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Phytoconstituents Profiling of Indigenous Herbal Drugs and Its in vitro microbial,in Silico Biological Examination against Severe Acute Respiratory Syndrome coronavirus 2

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World Journal of traditional chinese medicine 2024年第1期10卷 121-136页

作者： t.H.mohamed Ahadu Shareef mmohamed Divan masood Irfan Navabshan mSaiyad musthafa Department of chemistry The New College(Autonomous)Affiliated to the University of MadrasChennaiTamil NaduIndia School of computer Applications B.S.Abdur Rahman Crescent Institute of Science and TechnologyChennaiTamil NaduIndia crescent School of Pharmacy B.S.Abdur Rahman Crescent Institute of Science and TechnologyChennaiTamil NaduIndia Department of Zoology The New College(Autonomous)Affiliated to the University of MadrasChennaiTamil NaduIndia

Background:Habb-E-Shifa,Hamdard Sualin,and Hamdard Joshanda traditional herbal medicines may promote host resistance against infection by bacteria,viruses,and fungi which are easily accessible at inexpensive with no *** herbal medicines are used to cure sore throat,cough,fever,lung cancer,and asthma patients in developing South Asian *** traditional herbal medicines acted a crucial role in the prevention and control of coronavirus disease 2019(cOVID-19).Aims and Objectives:this research article aimed at conducting phytochemistry,antimicrobial activity,cOVID-19 docking and some spectroscopic(Infrared,Ultraviolet,13c-Nuclear magnetic Resonance(13c-NmR),1H-NmR,and mass Spectra)characterizations of the polyherbal drugs were carried ***,In-vitro and In-silico analyses were performed to measure activity against *** Performance-Liquid chromatography(HPLc),Gas chromatography-mass Spectrometry(Gc-mS),antimicrobial,and docking studies were carried *** preliminary phytochemical assay and bioactive compounds were screened using HPLc and *** study is an attempt to assess the promising effects of selected polyherbal indigenous drugs such as Habb-E-Shifa,Hamdard Sualin,and Hamdard Joshanda phytoconstituents against the severe acute respiratory syndrome coronavirus-2(SARS-co V-2).materials and methods:the extract of the selected polyherbal formulations showed high-to-moderate preventive effects on the growth inhibition in the pathogenic bacterium,namely Streptococcus oralis,Staphylococcus aureus,Propionibacterium acnes,Pseudomonas aeruginosa,Escherichia coli,and Proteus vulgaris,and three fungal candida albicans,Aspergillus fumigatus,and Aspergillus *** docking study evaluates the pharmacological activity of bioactive chemical compounds with SARS-co V-2 NSP5(PDB ID:7nxh)and SARS-co V-2 Omicron spike protein with human angiotensin-converting enzyme 2(AcE-2)(PDB ID:7wk6).Results:In this study,for the first time,we at

关键词： Antimicrobial herbal drug Omicron and coronavirus disease 2019 phytochemicals spectroscopic

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climate-influenced vector-borne diseases in Africa: a call to empower the next generation of African researchers for sustainable solutions

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贫困所致传染病(英文) 2024年第2期13卷 83-92页

作者： Obame-Nkoghe Judica?l Agossou Adjoavi Esse mboowa Gerald Kamgang Basile caminade cyril Duke Dawn c. Githeko Andrew Karanja Ogega Obed m. Elloué Nestor Engone Sarr Fatou Bintou Nkoghe Dieudonné Kengne Pierre Ndam Nicaise t. Paupy christophe Bockarie moses Otomo Patricks Voua molecular and cellular Biology Laboratory (Labmc) Biology Department University of Science and Technology of Masuku BP Franceville Gabon Ecology and Health Research Unit Interdisciplinary Center for Medical Research of Franceville BP Franceville Gabon Department of Zoology and Entomology Faculty of Natural and Agricultural Sciences University of the Free State Private Bag x13 Phuthaditjhaba Republic of South Africa Laboratory of Pharmacology and Improved traditional medicines Department of Animal Physiology Faculty of Science and Technology University of Abomey-Calavi BP Cotonou Benin the African center of Excellence in Bioinformatics and Data-Intensive Sciences Infectious Diseases Institute College of Health Sciences Makerere University P. O Box Kampala Uganda Africa centers for Disease control and Prevention African Union Commission Roosevelt Street P.O. Box WKAddis Ababa Ethiopia centre for Research in Infectious Diseases P.O. Box Yaoundé Cameroon Earth System Physics Department The Abdus Salam International Centre for Theoretical Physics Trieste Italy Africa Research Excellence Fund Charterhouse Street London EC1MHR UK community Health Support Program P.O. Box Kisumu Kenya the African Academy of Sciences Nairobi Kenya center for Phylosophical Studies and Research (cERP) Omar Bongo University (UOB) BP Libreville Gabon UmRED Health Training and Research Unit University of Iba Der Thiam of Thiès BP Thiès Senegal National Parasitic Diseases control Program Ministry of Health Libreville Gabon mIVEGEc Univ. Montpellier CNRS IRD Montpellier France mERIt IRD Paris Cité University Paris France Department of Parasitology Noguchi Memorial Institute for Medical Research University of Ghana LG Accra Ghana School of community Health Sciences Njala University Bo Sierra Leone

