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Helicobacter pylori infection and other bacteria in pancreatic cancer and autoimmune pancreatitis

World Journal of Gastrointestinal Oncology 2021年第8期13卷 835-844页

作者： Lumir Kunovsky petr Dite petr jabandziev Jiri Dolina Jitka Vaculova Martin Blaho Martina Bojkova Jana Dvorackova Magdalena Uvirova Zdenek Kala Jan Trna Department of Surgery University Hospital Brno and Faculty of MedicineMasaryk UniversityBrno 62500Czech Republic Department of Gastroenterology and Internal Medicine University Hospital Brno and Faculty of MedicineMasaryk UniversityBrno 62500Czech Republic Department of Gastroenterology and Internal Medicine University Hospital OstravaOstrava 70800Czech Republic Faculty of Medicine University of OstravaOstrava 70300Czech Republic Department of Pediatrics University Hospital Brno and Faculty of MedicineMasaryk UniversityBrno 61300Czech Republic Central European Institute of Technology Masaryk UniversityBrno 62500Czech Republic Department of Intensive Medicine Emergency Medicine and Forensic StudiesUniversity Hospital OstravaOstrava 70800Czech Republic CGB Laboratory a.s.Ostrava Ostrava 70300Czech Republic Department of Gastroenterology and Digestive Endoscopy Masaryk Memorial Cancer InstituteBrno 65653Czech Republic Department of Internal Medicine Hospital BoskoviceBoskovice 68001Czech Republic

Helicobacter pylori(***)is an infectious agent influencing as much as 50%of the world’s *** is the causative agent for several diseases,most especially gastric and duodenal peptic ulcer,gastric adenocarcinoma and mucosaassociated lymphoid tissue lymphoma of the stomach.A number of other,extragastric manifestations also are associated with *** *** include neurological disorders,such as Alzheimer’s disease,demyelinating multiple sclerosis and Parkinson’s *** is also evidence for a relationship between *** infection and such dermatological diseases as psoriasis and rosacea as well as a connection with infection and open-angle *** little is known about the relationship between *** infection and diseases of the *** evidence about *** and its potential role in the development of pancreatic diseases concerns pancreatic adenocarcinoma and autoimmune forms of chronic *** is data(albeit not fully consistent)indicating modestly increased pancreatic cancer risk in ***-positive *** pathogenetic mechanism of this increase is not yet fully elucidated,but several theories have been *** of antral Dcells in ***-positive patients causes a suppression of somatostatin secretion that,in turn,stimulates increased secretin *** stimulates pancreatic growth and thus increases the risk of ***,***,as a part of microbiome dysbiosis and the so-called oncobiome,is proven to be associated with pancreatic adenocarcinoma development via the promotion of cellular *** role of *** in the inflammation characteristic of autoimmune pancreatitis seems to be explained by a mechanism of molecular mimicry among several proteins(mostly enzymes)of *** and pancreatic *** with autoimmune pancreatitis often show positivity for antibodies against *** ***,as a part of microbiome dysbiosis,also

关键词： Helicobacter pylori Pancreatic cancer Autoimmune pancreatitis Carcinogenesis Microbiome Molecular mimicry

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