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Genome-wide MicroRnA Expression Profiles in COPD: Early Predictors for Cancer Development

Genomics, Proteomics & Bioinformatics 2018年第3期16卷 162-171页

作者： Andreas Keller Tobias Fehlmann nicole Ludwig Mustafa Kahraman Thomas Laufer Christina Backes Claus Vogelmeier Caroline Diener Frank Biertz Christian Herr Rudolf A. jorres Hans-peter Lenhof Eckart Meese Robert Bals Clinical Bioinformatics Saarland University 66123 Saarbriieken Germany Department of Human Genetics Saarland University Hospital 66421 Homburg Germany Hummingbird Diagnostics GmbH 69120 Heidelberg Germany Department of Internal Medicine Division for Pulmonary Diseases Philipps University of Marburg 35043 Marburg Germany Institute for Biostatistics Hannover Medical School 30625 Hanover Germany Department of Internal Medicine V- Pulmonology AlIergology Intensive Care Medicine Saarland University Hospital 66421 Homburg Germany Institute and Outpatient Clinic for Occupational Social and Environmental Medicine Comprehensive Pneumology Center Munich (CPC-M) Ludwig-Maximilians-University Munich Member of the German Center for Lung Research ( DZL) 80539 Munich Germany Bioinformatics Saarland University 66123 Saarbrucken Germany Center for Bioinformatics Saarland University 66123 Saarbrucken Germany

Chronic obstructive pulmonary disease （COPD） significantly increases the risk of developing cancer. Biomarker studies frequently follow a case-control set-up in which patients diagnosed with a disease are compared to controls. Longitudinal cohort studies such as the COPD-centered German COPD and SYstemic consequences-COmorbidities nETwork （COSYCOnET） study provide the patient and biomaterial base for discovering predictive molecular markers. We asked whether microRnA （miRnA） profiles in blood collected from COPD patients prior to a tumor diagnosis could support an early diagnosis of tumor development independent of the tumor type. From 2741 participants of COSYCOnET diagnosed with COPD, we selected 534 individuals including 33 patients who developed cancer during the follow-up period of 54 months and 501 patients who did not develop cancer, but had similar age, gender and smoking history. Genome-wide miRnA profiles were generated and evaluated using machine learning techniques. For patients developing cancer we identified nine miRnAs with significantly decreased abundance （two-tailed unpaired t-test adjusted for multiple testing P 〈 0.05）, including members of the miR-320 family. The identified miRnAs regulate different cancer-related pathways including the MAPK pathway （P - 2.3 × 10 -5）. We also observed the impact of confounding factors on the generated miRnA profiles, underlining the value of our matched analysis. For selected miRnAs, qRT-PCR analysis was applied to validate the results. In conclusion, we identified several miRnAs in blood of COPD patients, which could serve as candidates for biomarkers to help identify COPD patients at risk of developing cancer.

关键词： microRnA Cancer COPD Lung Biomarker COSYCOnET

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Recent progress on MOF/MXene nanoarchitectures:A new era in coordination chemistry for energy storage and conversion

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journal of Energy Chemistry 2023年第11期86卷 409-436,I0009页

作者： Sada Venkateswarlu Sowjanya Vallem Muhammad Umer n.V.V.jyothi Anam Giridhar Babu Saravanan Govindaraju Younghu Son Myung jong Kim Minyoung Yoon Department of Chemistry and Green-nano Materials Research Center Kyungpook National UniversityDaegu 41566Republic of Korea Department of Chemistry Gachon UniversitySeongnam 1320Republic of Korea Department of Physics Gachon UniversitySeongnam 13120Republic of Korea Center for Superfunctional Materials Department of ChemistryUlsan National Institute of Science and Technology(UNIST)Ulsan 44919Republic of Korea Department of Chemistry Sri Venkateswara UniversityTirupati 517502Andhra PradeshIndia Department of Civil Engineering Yeungnam UniversityGyeongsan 38541GyeongbukRepublic of Korea Department of Bionanotechnology Gachon UniversitySeongnam 13120Republic of Korea

