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Synthesis and characterization of NaYF4:Yb3+,Er3+@silica-N=folic acid nanocomplex for bioimaginable detecting MCF-7 breast cancer cells

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Journal of Rare Earths 2019年第11期37卷 1183-1187页

作者： Ha thi Phuong Tran Thu Huong Le thi Vinh Hoang thi Khuyen Do thi Thao Nguyen Thanh Huong pham thi lien Le Quoc Minh Institute of Materials Science Vietnam Academy of Science and Technology18 Hoang Quoc VietCau GiayHanoiViet Nam Graduate University of Science and Technology-Vietnam Academy of Science and Technology 18 Hoang Quoc VietCau GiayHanoiViet Nam Department of Chemistry Hanoi Medical University1-Ton That TungDong DaHanoiViet Nam Department of Chemistry Hanoi University of Mining and Geology18-Pho LienBac Tu LiemHanoiViet Nam Institute of Biotechnology Vietnam Academy of Science and Technology18-Hoang Quoc VietCau GiayHanoiViet Nam Duy Tan University K7/25 Quang TrungDa NangViet Nam

Upconversion nanophosphors are new promising nanomaterials to be used as biolabels for detection and imaging of cancer *** nanophosphors absorb long-wavelength excitation radiation in the infrared or near infrared region and emit shorter wavelength,higher energy radiation from ultraviolet to *** this paper,we studied the hydrothermal method and optical properties of the functionalized NaYF4:Yb^3+,Er^3+for biomedical *** synthesis,these NaYF4:Yb^3+,Er^3+nanophosphors were functionalized with aminosilanes and folic *** acid binds to the folate receptor on the surface of MCF-7 breast cancer cells and this binding promotes internalization of the nanophosphors via *** sizes of the functionalized NaYF4:Yb^3+,Er^3+@silica-N=FA(folic acid)nanophosphors can be controlled with length of the rod about 300-800 nm and diameter of the rod about 100-200 *** structure of NaYF4:Yb^3+,Er^3+is in hexagonal crystal *** photo luminescence(PL)spectra of the functionalized NaYF4:Yb^3+,Er^3+@silica-N=FA nanophosphors were *** nanophosphors emit in red color with the strongest band at 650 nm under 980 nm *** result can provide NaYF4:Er^3+,Yb^3+@silica-N=FA complex for developing fluorescence label and image tool in cancer biology and medicine.

关键词： Upconversion luminescence NaYF4:Yb^3+,Er^3+ Nanophosphors Bioimaging Cancer cell Rare earths

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Luminescent and magnetic properties of multifunctional europium(Ⅲ) complex based nanocomposite

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Journal of Rare Earths 2019年第11期37卷 1237-1241页

作者： Hoang thi Khuyen Nguyen Thanh Huong Tran Thu Huong pham thi lien Do thi Anh Thu Nguyen thi Anh Huong Wieslaw Strek Le Quoc Minh Institute of Materials Science Vietnam Academy of Science and Technology18 Hoang Quoc VietCau CiayHanoiViet Nam Graduate University of Science and Technology Vietnam Academy of Science and Technology18 Hoang Quoc VietCau GiayHanoiViet Nam Department of Chemistry University of Natural SciencesHanoi National University19 Le Thanh TongHoan KiemHanoiViet Nam Institute of Low Temperature and Structure Research PASOkolna 2Wroclaw 50-422Poland Duy Tan University K7/25 Quang TrungDa DangViet Nam

The luminescent rare earth(RE)complex based multifunctional nanocomposites offer new potential applications of multimodal imaging(magnetic resonance imaging(MRI),fluorescent bioimaging,etc.)that can be associated with therapeutic *** this study,we report some results obtained with novel multifunctional Fe3O4/Si-amine/Eu(NTA)3 nanocomposites that are composed of europium(Ⅲ)complex with 1-(2-naphthoyl)-3,3,3-trifluoroacetone ligands(NTA)(Eu(NTA)3)and superparamagnetic Fe3O4 *** nanocomposites were functionalized with an amine group for biomedicine *** multifunctional Fe3O4/Si-amine/Eu(NTA)3 nanocomposites exhibit both good magnetic behavior of Fe3O4 nanoparticles as a core and strong fluorescent property of europium(Ⅲ)*** characterizations were analyzed by XRD,SEM,EDX and FTIR *** optical properties were studied in detail by UV-VIS spectra and luminescent emission *** magnetic property was estimated by *** effect of concentrations of luminescent Eu(NTA)3 complex on luminescent and magnetic properties is discussed.

