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Carbohydrate malabsorption in patients with non-specific abdominal complaints

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World Journal of Gastroenterology 2007年第43期13卷 5687-5691页

作者： peter Born Department of Internal Medicine Tirschenreuth District Hospital Tirschenreuth 95643 Germany

Non-specific abdominal complaints are a considerable problem worldwide. Many patients are affected and many differential diagnoses have to be considered. Among these, carbohydrate malabsorption seems to play an important role. However, so far, only incomplete absorption of lactose is broadly accepted, while the malabsorption of fructose and sorbitol is still underestimated, although in many parts of the world it is much more frequent. Despite the success of dietary interventions in many patients, there are still a lot of unanswered questions that make further investigations

关键词： Non-specific abdominal disorders Carbohydrate malabsorption Fructose Sorbitol Lactose Dietary intervention

Vibrotactile coordinated reset stimulation for the treatment of Parkinson's disease

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Neural Regeneration Research 2022年第7期17卷 1495-1497页

作者： peter A.Tass Department of Neurosurgery Stanford University School of MedicineStanfordCAUSA

Introduction of the treatment concept:Regular deep brain stimulation(rDBS)is the standard therapy for the treatment of medically refractory Parkinson’s disease(PD)(Benabid et al.,2009).Notwithstanding its significant therapeutic effects,rDBS may cause side effects,characterized as rDBSinduced movement disorders(BaizabalCarvallo and Jankovic,2016).

关键词： stimulation al. treatment

Climate change and its consequences for water and wastewater management

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Frontiers of Environmental Science & Engineering 2009年第1期3卷 2-11页

作者： peter A.WILDERER Institute of Advanced Studies on Sustainability Amalienstr7580799 MunichGermany

Life,in combination with solar radiation and abiotic processes,is most probably the reason why liquid water has existed on Earth for over billions of years,and the global mean temperature has remained in a lifeenabling *** to limit or even reverse global warming must be derived from the knowledge of the Earth’s complex life-support *** this context,the balance between liquid and gaseous water plays a crucial role,and water management becomes an important field of innovation and action,globally,on the scale of watersheds but also on the very local *** use,reuse,and temporary storage of water in urban settings must be considered to limit over-extraction of water from natural resources,and to maintain the life supporting function of *** the same time,public health requirements,cost efficiency,and reliability demands are to be met.

关键词： ecosystem management tools self-regulation urbanization water-climate relationship water reuse

DNA Methylation Profiles of Protease Nexin 1 (SERPINE2) Gene in Human Cell Lines

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Chinese Journal of Cancer Research 2011年第2期23卷 92-98页

作者： peter A.Andreasen Danish-Chinese Centre for Proteases and Cancer Department of Molecular Biology University of Aarhus

Objective： To investigated whether epigenetic mechanisms contribute to the variable expression of variable protease nexin1（PN-1） encoded by the SERPINE2 gene in different cell types. Methods： Working with 5 human cell lines, we determined the CpG methylation status within two CpG islands in the SERPINE2 gene by bisulphate sequencing and the PN-1 mRNA level by Q-RT PCR. Results： A CpG island spanning the transcription initiation site showed little methylation in 3 of the cell lines and substantial methylation in 2 of the cell lines. A CpG island covering the translation starting site showed full methylation in all investigated cell lines. Methylation within the CpG island was not randomly distributed, but showed accumulation at specific sites. However, we were not able to distinguish any patterns which related the methylation frequency to the gene expression level. Inhibition of CpG methylation with 5-aza-2’-deoxycytidine led to a several fold increase in PN-1 mRNA levels, but based on the results on CpG methylation in the CpG island spanning the transcript, the effect is most likely indirect. Conclusion： We have carefully mapped the CpG methylation pattern in two CpG islands in the 5’ part of the SERPINE2 gene without finding any obvious inverse correlation between methylation frequency and expression level.