The development of urbanization and industrialization leads to rapid depletion of fossil ***,the production of fuel from renewable resources is highly *** energy conversion and storage is a benign technique with reliable output and is *** an exceptional electrochemical catalyst with tunable properties like a huge specific surface area,porous channels,and abundant active sites is critical ***,Metal-organic frameworks(MOFs)and two-dimensional(2D)transition-metal carbides/nitrides(MXenes)have been extensively investigated in the field of electrochemical energy conversion and ***,advances in the research on MOFs are hampered by their limited structural stability and conventionally low electrical conductivity,whereas the practical electrochemical performance of MXenes is impeded by their low porosity,inadequate redox sites,and ***,researchers have been designing MOF/MXene nanoarchitectures to overcome the limitations in electrochemical energy conversion and *** review explores the recent advances in MOF/MXene nanoarchitectures design strategies,tailoring their properties based on the morphologies(0D,1D,2D,and 3D),and broadening their future opportunities in electrochemical energy storage(batteries,supercapacitors)and catalytic energy conversion(HER,OER,and ORR).The intercalation of MOF in between the MXene layers in the nanoarchitectures functions synergistically to address the issues associated with bare MXene and MOF in the electrochemical energy storage and *** review gives a clear emphasis on the general aspects of MOF/MXene nanoarchitectures,and the future research perspectives,challenges of MOF/MXene design strategies and electrochemical applications are highlighted.

关键词： Metal-organicframework MXene MoF/MXene nanoarchitecture Battery Supercapacitor Electrochemical catalysis

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骨料烘干煤粉燃烧器火焰的影响规律

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煤炭学报 2019年第S02期44卷 673-682页

作者：王京程海鹰胡志勇 SELIVERSTOV n D 内蒙古工业大学机械工程学院内蒙古呼和浩特010051 莫斯科国立汽车道路技术大学莫斯科125319

受设备条件、燃料性质及工况参数的限制,骨料烘干煤粉燃烧器的火焰长度存在合理的变化范围,火焰长度不仅影响骨料烘干效果,并且影响煤粉燃烧效率和污染物排放特性。深入分析骨料烘干工艺及热力学需求,将理论分析与数值模拟计算相结合,... 详细信息

受设备条件、燃料性质及工况参数的限制,骨料烘干煤粉燃烧器的火焰长度存在合理的变化范围,火焰长度不仅影响骨料烘干效果,并且影响煤粉燃烧效率和污染物排放特性。深入分析骨料烘干工艺及热力学需求,将理论分析与数值模拟计算相结合,通过研究煤粉燃烧机理及污染物生成机理,运用燃烧学、流体力学中反应、着火、燃烧、湍流流动、传质传热等相关理论,准确构建煤粉射流湍流流动、燃烧、辐射以及污染物生成等行为的控制模型,数值模拟煤粉燃烧行为。此外,火焰长度受燃烧器内部流场湍流扩散和混合作用的影响,明确火焰长度的影响因素,探究火焰长度的控制规律,且深入分析不同火焰长度下煤粉燃烧效率及污染物排放特性,在提升煤粉燃烧效率和降低污染物排放的目标下,结合骨料烘干工艺需求,探索煤粉燃烧过程中火焰长度的控制规律。研究结果表明:一次风预热温度、一次风煤粉浓度、一次风风速、二次风旋流强度均对骨料烘干煤粉燃烧器的火焰长度造成影响;影响火焰长度最显著的因素是一次风煤粉浓度,一次风煤粉浓度越高,火焰越长,火焰长度的变化在4.1~5.0 m,长度可提高22%,而火焰直径的变化在0.7~1.1 m;合理调节各物理因素,可扩大火焰径长比调节范围、达到1∶5~1∶9(通常为1∶4~1∶7);燃烧室内部温度、组分浓度以及内部流场状态影响骨料烘干煤粉燃烧器的燃烧效率和排放特性,并且在不同结构参数和控制参数下,随火焰长度的变化,燃烧效率以及污染物排放量的变化规律不同;在满足骨料烘干火焰长度需求的前提下,可通过减小一次风预热温度、减小煤粉浓度、增大旋流强度和各次风风速来提高燃烧效率的同时降低污染物的排放。

关键词：煤粉燃烧器火焰长度燃烧效率排放特性

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The variable codons of H5n1 avian influenza A virus haemagglutinin genes

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Science China(Life Sciences) 2008年第11期51卷 987-993页

作者： Mark j.GIBBS Robert W.MURPHY School of Botany and Zoology Faculty of ScienceAustralian National UniversityACT 0200Australia Department of natural History Royal Ontario MuseumTorontoON M5S 2C6Canada