关键词： Multifunctional nanocomposite Luminescence Magnetic Europium(Ⅲ)complex Fe3O4 Rare earths

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Role of Aedes aegypti and Aedes albopictus during the 2011 dengue fever epidemics in Hanoi, Vietnam

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Asian Pacific Journal of Tropical Medicine 2015年第7期8卷 541-546页

作者： pham thi Kim lien Vu Trong Duoc Laurent Gavotte Emmanuel Cornillot Phan thi Nga Laurence Briant Roger Frutos Tran Nhu Duong National Institute of Hygiene and Epidemiology CPBS UMR 5236 CNRS-UM1-UM2 1919 route de Mende 34293 Montpellier Cedex 5France ISEM UMR 5554 CNRS-UM2-IRD Université Montpellier 2 CC065 Place E. Bataillon34095 Montpellier Cedex 5 France CPBS UMR 5236 CNRS-UM1-UM2 1919 route de Mende 34293 Montpellier Cedex 5France Intertryp UMR 17 Cirad-IRD Campus International de Baillarguet34398 Montpellier Cedex 5 France

Objective: To record the human cases of dengue fever(DF) and investigate the Aedes mosquito species circulating during the Hanoi 2011 DF epidemics. Methods: 24 different outbreak points were recorded in 8 districts between August and December 2011. Results: 140 patients were hospitalized following dengue diagnostic with a predominance of males(59.3%) and the 15-34 age class. Only DENV-1(11.27%) and DENV-2(88.73%) serotypes were detected in human samples. Mosquito sampling performed in and around patients households revealed the predominance of Aedes aegypti(95.15%) versus Aedes albopictus(4.85%). There is a positive correlation between the population density of Aedes aegypti and the number of human cases and duration of outbreaks. Conclusions: this was not observed for Aedes albopictus. 3 pools of Aedes aegypti were positive with dengue virus, two with DENV-1 and one with DENV-2.

关键词： Aedes aegypti Aedes albopictus Dengue Vector density

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Surveillance of dengue and chikungunya infection in Dong Thap,Vietnam:A 13-month study

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Asian Pacific Journal of Tropical Medicine 2016年第1期9卷 36-40页

作者： pham thi Kim lien Laurence Briant Truong Ba Tang Bui Minh Trang Laurent Gavotte Emmanuel Comillot Vu Trong Duoc Tran Nhu Duong Roger Frutos Phan thi Nga National Institute of Hygiene and Epidemiology University of Montpellier Department of Biology Dong Thap General Hospital Cirad TA-A17/GCampus International de Raillarguet

Objective:To establish a surveillance in Dong Thap,at the border with Cambodia by assessing the presence of DHNV serotypes and CHIKV among patients hospitalized at Dong Thap general ***:Cross-sectional descriptive analysis was conducted on a cohort of 131 patients hospitalized with acute fever and symptoms compatible with dengue or *** study was conducted from January 2012 to February *** full clinical picture was established as well as serological and molecular *** analysis was sequentially performed on blood samples collected on admission and an average of seven days after *** detection of IgM antibody to DENV was performed by IgM capture ELTSA and the detection of DENV and CHIKV RNA was done by reverse-transcription multiplex ***:101 patients out of 131(77%) were confirmed with *** four dengue serotypes were detected with a predominance of DENV2 and *** chikungunya infection was detected although reported in neighboring Cambodia.A differential efficiency of serological dengue detection was *** was 29%upon admission and 53%after seven days on the same patients.30 patients out of 131(23%) were negative with both DENV and ***:Dengue is at risk of being underestimated and chikungunya is not systematically *** in detection and surveillance procedures are therefore discussed to increase efficiency of dengue detection and continue the monitoring the emergence of CHIKV in Dong Thap province and in Vietnam.

