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International Journal of Ophthalmology(English edition) 2020年第1期13卷 120-123页

作者： peter w.MacIntosh S.Vijay Kumar V.R.Saravanan Virna M.Shah Illinois Eye and Ear Infirmary University of Illinois at ChicagoChicagoIL 60612USA Neuro-Ophthalmology Service Aravind Eye HospitalCoimbatore 641014India

AIM:To elucidate the changes of different ganglion cell layer(GCL)thinning patterns between the optic neuritis(ON)and non-arteritic anterior ischemic optic neuropathy(NAION).METHODS:A prospective,observational study was conducted to evaluate the timing of GCL changes between acute ON and NAION using optical coherence ***:Thinning on optical coherence tomography in the NAION group occurs as early as 11 d after symptomatic onset of vision loss and follows an altitudinal *** mean superior-inferior GCL thickness difference in the NAION cohort was clinically significant at 5.7μm in the NAION cohort compared to controls of 0.8μm(P=0.032),but not significant in the ON group compared to controls with both groups measuring 1.1μ*** thinning was significant for the ON group compared to controls at 7.2μm(P=0.011)but not the NAION group compared to controls at 1.35μ***:These findings suggest that future treatments for NAION should be given early,and possibly before 11 d in order to prevent GCL and irreversible vision loss.

关键词： optic neuritis non-arteritic ischemic optic neuropathy optical coherence tomography ganglion cell layer

The HIF-1α/PLOD2 axis integrates extracellular matrix organization and cell metabolism leading to aberrant musculoskeletal repair

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Bone Research 2024年第2期12卷 289-301页

作者： Heeseog Kang Amy L.Strong Yuxiao Sun Lei Guo Conan Juan Alec C.Bancroft Ji Hae Choi Chase A.Pagani Aysel A.Fernandes Michael woodard Juhoon Lee Sowmya Ramesh Aaron w.James David Hudson Kevin N.Dalby Lin Xu Robert J.Tower Benjamin Levi Center for Organogenesis Regeneration and TraumaDepartment of SurgeryUniversity of Texas SouthwesternDallasTX 75390USA Section of Plastic Surgery Department of SurgeryUniversity of MichiganAnn ArborMI 48109USA Quantitative Biomedical Research Center Peter O’Donnell Jr.School of Public HealthUniversity of Texas SouthwesternDallasTX 75390USA Department of Orthopedics and Sports Medicine University of WashingtonSeattleWA 98195USA Division of Chemical Biology and Medicinal Chemistry College of PharmacyUniversity of Texas at AustinAustinTX 78712USA Department of Pathology Johns Hopkins UniversityBaltimoreMD 21218USA

while hypoxic signaling has been shown to play a role in many cellular processes,its role in metabolism-linked extracellular matrix(ECM)organization and downstream processes of cell fate after musculoskeletal injury remains to be ***(HO)is a debilitating condition where abnormal bone formation occurs within extra-skeletal *** andhypoxia-inducible factor 1α(HIF-1α)activation have been shown to promote ***,the underlying molecular mechanisms bywhich the HIF-1αpathway in mesenchymal progenitor cells(MPCs)contributes to pathologic bone formation remain to ***,we used a proven mouse injury-induced HO model to investigate the role of HIF-1αon aberrant cell ***-cell RNA sequencing(scRNA-seq)and spatial transcriptomics analyses of the HO site,we found that collagen ECM organizationis the most highly up-regulated biological process in *** mesenchymal cell-specific deletion of Hif1α(Hoxa11-CreER^(T2);Hif1a^(fl/fl))significantly mitigated HO in ***-seq analysis of these Hoxa11-CreER^(T2);Hif1a^(fl/fl)mice identified the PLOD2/LOXpathway for collagen cross-linking as downstream of the HIF-1αregulation of ***,our scRNA-seq data and mechanisticstudies further uncovered that glucose metabolism in MPCs is most highly impacted by HIF-1α*** a translational aspect,a pan-LOX inhibitor significantly decreased HO.A newly screened compound revealed that the inhibition of PLOD2 activity in MPCssignificantly decreased osteogenic differentiation and glycolytic *** suggests that the HIF-1α/PLOD2/LOX axis linked tometabolism regulates HO-forming MPC *** results suggest that the HIF-1α/PLOD2/LOX pathway represents a promisingstrategy to mitigate HO formation.