We investigated the selection pressures on the haemagglutinin genes of H5n1 avian influenza viruses using fixed effects likelihood models. We found evidence of positive selection in the sequences from isolates from 1997 to 2007, except viruses from 2000. The haemagglutinin sequences of viruses from southeast Asia, Hong Kong and China's Mainland were the most polymorphic and had similar nonsyn-onymous profiles. Some sites were positively selected in viruses from most regions and a few of these sites displayed different amino acid patterns. Selection appeared to produce different outcomes in vi-ruses from Europe, Africa and Russia and from different host types. One position was found to be positively selected for human isolates only. Although the functions of some positively selected posi-tions are unknown, our analysis provided evidence of different temporal, spatial and host adaptations for H5n1 avian influenza viruses.

关键词： positive selection pressure H5n1 avian influenza virus HA codon

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Towards human well-being through proper chewing and safe swallowing:multidisciplinary empowerment of food design

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journal of Future Foods 2021年第1期1卷 1-24页

作者： Dongxiao Sun-Waterhouse Wenyi Kang Changyang Ma Geoffrey I.n.Waterhouse national R&D Center for Edible Fungus Processing Technology Henan UniversityKaifeng 475004China School of Chemical Sciences The University of AucklandPrivate Bag 92019AucklandNew Zealand

This review article provides an overview of the physiology and biomechanics of food oral processing,with a wider view towards the development of wellness foods that facilitate proper chewing and safe *** complexity of food oral processing is well recognized,involving food-mouth-gut-brain *** process requires precise coordination of chewing,oro-sensing,neural control,saliva secretion,bolus formation,swallowing and respiration,involving central and peripheral nervous systems,sensors and muscles of the oral cavity,pharynx,larynx and *** processing of an ingested food leads to its fragmentation,hydration,breakdown,transformation and reconstruction,and provides simultaneous oro-sensory perception and preliminary food digestion via mechanical fracture and chemical/enzymatic *** exists a complex food structure-property-processing relationship from the first bite of a food through to bolus formation for *** maximal deformability of a bolus is a key criterion for successful swallow-aided food *** structure is the main variable affecting food breakdown,food sensory perception and bolus *** research is needed to better understand the food structure-oral processing relationship,which guides the tailoring of foods/diets for individuals with chewing and swallowing difficulties to achieve balanced nutrition and an enjoyable eating experience.

关键词： Chewing Swallowing Food structure nutrition Health Eating experience

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Temporal Patterns in Symptoms of nitrogen Deficiency as Revealed by Remote Sensing of Corn Canopy

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Pedosphere 2010年第1期20卷 15-22页

作者： j. ZHAnG A. M. BLACKMER P. M. KYVERYGA M. j. GLADY T. M. BLACKMER Temple University CORE Program 3223 N. Broad Street Suite 175 Philadelphia Pennsylvania 19140 (USA) Department of Agronomy Iowa State University Ames Iowa 50011 (USA) Iowa Soybean Association On-Farm Network 1255 SW Prairie Trail Parkway Ankeny Iowa 50023 (USA) Winfield Solutions LLC. 114 Washington Avenue Montevideo Minnesota 56265 (USA)

To evaluate the temporal patterns of n deficiencies in corn and assess the ability of remote sensing to diagnose n deficiencies during the vegetative growth of corn, three field-scale experiments were conducted with various rates (56, 112, and 168 kg n ha-1 ), timing (early and late applications) and placement (injected into soil and dribbled on soil surface) of n fertilization in a split-plot design. Relationships between canopy reflectance during the growing season and yield data at the end of growing season were studied for different treatments. Results showed significant variation in both grain yields and canopy reflectance among the three cornfields. The n fertilization made in early june resulted in low canopy reflectance in early july, but the differences disappeared as the season progressed. The effect of n rates on canopy reflectance was not significant in early july but it gradually became detectable in mid-july and thereafter. The fertilizer placement had a significant effect on grain yields only in one field but not on canopy reflectance in all three fields. These observations suggest that the deficiency of n developed under field conditions is a dynamic phenomenon, which adds complexity for accurately defining "n deficiency" and effectively developing management strategies for in-season correction. Remote sensing throughout the season helps collect information about important interactions that have not been given enough attention in the past.