关键词： Protease nexin 1 SERPINE2 DNA methylation Cancer

The evolution and refinement of vasoepididymostomy techniques

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Asian Journal of Andrology 2013年第1期15卷 49-55页

作者： peter T Chan Department of Urology Royal Victoria Hospital McGill University Health Center Montreal Quebec H3A 1A1 Canada

Obstructive azoospermia secondary to epididymal obstruction can be corrected by microsurgical reconstruction with vasoepididymostomy （VE）. Although alternative management such as epididymal or testicular sperm aspiration in conjunction with intracytoplasmic sperm injection is feasible, various studies have established the superior cost-effectiveness of VE as a treatment of choice. Microsurgical VE is considered one of the most technically challenging microsurgeries. Its success rate is highly dependent on the skills and experience of the surgeons. Various techniques have been described in the literature for VE. We have pioneered a technique known as longitudinal intussusception VE （LIVE） in which the epididymal tubule is opened longitudinally to obtain a larger opening to allow its tubular content to pass through the anastomosis. Our preliminary data demonstrated a patency rate of over 90%. This technique has been widely referenced in the recent literature including robotic-assisted microsurgery. The history of the development of different VE approaches, the oreoDerative evaluation along with the techniaues of various VE will be described in this article.

关键词： longitudinal intussusception vasoepididymostomy (LIVE) intracytoplasmic sperm injection (ICSI) male infertility microsurgery obstructive azoospermia vasoepididymostomy (VE)

Prevalence,predictors,and clinical consequences of medical adherence in IBD:How to improve it?

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World Journal of Gastroenterology 2009年第34期15卷 4234-4239页

作者： peter Laszlo Lakatos 1st Department of Medicine Semmelweis University

Inflammatory bowel diseases(IBD)are chronic diseases with a relapsing-remitting disease course necessitating lifelong ***,non-adherence has been reported in over 40%of patients,especially those in remission taking maintenance therapies for IBD. The economical impact of non-adherence to medical therapy including absenteeism,hospitalization risk, and the health care costs in chronic conditions,is *** causes of medication non-adherence are complex,where the patient-doctor relationship, treatment regimen,and other disease-related factors play key ***,subjective assessment might underestimate *** adherence may result in more frequent relapses,a disabling disease course, in ulcerative colitis,and an increased risk for colorectal *** medication adherence in patients is an important challenge for *** the different patient types,the reasons given by patients for non-adherence,simpler and more convenient dosage regimens,dynamic communication within the health care team,a self-management package incorporating enhanced patient education and physician-patient interaction,and identifying the predictors of nonadherence will help devise suitable plans to optimize patient *** editorial summarizes the available literature on frequency,predictors,clinical consequences,and strategies for improving medical adherence in patients with IBD.

关键词： Inflammatory bowel disease Crohn's disease Ulcerative colitis Therapy Adherence Compliance 5-aminosalicylate Mesalazine Azathioprine

Maintaining biodiversity will define our long-term success

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Plant Diversity 2020年第4期42卷 211-220页

作者： peter Raven Mathis Wackernagel Missouri Botanical Garden 4344 Shaw BlvdSt.LouisMO63110USA Global Footprint Network 1528 Webster StreetSuite 11OaklandCA94612USA

Human beings are not only a part of our planet's ecosystems,but also,they are massively overusing *** makes ecosystem protection,including biodiversity preservation,vital for humanity's *** speed and scale of the threat are unprecedented in human *** long arch of evolution has been confronted with such a high level of human impact,that we are now facing the sixth mass extinction event,66 million years after the last *** threat heightens the imperative for bold human *** paper identifies three strategies for such an ***,and possibly most challenging,human demand needs to be curbed so it fits within the bounds of what Earth's ecosystems can *** meeting this quantitative goal,biodiversity preservation efforts will not be able to get ***,in the transition time,we must focus on those locations and areas where most biodiversity is *** a focus on‘hotspots’will help safeguard the largest portion of biodiversity with least ***,to direct biodiversity preservation strategies,we need to much better document the existence and distribution of biodiversity around the *** information technologies could help with this critical *** conclusion,biodiversity preservation is no longer just a concern for specialized biologist but is becoming a societal necessity if humanity wants to have a stable future.

