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Bioactive hydrogel microcapsules for guiding stem cell fate decisions by release and reloading of growth factors

Bioactive Materials 2022年第9期7卷 1-14页

作者： Kihak Gwon Hye Jin Hong Alan M.Gonzalez-Suarez Michael Q.Slama Daheui Choi Jinkee Hong Harihara Baskaran Gulnaz Stybayeva Quinn P.peterson Alexander Revzin Department of Physiology and Biomedical Engineering Mayo ClinicRochesterMN55902USA Department of Chemical and Biomolecular Engineering Yonsei UniversitySeoul03722Republic of Korea Department of Chemical and Biomolecular Engineering Case Western Reserve UniversityClevelandOH44106USA

Human pluripotent stem cells(hPSC)hold considerable promise as a source of adult cells for treatment of diseases ranging from diabetes to liver *** of the challenges that limit the clinical/translational impact of hPSCs are high cost and difficulty in scaling-up of existing differentiation *** this paper,we sought to address these challenges through the development of bioactive microcapsules.A co-axial flow focusing microfluidic device was used to encapsulate hPSCs in microcapsules comprised of an aqueous core and a hydrogel ***,the shell contained heparin moieties for growth factor(GF)binding and *** aqueous core enabled rapid aggregation of hPSCs into 3D spheroids while the bioactive hydrogel shell was used to load inductive cues driving pluripotency maintenance and endodermal ***,we demonstrated that one-time,1 h long loading of pluripotency signals,fibroblast growth factor(FGF)-2 and transforming growth factor(TGF)-β1,into bioactive microcapsules was sufficient to induce and maintain pluripotency of hPSCs over the course of 5 days at levels similar to or better than a standard protocol with soluble ***,stem cell-carrying microcapsules that previously contained pluripotency signals could be reloaded with an endodermal cue,Nodal,resulting in higher levels of endodermal markers compared to stem cells differentiated in a standard ***,bioactive heparin-containing core-shell microcapsules decreased GF usage five-fold while improving stem cell phenotype and are well suited for 3D cultivation of hPSCs.

关键词： Droplet microfluidics Bioactive core-shell microcapsule Growth factor release 3D stem cell culture Stem cell differentiation

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青少年抽烟与行为性格的关系——COX模型应用实例

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中国卫生统计 1990年第4期7卷 19-21,30页

作者：倪旱雨 Arthur V.peterson 华西医科大学卫生统计教研室美国华盛顿大学生物统计系

为了探讨青少年抽烟与行为性格的关系,调查了美国华盛顿州10年级学生的抽烟、史性格特征等。Cox比例风险模型分析结果表明,冒险型,叛逆型和改革型的青少年抽烟的危险性较大。应加强对这些学生的教育规划。

关键词：抽烟行为性格 Cox比例模型

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当代中国青少年价值系统的调查研究

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当代青年研究 1989年第1期 58-61页

作者：孙曰融陈欣银 C.peterson

人类价值系统是一种关于个人或社会所喜爱的行为方式或存在的终极状态的比较稳定的信念组织,它一直是心理学、社会学等学科的一个重要的课题。早在本世纪30年代,著名社会心理学家阿尔波特等人就曾进行了系统、深入的探索,并且,围绕理论... 详细信息

人类价值系统是一种关于个人或社会所喜爱的行为方式或存在的终极状态的比较稳定的信念组织,它一直是心理学、社会学等学科的一个重要的课题。早在本世纪30年代,著名社会心理学家阿尔波特等人就曾进行了系统、深入的探索,并且,围绕理论、经济、审美、社会、政治和宗教六种价值观编制了一套测量工具。70年代初,心理学家罗卡奇将人的价值系统分成终极性价值观和工具性价值观两部分,并编制了一套简便、有效的量表。此后,在这方面出现了大量的研究,为揭示人类价值活动的规律提供了科学的依据。人类价值观的先期因素可以追溯到文化、社会及其机构和人格之中”(Rokeach,1973,p.1)。

关键词：中国青少年价值系统价值观念终极性价值观美国青少年工具性价值观中学生国家安全世界和平刺激性

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走向英语世界阅读与基础写作

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丛书名：美国英语教学文库

1994年

作者：（美）彼得森（peterson P.w.）杨明川译注

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Reactive optical matter: light-induced motility in electrodynamically asymmetric nanoscale scatterers

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Light(Science & Applications) 2018年第1期7卷 26-32页

