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越南城市地区年轻人患结核病的增加未影响人群结核感染危险率的降低

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国际结核病与肺部疾病杂志 2010年第3期5卷 289-295页

作者： T.n.Buu H.T.Quy n.C.Qui n.T.n.Lan D.n.Sy F.G.J.Cobelens 范永德王雪静 pham ngoc Thach Tuberculosis and Lung Disease Hospital Ho Chi Minh CityHo Chi Minh Province national Tuberculosis Program and Central Tuberculosis and Lung Disease Hospital Ha Noi CityVietnam KnCV Tuberculosis Foundation The Hague Centre for Poverty-related Communicable Diseases Centre for Infection and Immunity AmsterdamAcademic Medical CentreAmsterdamThe Netherlands

目的:评价越南年轻成年人的结核病登记率增加是否造成结核病在大众人群中传播的增加。方法:使用1996—2005年间县/区级结核病防治机构常规报告的数据计算出新涂阳结核登记率的趋势。对6～9岁儿童进行结核菌素调查,使用其结果计算结核年... 详细信息

目的:评价越南年轻成年人的结核病登记率增加是否造成结核病在大众人群中传播的增加。方法:使用1996—2005年间县/区级结核病防治机构常规报告的数据计算出新涂阳结核登记率的趋势。对6～9岁儿童进行结核菌素调查,使用其结果计算结核年感染危险率的趋势。结果:自1996年至2006年间,15～24岁年龄组结核病登记率的年增长率为4.3%,且城市地区的年增长率(6.7%)比农村地区(1.7%)更高。城市地区的结核年感染危险率从1992年的2.4%下降到1998年的1.2%和2005年的0.9%;摘要农村地区的结核年感染危险率从1991年的0.7%上升到1997年的1.2%,之后下降到2006年的0.9%。结论:在胡志明省,年轻成年人结核病登记率升高,但同时儿童结核年感染危险率下降。这说明年轻成年人的结核病登记率变化趋势反映了在这一年龄段从结核菌感染发展成为结核病患者的比例升高了,以及/或在这一年龄段的结核病传播增加了,但不能说结核病在全人群中的传播增加了。

关键词：结核感染率病例登记越南城市地区

Boceprevir early-access for advanced-fibrosis/cirrhosis in Asia-pacific hepatitis C virus genotype 1 non-responders/relapsers

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World Journal of Gastroenterology 2015年第28期21卷 8660-8669页

作者： Wattana Sukeepaisarnjaroen Tri pham Tewesak Tanwandee Saroja nazareth Sam Galhenage Lindsay Mollison Leanne Totten Alan Wigg Rosalie Altus Anton Colman Brenda Morales Sue Mason Tracey Jones nadine Leembruggen Vince Fragomelli Cheryl Sendall Richard Guan Dede Sutedja Soek Siam Tan Yock Young Dan Yin Mei Lee Widjaja Luman Eng Kiong Teo Yin Min Than Teerha Piratvisuth Seng Gee Lim Srinagarind Hospital Cabramatta Practice Siriraj Hospital Bangkok Royal Perth Hospital Fremantle Hospital Flinders Medical Centre Royal Adelaide Hospital Austin Hospital Royal Prince Alfred Hospital John Hunter Hospital nepean Hospital Cairns Base Hospital Mount Elizabeth Medical Centre Gleneagles Hospital Selayang Hospital national University Health System Yong Loo Lin School of Medicine National University of Singapore Changi General Hospital nKC Institute of Gastroenterology and Hepatology Prince of Songkla University