We look at the link between climate change and vector-borne diseases in low- and middle-income countries in Africa. the large endemicity and escalating threat of diseases such as malaria and arboviral diseases, intensified by climate change, disproportionately affects vulnerable communities globally. We highlight the urgency of prioritizing research and development, advocating for robust scientific inquiry to promote adaptation strategies, and the vital role that the next generation of African research leaders will play in addressing these challenges. Despite significant challenges such as funding shortages within countries, various pan-African-oriented funding bodies such as the African Academy of Sciences, the Africa Research Excellence Fund, the Wellcome trust, the U.S. National Institutes of Health, and the Bill and melinda Gates Foundation as well as initiatives such as the African Research Initiative for Scientific Excellence and the Pan-African mosquito control Association, have empowered (or are empowering) these researchers by supporting capacity building activities, including continental and global networking, skill development, mentoring, and African-led research. this article underscores the urgency of increased national investment in research, proposing the establishment of research government agencies to drive evidence-based interventions. collaboration between governments and scientific communities, sustained by pan-African funding bodies, is crucial. through these efforts, African nations are likely to enhance the resilience and adaptive capacity of their systems and communities by navigating these challenges effectively, fostering scientific excellence and implementing transformative solutions against climate-sensitive vector-borne diseases.

关键词： climate change Vector-borne diseases Africa Environmental justice Research and development Pan-African funding initiatives

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In vivo measurement of NADH fluorescence lifetime in skeletal muscle via -ber-coupled time-correlated single photon counting

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Journal of Innovative Optical Health Sciences 2024年第1期17卷 121-134页

作者： Kathryn m.Priest Jacob V.Schluns Nathania Nischal colton L.Gattis Jeffrey c.Wolchok timothy J.muldoon Department of Biomedical Engineering University of Arkansas FayettevilleARUSA

Nicotinamide adenine dinucleotide(NADH)is a cofactor that serves to shuttle electrons during metabolic processes such as glycolysis,the tricarboxylic acid cycle,and oxidative phosphorylation(OXPHOS).NADH is autofluorescent,and itsfluorescence lifetime can be used to infer metabolic dynamics in living ***-coupled time-correlated single photon counting(tcSPc)equipped with an implantable needle probe can be used to measure NADH lifetime in vivo,enabling investigation of changing metabolic demand during muscle contraction or tissue *** study illustrates a proof of concept for point-based,minimally-invasive NADHfluorescence lifetime measurement in *** muscle loss(VmL)injuries were created in the left tibialis anterior(tA)muscle of male Sprague Dawley *** lifetime measurements were collected before,during,and after a 30 s tetanic contraction in the injured and uninjured tA muscles,which was subsequently-t to a biexponential decay model to yield a metric of NADH utilization(cytoplasmic vs protein-bound NADH,the A11/A22 ratio).On average,this ratio was higher during and after contraction in uninjured muscle compared to muscle at rest,suggesting higher levels of free NADH in contracting and recovering muscle,indicating increased rates of *** injured muscle,this ratio was higher than uninjured muscle overall but decreased over time,which is consistent with current knowledge of inflammatory response to injury,suggesting tissue regeneration has *** data suggest that-ber-coupled tcSPc has the potential to measure changes in NADH binding in vivo in a minimally invasive manner that requires further investigation.