关键词： metabolism skeletal aberrant

阿多诺对利盖蒂的影响——对二者通信的考察兼论歌剧《伟大的死亡》

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中央音乐学院学报 2024年第1期174卷 58-68,142页

作者： [德]约恩·彼得·希克尔孙冰洁(译) 班丽霞(校) 德国德累斯顿卡尔·玛利亚·冯·韦伯音乐学院新音乐学系中央音乐学院中央音乐学院音乐学系

作曲家利盖蒂长期以来与哲学家阿多诺保持着通信联系,而且利盖蒂对20世纪后半叶的新音乐发展也具有重要的参照作用,但这些方面一直被人们所忽视。作者在考证大量史料的基础上,以开放的“音乐现代主义”概念为前提,结合对《伟大的死亡》... 详细信息

作曲家利盖蒂长期以来与哲学家阿多诺保持着通信联系,而且利盖蒂对20世纪后半叶的新音乐发展也具有重要的参照作用,但这些方面一直被人们所忽视。作者在考证大量史料的基础上,以开放的“音乐现代主义”概念为前提,结合对《伟大的死亡》①等作品的分析与阐释,剖析了利盖蒂与阿多诺之间的理念关联,特别是阿多诺《困境》一文对利盖蒂的影响,重新审视了作曲家在现代主义中的地位与立场。本文最终认为,利盖蒂深受阿多诺的“否定性”与“非形象音乐”等理念的影响,以具有表现性与意象性的音乐瞬间来表达死亡等方式,瓦解了“保守”与“先锋”之间的二元对立,展现出“主观性”与“客观性”相结合的悖论美学。

关键词：利盖蒂阿多诺《伟大的死亡》音乐现代主义

Transient thermal response of micro-thermal conductivity detector (μTCD) for the identification of gas mixtures:An ultra-fast and low power method

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Microsystems & Nanoengineering 2015年第1期1卷 52-58页

作者： Alireza Mahdavifar Milad Navaei peter J.Hesketh Melvin Findlay Joseph R.Stetter Gary w.Hunter School of Mechanical Engineering Georgia Institute of TechnologyAtlantaGA 30332USA KwJ Engineering Inc. NewarkCA 94560USA NASA Glenn Research Center ClevelandOH 44135USA

Micro-thermal conductivity detector(μTCD)gas sensors work by detecting changes in the thermal conductivity of the surrounding medium and are used as detectors in many applications such as gas chromatography *** TCDs use steady-state resistance(i.e.,temperature)measurements of a *** this work,we developed a new measurement method and hardware configuration based on the processing of the transient response of a low thermal mass TCD to an electric current *** method was implemented for a 100-μm-long and 1-μm-thick micro-fabricated bridge that consisted of doped polysilicon conductive film passivated with a 200-nm silicon nitride *** resistance variations of theμTCD in response to a square current pulse were studied in multiple mixtures of dilute gases in *** and experimental results are presented and compared for the time resolved and steady-state regime of the sensor *** analysis and simulation show that the sensor response is exponential in the transient state,that the time constant of this exponential variation was a linear function of the thermal conductivity of the gas ambient,and that the sensor was able to quantify the mixture *** level of detection in nitrogen was estimated to be from 25 ppm for helium to 178 ppm for carbon *** this novel approach,the sensor requires approximately 3.6 nJ for a single measurement and needs only 300μs of sampling *** is less than the energy and time required for steady-state DC measurements.

关键词： gas sensor MEMS micro-bridge micro-heater μTCD thermal conductivity sensor transient heat transfer modeling

Long-term irritable bowel syndrome symptom control with reintroduction of selected FODMAPs

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world Journal of Gastroenterology 2017年第25期23卷 4632-4643页

作者： Ruth M Harvie Alexandra w Chisholm Jordan E Bisanz Jeremy P Burton peter Herbison Kim Schultz Michael Schultz Department of Medicine Dunedin School of MedicineUniversity of Otago Department of Human Nutrition University of Otago Departments of Surgery and Microbiology&Immunology Western UniversityOntario Department of Preventative and Social Medicine University of Otago