AIM:To examined the efficacy and safety of treatment with boceprevir,PEGylated-interferon and ribavirin(PR)in hepatitis C virus genotype 1(HCVGT1) PR treatmentfailures in ***:The Boceprevir named-Patient Program provided boceprevir to HCVGT1 PR *** physicians were invited to contribute data from their patients:baseline characteristics,ontreatment responses,sustained virological response at week 12(SVR12),and safety were collected and *** analysis was performed to determine predictors of ***:150 patients were enrolled from Australia,Malaysia,Singapore and Thailand(Asians = 86,Caucasians = 63).Overall SVR12 was 61%(Asians= 59.3%,Caucasians = 63.5%).SVR12 was higher in relapsers(78%) compared with non-responders(34%).On-treatment responses predicted SVR,with undetectable HCVRnA at week 4,8 and 12 leading to SVR12 s of 100%,87%,and 82%respectively,and detectable HCVRnA at week 4,8 and 12,leading to SVR12 s of 58%,22%and 6%*** patients were similar to Caucasian patients with regards to on-treatment *** with cirrhosis(n= 69) also behaved in the same manner with regards to on-treatment *** with the IL28 B CC genotype(80%) had higher SVRs than those with the CT/TT(56%) genotype(P = 0.010).Multivariate analysis showed that TW8 and TW12 responses were independent predictors of *** adverse events occurred in 18.6%:sepsis(2%),decompensation(2.7%) and blood transfusion(14%).Discontinuations occurred in 30.7%,with 18.6%fulfilling stopping ***:Boceprevir can be used successfully in PR treatment failures with a SVR12 > 80%if they have good on-treatment responses;however,discontinuations occurred in 30%because of virological failure or adverse events.

关键词： Chronic hepatitis C Treatment failure Rapid virological response Lead-in null response Partial response Relapse Cirrhosis Response guidedtherapy

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CD10在毛发上皮瘤和基底细胞癌中的表达

世界核心医学期刊文摘（皮肤病学分册） 2006年第5期2卷 57-57页

作者： pham T.T.n. Selim M.A. Burchette Jr. J.L. C. Herman 党倩丽 Box 3712 Davison Building Duke University Medical Center Durham NC 27710 United States Dr.

Background: Trichoepithelioma (TE) is a benign neoplasm that shares both clinical and histologic features with basal cell carcinoma (BCC). However, it is important to distinguish these neoplasms. Limited immunohistochemical stains are available to separate these two tumors. Methods: CD10 protein immunohistochemistry was performed on paraffin-embedded biopsies of 13 TE and 23 BCC diagnosed by routine microscopy. Cases were analyzed for pattern of CD10 expression by tumor cells and surrounding stroma. Results: Twelve of 13 (92% ) TE showed positive stromal immunoreactivity. Of these, eight cases also demonstrated positivity of the papilla, and two also showed positivity of the basaloid cells. no TE demonstrated epithelial expression alone. On the other hand, expression of CD10 by basaloid cells was identified in 20 (87% ) cases of BCC. Stromal positivity was also identified in three cases of BCC. Condensation of CD10-positive stromal cells around basaloid nests was statistically significant in differentiating TE from BCC (p nversely, CD10-positive basaloid cells were seen predominantly in BCC (p nclusions: This study demonstrates a statistically significant difference in CD10 staining pattern between TE and BCC. Thus, CD10 may be a useful adjunct marker in distinguishing these tumors.

关键词：毛发上皮瘤 CD10 基底细胞癌免疫组化染色石蜡包埋标本常规病检组织学特征真皮乳头表皮细

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岗松枝叶正丁醇萃取部位的化学成分

药学与临床研究 2017年第5期25卷 389-392页

作者：周俊能侯继芹范氏英汪豪中国药科大学天然药物化学教研室南京210009

从岗松(Baeckea frutescens L.)枝叶正丁醇萃取部位分离鉴定了12个化合物,分别为:槲皮素(1),杨梅素(2),槲皮素3-O-α-L-吡喃鼠李糖苷(3),杨梅素3-O-α-L-吡喃鼠李糖苷(4),槲皮素3-O-α-L-呋喃阿拉伯糖苷(5),槲皮素3-O-β-D-吡喃木糖苷(... 详细信息

