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Protective effect of Tetracera scandens *** extract against CCl_4-induced acute liver injury in rats

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Asian Pacific Journal of Tropical Biomedicine 2015年第3期5卷 221-227页

作者： Tung Bui Thanh Hai Nguyen Thanh Hue pham thi Minh Huong Le-thi-Thu Huong Duong thi Ly Loi Vu Duc School of Medicine and Pharmacy Vietnam National University Hanoi University of Pharmacy

Objective:To investigate the protective potential of ethanolic extracts of Tetracera scandens L.(***) against CCl_4 induced oxidative stress in liver ***:Dried leaf powder of *** was extracted with ethanol and concentrated to yield a dry *** were administered with 100 mg/kg of ethanolic extracts orally once daily for one *** were subsequently administered with a single dose of CCl_4(I mL/kg body weight,intraperitoneal injection).Various assays,such as serum levels of alanine aminotransferase,aspartate aminotransferase,lipid peroxidation,protein oxidation(carbonyl protein group),tumor necrosis factor alpha,catalase,superoxide dismutase,and glutathione peroxidase,were used to assess damage caused by CCl_4 and the protective effects of the ethanol extract on liver ***:Hepatotoxicity induced by CCl_4 was evidenced by a significant increase in serum aspartate aminotransferase and alanine aminotransferase level,lipid peroxidation,protein carbonyl group,and tumor necrosis factor alpha,as well as decreased activity of the hepatic antioxidant enzymes(*** *** glutathione peroxidase).Treatment with ethanolic *** extracts prevented all of these typically observed changes in CCl_4-treated ***:Our findings indicate that *** has a significant protective effect against CCl_4 induced hepatotoxicity in *** may be due to its antioxidant properties.

关键词： Tetracera scandens L Antioxidant Carbon tetrachloride Liver toxicity Lipid peroxidation

Public Awareness and Participation in Canal Environmental Protection： Case Studies in Ho Chi Minh City, Vietnam

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Journal of Shipping and Ocean Engineering 2017年第3期7卷 121-126页

作者： pham thi Anh Institute for Environmental and Transport Studies Ho Chi Minh City University of Transport Ho Chi Minh City Vietnam

Raising public awareness and participation of the local communities in the environmental protection has become a major objective of sound development programs. In the framework of the canal environmental protection program of Ho Chi Minh City, we had developed 32 public awareness meetings for 14 districts with about 2,726 participants from year 2012 to 2015. The program had been organized in various forms such as training, brochure, leaflet, poster, propaganda gifts, face-to-face discussion, study visits, survey questionnaire. The results of the program can add substantial value to the canal environmental protection program of the city. The information gained through public comments can help identify key issues and solutions for the authorities as district and city levels. It was determined that most important outcomes from the public participation were educating the public, incorporating public values, assumptions and preferences into decision making process.

关键词： Public awareness participation environmental canal.

How knowledge of hepatitis B disease and vaccine influences vaccination practices among parents in Ho Chi Minh City, Vietnam

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Asian Pacific Journal of Tropical Medicine 2021年第3期14卷 122-127页

作者： Giao Huynh Le An pham thien Thuan Tran Ngoc Nga Cao thi Ngoc Han Nguyen Quang Vinh Bui Faculty of Public Health University of Medicine and Pharmacy at Ho Chi Minh CityVietnam Center for Training of Family Medicine University of Medicine and Pharmacy at Ho Chi Minh CityVietnam Department of Infectious Diseases University of Medicine and Pharmacy at Ho Chi Minh CityVietnam Infection Control Department University Medical Center at Ho Chi Minh CityVietnam Department of Pediatrics University of Medicine and Pharmacy at Ho Chi Minh CityVietnam

Objective:To assess the influences of the knowledge of parents about hepatitis B virus(HBV)infection and the benefit of HBV vaccination on the practice of HBV vaccination among ***:A prospective cross-sectional study recruited parents whose children,aged 12-24 months,received HBV vaccination at Commune Health Centers(CHCs)in Ho Chi Minh City from Feb.2016 to *** were interviewed using a questionnaire that included 11-item binary knowledge questions and checked their children’s vaccination ***:A total of 768 parents had a mean age of(30.8±5.1)*** mean knowledge score of the 11-item questions was(7.0±2.4).The knowledge score was positively associated with full and timely HBV *** addition,children who received complete and timely HBV vaccination were significantly more likely to live in rural areas(Adjusted OR 4.02,95%CI 2.79-5.79,P<0.001).Also,children whose parents received vaccination information from health care providers,and had knowledge about HBV risk,had a higher rate of full and timely HBV vaccination(Adjusted OR 1.60,95%CI 1.13-2.29,and Adjusted OR 1.47,95%CI 1.01-2.13,P all<0.05).Conclusions:Parents possessed a great deal of incorrect knowledge about *** health education from health care providers should target parents living in specific locations and focus on the benefits of HBV vaccine.