To investigate the long-term effect of dietary education on a low fermentable oligosaccharide, disaccharide and polyol (FODMAP) diet on irritable bowel syndrome (IBS) symptoms and quality of life (QoL). METHODSParticipants with IBS (Rome III) were randomized to two groups. Group I commenced a low FODMAP diet at baseline. At three months, group II, so far a comparator group, crossed over to a low FODMAP diet while group I started re-challenging foods. All patients completed the IBS SSS (IBS symptom severity scoring system, 0-500 points increasing with severity), IBS QoL questionnaire (0-100 increasing with QoL), a FODMAP specific food frequency questionnaire and provided a stool sample at baseline, three and six months for microbiome analysis. RESULTSFifty participants were enrolled into group I (n = 23) or group II (n = 27). Participants in both groups were similar in baseline values but with more men in group I. There was a significantly lower IBS SSS (275.6 ± 63.6 to 128.8 ± 82.5 vs 246.8 ± 71.1 to 203.6 ± 70.1) (P was sustained at 6 mo in group I (160 ± 102) and replicated in group II (124 ± 76). Fiber intake decreased on the low FODMAP diet (33 ± 17 g/d to 21 ± 8 g/d) (P was no change seen in the intestinal microbiome when participants adopted a low FODMAP diet. CONCLUSIONThis study demonstrated that a reduction in FODMAPs improves symptoms in IBS and this improvement can be maintained while reintroducing FODMAPs.

关键词： Irritable bowel syndrome FODMAP Short chain fermentable carbohydrates Microbiota Diet Microbiome

Long-term predictors of dengue outbreaks in Bangladesh:A data mining approach

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Infectious Disease Modelling 2018年第1期3卷 322-330页

作者： Olav Titus Muurlink peter Stephenson Mohammad Zahirul Islam Andrew w.Taylor-Robinson Central Queensland University BrisbaneAustralia International Centre for Diarrhoeal Disease Research Bangladesh Griffith Institute of Educational Research Australia

The effects of weather variables on the transmission of vector-borne diseases are *** can be non-linear,specific to particular geographic locations,and involve long lag times between predictors and outbreaks of *** study expands the geographical and temporal range of previous studies in Bangladesh of the mosquitotransmitted viral infection dengue,a major threat to human public health in tropical and subtropical regions *** analysis incorporates new compound variables such as anomalous events,running averages,consecutive days of particular weather characteristics,seasonal variables based on the traditional Bangla six-season annual calendar,and lag times of up to one year in predicting either the existence or the magnitude of each dengue *** study takes a novel,comprehensive data mining approach to show that different variables optimally predict the occurrence and extent of an *** best predictors of an outbreak are the number of rainy days in the preceding two months and the average daily minimum temperature one month prior to the outbreak,while the best predictor of the number of clinical cases is the average humidity six months prior to the month of *** magnitude of relationships between humidity 6,7 and 8 months prior to the outbreak suggests the relationship is multifactorial,not due solely to the cyclical nature of prevailing weather conditions but likely due also to the immunocompetence of human hosts.

关键词： Vector-borne disease Climate Data mining Bangladesh Dengue Long-term predictors

Pro12Ala polymorphism of the peroxisome proliferator-activated receptor γ2 in patients with fatty liver diseases

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world Journal of Gastroenterology 2010年第46期16卷 5830-5837页

作者： Johannes w Rey Andrea Noetel Aline Hardt Ali Canbay Hakan Alakus Axel zur Hausen Hans peter Dienes Uta Drebber Margarete Odenthal Institute for Pathology University Hospital of Freiburg Department of Gastroenterology and Hepatology University Hospital of Essen Department of General Visceral and Cancer SurgeryUniversity Hospital of Cologne

AIM:To test the occurrence of the Pro12Ala mutation of the peroxisome proliferator-activated receptor-γ (PPARγ)2-gene in patients with non-alcoholic fatty liver disease (NAFLD) or alcoholic fatty liver disease (AFLD).METHODS:DNA from a total of 622 specimens including 259 blood samples of healthy blood donors and 363 histologically categorized liver biopsies of patients with NAFLD (n=263) and AFLD (n=100) were analyzed by Real-time polymerase chain reaction using allele-specific ***:In the NAFLD and the AFLD collective,3% of the patients showed homozygous occurrence of the Ala12 PPARγ2-allele,differing from only 1.5% cases in the healthy *** NAFLD patients,a high incidence of the Ala12 mutant was not associated with the progression of fatty liver ***,we observed a significantly higher risk (odds ratio=2.50,CI:1.05-5.90,P=0.028) in AFLD patients carrying the mutated Ala12 allele to develop inflammatory *** linkage of the malfunctioning Ala12-positive PPARγ2 isoform to an increased risk in patients with AFLD to develop severe steatohepatitis and fibrosis indicates a more prominent anti-inflammatory impact of PPARγ2 in progression of AFLD than of ***:In AFLD patients,the Pro12Ala single nuclear polymorphism should be studied more extensively in order to serve as a novel candidate in biomarker screening for improved prognosis.

