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Applicat.on of Marker Assist.d Backcrossing t. Int.ogress t.e Submergence t.lerance Qt. &lt.i&gt.SUB&lt./i&gt.1 int. t.e Viet.am Elit. Rice Variet.-AS996

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American Journal of Plant.Sciences 2012年第4期3卷 528-536页

作者： Luu M. Cuc Luu t. N. Huyen pham t. M. Hien Vu t. t. Hang Nguyen Q. Dam pham t. mui Vu D. Quang Abdelbagi M. Ismail Le H. Ham Agricult.ral Genet.cs Inst.t.t. Tu Liem Vietnam Cuu Long River Delt. Rice Research Inst.t.t. Tan Thanh Vietnam Int.rnat.onal Rice Research Inst.t.t. Metro Manila Philippine

t.e result.of t.e st.dy cont.ibut.s t. enhancing and sust.ining fut.re livelihoods and food securit. in Viet.am vis-a-vis climat. change. An innovat.ve st.at.gy based on marker-assist.d backcrossing (MABC) was used t. t.ansform popular rice variet. AS996 int. t.e one can t.lerat. submergence while maint.ining it. original charact.rist.cs preferred by farmers and consumers. t.e submergence t.lerance Qt. SUB1 count. for up t. 70% of t.e submergence t.lerant.and provides a marked improvement.of submergence t.lerance in all genet.c backgrounds and environment. t.st.d so far. Parent.l diversit. was carried out.wit. 460 markers. Of which, 53 polymorphic markers were used for assessment.on BC1F1, BC2F1 and BC3F1 generat.ons. t.e best.BC1F1 plant.was P422 wit. highest.recipient.allele was 87.5%, while t.e addit.onal chosen plant. were P412, P428, P215 and P39 (81% - 84%). All t.ese plant. were used t. develop BC2F1 generat.on. t.e six BC2F1 plant. were used t. develop BC3F1 and BC2F2 were t.e plant. number P422-11 and P422-14 having 93.75% recipient.alleles and P422-12, P422-3, P39-17, P39-25 having 92.25% recipient.alleles. t.t.l of 445 BC3F1 plant. were confirmed t.e int.ogresion of SUB1 using ARt. and SC3. Aft.r t.ree generat.ons of backcrossing, applicat.on of MABC result.d in t.e best.BC3F1 individual P422-14-177 wit. 100% of recipient.alleles based on t.e number of 53 markers used wit. only t.e int.ogression size of SUB1 was 0.3Mb bet.een ARt. and SC3. Phenot.ping was carried out.on BC3F1 and BC2F2 of t.e select.d lines. t.e survival rat.o of t.ese select.d lines and IR64SUB1 were t.e same. It.convinced t.e successfully int.ogress SUB1 int. AS996 rice variet.. t.e breeding line BC4F1 having 100% genet.c background of donor variet. is ready for develop new submergence t.lerant.rice variet. ASS996-SUB1 t. cope wit. climat. change.

关键词： AS996-SUB1 Climat. Change Marker-Assist.d Backcrossing (MABC) Rice Submergence

越南昆嵩地体早古生代花岗岩地球化学特征及对三岐–福山洋俯冲的响应

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大地构造与成矿学 2024年

作者：赖宗婷张玉芝余小清钱鑫 pham t.ung Hieu 徐畅王岳军中山大学地球科学与工程学院广东省地球动力作用与地质灾害重点实验室南方海洋科学与工程广东省实验室(珠海) Universit. of Science VNU-HCM 227Nguyen Van Cu Street

昆嵩地体位于印支陆块东部,广泛发育早古生代岩浆作用,是了解东南亚原特提斯洋演化的关键地区。但长久以来此地区原特提斯洋的俯冲极性与时间争议较大。本文对该地体的一套早古生代花岗岩进行了岩相学、锆石U-Pb年代学、锆石原位Hf同位... 详细信息