关键词： Glycolysis oxidative phosphorylation energy metabolism volumetric muscle loss

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Superior antibody and membrane protein‑specific t‑cell responses to coronaVac by intradermal versus intramuscular routes in adolescents

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World Journal of Pediatrics 2024年第4期20卷 353-370页

作者： Jaime S.Rosa Duque Samuel m.S.cheng carolyn A.cohen Daniel Leung Xiwei Wang Xiaofeng mu Yuet chung tsun ming Lau manni Wang Wenyue Zhang Yanmei Zhang Howard H.W.Wong Leo c.H.tsang Sara chaothai tsz chun Kwan John K.c.Li Karl c.K.chan Leo L.H.Luk Jenson c.H.Ho Wing Yan Li Amos m.t.Lee Jennifer H.Y.Lam Sau man chan Wilfred H.S.Wong Issan Y.S.tam masashi mori Sophie A.Valkenburg malik Peiris Wenwei tu Yu Lung Lau Department of Paediatrics and Adolescent medicine The University of Hong KongHong KongChina School of Public Health The University of Hong KongHong KongChina HKU‑Pasteur Research Pole School of Public HealthThe University of Hong KongHong KongChina Research Institute for Bioresources and Biotechnology Ishikawa Prefectural UniversityNonoichiJapan Department of microbiology and Immunology Peter Doherty Institute for Infectionand ImmunityUniversity of MelbourneMelbourneVICAustralia center for Immunology and Infection c2i Hong KongChina

Background Optimising the immunogenicity of cOVID-19 vaccines to improve their protection against disease is *** dosing by intradermal(ID)administration has been shown to be equally immunogenic as intramuscular(Im)administration for several vaccines,but the immunogenicity of ID inactivated whole severe acute respiratory syndrome coronavirus 2(SARS-coV-2)at the full dose is *** study(Nct04800133)investigated the superiority of antibody and t-cell responses of full-dose coronaVac by ID over Im administration in *** Participants aged 11–17 years received two doses of Im or ID vaccine,followed by the 3rd dose 13–42 days *** and cellular immunogenicity outcomes were measured post-dose 2(Im-cc versus ID-cc)and post-dose 3(Imccc versus ID-ccc).Doses 2 and 3 were administered to 173 and 104 adolescents,*** Spike protein(S)immunoglobulin G(IgG),S-receptor-binding domain(RBD)IgG,S IgG Fcγreceptor IIIa(FcγRIIIa)-binding,SNm[sum of individual(S),nucleocapsid protein(N),and membrane protein(m)peptide pool]-specific interleukin-2(IL-2)+cD4^(+),SNm-specific IL-2^(+)cD8^(+),S-specific IL-2^(+)cD8^(+),N-specific IL-2^(+)cD4^(+),N-specific IL-2^(+)cD8^(+)and m-specific IL-2^(+)cD4^(+)responses fulfilled the superior and non-inferior criteria for ID-cc compared to Im-cc,whereas IgG avidity was *** ID-ccc,S-RBD IgG,surrogate virus neutralisation test,90%plaque reduction neutralisation titre(PRNt90),PRNt50,S IgG avidity,S IgG FcγRIIIa-binding,m-specific IL-2^(+)cD4^(+),interferon-γ+cD8^(+)and IL-2^(+)cD8^(+)responses were superior and non-inferior to *** estimated vaccine efficacies were 49%,52%,66%and 79%for Im-cc,ID-cc,Im-ccc and ID-ccc,*** ID groups reported more local,mild adverse *** this is the first study to demonstrate superior antibody and m-specific t-cell responses by ID inactivated SARScoV-2 vaccination and serves as the basis for future research to improve the

关键词： coronaVac coronavirus disease 2019 Immunity Intradermal Vaccine

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metrology for sub-Rayleigh-length target positioning in ～1022W/cm2 laser-plasma experiments

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High Power Laser Science and Engineering 2024年第3期 95-110页

作者： E.A.Vishnyakov A.Sagisaka K.Ogura t.Zh.Esirkepov B.Gonzalez-Izquierdo c.D.Armstrong t.A.Pikuz S.A.Pikuz W.Yan t.m.Jeong S.Singh P.Hadjisolomou O.Finke G.m.Grittani m.Nevrkla c.m.Lazzarini A.Velyhan t.Hayakawa Y.Fukuda J.K.Koga m.Ishino K.Kondo Y.miyasaka A.Kon m.Nishikino Y.V.Nosach D.Khikhlukha I.P.tsygvintsev D.Kumar J.Nejdl D.margarone P.V.Sasorov S.Weber m.Kando H.Kiriyama Y.Kato,G.Korn K.Kondo S.V.Bulanov t.Kawachi A.S.Pirozhkov ELI Beamlines Facility The Extreme Light Infrastructure ERIC Kansai Institute for Photon Science (KPSI) central Laser Facility Rutherford Appleton LaboratorySTFC Institute for Open and transdisciplinary Research Initiatives Osaka University HB11 Energy Holdings Key Laboratory for Laser Plasmas (ministry of Education) School of Physics and AstronomyShanghai Jiao Tong University collaborative Innovation center of IFSA Shanghai Jiao Tong University Institute of Plasma Physics AScR FZU±Institute of Physics AScR czech technical University in Prague Institute of Laser Engineering Osaka University Institute of Physics National Academy of Sciences of Ukraine IStEQ AR