从岗松(Baeckea frutescens L.)枝叶正丁醇萃取部位分离鉴定了12个化合物,分别为:槲皮素(1),杨梅素(2),槲皮素3-O-α-L-吡喃鼠李糖苷(3),杨梅素3-O-α-L-吡喃鼠李糖苷(4),槲皮素3-O-α-L-呋喃阿拉伯糖苷(5),槲皮素3-O-β-D-吡喃木糖苷(6),槲皮素3-O-α-L-吡喃阿拉伯糖(7),槲皮素4′-O-β-D-吡喃葡萄糖苷(8),山柰酚3-O-α-L-呋喃阿拉伯糖苷(9),山柰酚3-O-α-L-吡喃鼠李糖苷(10),myricetin 3-O-(2′′-O-galloyl)-α-Lrhamnopyranoside(11),myricetin 3-O-(3′′-O-galloyl)-α-L-rhamnopyranoside(12)。其中化合物5~12为首次从该植物枝叶中分离得到。

关键词：岗松化学成分黄酮类

食管癌放疗前18F-FDGPET有助于识别罹患放射性肺炎的高危人群

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国际医学放射学杂志 2015年第4期 384-384页

作者： R.Castillo n.pham E.Castillo S.Aso-Gonzalez S.Ansari B.Hobbs 麻智慧 Department of Radiation Oncology The University of Texas Medical Branch Galveston Tex

摘要目的研究放疗(RT)前18F-FDG的摄取与放疗后症状性放射性肺炎(RP)的相关性。材料与方法本研究经机构伦理委员会批准,回顾性分析放化疗前行FDG PET/CT检

关键词：食管癌症状性 RP FDG 放化疗食管肿瘤放射性肺炎放射损伤 F-FDGPET

MRI引导下定向乳腺超声探查中附加剪切波成像:对病灶检测和靶向活检的作用

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国际医学放射学杂志 2014年第6期 572-572页

作者： D.M.Plecha R.M.pham n.Klein A.Coffey A.Sattar H.Marshall 李志超 Department of Radiology University Hospitals Case Medical Center11100 Euclid AveClevelandOH 44106

摘要目的确定乳腺动态增强(DCE)MR检查后,定向超声中附加剪切波成像(SWE)是否有助于发现或定位MRI检出的病灶。材料与方法本前瞻性研究遵从HIPAA,并得到

关键词： MRI 病灶剪切波乳腺乳房

一个病例系列:越南胡志明市WHO标准复治方案治疗耐多药结核病人初步结果

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国际结核病与肺部疾病杂志 2001年第3期 137-139页

作者： n. T. n. Lan M. F. lademarco n. J. Binkin L. B. Tung H. T. Quy n. V. Co 张本 pham ngoc Thach Tuberculosis and Lung Diseases Center Ho Chi Minh City Vietnam Division of Tuberculosis Elimination National Center for HIV STD and TB Prevention Centers for Disease Control and Prevention Atlanta Georgia USA national Institute of Tuberculosis and Respiratory Diseases Hanoi Vietnam

阐述耐多药结核病人(MDR-TB),即至少对异烟肼和利福平耐药,初治后复发或失败后接受WHO推荐的标准复治方案病人转归的有关资料很少。在这一病例系列中,我们检查了常规样本,42例已记录为MDR-TB并已接受WHO标准复治方案(2SHRZE/1HRZE/5H_3R... 详细信息

阐述耐多药结核病人(MDR-TB),即至少对异烟肼和利福平耐药,初治后复发或失败后接受WHO推荐的标准复治方案病人转归的有关资料很少。在这一病例系列中,我们检查了常规样本,42例已记录为MDR-TB并已接受WHO标准复治方案(2SHRZE/1HRZE/5H_3R_3E_3)的复发或失败病人的治疗结果。一例病人在治疗的最后一个月内死亡;其余41例病人完成复治方案。42例病人中,14例(33％)完成治疗时痰涂片阴性。MDR-TB用WHO复治方案治愈的病人比例与结核病无化疗的时代结果相似。

