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Further-Adjusted Long-Term Temperature Series in China Based on MASH

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Advances in Atmospheric Sciences 2018年第8期35卷 13-21页

作者： Zhen LI Zhongwei YAN Lijuan CAO phil d. jones Key Laboratory of Regional Climate-Environment in Temperate East Asia Institute of Atmospheric Physics Beijing 100029 China University of the Chinese Academy of Sciences Beijing 100049 China National Meteorological Information Center China Meteorological Administration Beijing 100081 China Climatic Research Unit University of East Anglia Norwich Norfolk NR4 7TJ United Kingdom Center of Excellence for Climate Change Research/department of Meteorology King Abdulaziz University Jeddah 21589 Saudi Arabia

A set of homogenized monthly mean surface air temperature （SAT） series at 32 stations in China back to the 19th century had previously been developed based on the RHtest method by Cao et al., but some inhomogeneities remained in the dataset. The present study produces a further-adjusted and updated dataset based on the Multiple Analysis of Series for Homogenization （MASH） method. The MASH procedure detects 33 monthly temperature records as erroneous outliers and 152 meaningful break points in the monthly SAT series since 1924 at 28 stations. The inhomogeneous parts are then adjusted relative to the latest homogeneous part of the series. The new data show significant warming trends during 1924-2016 at all the stations, ranging from 0.48 to 3.57℃ （100 yr）^-1, with a regional mean trend of 1.65℃ （100 yr）^-1 ; whereas, the previous results ranged from a slight cooling at two stations to considerable warming, up to 4.5℃ （100 yr）^-1. It is suggested that the further-adjusted data are a better representation of the large-scale pattern of climate change in the region for the past century. The new data axe available online at http：//***/10.11922/sciencedb.516.

关键词： homogenization Multiple Analysis of series for homogenization (MASH) monthly temperature series long-term trend China

The Use of Far Infrared Treatment Prior to Exercise in Horses: An mfBIA and Acoustic Myography Three Case Study

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Open Journal of Veterinary Medicine 2024年第4期14卷 69-89页

作者： Adrian Harrison d.phil department for Veterinary and Animal Sciences (IVH) Faculty of Health & Medical Sciences University of Copenhagen K&#248benhavn Denmark

Background: Acute effects of Far Infrared (FIR) treatment in horses are unknown, especially short periods of 30 minutes, as is any effect on such muscle parameters as warm-up balance, overall exercise balance and laterality asymmetries. Aim: This study examines three equine cases in detail to measure any effects of a short period of FIR treatment. Methods: Multi-frequency bioimpedance (mfBIA) and acoustic myography (AMG), non-invasive techniques, were applied pre- and post-treatment with FIR to the back (T5-L4/5) and for *** dorsi and *** medius was recorded during a 15-minute warm-up regimen. mfBIA parameters included extracellular resistance (Re), centre frequency (fc), membrane capacitance (Mc), intracellular resistance (Ri) and phase angle (PA) which indicates level of training and health status. Results: FIR treatment responses for mfBIA parameters were found to be horse-specific and different, whilst in terms of AMG, FIR treatment for 30 minutes had a beneficial effect on overall balance in all three horses (5 out of 6 muscles), and a beneficial effect on the AMG parameter ST (force symmetry) in all three horses (6 out of 6 muscles). An overall improvement for combined balance and ST values for both muscles and all three horses of 86% was noted with FIR treatment, compared to 56% without. Conclusions: This preliminary study of FIR treatment in three horses, has been found to result in an overall improvement in combined balance and ST values for both muscles. FIR has potential as a promising treatment to reduce the risk of warm-up-related injuries in athletic horses.

关键词： Equine FIR Muscle Balance Muscle Force Injury Prevention

从全球地表平均温度时间序列中识别自然气候变率信号

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沙漠与绿洲气象 2010年第5期4卷 61-62页

作者： david W J Thompson John M Wallace phil d jones John J Kenndhy 尹仔锋

全球表面平均温度受到自然变率和人为强迫两方面影响。本文研究有关1900年1月—2009年3月全球平均温度时间序列即自然气候变率中的信号鉴别和剔除问题,研发了一系列简单的、基于物理学的方法,并将其应用于区分厄尔尼诺—南方涛动（ENSO... 详细信息