关键词： Knowledge Hepatitis Health Belief Model Vaccination Questionnaire

Selection of Sesame Accessions(Sesamum indicum L.)in Thua thien Hue Province,Vietnam

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Journal of Agricultural Science and Technology(A) 2017年第B10期7卷 24-31页

作者： Tram thi hoai Nguyen The thi Dieu Nguyen Hai thi Hong Truong Institute of Biotechnology Hue UniversityTinh Lo 10 StreetHue City 530000Vietnam Hue University 03 Le Loi StreetHue City 530000Vietnam

The main objective of this study was to select the best accessions for use as potential breeding sources in Thua thien Hue province.A total of 16 accessions were used in this study,of which three accessions from Ho Chi Minh city in Vietnam,four accessions supplied by Japan,six accessions collected from China,two accessions provided by the United States and one MèVàng local accession(control)from Thua thien *** field experiment was conducted from August 2016 to November 2016 and laid out in a random complete block design(RCBD)for three replications at Huong Long ward,Hue city,Thua thien Hue *** accession was observed 10 plants per *** size of each plot was 10 m2 and the spacing of 25 cm×10 cm was *** results showed that experiment accessions can grow under Thua thien Hue *** those,the actual yield of VV12,VDM21,VH12,VDM50,VH01 and VDM45 were higher than the other accessions with 1.65,1.64,1.55,1.54,1.52 and 1.45 tons/ha,*** content of these six accessions was above 50%.Therefore,VV12,VDM21,VH12,VDM50,VH01 and VDM45 can be used for breeding and cultivation under local condition.

关键词： Sesame accession growth yield Thua thien Hue province

Prediction of Flash Flood Susceptibility of Hilly Terrain Using Deep Neural Network:A Case Study of Vietnam

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Computer Modeling in Engineering & Sciences 2023年第6期135卷 2219-2241页

作者： Huong thi Thanh Ngo Nguyen Duc Dam Quynh-Anh thi Bui Nadhir Al-Ansari Romulus Costache Hang Ha Quynh Duy Bui Sy Hung Mai Indra Prakash Binh Thai pham University of Transport Technology Hanoi100000Vietnam Department of Civil Environmental and Natural Resources EngineeringLulea University of TechnologyLulea97187Sweden Department of Civil Engineering Transilvania University of BrasovBrasov500152Romania Danube Delta National Institute for Research and Development Tulcea820112Romania Departement of Geodesy and Geomatics National University of Civil EngineeringHanoi100000Vietnam Faculty of Hydraulic Engineering National University of Civil EngineeringHanoi100000Vietnam DDG(R)Geological Survey of India Gandhinagar382010India

Flash floods are one of the most dangerous natural disasters,especially in hilly terrain,causing loss of life,property,and infrastructures and sudden disruption of *** types of floods are mostly associated with landslides and erosion of roads within a short *** of Vietnamis hilly and mountainous;thus,the problem due to flash flood is severe and requires systematic studies to correctly identify flood susceptible areas for proper landuse planning and traffic *** this study,three Machine Learning(ML)methods namely Deep Learning Neural Network(DL),Correlation-based FeatureWeighted Naive Bayes(CFWNB),and Adaboost(AB-CFWNB)were used for the development of flash flood susceptibility maps for hilly road section(115 km length)of National Highway(NH)-6 inHoa Binh province,*** the proposedmodels,88 past flash flood events were used together with 14 flash floods affecting topographical and geo-environmental *** performance of themodels was evaluated using standard statisticalmeasures including Receiver Operating Characteristic(ROC)Curve,Area Under Curve(AUC)and Root Mean Square Error(RMSE).The results revealed that all the models performed well(AUC>0.80)in predicting flash flood susceptibility zones,but the performance of the DL model is the best(AUC:0.972,RMSE:0.352).Therefore,the DL model can be applied to develop an accurate flash flood susceptibility map of hilly terrain which can be used for proper planning and designing of the highways and other infrastructure facilities besides landuse management of the area.

