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Molecular pathways of liver regeneration:A comprehensive review

World Journal of Hepatology 2021年第3期13卷 270-290页

作者： Yana v Kiseleva Sevak Z Antonyan Tatyana S Zharikova Kirill A Tupikin Dmitry v Kalinin yuri O Zharikov International School“Medicine of the Future” I.M.Sechenov First Moscow State Medical University(Sechenov University)Moscow 119435Russia Department of Emergency Surgical Gastroenterology N.V.Sklifosovsky Research Institute for Emergency MedicineMoscow 129010Russia Department of Human Anatomy I.M.Sechenov First Moscow State Medical University(Sechenov University)Moscow 119048Russia Laboratory of Minimally Invasive Surgery A.I.Evdokimov Moscow State University of Medicine and DentistryMoscow 127473Russia Pathology Department A.V.Vishnevsky National Medical Research Center of Surgery of the Russian Ministry of HealthcareMoscow 117997Russia

The liver is a unique parenchymal organ with a regenerative capacity allowing it to restore up to 70%of its *** knowledge of this phenomenon dates back to Greek mythology(the story of Prometheus),many aspects of liver regeneration are still not understood.A variety of different factors,including inflammatory cytokines,growth factors,and bile acids,promote liver regeneration and control the final size of the organ during typical regeneration,which is performed by mature hepatocytes,and during alternative regeneration,which is performed by recently identified resident stem cells called“hepatic progenitor cells”.Hepatic progenitor cells drive liver regeneration when hepatocytes are unable to restore the liver mass,such as in cases of chronic injury or excessive acute *** liver maintenance,the body mass ratio is essential for homeostasis because the liver has numerous functions;therefore,a greater understanding of this process will lead to better control of liver injuries,improved transplantation of small grafts and the discovery of new methods for the treatment of liver *** current review sheds light on the key molecular pathways and cells involved in typical and progenitor-dependent liver mass regeneration after various acute or chronic *** studies and a better understanding of liver regeneration will lead to the development of new therapeutic methods for liver diseases.

关键词： Liver regeneration Molecular pathways Hepatic progenitor cells Cytokines Micro ribonucleic acid Partial hepatectomy

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Directional coherent light via intensity-induced sideband emission

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Light(Science & Applications) 2016年第1期5卷 33-38页

作者： Andrew J Traverso Chris O’Brien Brett H Hokr Jonathan v Thompson Luqi Yuan Charles W Ballmann Anatoly A Svidzinsky Georgi I petrov Marlan O Scully vladislav v Yakovlev Texas A&M University College StationTX 77843USA Princeton University PrincetonNJ 08544USA Baylor University WacoTX 76798USA

We introduce a unique technique for generating directional coherent emissions that could be utilized to create coherent sources in a wide range of frequencies from the extreme ultraviolet(XUv)to the deep *** is accomplished without population inversion by pumping a two-level system with a far-detuned strong optical field that induces the splitting of the two-level system.A nonlinear process of four-wave mixing then occurs across the split system,driving coherent emission at sidebands both redand blue-detuned from the pump frequency,and propagates both forward and backward along the pump beam *** observed this phenomenon in dense rubidium vapor along both the D_(1) and D_(2) *** sideband emission exhibits a short pulse duration(o1 ns)with threshold-like behavior dependent on both the pump intensity and Rb vapor *** technique offers a new capability for manipulating the emission frequency simply through intensity-induced atomic modulation that can be scaled to most frequency regimes using various atomic/molecular ensembles and pump energies.

关键词： coherent emission collective coherence four-wave mixing

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Globalization as a Social Utopia： Towards the Modem Sociological Criticism of a Mythological Discourse

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Journal of Literature and Art Studies 2017年第4期7卷 465-469页

作者： Alexander v. petrov Saint-Petersburg State University Saint Petersburg Russia

The article presents a social analysis of global transformation processes. The global transformation processes are treated as contradictory. These processes are not as positive as the negative impact on the system of modem societies. Globalization as a popular ideology is based on the mythologizing of global neoliberal pseudo-integration, standardlization and unification. Thus it was formulated mythological discourse of global changes research. Apology of this mythological discourse became the intellectual foundation of globalization as a new social utopia. The article presents a critique of the mythological discourse of globalization. The ideology of globalization is interpreted as social dystopia.