关键词： Dengue Chikungunya Arbovirus Dong ThapVietnam

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越南河江省高中教师队伍发展问题与对策研究

越南河江省高中教师队伍发展问题与对策研究

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作者：范氏莲（pham thi lien）广西师范大学

学位级别：硕士

“教育发展,教师为先”。教育的发展关系到国家和民族的兴衰存亡,而教师队伍的发展直接影响着学校的教学质量。作为“太阳底下最崇高最光辉的职业”,教师身上承担着培育国家和民族下一代的重担。因此,发展一支师德高尚、结构合理、水平... 详细信息

“教育发展,教师为先”。教育的发展关系到国家和民族的兴衰存亡,而教师队伍的发展直接影响着学校的教学质量。作为“太阳底下最崇高最光辉的职业”,教师身上承担着培育国家和民族下一代的重担。因此,发展一支师德高尚、结构合理、水平较高的教师队伍,对于每个学校的长远发展和每位学生的健康成长具有重要意义。在国民教育系统中,高中教育是一个为国家提供人才储备的关键阶段。为国家培养有理想、有抱负、有终身学习动机及身心健康的预备人才是每一位教师的心愿。高中教育阶段的培养目标是培养学生的学习能力和理解能力,为今后的进一步学习和职业选择打好基础。如何发展一支教师数量充足、质量优良、结构均衡发展的高中教师队伍是每个中学思考的问题,也成为教育中的研究热点。越南河江省高中教师队伍虽然在规模上扩大,训练水平也有显著提高,但仍未满足教育创新的要求。主要问题有教师管理不足、待遇政策不完善、培训不充分和培养教师队伍的能力有限等。发展高中学校教师队伍,教育和培训要有创新、科学和系统的研究。近年来,在越南虽然出现了许多对各个省市高中教师队伍发展的论文研究,但这些论文中,还没有对河江省高中教师队伍发展的研究。研究者首先对美国、英国、法国和中国等教师队伍建设体系比较成熟的国家进行文献研究分析,总结其在教师入职标准、教师评价和教师培训等方面的经验,在搜集和整理相关文献资料的基础上,设计了调查问卷及访谈提纲,对越南河江省高中教师进行了问卷调查及现场访谈的实证研究,获取了大量的第一手资料。研究者再运用人力资源管理相关理论对这些资料进行深入细致地分析和思考,进一步明确了教师队伍素质发展的涵义及重要性,理清了河江省高中教师队伍发展的现状和问题及其原因,并从个人、学校、教育行政部门等三个层面提出切实可行的解决高中教师队伍对策措施。

关键词：越南河江省高中教育高中教师队伍发展教师素质发展

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中国电视剧在越南的网络传播及文化影响研究

中国电视剧在越南的网络传播及文化影响研究

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作者：范氏红莲（pham thi HONG lien）华中师范大学

学位级别：硕士

自1991年以来,随着中越邦交正常化,两国的文化交流也随之蓬勃发展,其中电视剧是文化传播的重要载体。中国电视剧最初主要是在越南各大电视台播放,到2010年左右,重心转向网络传播。中国电视剧凭借网络的力量在越南开启了新的传播时代。... 详细信息

自1991年以来,随着中越邦交正常化,两国的文化交流也随之蓬勃发展,其中电视剧是文化传播的重要载体。中国电视剧最初主要是在越南各大电视台播放,到2010年左右,重心转向网络传播。中国电视剧凭借网络的力量在越南开启了新的传播时代。互联网的发展带动了在越南传播的中国电视剧数量不断增加,观众可以根据自己的情况,自由选择想看的电视剧内容和观看时间。因此,中国电视剧在越南网络传播的效果远远超过了传统电视台。近几年,随着网络视频业务的迅猛发展,网站已成为越南观众观看中国电视剧的主要渠道。中国电视剧在越南的网络热播对中国文化的传播起了重大作用。中国电视剧带领越南观众“走进中国”,了解中国情况,感受中国文化魅力。随着中国电视剧在越南传播数量和种类的增多,中国文化对越南文化的影响也日益深广。本文以“越南网络热播的中国电视剧”为研究对象,从跨文化传播学的视角,考察了中国电视剧在越南网络传播的历程与现状,进而探讨中国电视剧在越南网络热播的原因,最后对中国电视剧在越南网络传播的文化影响进行深入解析。希望研究结果能对越南影视行业的发展以及中国文化“走出去”战略有一定的借鉴意义。