tight focusing with very small f-numbers is necessary to achieve the highest at-focus ***,tight focusing imposes strong demands on precise target positioning in-focus to achieve the highest on-target irradiance We describe several near-infrared,visible,ultraviolet and soft and hard X-ray diagnostics employed in a～1022W/cm2laser±plasma *** used nearly 10 J total energy femtosecond laser pulses focused into an approximately1.3-μm focal spot on 5±20μm thick stainless-steel *** discuss the applicability of these diagnostics to determine the best in-focus target position with approximately 5μm accuracy （i.e.,around half of the short Rayleigh length）and show that several diagnostics （in particular,3ωreflection and on-axis hard X-rays） can ensure this *** demonstrated target positioning within several micrometers from the focus,ensuring over 80%of the ideal peak laser intensity *** approach is relatively fast （it requires 10±20 laser shots） and does not rely on the coincidence of low-power and high-power focal planes.

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metabolic syndrome and the urinary microbiome of patients undergoing percutaneous nephrolithotomy

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Asian Journal of Urology 2024年第2期11卷 316-323页

作者： Ryan A.Dornbier chirag P.Doshi Shalin c.Desai Petar Bajic michelle Van Kuiken mark Khemmani Ahmer V.Farooq Larissa Bresler thomas m.t.turk Alan J.Wolfe Kristin G.Baldea Loyola University medical center Department of UrologyMaywoodILUSA Loyola University chicago Department of Microbiology and ImmunologyMaywoodILUSA

Objective:to identify possible stone-promoting microbes,we compared the profiles of microbes grown from stones of patients with and without metabolic syndrome(metS).the association between metS and urinary stone disease is well established,but the exact pathophysiologic relationship remains *** evidence suggests urinary tract dysbiosis may lead to increased nephrolithiasis ***:At the time of percutaneous nephrolithotomy,bladder urine and stone fragments were collected from patients with and without *** sample types were subjected to expanded quantitative urine culture(EQUc)and 16 S ribosomal RNA gene ***:Fifty-seven patients included 12 controls(21.1%)and 45 metS patients(78.9%).Both cohorts were similar with respect to demographics and non-metS *** controls had uric acid stone *** EQUc,bacteria were detected more frequently in metS stones(42.2%)compared to controls(8.3%)(p=0.041).Bacteria also were more abundant in stones of metS patients compared to *** validate our EQUc results,we performed 16 S ribosomal RNA gene *** 12/16(75.0%)sequence-positive stones,EQUc reliably isolated at least one species of the sequenced *** were detected in both“infectious”and“non-infectious”stone ***:Bacteria are more common and more abundant in metS stones than control *** findings support a role for bacteria in urinary stone disease for patients with metS regardless of stone composition.

关键词： Nephrolithiasis Urolithiasis metabolic syndrome Urinary microbiome Percutaneous nephrolithotomy

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Recent Advances in catalytic carbonylation Reactions in Alternative Reaction media

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chinese Journal of chemistry 2024年第4期42卷 406-429页

作者： csaba Árvai László t.mika Department of chemical and Environmental Process Engineering Faculty of Chemical Technology and BiotechnologyBudapest University of Technology and EconomicsMűegyetem rkp.3H-1111 BudapestHungary

Since the discovery of the hydroformylation(oxo-synthesis or Roelen reaction)and the Reppe-reaction,the transition metal-catalyzed carbonylation reactions,providing versatile,facile,and even atom-economic methods for the selective incorporation of c=O functionality to various skeletons,have gained tremendous importance in synthetic organic chemistry from laboratories to industrial *** carbonylation of carbon-carbon multiple bonds,aromatic halides,triflates,etc.,in the presence of various nucleophiles has led the way to produce aldehydes,carboxylic acids,esters,amides,etc.,in the fine chemical ***,these protocols usually proceed in conventional,fossil-based,and usually toxic reaction ***,several attempts have been directed to developing efficient carbonylation methods in alternative,less harmful,non-fossil-based and even in renewable reaction *** this review,we overview the recent applications of alternative solvents such as water,biomass-based alcohols,γ-valerolactone(GVL),2-methyltetrahydrofuran(2-metHF),ionic liquids(ILs),deep eutectic solvents(DES),alkyl levulinates,limonene,α-pinene,and dimethyl carbonate as well as fluorous media to improve efficiency,safety and environmentally benign nature of carbonylation protocols.