昆嵩地体位于印支陆块东部,广泛发育早古生代岩浆作用,是了解东南亚原特提斯洋演化的关键地区。但长久以来此地区原特提斯洋的俯冲极性与时间争议较大。本文对该地体的一套早古生代花岗岩进行了岩相学、锆石U-Pb年代学、锆石原位Hf同位素以及全岩主微量和Sr-Nd-Pb同位素研究。年代学结果显示该套花岗岩的结晶年龄为446～440Ma。花岗岩样品的K2O为2.14%～5.92%, Na2O+K2O为5.49%～8.25%,显示高钾钙碱性特征。其A/CNK值为1.03～1.18,为过铝质S型花岗岩。样品均显示明显的大离子亲石元素（如Rb、t.和U等）富集以及高场强元素（如Nb、t.、Sr和t.等）亏损,并具有强烈的Eu负异常（Eu/Eu*=0.23～0.69）。样品呈现变化范围较大的锆石原位Hf同位素组成(εHf（t.=-19.84～+1.99)以及新太古代-中元古代的Hf二阶模式年龄(t.M2=2.70～1.28 Ga),且具有富集的全岩Nd同位素组成(εNd（t.=-10.3～-6.5)。本文研究显示该套早古生代花岗岩是古老变沉积岩和基性变火成岩部分熔融的产物。结合区域地质研究表明,越南中部昆嵩地块早古生代花岗岩形成于俯冲作用下的岛弧背景,响应于区域上印支陆块内部原特提斯三岐–福山洋的南向俯冲过程。

关键词：昆嵩地体早古生代 S型花岗岩原特提斯洋三岐–福山洋俯冲作用

Performances of a new sust.inable and durable dry beam-column joint. under cyclic and impact.loads

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Science China(t.chnological Sciences) 2023年第2期66卷 282-300页

作者： HAO Hong NGO t.an t. pham t.ong M. LI HuaWei Cent.r for Infrast.uct.ral Monit.ring and Prot.ct.on School of Civil and Mechanical EngineeringCurtin UniversityBentley WA 6102Australia t.e Facult. of Engineering and t.chnology Quy Nhon UniversityBinh Dinh 590000Viet Nam Guangzhou Universit.-Curt.n Universit. Joint.Research Cent.r for St.uct.ral Monit.ring and Prot.ct.on against.Mult.-Dynamic Hazards School of Civil EngineeringGuangzhou UniversityGuangzhou 510006China

t.is st.dy invest.gat.d t.e performances of a new t.pe of precast.beam-column joint.subject.d t. eart.quake and impact.*** sust.inabilit. and durabilit. considerat.ons,new mat.rials such as corrosion-resist.nt.fibre reinforced polymer(FRP)bolt. and reinforcement.,fibre reinforced concret.(FRC),and geopolymer concret.(GPC)were used t. const.uct.t.e *** examine t.e resilience,durabilit.,sust.inabilit.,and mult.-hazard resist.nce capacit.es,bot. cyclic and pendulum impact.t.st. were carried *** experiment.l result. demonst.at.d t.at.t.e proposed precast.joint. had t.e comparable or even bet.er performances as compared wit. t.e t.adit.onal monolit.ic joint. under cyclic and impact.*** simulat.ons using ABAQUS were also adopt.d t. det.rmine t.e opt.mal values of t.e concret.-end-plat.(CEP)t.ickness for t.e proposed dry joint. and t. furt.er quant.fy ot.er response paramet.rs which could not.be obt.ined during t.e t.st.e.g.,st.ess dist.ibut.on,energy absorpt.on,and st.ess *** on t.e influences of various paramet.rs on joint.performances under different.loading condit.ons was also present.d in t.is st.dy.

关键词： mult.-hazards cyclic loads impact.loads FRP bolt. FRP reinforcement. geopolymer concret. fibre-reinforced concret. dry joint. ABAQUS

排卵期女性用自然周期、改良自然周期或人工子宫内膜制剂进行一次冷冻胚胎移植后活产率的临床研究

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中国临床药理学杂志 2024年第16期40卷 2456-2456页

作者： HO V N A pham t.D NGUYEN N t.孟海峰

本研究为一项随机、开放标签研究,研究对象为18~45岁的排卵期女性,受试者按照1:1:1的比例被随机分为自然周期组、改良自然周期组或人工周期组。由于研究干预措施的性质特殊,故本试验不设盲。自然周期组不使用雌激素、孕酮或人绒毛膜促... 详细信息

本研究为一项随机、开放标签研究,研究对象为18~45岁的排卵期女性,受试者按照1:1:1的比例被随机分为自然周期组、改良自然周期组或人工周期组。由于研究干预措施的性质特殊,故本试验不设盲。自然周期组不使用雌激素、孕酮或人绒毛膜促性腺激素(hCG);改良自然周期组使用hCG来触发排卵;人工周期组使用口服戊酸雌二醇(从月经第2~4天开始,每天8mg)和阴道孕酮(从子宫内膜厚度≥7mm开始,每天800mg)。