关键词：中国电视剧网络传播文化影响越南影视剧网站

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鲁迅作品在越南文化界的翻译、接受与影响研究

鲁迅作品在越南文化界的翻译、接受与影响研究

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作者：范氏芳莲（pham thi PHUONG lien）华侨大学

学位级别：硕士

中国现代文学作家当中,鲁迅是被传播到越南的第一位,也是被越南普通高校选择其作品作为教材的唯一的一位。鲁迅得到了越南人民的喜爱与敬仰,其越南读者日益增多。越南人喜爱鲁迅不仅因为他是越中两国文学交往的主要桥梁,而且还因为他的... 详细信息

中国现代文学作家当中,鲁迅是被传播到越南的第一位,也是被越南普通高校选择其作品作为教材的唯一的一位。鲁迅得到了越南人民的喜爱与敬仰,其越南读者日益增多。越南人喜爱鲁迅不仅因为他是越中两国文学交往的主要桥梁,而且还因为他的作品与越南人民的解放事业息息相关。鲁迅在越南的传播与影响极为深刻,他在越南文学事业上占有举足轻重的地位。本论文希望通过研究鲁迅所创作的文学作品在越南的文学领域从翻译、接受到研究的情况,来探讨鲁迅文学对于越南文学产生的影响,进一步证明伟大的作家鲁迅不仅属于中国人民,同时也属于全世界的人民。

关键词：鲁迅作品文学精神越南文化界南高

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Forecasting measured responses of structures using temporal deep learning and dual attention

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Frontiers of Structural and Civil Engineering 2024年第6期18卷 832-850页

作者： Viet-Hung DANG Trong-Phu NGUYEN thi-lien pham Huan X.NGUYEN Department of Structural Mechanics Hanoi University of Civil EngineeringHanoi 11600Vietnam Faculty of Applied Science University of Economics-Technology for IndustriesHanoi 11600Vietnam London Digital Twin Research Centre Faculty of Science and TechnologyMiddlesex UniversityLondon NW44BTUK International School Vietnam National UniversityHanoi 11600Vietnam

The objective of this study is to develop a novel and efficient model for forecasting the nonlinear behavior of structures in response to time-varying random *** key idea is to design a deep learning architecture to leverage the relationships,between external excitations and structure's vibration signals,and between historical values and future values,within multiple time-series *** proposed method consists of two main steps:the first step applies a global attention mechanism to combine multiple-measured time series and time-varying excitation into a weighted time series before feeding it to a temporal architecture;the second step utilizes a self-attention mechanism followed by a fully connected layer to predict multi-step future *** viability of the proposed method is demonstrated via two case studies involving synthetic data from a three-dimensional(3D)reinforced concrete structure and experimental data from an 18-story steel ***,comparison and robustness studies are carried out,showing that the proposed method outperforms conventional methods and maintains high performance in the presence of noise with an amplitude of less than 10%.