关键词： carbonylation catalysis Solvents Green chemistry carbon monoxide transition metals Homogeneous catalysis Palladium

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Radioisotope production using lasers:From basic science to applications

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matter and Radiation at Extremes 2024年第3期9卷 31-44页

作者： m.R.D.Rodrigues A.Bonasera m.Scisciò J.A.Pérez-Hernández m.Ehret F.Filippi P.L.Andreoli m.Huault H.Larreur D.Singappuli D.molloy D.Raffestin m.Alonzo G.G.Rapisarda D.Lattuada G.L.Guardo c.Verona Fe.consoli G.Petringa A.mcNamee m.La cognata S.Palmerini t.carriere m.cipriani G.Di Giorgio G.cristofari R.De Angelis G.A.P.cirrone D.margarone L.Giuffrida D.Batani P.Nicolai K.Batani R.Lera L.Volpe D.Giulietti S.Agarwal m.Krupka S.Singh Fa.consoli cyclotron Institute Texas A&M UniversityCollege StationTexas 77840USA Laboratori Nazionali del Sud Istituto Nazionale di Fisica Nucleare(LNS-INFN)CataniaItaly ENEA Fusion and Technologies for Nuclear Safety and Security Department-CFrascatiItaly centro de Láseres Pulsados(clpu) VillamayorSpain Universidad de Salamanca SalamancaSpain centre Lasers Intenses et Applications(cELIA) Universitéde BordeauxCNRSCEATalenceFrance HB11 Energy Holdings Pty FreshwaterNew South WalesAustralia School of mathematics and Physics Queen’s University BelfastBelfastUnited Kingdom Dipartimento di Fisica e Astronomia“E.majorana ”Università di CataniaCataniaItaly Facoltàdi Ingegneria e Architettura Universitàdegli Studi di Enna“Kore”EnnaItaly Dipartimento di Ingegneria Industriale Universitàdi Roma“Tor Vergata”RomaItaly Dipartimento di Fisica e Geologia Universitàdegli Studi di PerugiaPerugiaItaly Istituto Nazionale di Fisica Nucleare Sezione di PerugiaPerugiaItaly ELI Beamlines Facility the Extreme Light Infrastructure ERICDolni BrezanyCzech Republic EtSIA Universidad Politécnica de MadridMadridSpain Dipartimento Fisica “E.Fermi”Universitàdi Pisa and INFNPisaItaly FZU–Institute of Physics of czech Academy of Sciences PragueCzech Republic Institute of Plasma Physics of czech Academy of Sciences PragueCzech Republic

the discovery of chirped pulse amplification has led to great improvements in laser technology,enabling energetic laser beams to be compressed to pulse durations of tens of femtoseconds and focused to a few *** with energies of tens of meV can be accelerated using,for instance,target normal sheath acceleration and focused on secondary *** such conditions,nuclear reactions can occur,with the production of radioisotopes suitable for medical *** use of high-repetition lasers to produce such isotopes is competitive with conventional methods mostly based on *** this paper,we study the production of^(67)cu,^(63)Zn,^(18)F,and^(11)c,which are currently used in positron emission tomography and other *** the same time,we study the reactions^(10)B(p,α)^(7)Be and^(70)Zn(p,4n)^(67)Ga to put further constraints on the proton distributions at different angles,as well as the reaction^(11)B(p,α)^(8)Be relevant for energy *** experiment was performed at the 1 PW laser facility at VegaⅢin Salamanca,*** distributions of radioisotopes in the forward(with respect to the laser direction)and backward directions were measured using a high purity germanium *** results are in reasonable agreement with numerical estimates obtained following the approach of Kimura and Bonasera[*** ***.,Sect.A 637,164–170(2011)].