关键词：耐多药结核病复发和失败病例复治方案

DPHL:A DIA Pan-human Protein Mass Spectrometry Library for Robust Biomarker Discovery

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Genomics, Proteomics & Bioinformatics 2020年第2期18卷 104-119页

作者： Tiansheng Zhu Yi Zhu Yue Xuan Huanhuan Gao Xue Cai Sander R.Piersma Thang V.pham Tim Schelfhorst Richard R.G.D.Haas Irene V.Bijnsdorp Rui Sun Liang Yue Guan Ruan Qiushi Zhang Mo Hu Yue Zhou Winan J.Van Houdt Tessa Y.S.Le Large Jacqueline Cloos Anna Wojtuszkiewicz Danijela Koppers-Lalic Franziska Bottger Chantal Scheepbouwer Ruud H.Brakenhoff Geert J.L.H.van Leenders Jan n.M.Ijzermans John W.M.Martens Renske D.M.Steenbergen nicole C.Grieken Sathiyamoorthy Selvarajan Sangeeta Mantoo Sze S.Lee Serene J.Y.Yeow Syed M.F.Alkaff nan Xiang Yaoting Sun Xiao Yi Shaozheng Dai Wei Liu Tian Lu Zhicheng Wu Xiao Liang Man Wang Yingkuan Shao Xi Zheng Kailun Xu Qin Yang Yifan Meng Cong Lu Jiang Zhu Jin'e Zheng Bo Wang Sai Lou Yibei Dai Chao Xu Chenhuan Yu Huazhong Ying Tony K.Lim Jianmin Wu Xiaofei Gao Zhongzhi Luan Xiaodong Teng Peng Wu Shi'ang Huang Zhihua Tao narayanan G.Iyer Shuigeng Zhou Wenguang Shao Henry Lam Ding Ma Jiafu Ji Oi L.Kon Shu Zheng Ruedi Aebersold Connie R.Jimenez Tiannan Guo Zhejiang Provincial Laboratory of Life Sciences and Biomedicine Westlake UniversityHangzhou 310024China Key Laboratory of Structural Biology of Zhejiang Province School of Life SciencesWestlake UniversityHangzhou 310024China Institute of Basic Medical Sciences Westlake Institute for Advanced StudyHangzhou 310024China School of Computer Science Shanghai Key Laboratory of Intelligent Information ProcessingFudan UniversityShanghai 200433China Thermo Fisher Scientific(BREMEn)GmbH Bremen 28195Germany OncoProteomics Laboratory Department of Medical OncologyVU University Medical CenterVU UniversityAmsterdam 1011The Netherlands Amsterdam UMC Vrije Universiteit AmsterdamUrologyCancer Center AmsterdamAmsterdam 1011The Netherlands Thermo Fisher Scientific Shanghai 201206China The netherlands Cancer Institute Surgical OncologyAmsterdam 1011The Netherlands Amsterdam UMC Vrije Universiteit AmsterdamSurgeryCancer Center AmsterdamAmsterdam 1011The Netherlands Amsterdam UMC Vrije Universiteit AmsterdamPediatric Oncology/HematologyCancer Center AmsterdamAmsterdam 1011The Netherlands Amsterdam UMC Vrije Universiteit AmsterdamHematologyCancer Center AmsterdamAmsterdam 1011The Netherlands Amsterdam UMC Vrije Universiteit AmsterdamMedical OncologyCancer Center AmsterdamAmsterdam 1011The Netherlands Amsterdam UMC Vrije Universiteit AmsterdamNeurosurgeryCancer Center AmsterdamAmsterdam 1011The Netherlands Amsterdam UMC Vrije Universiteit AmsterdamPathologyCancer Center AmsterdamAmsterdam 1011The Netherlands Amsterdam UMC Vrije Universiteit AmsterdamOtolaryngology/Head and Neck SurgeryCancer Center AmsterdamAmsterdam 1011The Netherlands Erasmus MC University Medical Center PathologyRotterdam 1016LVThe Netherlands Erasmus MC University Medical Center SurgeryRotterdam 1016LVThe Netherlands Erasmus MC University Medical Center Medical OncologyRotterdam 1016LVThe Netherlands Department of Anatomical Pathology Singapore General HospitalSingapore 169608Singapore Division of Medical Scie