关键词： globalization social science mythological discourse neoliberal ideology modem societies socialutopia social dystopia

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Contribution of functional KIR3DL1 to ankylosing spondylitis

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Cellular & Molecular Immunology 2010年第6期7卷 471-476页

作者： Ivan v Zvyagin Ilgar Z Mamedov Olga v Britanova Dmitriy B Staroverov Evgeni L Nasonov Anna G Bochkova Anna v Chkalina Alexei A Kotlobay Dmitriy O Korostin Denis v Rebrikov Sergey Lukyanov yuri B Lebedev Dmitriy M Chudakov Shemiakin-Ovchinnikov Institute of Bioorganic Chemistry RASMoscowRussia Institute of Rheumatology RAMSMoscowRussia DNA-Technology JSC MoscowRussia vavilov Institute of General Genetics MoscowRussia

Increasing evidence points to a role for killer immunoglobulin-like receptors(KIRs)in the development of autoimmune *** particular,a positive association of KIR3DS1(activating receptor)and a negative association of KIR3DL1(inhibitory receptor)alleles with ankylosing spondylitis(AS)have been reported by several ***,none of the studies analyzed these associations in the context of functionality of polymorphic *** better understand how the KIR3DL1/3DS1 genes determine susceptibility to AS,we analyzed the frequencies of alleles and genotypes encoding functional(KIR3DL1*F)and non-functional(KIR3DL1*004)*** genotyped 83 AS patients and 107 human leukocyte antigen(HLA)-B27-positive healthy controls from the Russian Caucasian population using a two-stage sequence-specific primer PCR,which distinguishes KIR3DS1,KIR3DL1*F and KIR3DL1*004 *** the patients carrying two functional KIR3DL1 alleles,those alleles were additionally genotyped to identify KIR3DL1*005 and KIR3DL1*007 alleles,which are functional but are expressed at low ***3DL1 was negatively associated with AS at the expense of KIR3DL1*F but not of KIR3DL1**** finding indicates that the inhibitory KIR3DL1 receptor protects against the development of AS and is not simply a passive counterpart of the segregating KIR3DS1 allele encoding the activating ***,analysis of genotype frequencies indicates that the presence of KIR3DS1 is a more important factor for AS susceptibility than the absence of KIR3DL1**** activation of either natural killer(NK)or T cells via the KIR3DS1 receptor can be one of the critical events in AS development,while the presence of the functional KIR3DL1 receptor has a protective ***,even individuals with a genotype that carried two inhibitory KIR3DL1 alleles expressed at high levels could develop AS.

关键词： ankylosing spondylitis autoimmune disease HLA-B27 KIR KIR3DL1 KIR3DS1 KIR3DL1*004 NK cell T cell

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An HPC Based Real-time Path Rating Calculation Tool for Congestion Management with High Penetration of Renewable Energy

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CSEE Journal of Power and Energy Systems 2017年第4期3卷 431-439页

作者： Ruisheng Diao Zhenyu Huang yuri v.Makarov Yousu Chen Bruce Palmer Shuangshuang Jin James Wong Pacific Northwest National Laboratory RichlandWA 99352USA Pacific Northwest National Laboratory SeattleWA 98109USA Bonneville Power Administration(BPA) SpokaneWA99201USA

Every year, transmission congestion costs billions ofdollars for electricity customers. This clearly identifies the criticalneed for more transmission capacity and also poses big challengesfor power grid reliability in stressed conditions due to heavyloading and in uncertain situations due to variable renewableresources and responsive smart loads. However, it becomesincreasingly difficult to build new transmission lines, whichtypically involve both economic and environmental *** this paper, advanced computing techniques are developedto enable a non-wire solution that realizes unused transfercapabilities of existing transmission facilities. An integratedsoftware prototype powered by high-performance computing(HPC) is developed to calculate ratings of key transmission pathsin real time for relieving transmission congestion and facilitatingrenewable integration, while complying with the North AmericanElectric Reliability Corporation (NERC) standards on assessingtotal transfer capabilities. The innovative algorithms include: (1)massive contingency analysis enabled by dynamic load balancing,(2) parallel transient simulation to speed up single dynamicsimulation, (3) a non-iterative method for calculating voltagesecurity boundary and (4) an integrated package consideringall NERC required limits. This tool has been tested on realisticpower system models in the Western Interconnection of NorthAmerica and demonstrates satisfactory computational speedusing parallel computers. various benefits of real-time path ratingare investigated at Bonneville Power Administration using realtime EMS snapshots, demonstrating a significant increase in pathlimits. These technologies would change the traditional goals ofpath rating studies, fundamentally transforming how the grid isoperated, and maximizing the utilization of national transmissionassets, as well as facilitating integration of renewable energy andsmart loads.