关键词： Flash flood deep learning neural network(DL) machine learning(ML) receiver operating characteristic curve(ROC) Vietnam

Influence of phytochemicals in piper betle linn leaf extract on wound healing

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Burns & Trauma 2015年第3期3卷 143-150页

作者： Le thi Lien Nguyen thi Tho Do Minh Ha pham Luong Hang Phan Tuan Nghia Nguyen Dinh Thang Department of Biochemistry and Plant Physiology VNU University of ScienceVietnam National University334 Nguyen Trai St.Thanh Xuan DistrictHanoiVietnam Key laboratory of Enzyme and Protein Technology(KLEPT) VNU University of ScienceVietnam National UniversityHanoiVietnam

Background:Wound healing has being extensively investigated over the *** impairment is caused by many reasons including increasing of free-radicals-mediated damage,delaying in granulation tissue formation,reducing in angiogenesis and decreasing in collagen *** facts consequently lead to chronic wound *** betle Linn(Betle)leaves have been folklore used as an ingredient of drugs for cutaneous wound ***,the effect of betle leaf on wound healing is not yet well *** this study,we aimed to investigate the healing efficacy of methanol leaf extract of Piper betle Linn on proliferation of fibroblast NIH3T3 cells as well as full-thickness burn and excision wounds in swiss ***:Scratch wound healing assays were conducted to examine the effects of betle leaf extract on healing activity of fibroblast *** and excision wounds on swiss mouse skins were created for investigating the wound healing progress caused by the betle leaf ***(MDA)was also evaluated to examine the products of lipid hydroperoxide(LPO)under conditions of with or without betle leaf extract ***:The results of this study showed that Piper betle Linn leaf extract in methanol increased proliferation of NIH3T3 cells and promoted wound healing in vitro and in vivo with both burn wound and excision wound *** addition,this extract significant decreased level of malondialdehyde(MDA)in liver of treated-mice compared with that in non-treated ***:Our results suggest that Piper betle Linn can be used as an ingredient in developing natural origin drugs for treatment of cutaneous wounds.

关键词： Piper betle Linn Leaf extract Wound healing Malondialdehyde(MDA) Fibroblast(NIH3T3)

Drought and conflicts at the local level: Establishing a water sharing mechanism for the summer-autumn rice production in Central Vietnam

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International Soil and Water Conservation Research 2019年第4期7卷 362-375页

作者： Chuong Van Huynh Catharien Terwisscha van Scheltinga Ty Huu pham Non Quoc Duong Phuong thi Tran Linh Hoang Khanh Nguyen Tung Gia pham Ngoc Bich Nguyen Jos Timmerman Hue University Viet Nam Climate Change and Adaptive Land and Water Management Group Wageningen Environmental ResearchNetherlands University of Agriculture and Forestry Hue UniversityViet Nam

In recent years,water for agricultural production gradually became a significant challenge in the context of climate change in *** solutions are required,which consider the use of resources for both human needs and ecology,and that account for the equitable distribution and the livelihood of the farmers now and in the *** particular,the farmers in the province of Quang Nam faring water shortage in the cultivation of paddy in the summer-autumn *** arise regarding the sharing of the water between the farmers,the drinking water company and the hydropower *** the context of climate change,the water shortage is expected to increase in the *** article presents the results of participatory action research (PAR) approach to develop a local level mechanism for water sharing,in which stakeholders actively *** sharing mechanism was developed,envisioning a sustainable solution for inclusive water *** mechanism was successfully implemented in two cases,one at commune level (Tho stream) and one at the district level (Mo stream).The participatory approach proved to be successful in setting up a broadly acceptable mechanism that will need to be further incorporated in the institutional set-up.