To address the increasing need for detecting and validating protein biomarkers in clinical specimens,mass spectrometry(MS)-based targeted proteomic techniques,including the selected reaction monitoring(SRM),parallel reaction monitoring(PRM),and massively parallel dataindependent acquisition(DIA),have been *** optimal performance,they require the fragment ion spectra of targeted peptides as prior *** this report,we describe a MS pipeline and spectral resource to support targeted proteomics studies for human tissue *** build the spectral resource,we integrated common open-source MS computational tools to assemble a freely accessible computational workflow based on *** then applied the workflow to generate DPHL,a comprehensive DIA pan-human library,from 1096 data-dependent acquisition(DDA)MS raw files for 16 types of cancer *** extensive spectral resource was then applied to a proteomic study of 17 prostate cancer(PCa)***,PRM validation was applied to a larger study of 57 PCa patients and the differential expression of three proteins in prostate tumor was *** a second application,the DPHL spectral resource was applied to a study consisting of plasma samples from 19 diffuse large B cell lymphoma(DLBCL)patients and 18 healthy control *** expressed proteins between DLBCL patients and healthy control subjects were detected by DIA-MS and confirmed by *** data demonstrate that the DPHL supports DIA and PRM MS pipelines for robust protein biomarker *** is freely accessible at https://***/page/***?id=IPX0001400000.

关键词： Data-independent acquisition Parallel reaction monitoring Spectral library Prostate cancer Diffuse large B cell lymphoma

Composition of Starch and Protein in the Endosperm of newly Generated Double Recessive Waxy and Opaque 2 Maize （Zea mays L.） Genotypes

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Journal of Agricultural Science and Technology(B) 2011年第5期1卷 631-637页

作者： n. C. Dang M. Munsch I. Aulinger W. Renlai H. Le-Huy S. Jampaton P. Stamp Institute of Plant Animal and Agroecosystem Sciences ETH Zurich Universitaetstrasse 2 Zurich 8092 Switzerland Guangxi Maize Research Institute Mingyang Nanning 530227 Guangxi P.R.China Agricultural Genetics Institute VAAS Pham Van Dong Street Hanoi 9 Vietnam national Corn and Sorghum Research Center Suwan Farm Pakchong Nakoenratchasima 30130 Thailand

Waxy maize with its pure amylopectin starch is the staple food of many ethnic minorities in hilly regions of Southeast Asia (SEA). A combination of waxy and quality protein maize (QPM) traits would improve the quality of protein of waxy maize for human consumption. Double recessive waxy-QPM (wx-o2) genotypes had been generated from Southern Chinese material by haploid induction of crosses heterozygous for the two quality traits with an absolutely conserved waxy type and an improved amino acid profile. The vitreous kernel trait (due to the additional modifier genes present in QPM) was lost in the wx-o2 plant material; this may be due to the waxy mutation, this is anyhow desirable for acceptance as waxy maize is preferred due to its soft grains. The content of the quality limiting amino acid lysine was greatly increased in double recessive wx-o2 genotypes compared to standard waxy maize, but still with a high variation among genotypes for future improvement. Conclusively, it was indeed possible to combine two grain quality mutations successfully within one genotype and prototypes of double quality wx-o2 are available now to contribute to meet human requirements in essential amino acids and thus reduce malnutrition in various regions of Asia.

关键词：氨基酸组成支链淀粉糯玉米基因型双隐性蛋白质不透明质量突变