关键词： structural dynamic time-varying excitation deep learning signal processing response forecasting

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Infectious keratitis in Vietnam:etiology,organisms,and management at Vietnam National Eye Hospital

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International Journal of Ophthalmology(English edition) 2022年第1期15卷 128-134页

作者： pham Ngoc Dong Do thi Thuy Hang Nguyen thi Nga Duong Mai thi lien Angela C.Chen Anthony J.Aldave Vietnam National Eye Hospital Hanoi 10000Vietnam Nam Dinh Eye Hospital Nam Dinh 420000Vietnam Stein Eye Institute UCLA David Geffen School of MedicineLos AngelesCA 90095USA

AIM:To report the etiologies,risk factors,treatments,and outcomes of infectious keratitis(IK)at a major Vietnamese eye ***:this is a retrospective review of all cases of IK at Vietnam National Eye Hospital(VNEH)in Hanoi,*** histories,demographics,clinical features,microbiological results,and treatment outcomes were ***:IK was diagnosed in 1974 eyes of 1952 patients,with ocular trauma being the greatest risk factor for IK(34.2%),frequently resulting from an agriculturerelated injur y(53.3%).The mean duration between symptom onset and presentation to VNEH was 19.3±14.4 d,and 98.7%of patients had been treated with topical antibiotic and/or antifungal agents prior to evaluation at *** on smear results of 1706 samples,the most common organisms identified were bacteria(n=1107,64.9%)and fungi(n=1092,64.0%),with identification of both bacteria and fungi in 614(36.0%)***-five of 374 bacterial cultures(14.7%)and 426 of 838 fungal cultures(50.8%)were positive,with the most commonly cultured pathogens being Pseudomonas aeruginosa,Streptococcus pneumonia,Fusarium spp.,and Aspergillus *** perforation and descemetocele developed in 391(19.8%)and 93(4.7%)eyes,*** treatment was successful in resolving IK in 50.4%eyes,while 337(17.1%)eyes underwent penetrating or anterior lamellar *** was performed in 7.1%of eyes,most commonly in the setting of fungal ***:Ocular trauma is a major risk factor for IK in Vietnam,which is diagnosed in almost 400 patients each year at *** this,and as approximately one quarter of the eyes that develop IK require corneal transplantation or evisceration,greater emphasis should be placed on the development of prevention and treatment programs for IK in Vietnam.

关键词： infectious keratitis bacterial keratitis fungal keratitis microsporidial keratitis Acanthamoeba keratitis herpes simplex virus keratitis Vietnam

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Influence of phytochemicals in piper betle linn leaf extract on wound healing

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Burns & Trauma 2015年第3期3卷 143-150页

作者： Le thi lien Nguyen thi Tho Do Minh Ha pham Luong Hang Phan Tuan Nghia Nguyen Dinh Thang Department of Biochemistry and Plant Physiology VNU University of ScienceVietnam National University334 Nguyen Trai St.Thanh Xuan DistrictHanoiVietnam Key laboratory of Enzyme and Protein Technology(KLEPT) VNU University of ScienceVietnam National UniversityHanoiVietnam

Background:Wound healing has being extensively investigated over the *** impairment is caused by many reasons including increasing of free-radicals-mediated damage,delaying in granulation tissue formation,reducing in angiogenesis and decreasing in collagen *** facts consequently lead to chronic wound *** betle Linn(Betle)leaves have been folklore used as an ingredient of drugs for cutaneous wound ***,the effect of betle leaf on wound healing is not yet well *** this study,we aimed to investigate the healing efficacy of methanol leaf extract of Piper betle Linn on proliferation of fibroblast NIH3T3 cells as well as full-thickness burn and excision wounds in swiss ***:Scratch wound healing assays were conducted to examine the effects of betle leaf extract on healing activity of fibroblast *** and excision wounds on swiss mouse skins were created for investigating the wound healing progress caused by the betle leaf ***(MDA)was also evaluated to examine the products of lipid hydroperoxide(LPO)under conditions of with or without betle leaf extract ***:The results of this study showed that Piper betle Linn leaf extract in methanol increased proliferation of NIH3T3 cells and promoted wound healing in vitro and in vivo with both burn wound and excision wound *** addition,this extract significant decreased level of malondialdehyde(MDA)in liver of treated-mice compared with that in non-treated ***:Our results suggest that Piper betle Linn can be used as an ingredient in developing natural origin drugs for treatment of cutaneous wounds.

关键词： Piper betle Linn Leaf extract Wound healing Malondialdehyde(MDA) Fibroblast(NIH3T3)

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