subjects in Western *** nearly 80%of all type 3c d.abetes mellitus cases,chronic pancreatitis seems to be the und.rlying *** prevalence and.clinical importance of d.abetes second.ry to chronic pancreatitis has certainly been und.restimated.and.und.rappreciated.so *** contrast to the management of type 1 or type2 d.abetes mellitus,the end.crinopathy in type 3c is very *** course of the d.sease is complicated.by ad.itional present comorbid.ties such as mald.gestion and.concomitant qualitative *** awareness that patients with known and.or clinically overt chronic pancreatitis will d.velop type 3c d.abetes mellitus(up to 90%of all cases)is rather ***,in a patient first presenting with d.abetes mellitus,chronic pancreatitis as a potential causative cond.tion is seld.m *** many patients are *** failure to correctly d.agnose type 3 d.abetes mellitus lead. to a failure to implement an appropriate med.cal *** patients with type 3c d.abetes mellitus treating exocrine pancreatic insufficiency,preventing or treating a lack of fat-soluble vitamins(especially vitamin d.and.restoring impaired.fat hyd.olysis and.incretin secretion are key-features of med.cal therapy.

关键词： d.abetes mellitus Chronic pancreatitis Type 3c d.abetes Pancreatogenic d.abetes Pancreatitis

A Multigrid.Method.for a Mod.l of the Implicit Immersed.Bound.ry Equations

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Communications in Computational Physics 2012年第7期12卷 378-400页

作者： Robert d.Guy Bobby philip d.partment of Mathematics University of California DavisDavisCA 95616USA Oak Rid.e National Laboratory Oak RidgeTN 37831USA

Explicit time stepping schemes for the immersed.bound.ry method.require very small time steps in ord.r to maintain *** the equations that arise from an implicit d.scretization is ***,several d.fferent approaches have been proposed.but a complete und.rstand.ng of this problem is still emerging.A multigrid.method.is d.veloped.and.explored.for solving the equations in an implicittime d.scretization of a mod.l of the immersed.bound.ry *** mod.l problem consists of a scalar Poisson equation with conformation-d.pend.nt singular forces on an immersed.*** mod.l d.es not includ. the inertial terms or the incompressibility *** method.is more efficient than an explicit method.but the efficiency gain is *** multigrid.method.alone may not be an effective solver,but when used.as a precond.tioner for Krylov method.,the speed.up over the explicit-time method.is *** example,d.pend.ng on the constitutive law for the bound.ry force,with a time step 100 times larger than the explicit method.the implicit method.is about 15-100 times more efficient than the explicit method.A very attractive feature of this method.is that the efficiency of the multigrid.precond.tioned.Krylov solver is shown to be ind.pend.nt of the number of immersed.bound.ry points.

关键词： Precond.tioning implicit method. fluid.structure interaction