全球表面平均温度受到自然变率和人为强迫两方面影响。本文研究有关1900年1月—2009年3月全球平均温度时间序列即自然气候变率中的信号鉴别和剔除问题,研发了一系列简单的、基于物理学的方法,并将其应用于区分厄尔尼诺—南方涛动（ENSO）,高纬度大陆冬季海洋气团平流变化和由火山爆发导致的大量气溶胶进入平流层这三种自然现象对气候的影响。在ENSO和高纬度温度平流的作用从全球平均温度的记录中剔除之后,显示于仪表的火山爆发及其变化的信号变得更加显而易见。随后火山爆发的影响就从记录中过滤掉,而剩下的时间序列则显示出自1950年以来全球气温几乎是一个单调的递增模式。结果还揭示,年际时间尺度海陆耦合的影响超过了ENSO和火山爆发。一般而言,全球陆地和海洋平均温度的情况紧密地同海洋气团主导陆地的那2~3个月相关。大西洋海面温度大振幅的扰动使这些耦合波动呈现为一个复杂的空间信号。

关键词：表面平均温度气候变率自然现象时间序列信号鉴别火山爆发识别地表

Relating estimates of wood properties of birch to stem form, age and species

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Journal of Forestry Research 2024年第3期35卷 1-11页

作者： Grace jones Maria Ulan Mateusz Liziniewicz Johan Lindeberg Stergios Adamopoulos Teagasc Forestry development department Ashtown Research CentreDublin 15 D15DY05Ireland Research Institutes of Sweden(RISE) GoteborgSweden The Forest Research Institute of Sweden(Skogforsk) Ekebo 225026890SvalovSweden department of Forestry and Wood Technology Linnaeus University35195VaxjoSweden department of Forest Biomaterials and Technology Swedish University of Agricultural SciencesBox 700875007 UppsalaSweden

Birch has long suffered from a lack of active forest management,leading many researchers to use mate-rial without a detailed management *** collected from three birch(Betula pendula Roth,*** Ehrh.)sites in southern Sweden were analyzed using regression analysis to detect any trends or differences in wood proper-ties that could be explained by stand history,tree age and stem *** sites were genetics trials established in the same *** of acoustic velocity(AV)from non-destructive testing(NdT)and predicted AV had a higher correlation if data was pooled across sites and other stem form factors were considered.A subsample of stems had radial profiles of X-ray wood density and ring width by year created,and wood density was related to ring number from the pith and ring *** seemed likely that wood density was negatively related to ring width for both birch *** models had slight improvements if site and species were included,but only the youngest site with trees at age 15 had both birch *** paper indicated that NdT values need to be considered separately,and any predictive models will likely be improved if they are specific to the site and birch species measured.

关键词： Acoustic velocity Non-destructive testing Predictive models Regression analysis Wood density

A phase Ⅰ study of Hemay022, an irreversible dual EGFR/HER2 tyrosine kinase inhibitor in Chinese patients with HER2-positive advanced breast cancer

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Chinese Journal of Cancer Research 2024年第1期36卷 46-54页

作者： Pin Zhang Lin Wang Yueying Zhen Zhihong Wang Hesheng Zhang Richard jones Binghe Xu department of Medical Oncology National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China Tianjin Hemay Pharmaceutical Co. LTDTianjin 300308China

Objective: Hemay022 is a novel small-molecule and an irreversible tyrosine kinase inhibitor with the target of epidermal growth factor receptor(EGFR)/human epidermal growth factor receptor 2(HER2), which demonstrated anti-tumor activity in preclinical studies. This first-in-human study evaluated the safety, pharmacokinetics,tolerability and preliminary anti-tumor activity of Hemay022 in HER2-positive advanced breast cancer ***: Heavily pretreated patients with HER2-positive advanced breast cancer were assigned to eight dose cohorts in a 3+3 dose-escalation pattern at doses of 50-600 mg Qd and 300 mg BId. Eligible patients were given a single dose of Hemay022 on d 1 in week 0, followed by once daily continuous doses for four weeks in 28-day *** samples were obtained on d 1 and d 28. Clinical responses were assessed every eight ***: Twenty-eight patients with advanced breast cancer were treated with Hemay022. The most frequently reported drug-related adverse events were diarrhoea(85.7%), vomiting(28.6%), nausea(25.0%) and decreased appetite(17.9%). No grade 4 drug-related adverse events were reported. At 50-600 mg doses, steady state areas under the concentration-time curve and peak concentrations increased with doses. One patient achieved complete response(CR), and three achieved partial response(PR). The objective response rate(ORR) and disease control rate(dCR) were 14.3% and 46.4% in 28 patients, respectively. The median progression-free survival(PFS) was3.98 ***: Hemay022 at the dose of 500 mg once daily was well tolerated. The pharmacokinetic properties and encouraging anti-tumor activities of Hemay022 in advanced breast cancer patients warranted further evaluation of Hemay022 for treating breast cancer patients in the current phase Ⅲ trial(No. NCT05122494).