关键词： Adaptation Agriculture Climate change Governance Rice production Water sharing

Ecoregional variations of aboveground biomass and stand structure in evergreen broadleaved forests

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Journal of Forestry Research 2020年第5期31卷 1713-1722页

作者： Tran Van Do Mamoru Yamamoto Osamu Kozan Vo Dai Hai Phung Dinh Trung Nguyen Toan Thang Lai Thanh Hai Vu Thanh Nam Trieu Thai Hung Hoang Van Thang Tran Duc Manh Cao Chi Khiem Vu Tien Lam Nguyen Quang Hung Tran Hoang Quy pham Quang Tuyen Trinh Ngoc Bon Nguyen thi Thu Phuong Ninh Viet Khuong Nguyen Van Tuan Dang thi Hai Ha Tran Hai Long Dang Van Thuyet Dang thinh Trieu Nguyen Van thinh Tran Anh Hai Duong Quang Trung Nguyen Van Bich Dinh Hai Dang pham Tien Dung Nguyen Huy Hoang Le thi Hanh Phan Minh Quang Nguyen thi Thuy Huong Hoang Thanh Son Nguyen Thanh Son Nguyen thi Van Anh Nguyen thi hoai Anh pham Dinh Sam Hoang thi Nhung Hoang Van Thanh Nguyen Huu thinh Tran Hong Van Ho Trung Luong Bui Kieu Hung Research Institute for Sustainable Humanosphere Kyoto UniversityUjiKyotoJapan Silviculture Research Institute Vietnamese Academy of Forest SciencesNorth Tu LiemHanoiVietnam Center for Southeast Asian Studies Kyoto UniversityKyotoJapan Vietnamese Academy of Forest Sciences North Tu LiemHanoiVietnam Vietnam Administration of Forestry No.2 Ngoc HaBa DinhHanoiVietnam

Biotic and abiotic factors control aboveground biomass(AGB)and the structure of forest *** study analyses the variation of AGB and stand structure of evergreen broadleaved forests among six ecoregions of Vietnam.A data set of 1731-ha plots from 52 locations in undisturbed old-growth forests was *** results indicate that basal area and AGB are closely correlated with annual precipitation,but not with annual temperature,evaporation or hours of *** area and AGB are positively correlated with trees>30 cm *** areas surveyed(52.6%)in these old-growth forests had AGB of 100–200 Mg ha^-1;5.2%had AGB of 400–500 Mg ha^-1,and 0.6%had AGB of>800 Mg ha^-*** percent of the areas surveyed had stand densities of 300–600 ***^-1,and 64%had basal areas of 20–40 m^2 ha^-*** is an important factor influencing the AGB of old-growth,evergreen broadleaved forests in *** causing the loss of large-diameter trees(e.g.,>100 cm DBH)affects AGB but may not seriously affect stand density.

关键词： Aboveground biomass Carbon storage Climatic variables Ecoregion Edaphic variables Oldgrowth forest

Adiponectin restores the obesity-induced impaired immunomodulatory function of mesenchymal stromal cells via glycolytic reprogramming

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Acta Pharmaceutica Sinica B 2024年第1期14卷 273-291页

作者： Duc-Vinh pham thi-Kem Nguyen Bao-Loc Nguyen Jong-Oh Kim Jee-Heon Jeong Inho Choi Pil-Hoon Park Department of Pharmacology Hanoi University of PharmacyHanoi 100000Viet Nam College of Pharmacy Yeungnam UniversityGyeongsan 38541Republic of Korea Department of Medical Biotechnology Yeungnam UniversityGyeongsan 38541Republic of Korea Research Institute of Cell Culture Yeungnam UniversityGyeongsan 38541Republic of Korea Department of Precision Medicine School of MedicineSungkyunkwan UniversitySuwon 16419Republic of Korea

Obesity has been known to negatively modulate the life-span and immunosuppressive potential of mesenchymal stromal cells(MSC).However,it remains unclear what drives the compromised potency of obese *** this study,we examined the involvement of adiponectin,an adipose tissuederived hormone,in obesity-induced impaired therapeutic function of ***-induced obesity leads to a decrease in serum adiponectin,accompanied by impairment of survival and immunomodulatory effects of adipose-derived MSC(ADSC).Interestingly,priming with globular adiponectin(gAcrp)improved the immunomodulatory potential of obese *** effects were also observed in lean *** addition,gAcrp potentiated the therapeutic effectiveness of ADSC in a mouse model of DSS-induced ***,while obesity inhibited the glycolytic capacity of MSC,gAcrp treatment induced a metabolic shift toward glycolysis through activation of adiponectin receptor type 1/p38 MAPK/hypoxia inducible factor-1a *** findings suggest that activation of adiponectin signaling is a promising strategy for enhancing the therapeutic efficacy of MSC against immune-mediated disorders.

关键词： Adiponectin Adipose-derived stromal cells Colitis Glycolytic induction HIF1a Immunomodulation Mesenchymal stromal cells Obesity