关键词： Real-time path rating high performance computing total transfer capability transmission congestion voltage stability transient stability massive contingency analysis

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Chirping instabilities produced by a runaway electron beam at a spherical tokamak

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Plasma Science and Technology 2023年第7期25卷 19-24页

作者： I M BALACHENKOv N N BAKHAREv v K GUSEv M v ILIASOvA E M KHILKEvICH P S KORENEv A E KONKOv v B MINAEv Yu v MITRIZHKIN M I PATROv Yu v petrov N v SAKHAROv A E SHEvELEv O M SKREKEL Ioffe Institute Saint-Petersburg 194021Russia Lomonosov Moscow State University Moscow 119991Russia

Two different types of MHD instabilities with rapidly chirping frequency were found to arise in the Globus-M2 spherical tokamak in substantially different frequency *** first type arises at frequencies of an order of 1 MHz in ohmic plasmas at relatively low density(n_(e))ven waves,driven by electrons,accelerated during a sawtooth *** was found that the mode frequency is sweeping in time,according to the Berk-Breizman hole-clump nonlinear chirping *** second type of wave arises in a specific single-swing regime of the central solenoid current with a very narrow plasma column,when the plasma tends to decay at extremely low density(n_(e))ver the whole observed frequency range and are divided into several(two or three)frequency regions:approximately 0-30 MHz,60-120 MHz and sometimes 30-60 *** of the branches was also *** chirps are more rapid than for 1 MHz Alfven instability and follow an exponential *** paper,to our knowledge,is the first report of frequency chirping instabilities excited by accelerated electrons at a spherical tokamak.

关键词： Alfvén waves chirping instability spherical tokamak runaway electrons

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Optical measuring systems and technologies for some urgent tasks in industry and science

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电子测量与仪器学报 2010年第4期24卷 303-306页

作者： yuri v. Chugui Technological Design Institute of Scientific Instrument Engineering of Siberian Branch of the Russian Academy of Sciences (TDI SIE SB RAS) 41 Russkaya str. Novosibirsk 630058 Russia Novosibirsk State University 2 Pirogova str. Novosibirsk 630090 Russia Novosibirsk State Technical University 20 K. Marksa prospekt Novosibirsk 630092 Russia

Modern industry and science take novel optical measuring systems and laser technologies with high resolution and productivity for solving actual tasks,including safety problems for mining,oil,atomic and railway *** TD... 详细信息

关键词：光学测量系统现代工业测量技术发展现状

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R&D synergy between local and foreign-owned enterprises in post-communist economies

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International Journal of Innovation Studies 2023年第2期7卷 101-114页

作者： Maksim A.Yurevich yuri v.Simachev Michail G.Kuzyk Anna A.Fedyunina Centre for Industrial Policy Studies National Research University Higher Schoolof EconomicMoscowRussia Center for MacroeconomicStudies The Financial University Under the Government of the Russian FederationMoscowRussia

This study examines how internal research and development(R&D),external knowledge acquisition,and R&D contracted with other companies interact in local and foreign-owned enterprises in post-communist economies.A large sample of firm-level data from the Business Environment and Enterprise Performance Survey(BEEPS)across 26 postcommunist countries(including European Union(EU)members and non-EU states of Eastern Europe,Caucasian countries,and Central Asian countries)and country-level data from the Global Innovation Index and the International Property Rights Index were *** findings show that enterprises with majority foreign ownership are relatively more likely to acquire external R&*** demonstrate that the R&D behavior of enterprises with majority foreign ownership and local firms are interrelated,that is,we find a synergy *** to the results,decisions on internal R&D and the purchase of external knowledge for enterprises with majority foreign ownership are similar to those of local ***,enterprises with foreign ownership contract R&D with other companies more often if local firms conduct internal R&*** results indicate the presence of knowledge spillover and cross-learning effects in both types of enterprises in postcommunist ***,we find that the national innovation environment is not significant for the R&D intensity of enterprises with majority foreign ownership,which suggests their high dependence on the parent structures of multinational enterprises.