关键词： Advanced breast cancer HER2-positive Hemay022 first-in-human trial

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霜冻时的热泵

科技纵览 2024年第5期 16-17页

作者： Willie d.jones 不详

有批评意见认为,空气源热泵为房屋供暖的能力会在温度降到4℃以下时下降。不过,8家领先的热泵制造商表示,他们已经开发出了能够在室外严寒中保持室内温暖舒适的热泵。通过参加由美国能源部与加拿大自然资源部合作主办的住宅寒冷气候热... 详细信息

有批评意见认为,空气源热泵为房屋供暖的能力会在温度降到4℃以下时下降。不过,8家领先的热泵制造商表示,他们已经开发出了能够在室外严寒中保持室内温暖舒适的热泵。通过参加由美国能源部与加拿大自然资源部合作主办的住宅寒冷气候热泵挑战赛(Residential ColdClimate Heat Pump Challenge),他们正在证明这一点。参赛公司之一的特灵科技公司在美国得克萨斯州泰勒的冷藏室测试了其热泵。在实验室测试中,有些原型机能够经受住低至-30℃的温度,之后这些原型机在美国北部十个州和加拿大两个省的些家庭中经受着严寒环境的考验。

关键词：空气源热泵美国能源部批评意见实验室测试寒冷气候自然资源部

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机械巨星

科技纵览 2024年第4期 14-15页

作者： WILLIE d.jones 不详

2023年末,位于美国亚特兰大的乔治亚理工大学的研究人员发布了一个机器人表演雕塑作品,他们将其命名为美杜莎.它以神话中的蛇发女怪美杜莎为原型,美杜莎将所有看着她的人都变成了石头.该机器人有着蛇形机械臂,可以同时演奏打击乐和弦乐... 详细信息

2023年末,位于美国亚特兰大的乔治亚理工大学的研究人员发布了一个机器人表演雕塑作品,他们将其命名为美杜莎.它以神话中的蛇发女怪美杜莎为原型,美杜莎将所有看着她的人都变成了石头.该机器人有着蛇形机械臂,可以同时演奏打击乐和弦乐,并可与观众互动"跳舞".乔治亚理工大学音乐技术中心教授吉尔·温伯格(Gil Weinberg)是美杜莎团队的负责人,他解释道:"这件作品一方面揭示了由人工智能驱动的机器蛇跟踪和威胁人类的怪异概念,另一方面激发了人类突破创造力和表达极限的潜力;这两者在作品中达到了完美的平衡."

关键词：美国亚特兰大人工智能雕塑作品温伯格观众互动美杜莎机械臂理工大学

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城市模型制作

科技纵览 2024年第6期 14-15页

作者： Wilie d.jones 不详

德国慕尼黑联邦国防军大学的研究人员开发了一种深度学习系统,可利用卫星发射的合成孔径雷达(SAR)信号生成2d图像来生成城市的3d地形图。研究人员还使用相同城市的机载激光雷达或立体摄像机图像对其SAR2Height算法进行了训练,该算法能... 详细信息

德国慕尼黑联邦国防军大学的研究人员开发了一种深度学习系统,可利用卫星发射的合成孔径雷达(SAR)信号生成2d图像来生成城市的3d地形图。研究人员还使用相同城市的机载激光雷达或立体摄像机图像对其SAR2Height算法进行了训练,该算法能够渣染3d城市景观(比如慕尼黑的3d地形图),其建筑高度精确到了3米。

关键词：机载激光雷达信号生成模型制作立体摄像机深度学习卫星发射联邦国防军城市景观

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鼠眼视角

科技纵览 2024年第3期 16-17页

作者： Willie d.jones 不详

在自然界中,很多动物没有第二次尝试的机会。啮齿动物等小型生物提升躲避捕食者技巧的同时,也丧失了安全的栖息空间。不过,位于伊利诺伊州埃文斯顿的美国西北大学的研究人员开发了适合小鼠大小的虚拟现实护目镜,可以让实验室里的小动物... 详细信息

在自然界中,很多动物没有第二次尝试的机会。啮齿动物等小型生物提升躲避捕食者技巧的同时,也丧失了安全的栖息空间。不过,位于伊利诺伊州埃文斯顿的美国西北大学的研究人员开发了适合小鼠大小的虚拟现实护目镜,可以让实验室里的小动物在没有被猫头鹰吃掉的实际威胁时获得生死攸关的体验。这些虚拟现实实验也对人类有益。

关键词：伊利诺伊州虚拟现实美国西北大学埃文斯护目镜啮齿动物猫头鹰捕食者