关键词： Biodiversity Hotspots Biocapacity Conservation strategy

Spatial and Temporal Validation of In-Situ and Satellite Weather Data for the South West Agricultural Region of Australia

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Journal of Meteorological Research 2022年第1期36卷 175-192页

作者： Tristan CAMPBELL peter FEARNS Centre for Mine Site Restoration Curtin University of TechnologyWA 6102Australia Remote Sensing and Satellite Research Group Curtin University of TechnologyWA 6102Australia

Seasonal variations in weather have significant impacts on crop *** accuracy of weather data is an important consideration for crop yield *** study uses an independent in-situ weather station network to validate the accuracy of monthly temperature and precipitation data from the in-situ weather station network operated by the Bureau of Meteorology(BOM),interpolated gridded data from this network,and satellite weather data for the South West Agricultural Region of *** region covers five classes of the K?ppen-Geiger climate classification system and is responsible for 10 billion AUD of agricultural produce annually.A strong bias was found for the maximum temperatures in the Copernicus LST(land surface temperature)satellite *** bias was linearly correlated with the in-situ temperature and exceeded 20℃in warmer *** to the bias’s linear nature,a linear correction was able to reduce the root-mean-square error(RMSE)of the Copernicus LST product by 82%.This process was tested for other regions of Australia and,despite some regional differences,a linear correction consistently reduced RMSE by 80%.The validation process demonstrated that the dataset with reliably the lowest RMSE is the gridded weather data calculated from BOM’s in-situ weather *** neighbor in-situ weather stations generally had the next lowest RMSE,followed by weather-station corrected satellite products and lastly the non-weather station corrected satellite *** the in-situ gridded product generally had the lowest RMSE,there were spatial and seasonal *** maximum temperatures were more accurately measured by the bias-corrected Copernicus LST product in the northern and eastern extents(where there is a lower density of BOM in-situ stations).Monthly minimum temperatures from the Copernicus LST product had similar to slightly better RMSE than the Australian Water Availability Project(AWAP)product for the southern half of the study ar

关键词： Australian Water Availability Project land surface temperature satellite precipitation validation

SE Asian Cenozoic Larger Foraminifera:Taxonomic Questions,Apparent Radiation and Abrupt Extinctions

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Journal of Earth Science 2022年第6期33卷 1378-1399页

作者： peter Lunt Xiwu Luan College of Earth Science and Engineering Shandong University of Science and Technology(SDUST)Qingdao266579China Stratos Energy Advisors Kuala LumpurMalaysia

The Cenozoic larger foraminifera are important for biostratigraphy in SE *** review examines the taxonomic inconsistencies of this group and especially the confusion over concepts of evolution,migration,radiation and *** is proposed that from the Mediterranean to Indo-Pacific,Latest Eocene through Miocene,larger foraminifera populations were more homogenous than previously *** show a slow morphological radiation interrupted by several *** pattern is superimposed on a long-term decline in larger foraminiferal *** dating of the major biostratigraphic events are *** main lineages of larger foraminifera can be classified by their evolutionary *** classically“large”genera have highly peramorphic trends achieved through strong orthoselection,and these lineages were the most severely hit by a series of Mid-Eocene to Mid-Miocene extinction *** carbonate facies taxa that are traditionally grouped with the larger foraminifera are characterised by weak paramorphism,and these were much less affected by the extinction *** of these weakly peramorphic forms underwent Latest Miocene to recent radiation to and locally become rock-forming *** three major and one minor larger foraminiferal extinction events since the Mid Eocene coincide with abrupt tectonic events across SE ***,there are probably multiple causes for these extinctions,including global climatic changes.

关键词： larger foraminifera evolution biostratigraphy extinction