关键词： Single nucleotide polymorphism Peroxisome proliferator-activated receptor γ Non-alcoholic steatohepatitis Alcoholic steatohepatitis Inflammation Fibrosis Hepatitis Steatosis Steatohepatitis

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中国大学管理面临的挑战

清华大学教育研究 2000年第3期21卷 27-29页

作者： peter w A west 经济合作与发展组织（OECD）高校管理项目指导组

Biomimetic flexible plate actuators are faster and more efficient with a passive attachment

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Acta Mechanica Sinica 2016年第6期32卷 1001-1011页

作者： peter D.Yeh Alexander Alexeev George w.woodruff School of Mechanical Engineering Georgia Institute of Technology

Using three-dimensional computer simulations, we probe biomimetic free swimming of an internally actuated flexible plate in the regime near the first natural frequency. The plate is driven by an oscillating internal moment approximating the actuation mechanism of a piezoelectric macro fiber composite (MFC) bimorph. we show in our simulations that the addition of a passive attachment increases both swimming velocity and efficiency. Specifically, if the active and passive sections are of similar size, the overall performance is the best. we determine that this optimum is a result of two competing factors. If the passive section is too large, then the actuated portion is unable to generate substantial deflection to create sufficient thrust. On the other hand, a large actuated section leads to a bending pattern that is inefficient at generating thrust especially at higher frequencies.

关键词： Flexible plate Biomimetic Lattice Boltzmann Fluid-structure interaction Robotic fish Piezoelectric actuator

Structure and magnetostructural correlation of ferrimagnetic meso-tetraphenylporphinatomanganese(Ⅲ) dimethyl- N,N′-dicyanoquinone diiminide, [MnTPP]^+[Me_2DCNQI]^(.-)

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Science China Chemistry 2012年第6期55卷 987-996页

作者： Jordan L. Arthur Saul H. Lapidus peter w. Stephens Joel S. Miller Department of Chemistry University of Utah Salt Lake City Utah 84112-0850 USA Department of Physics & Astronomy Stony Brook University Stony Brook NY 11794-3800 USA Photon Sciences Directorate Brookhaven National Laboratory Upton NY 11973 USA

The structure [MnmTPP][Me2DCNQI] （TPP = tetraphenylporphinato; Me2DCNQI = 2,5-dimethyl-N,N＇-dicyanoquinonediimine） has been determined from X-ray powder diffraction data. The nonsolvated structure is composed of linear （I-D） chains of alternating [MnmTPP]＋ and ta-[MezDCNQI]＇- with intrachain Mn...Mn separations of 12.83 A, and a Mn-NDcNQI distance of 2.18A. The dihedral angle between the mean Mn（N4）xpp and [MezDCNQI]＇-planes, and the Mn-（N-C）ocNQ1 angle are 84.18° and 143.6°, respectively. [MnInTpP][MezDCNQI] has a Tc of 4.3 K from the 10 Hz x（T） data, 2-K coercivity of 5,600 Oe, and 6,300 emuOe/mol remnant magnetization that are reduced from that observed for related materials, and their in- clusion extends the magnetostructural correlation between the intrachain coupling and both the dihedral angle between the mean Mn（N4）xPp and [TCNE]＇-（TCNE --- tetracyanoethylene） planes and Mn-（N-C）Tcr angles. This is in accord with the in- trachain coupling arising from the overlap of the Mnm dz2-1ike singly occupied molecular orbital （SOMO） and the z component of the [TCNE]- π＊（π2＊） SOMO, which increases with decreasing dihedral angle between the mean Mn（N4）xep and [TCNE]＇- planes and Mn-（N-C）TcNE angle.

关键词： metalloporphyrin magnetic ordering ferrimagnet crystal structure