关键词： Foreign ownership BEEPS R&D Market environment

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Specificity of electrophysical and gas-sensitive properties of nanocomposite ZnO–TiO_(2) films formed by solid-phase pyrolysis

ChemPhysMater

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ChemPhysMater 2024年第3期3卷 314-319页

作者： victor v.petrov Maria G.volkova Alexsandra P.Ivanishcheva Gleb v.Tolstyak Ekaterina M.Bayanb Institute of Nanotechnologies Electronicsand Equipment EngineeringSouthern Federal UniversityTaganrog 347922Russia Faculty of Chemistry Southern Federal UniversityRostov-on-Don 344090Russia

ZnO–TiO_(2) thin films containing 0.5 mol%,1.0 mol%,and 5.0 mol%ZnO were synthesized by oxidative solidphase *** materials contained anatase and rutile phases with particle size of 6–13 nm,as confirmed using X-ray phase analysis and scanning electron *** a certain number of ZnO crystallites appeared in the TiO_(2) film structure in the temperature range of room temperature to 220℃,a two-level response of the film resistance was observed,differing by approximately 10%,as obtained by electrophysical *** two-level response correlates with the formation of two donor energy levels of 0.28 and 0.33 ev in the band structure of the ZnO–TiO_(2) *** donor level with a higher activation energy corresponded to the Ti vacancy(v−Ti),and that with a lower activation energy corresponded to the Zn vacancy(v−Zn).Two levels of gas-sensitive properties were noted for 0.5ZnO–TiO_(2),1ZnO–TiO_(2),and 5ZnO–TiO_(2) under the influence of 50 ppm NO_(2) at 250℃.Such two-level responses can be ascribed to the pinning of the Fermi level on ZnO and TiO_(2) *** mechanism of the beak-shaped and two-level responses of sensors based on composite nanomaterials when exposed to various gases was elucidated.

关键词： Thin film ZnO TiO_(2) Nanocomposites Pyrolysis Gas sensors

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Investigation of WZ Sge-type Dwarf Nova ASASSN-19oc:Optical Spectroscopy and Multicolor Light Curve Analysis

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Research in Astronomy and Astrophysics 2024年第8期24卷 20-31页

作者： viktoriia Krushevska Sergey Shugarov Paolo Ochner Yuliana Kuznyetsova Mykola petrov Peter Kroll Astronomical Institute of the Slovak Academy of Sciences Tatranska Lomnica05960 VysokéTatrySlovakia Main Astronomical Observatory of NAS of Ukraine 27 Akademika Zabolotnoho St.03143 KyivUkraine INAF—Osservatorio Astronomico di Padova Vicolo dell’Osservatorio 5I-35122 PadovaItaly Department of Physics and Astronomy University of PadovaVia F.Marzolo 8I-35131 PadovaItaly Max Planck Computing and Data Facility(MPCDF) Gießenbachstrasse 2D-85748 GarchingGermany Sonneberg Observatory Sternwartestr.32D-96515 SonnebergGermany

In this study,we present an investigation of the newly discovered dwarf nova ASASSN-19oc during its superoutburst on 2019 June *** carried out detailed UBvRcIc-photometric observations and also obtained a spectrum on day 7 of the outburst,which shows the presence of hydrogen absorption lines commonly found in dwarf nova *** of photometric data reveals the occurrence of early superhumps in the initial days of observations,followed by ordinary and late *** have accurately calculated the period of the ordinary superhumps as Pord=0.05681(10)days and determined the periods at different stages,as well as the rate of change of the superhump period(P_(dot)=(5)P/P=8.1×10^(-5)).Additionally,we have derived the mass ratio of the components(q=0.09),and estimated the color temperature during the outburst as~11,000 K,the distance to the system(d=560 pc)and absolute magnitude of the system in outburst(Mv=5.3).We have shown that outbursts of this star are very rare:based on brightness measurements on 600 archival photographic plates,we found only one outburst that occurred in *** fact,as well as the properties listed above,convincingly shows that the variable ASASSN-19oc is a dwarf nova of WZ Sge type.

关键词： (stars)binaries(including multiple) close-(stars)novae-cataclysmic variables-stars dwarf novae

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