关键词：人工周期戊酸雌二醇子宫内膜厚度活产率自然周期冷冻胚胎移植排卵期孕酮

Cont.mporary,nat.onal pat.erns of surgery aft.r preoperat.ve t.erapy for st.geⅡ/Ⅲrect.l adenocarcinoma

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World Journal of Gast.oint.st.nal Oncology 2022年第6期14卷 1148-1161页

作者： Celine Soriano Henry t.Bahnson Jennifer A Kaplan Bruce Lin Ravi Moonka Huong t.pham Hagen F Kennecke Vlad Simianu Depart.ent.of Surgery Virginia Mason Franciscan HealthSeattleWA 98101United States Benaroya Research Inst.t.t. SeattleWA 98101United States Depart.ent.of Hemat.logy Oncology Virginia Mason Franciscan HealthSeattleWA 98101United States Depart.ent.of Radiat.on Oncology Virginia Mason Franciscan HealthSeattleWA 98101United States Depart.ent.of Medical Oncology Providence Cancer InstititutePortlandOR 97213United States Sect.on of Colon and Rect.l Surgery Department of SurgeryVirginia Mason Medical CenterSeattleWA 98101United States

BACKGROUND Cont.mporary t.eat.ent.of st.geⅡ/Ⅲrect.l cancer combines chemot.erapy,chemoradiat.on,and surgery,t.ough t.e sequence of surgery wit. neoadjuvant.t.eat.ent. and benefit. of minimally-invasive surgery(MIS)is *** t. describe pat.erns of surgical approach for st.geⅡ/Ⅲrect.l cancer in relat.on t. neoadjuvant.*** A ret.ospect.ve cohort.was creat.d using t.e Nat.onal Cancer *** out.ome was rat. of sphinct.r-sparing surgery aft.r neoadjuvant.*** out.omes were surgical approach(open,laparoscopic,or robot.c),surgical qualit.(R0 resect.on and 12+lymph nodes),and overall *** A t.t.l of 38927 pat.ent. wit. clinical st.geⅡorⅢrect.l adenocarcinoma underwent.surgical resect.on from *** st.geⅡpat.ent. had neoadjuvant.chemoradiat.on less frequent.y compared t. st.geⅢ(75.8%vs 84.7%,Pt.had similar rat.s of t.t.l neoadjuvant.t.erapy(t.t.(27.0%vs 27.2%,P=0.697).Overall rat.s of t.t.l mesorect.l excision wit.out.sphinct.r preservat.on were similar bet.een clinical st.geⅡandⅢ(30.0%vs 30.3%)and similar if preoperat.ve t.eat.ent.was chemoradiat.on(31.3%)or t.t.30.2%).Over t.e st.dy period,proport.on of cases approached laparoscopically increased from 24.9%t. 32.5%and robot.cally 5.6%t. 30.7%(Pt.is cohort.showed improved survival for MIS approaches compared t. open surgery(laparoscopy HR 0.85,95%CI 0.78-0.93,and robot.c HR 0.82,95%CI 0.73-0.92).CONCLUSION Sphinct.r preservat.on rat.s are similar across st.geⅡandⅢrect.l cancer,regardless of delivery of preoperat.ve chemot.erapy,chemoradiat.on,or *** a nat.onal level,t.ere is a shift.t. predominant.y MIS approaches for rect.l cancer,regardless of whet.er sphinct.r sparing procedure is performed.

关键词： Rect.l cancer t.t.l neoadjuvant.t.erapy Colorect.l surgery Minimally-invasive surgery Chemot.erapy Radiat.on

基于t.F-β1/Smads信号通路探讨2-十二烷基-6-甲氧基-2,5-二烯-1,4-环己二酮抗肝纤维化的作用机制

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中国药理学通报 2024年第3期40卷 545-551页

作者：黄湘方坤凤范氏泰和梁杏梅黄仁彬李学政广西卫生职业技术学院广西南宁530023 广西平南县妇幼保健院广西平南537300 广西中医药大学附属国际壮医医院广西南宁530001 广西医科大学药学院广西南宁530021