关键词： purity estimates backward

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Development,validation,and transportability of several machine-learned,non-exercise-based VO_(2max)prediction models for older adults

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Journal of Sport and Health Science 2024年第5期13卷 611-620页

作者： Benjamin t.Schumacher michael J.Lamonte Andrea Z.Lacroix Eleanor m.Simonsick Steven P.Hooker Humberto Parada Jr. John Bellettiere Arun Kumar Herbert Wertheim School of Public Health and Human Longevity Science University of California San DiegoLa JollaCA 92093USA Department of Epidemiology and Environmental Health School of Public Health and Health ProfessionsUniversity at BuffaloState University of New YorkBuffaloNY 14214USA translational Gerontology Branch Intramural Research ProgramNational Institute on AgingNational Institutes of HealthBaltimoreMD 21225USA college of Health and Human Services San Diego State UniversitySan DiegoCA 92182USA Division of Epidemiology and Biostatistics School of Public HealthSan Diego State UniversitySan DiegoCA 92182USA University of california San Diego moores cancer center La JollaCA 92093USA computer Science and Engineering and Halicioglu Data Science Institute University of California San DiegoLa JollaCA 92093USA

Background:there exist few maximal oxygen uptake(VO_(2max))non-exercise-based prediction equations,fewer using machine learning(mL),and none specifically for older *** direct measurement of VO_(2max)is infeasible in large epidemiologic cohort studies,we sought to develop,validate,compare,and assess the transportability of several mL VO_(2max)prediction ***:the Baltimore Longitudinal Study of Aging(BLSA)participants with valid VO2_(max)tests were included(n=1080).Least absolute shrinkage and selection operator,linear-and tree-boosted extreme gradient boosting,random forest,and support vector machine(SVm)algorithms were trained to predict VO_(2max)*** developed these algorithms for:(a)the overall BLSA,(b)by sex,(c)using all BLSA variables,and(d)variables common in aging ***,we quantified the associations between measured and predicted VO_(2max)and ***:the age was 69.0±10.4 years(mean±SD)and the measured VO_(2max)was 21.6±5.9 mL/kg/*** absolute shrinkage and selection operator,linear-and tree-boosted extreme gradient boosting,random forest,and support vector machine yielded root mean squared errors of 3.4 mL/kg/min,3.6 mL/kg/min,3.4 mL/kg/min,3.6 mL/kg/min,and 3.5 mL/kg/min,*** quartiles of measured VO_(2max)showed an inverse gradient in mortality *** VO_(2max)variables yielded similar effect estimates but were not robust to ***:measured VO_(2max)is a strong predictor of *** mL can improve the accuracy of prediction as compared to simpler approaches but estimates of association with mortality remain sensitive to *** studies should seek to reproduce these results so that VO_(2max),an important vital sign,can be more broadly studied as a modifiable target for promoting functional resiliency and healthy aging.

关键词： cardiorespiratory fitness Prediction algorithms Epidemiology mortality

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Prompt neutron emission in ^(250)No spontaneous fission associated with ground and isomeric state decays

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chinese Physics c 2024年第6期48卷 112-117页

作者： R.S.mukhin A.V.Isaev A.V.Andreev m.L.chelnokov V.I.chepigin H.m.Devaraja I.N.Izosimov A.A.Kuznetsova O.N.malyshev A.G.Popeko Yu.A.Popov A.Rahmatinejad B.Sailaubekov t.m.Shneidman E.A.Sokol A.I.Svirikhin m.S.tezekbayeva m.A.Bychkov A.V.Yeremin O.Dorvaux B.Gall K.Kessaci K.Hauschild A.Lopez-martens Joint Institute for Nuclear Research Dubna141980Russia Dubna State University Dubna141982Russia Institute of Nuclear Physics Almaty050032Kazakhstan L.N.Gumilyov Eurasian National University Astana010008Kazakhstan Kazan Federal University Kazan420008Russia Universitéde Strasbourg CNRSStrasbourg67000France IJcLab IN2P3-CNRSUniversitéParis-SaclayOrsay91400France

the complete-fusion reaction^(204)Pb(^(48)ca,2n)^(250)No was used to study two activities of^(250)No with distinct half-lives.A total of 1357 events were observed in the SFiNx neutron detection *** average number of neutrons emitted per spontaneous fission of^(250)No was determined to be(4.1±0.1).the unusually symmetrical shape of the prompt neutron multiplicity distribution was restored and presented for the first *** tests were performed to compare the prompt neutron multiplicity distributions associated with the ground state and K-isomer state decays.

关键词： spontaneous fission prompt neutrons actinide

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