作者： Yuval Yifat Delphine Coursault Curtis w.peterson John Parker Ying Bao Stephen K.Gray Stuart A.Rice Norbert F.Scherer James Franck Institute The University of Chicago929 E.57th StreetChicagoIL 60637USA Department of Chemistry The University of Chicago929 East 57th StreetChicagoIL 60637USA Department of Physics The University of Chicago929 East 57th StreetChicagoIL 60637USA Center for Nanoscale Materials Argonne National Laboratory9700 South Cass AvenueArgonneIL 60439USA UniversitéBordeaux CNRS LOMAUMR 5798F-33400 TalenceFrance Department of Chemistry Western Washington University516 High StreetBellinghamWA 98225USA

From Newton’s third law,which is known as the principle of actio et reactio1,we expect the forces between interacting particles to be equal and opposite for closed ***,“nonreciprocal”forces can arise.2 This has been shown theoretically in the interaction between dissimilar optically trapped particles that are mediated by an external field.3 As a result,despite the incident external field not having a transverse component of momentum,the particle pair experiences a force in a direction that is transverse to the light propagation direction.3,4 In this letter,we directly measure the net nonreciprocal forces in electrodynamically interacting asymmetric nanoparticle dimers and nanoparticle structures that are illuminated by plane waves and confined to pseudo one-dimensional *** show via electrodynamic theory and simulations that interparticle interactions cause asymmetric scattering from ***,the putative nonreciprocal forces are actually a consequence of momentum *** study demonstrates that asymmetric scatterers exhibit directed motion due to the breakdown of mirror symmetry in their electrodynamic interactions with external fields.

关键词： asymmetric forces reciprocal

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Concussion and risk of lower extremity injury

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中华物理医学与康复杂志 2016年第6期38卷 416-416页

作者： Brooks MA peterson K Biese K

BACKGROUND AND OBJECTIVE After a single concussion,the probability of a second concussion increases by a factor of *** addition a history of concussion has been shown to be associated with altered motor control and adoption of conservative gait strategies among clinically asymptomatic *** study assessed the risk of musculoskeletal injuries within 90 days of return to sport post-concussion.

关键词：震荡下肢侵害传递因数案例

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高速铣削用PCD刀具的研制

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工业金刚石 2009年第3期 20-24页

作者： w．peterson P．R．Davis H．Hack 美国．梅加金刚石有限公司

高速铣削的应用在当前机械制造中越来越盛行。虽然PCD材料科学总的来说已很成熟，但高速铣削的需求促使PCD供应商不断改进与完善其产品。中粒度尺寸品级PCD材料通常用于既具有良好的耐磨性（工具寿命），同时又能保持良好的工件表面光... 详细信息

高速铣削的应用在当前机械制造中越来越盛行。虽然PCD材料科学总的来说已很成熟，但高速铣削的需求促使PCD供应商不断改进与完善其产品。中粒度尺寸品级PCD材料通常用于既具有良好的耐磨性（工具寿命），同时又能保持良好的工件表面光洁度的产品。铣削刀具典型的损坏模式是由于工件毛刺的形成而丧失切削刃的锋利度。要求是在改进表面光洁度时，减少毛刺的产生与形成。这种特有的材料性能，诸如弯曲强度和韧性的提高与改进，可通过控制金刚石粒度尺寸的分布和先进的处理工艺来达到。结果是使PCD刀具材料改进切削刃的良好性能，有更好的工件表面光洁度，而不牺牲刀具的耐磨性。这样，使最终产品的性能将在高速铣削中获得应用。

关键词： PCD刀具高速铣削表面光洁度金刚石粒度材料性能最终产品材料科学机械制造

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一种基于层选择的弥散张量优化算法

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东南大学学报（自然科学版） 2013年第1期43卷 30-34页

作者：刘薇周振宇刘小征严序杨光王遵亮周永迪 peterson Bradley S 徐冬溶华东师范大学脑功能基因组学教育部重点实验室上海200062 华东师范大学上海市磁共振重点实验室上海200062 哥伦比亚大学精神病学系纽约10032 纽约州立精神疾病研究所纽约10032 东南大学生物科学与医学工程学院南京210096

为了从带伪影的弥散加权数据中重建更准确的张量,提出了一种基于层选择的张量优化算法.首先对弥散加权图像中常见的3种伪影(波状、层间运动和对比度伪影)进行定性分析,分别提取3种对应的特征(小波标记、相似度和相关性)来识别这些伪影,... 详细信息

为了从带伪影的弥散加权数据中重建更准确的张量,提出了一种基于层选择的张量优化算法.首先对弥散加权图像中常见的3种伪影(波状、层间运动和对比度伪影)进行定性分析,分别提取3种对应的特征(小波标记、相似度和相关性)来识别这些伪影,从而区分出正常图层和伪影图层.然后,利用正常图层数据进行张量重建.模拟实验结果验证了这3种特征对弥散加权图像中相关伪影判断的有效性,且对波状伪影和层间运动伪影的判断率均大于90%.真实数据实验结果表明,与类似算法相比,所提算法可以更好地改善部分各向异性伪彩图中的偏色现象,在白质结构分析中提供了更准确的方向信息.