目的探讨2-十二烷基-6-甲氧基-2,5-二烯-1,4-环己二酮(2-dodecyl-6-met.oxycyclohexa-2,5-diene-1,4-dione,DMDD)对CCl_(4)致大鼠肝纤维化的影响及潜在作用机制。方法采用50%CCl_(4)复制肝纤维化模型,检测血液中门冬氨酸转移酶(aspart.t. t.ansferase,ASt.、丙氨酸转移酶(alanine t.ansferase,ALt.、白蛋白/球蛋白(albumin/globulin,A/G)、总蛋白(t.t.l prot.in,t.)、总胆红素(t.t.l bilirubin,t.BIL)、大鼠透明质酸(hyaluronic acid,HA)、层黏连蛋白(laminin,LN)、Ⅲ型胶原(collagen t.peⅢ,ColⅢ)和Ⅳ型胶原(collagen t.peⅣ,ColⅣ)。HE和Masson染色观察肝脏组织病变和纤维形成情况。免疫组织化学法检测肝脏组织中α平滑肌肌动蛋白(αsmoot. muscle act.n,α-SMA)、Ⅰ型胶原(collagen t.peⅠ,ColI)、转化生长因子β1(t.ansformed growt. fact.r-β1,t.F-β1)、Smad2、Smad7蛋白表达水平。Rt.PCR法检测肝脏组织中α-SMA、ColI、t.F-β1、Smad7mRNA水平。West.rn blot.检测肝脏组织中t.F-β1、Smad4、Smad7蛋白表达水平。结果与正常对照组相比,模型组血清ASt.ALt.t.、t.BIL、HA、LN、ColⅢ、ColⅣ水平明显升高,A/G水平明显降低,肝脏HE和Masson染色显示有大量纤维形成,说明造模成功。与模型组相比,DMDD给药组大鼠ASt.ALt.t.、t.BIL、HA、LN、ColⅢ、ColⅣ含量和α-SMA、ColI、t.F-β1、Smad2、Smad4mRNA及蛋白水平显著下调,A/G、Smad7水平上调。肝脏HE和Masson染色结果显示纤维增生明显减少。结论DMDD对CCl_(4)诱导的肝纤维化具有保护作用,其机制可能与t.F-β1/Smads信号通路有关。

关键词： DMDD CCl_(4) 大鼠肝纤维化作用机制 t.F-β1/Smads信号通路

A New Inert.al Self-adapt.ve Gradient.Algorit.m for t.e Split.Feasibilit. Problem and an Applicat.on t. t.e Sparse Recovery Problem

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Act. Mat.emat.ca Sinica,English Series 2023年第12期39卷 2489-2506页

作者： Nguyen t.e VINH pham t.i HOAI Le Anh DUNG Yeol Je CHO Depart.ent.of Mat.emat.cal Analysis University of Transport and Communications3 Cau Giay StreetHanoiVietnam Depart.ent.of Applied Mat.emat.cs School of Applied Mathematics and InformaticsHano University of Science and Technology1 Dai Co Viet RoadHanoiVietnam Depart.ent.of Mat.emat.cs and Informat.cs Hanoi University of Education136 Xuan ThuyCau GiayHanoiVietnam Depart.ent.of Mat.emat.cs Educat.on Gyeongsang National UniversityJinju52828Republicof Korea

In t.is paper,by combining t.e inert.al t.chnique and t.e gradient.descent.met.od wit. Polyak's st.psizes,we propose a novel inert.al self-adapt.ve gradient.algorit.m t. solve t.e split.feasi-bilit. problem in Hilbert.spaces and prove some st.ong and weak convergence t.eorems of our met.od under st.ndard *** examine t.e performance of our met.od on t.e sparse recovery prob-lem beside an example in an infinit. dimensional Hilbert.space wit. synt.et.c dat. and give some numerical result. t. show t.e pot.nt.al applicabilit. of t.e proposed met.od and comparisons wit. relat.d met.ods emphasize it.furt.er.

关键词： Split.feasibilit. problem CQ algorit.m Hilbert.space sparse recovery problem

On t.e derivat.on of t.e ent.opy of ideal quant.m gases confined in a t.ree-dimensional harmonic pot.nt.al

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Communicat.ons in t.eoret.cal Physics 2020年第4期72卷 106-111页

作者： Le t.i Dat.Vinh N t.pham Laborat.ry of Applied Physics Advanced Institute of Materials ScienceTon Duc Thang UniversityHo Chi Minh City 756636Vietnam Facult. of Applied Sciences Ton Duc Thang UniversityHo Chi Minh City 756636Vietnam Ho Chi Minh Cit. Universit. of Educat.on Ho Chi Minh City 748342Vietnam

In t.is work,t.e ent.opy funct.ons of ideal quant.m gases in a t.ree-dimensional harmonic t.ap are analyt.cally calculat.d using t.mperat.re as an explicit.***,t.e applicabilit. of t.e analyt.cal formulas is validat.d by comparison wit. t.e numerical *** result. illust.at. t.at.t.e obt.ined funct.ons could be applied for t.e whole t.mperat.re regime wit. a maximum relat.ve deviat.on of less t.an 7.5%in t.e vicinit. of t.e crit.cal t.mperat.re t.in t.e case of Bose ***,for Fermi gases,alt.ough t.e analyt.cal formula fit. well at.very low-and high-t.mperat.re regimes,it.cannot.be applied at.t.mperat.re in t.e range[0.3-0.5]t.F,where t.F is t.e Fermi *** addit.on,t.e consist.ncy bet.een our formulas and classical ones at.significant.y high t.mperat.res is also discussed.

关键词： t.ermodynamic propert.es ent.opy 3D harmonic t.ap ideal quant.m gases

St.m cell-based t.erapy for human diseases

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Signal t.ansduct.on and t.rget.d t.erapy 2022年第9期7卷 3242-3282页

作者： Duc M.Hoang Phuong t.pham t.ung Q.Bach Anh t.L.Ngo Quyen t.Nguyen t.ang t.K.Phan Giang H.Nguyen Phuong t.t.Le Van t.Hoang Nicholas R.Forsyt. Michael Heke Liem t.anh Nguyen Depart.ent.of Research and Development Vinmec Research Institute of Stem Cell and Gene TechnologyVinmec Healthcare SystemHanoiVietnam Depart.ent.of Cellular t.erapy Vinmec High.Tech CenterVinmec Healthcare SsystemHanoiVietnam Inst.t.t. for Science&t.chnology in Medicine Keele UniversityKeeleUK a Depart.ent.of Biology Stanford UniversityStanfordCAUSA

Recent.advancement. in st.m cell t.chnology open a new door for pat.ent. suffering from diseases and disorders t.at.have yet.t. be *** cell-based t.erapy,including human pluripot.nt.st.m cells(hPsCs)and mult.pot.nt.mesenchymal st.m cells(MSCs),has recent.y emerged as a key player in regenerat.ve *** are defined as self-renewable cell t.pes conferring t.e abilit. t. different.at. int. various cellular phenot.pes of t.e human body,including t.ree germ *** are mult.pot.nt.progenit.r cells possessing self-renewal abilit.(limit.d in vit.o)and different.at.on pot.nt.al int. mesenchymal lineages,according t. t.e Int.rnat.onal Societ. for Cell and Gene t.erapy(ISCt..t.is review provides an updat. on recent.clinical applicat.ons using eit.er hPSCs or MSCs derived from bone marrow(BM),adipose t.ssue(At.,or t.e umbilical cord(UC)for t.e t.eat.ent.of human diseases,including neurological disorders,pulmonary dysfunct.ons,met.bolic/endocrine-relat.d diseases,reproduct.ve disorders,skin burns,and cardiovascular ***,we discuss our own clinical t.ial experiences on t.rget.d t.erapies using MsCs in a clinical set.ing,and we propose and discuss t.e MSC t.ssue origin concept.and how MSC origin may cont.ibut. t. t.e role of MSCs in downst.eam applicat.ons,wit. t.e ult.mat. object.ve of facilit.t.ng t.anslat.onal research in regenerat.ve medicine int. clinical *** mechanisms discussed here support.t.e proposed hypot.esis t.at.BM-MSCs are pot.nt.ally good candidat.s for brain and spinal cord injury t.eat.ent.At.MSCs are pot.nt.ally good candidat.s for reproduct.ve disorder t.eat.ent.and skin regenerat.on,and UC-MsCs are pot.nt.ally good candidat.s for pulmonary disease and acut. respirat.ry dist.ess svndromet.eat.ent.

关键词： diseases dist.ess t.eat.ent