关键词：弥散加权成像弥散张量成像张量优化小波标记互信息灰度共生矩阵

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The Emergence of Rapid Counter Immunostaining in the Controlled Narrow Excision of Malignant Melanoma—How we Do It

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Journal of Cancer Therapy 2013年第6期4卷 1082-1084页

作者： Jordan Troxel Grace Brummer Kristin Cox S. Ray peterson Department of Dermatology Central Utah Clinic Provo USA

Mohs Micrographic Surgery (MMS) is widely employed in the treatment of non-melanoma skin cancer and is a preferred treatment for many cutaneous malignancies, particularly in high risk locations and tumors [1,2]. It has also been used in the narrow excision of malignant melanoma with local control rates equivalent to standard margins [3]. It has gained acceptance in the treatment of noninvasive melanoma where standard 0.5 cm margins may be inadequate for local control [4]. The frozen section processing used in MMS has been assumed by some to be inadequate in assessing melanocyte populations or residual melanoma within excision margins. This difficulty has likely led to a majority of surgeons with fellowship training to process margins with slow, permanent hematoxylin and eosin sections (“slowmohs”) or to simply resort to standard 0.5, 1.0, or 2.0 cm margins with traditional excision and outside pathology confirmation of clear margins. A recent survey of practicing fellowship-trained Mohs surgeons revealed roughly one-third (35.9%) of Mohs surgeons felt comfortable interpreting MART-1 immunostains, and far fewer were actually performing immunostains in their labs [5]. Some Mohs surgeons currently refer melanoma to a colleague experienced in processing and reading melanoma with available rapid immunostaining. The development of rapid immunohistochemistry, which can be implemented into a traditional frozen section laboratory, has greatly improved the ease of interpreting margins in the excision of melanoma. Although the process is considerably more complicated than staining with H&E or Toluidine Blue (T-Blue), it easily falls within the skill-set and equipment of most busy frozen section laboratories. The additional cost of biologic reagents may be fully recovered by proper billing of immunohistochemical laboratory work and interpretation of slides.

关键词： Moh’s Surgery Malignant Melanoma Rapid MART-1

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The Production of Interleukin-8 is Increased in Plasma and Peripheral Blood Mononuclear Cells of Patients with Fatigue

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Neuroscience & Medicine 2012年第1期3卷 47-53页

作者： Matthew Sorenson Leonard Jason Athena Lerch Nicole Porter Jonna peterson Herbert Mathews Department of Psychology DePaul University Chicago Illinois Microbiology and Immunology Loyola University Chicago Chicago Illinois United States Rush University Medical Center Chicago Illinois United States School of Nursing DePaul University Chicago Illinois United States

Background and Objective: Previous research has speculated on the role of pro- and inflammatory immune mediators in the etiologic process of fatigue, with contrasting findings. The preponderance of the evidence supports the role of inflammatory mediators in the disease process of Chronic Fatigue Syndrome (CFS). The purpose of this study was to evaluate the production of interleukin (IL)-8 by peripheral blood mononuclear cells derived from individuals with chronic fatigue. A secondary objective was to determine if there was a significant relationship between IL-8 production and plasma cortisol level. Materials and Methodology: Data was collected from three groups, a sample of individuals with CFS (n = 15), a comparison sample of individuals with fatigue that did not meet criteria for CFS (n = 30) and a group of putatively health normative controls (n = 23). Peripheral blood was drawn and plasma samples derived. Peripheral blood mononuclear cells were stimulated with a mitogenic protocol and levels of IL8 in unstimulated and stimulated bulk supernatant determined. Results: Both fatigue groups displayed significantly higher levels of IL8 than the control group. The CFS group demonstrated higher levels of IL8 in plasma than the fatigue comparison group. Conclusion: The findings demonstrate a clear association between fatigue and IL8. The ability to identify an inflammatory marker in association with fatigue could provide a means of identifying those who may be at risk for the development of this disorder.

关键词： Cytokines Fatigue Interleukin PBMC

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