关键词： canopy reflectance fertilizer placement timing yield response

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电力系统实时动态安全评估及预警仿真系统的实现

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系统仿真学报 2007年第23期19卷 5401-5405,5442页

作者：石立宝周华锋 peter T.C.Tam 常乃超兰洲倪以信徐政清华大学深圳研究生院电力系统国家重点实验室深圳研究室深圳518055 香港大学电机电子工程学系

以电力系统电网运行的动态行为为研究对象,提出建立以维持系统运行在安全区间、监视预想事故集下系统动态安全裕度以及确保系统安全可靠运行为目的的电力系统实时动态安全评估及预警仿真系统。该系统的设计框架是基于TCP/IP协议的C/S及... 详细信息

以电力系统电网运行的动态行为为研究对象,提出建立以维持系统运行在安全区间、监视预想事故集下系统动态安全裕度以及确保系统安全可靠运行为目的的电力系统实时动态安全评估及预警仿真系统。该系统的设计框架是基于TCP/IP协议的C/S及B/S的运行模式,同时结合Visual ***、SQL 、Shell编程、并行计算等软件平台及软件组件设计思想实现系统搭建。此系统不仅可灵活、方便地与现有的能量管理系统(EMS)进行集成,实现实时动态安全评估,而且可提供离线分析仿真平台,对系统进行更广泛、细致的分析研究。

关键词：电压稳定分析暂态稳定分析能量管理系统安全预警实时模式训练模式

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Organosilicon Ion-Exchange and Complexing Adsorbents

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复旦学报(自然科学版) 2005年第5期 23-24页

作者： M. Voronkov,n. Vlasova,Yu. Pozhidaev,L. Belousova Irkutsk Institute of Chemistry Siberian Branch of the Russian Academy of Sciences Irkutsk 664033 Russia Irkutsk Institute of Chemistry Siberian Branch of the Russian Academy of Sciences Irkutsk 664033 Russia Irkutsk State Technical University Irkutsk 664074 Russia

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Operating limits and features of direct air capture on K_(2)CO_(3)/ZrO_(2) composite sorbent

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Chinese journal of Chemical Engineering 2022年第6期35卷 11-20页

作者： Vladimir S.Derevschikov janna V.Veselovskaya Anton S.Shalygin Dmitry A.Yatsenko Andrey Z.Sheshkovas Oleg n.Martyanov Boreskov Institute of Catalysis SB RAS Akademika Lavrentieva Av.5630090 NovosibirskRussia novosibirsk State University Pirogova Str.1630090 NovosibirskRussia

Potassium carbonate-based sorbents are prospective materials for direct air capture(DAC).In the present study,we examined and revealed the influence of the temperature swing adsorption(TSA)cycle conditions on the CO_(2) sorption properties of a novel aerogel-based K_(2)CO_(3)/ZrO_(2) sorbent in a DAC *** was shown that the humidity and temperature drastically affect the sorption dynamic and sorption capacity of the *** a temperature at the sorption stage was 29℃ and a water vapor pressure P_(H2O) in the feed air was 5.2 mbar(1 bar=105 Pa),the composite material demonstrated a stable CO_(2) sorption capacity of 3.4%(mass).An increase in sorption temperature leads to a continuous decrease in the CO_(2) absorption capacity reaching a value of 0.7%(mass)at T=80℃.The material showed the retention of a stable CO_(2) sorption capacity for many cycles at each temperature in the *** PH2O in the inlet air from 5.2 to 6.8 mbar leads to instability of CO_(2) sorption capacity which decreases in the course of 3 consecutive TSA cycles from 1.7%to 0.8%(mass)at T=29℃.A further increase in air humidity only facilitates the deterioration of the CO_(2) sorption capacity of the material.A possible explanation for this phenomenon could be the filling of the porous system of the sorbent with solid reaction products and an aqueous solution of potassium salts,which leads to a significant slowdown in the CO_(2) diffusion in the composite sorbent *** investigate the regeneration step of the TSA cycle in situ,the macro ATRFTIR(attenuated total reflection Fourier-transform infrared)spectroscopic imaging was applied for the first *** was shown that the migration of carbonate-containing species over the surface of sorbent occurs during the thermal regeneration stage of the TSA *** movement of the active component in the porous matrix of the sorbent can affect the sorption characteristics of the composite *** revealed features make it possible

关键词： Zirconia aerogel Potassium carbonate Carbon dioxide Direct air capture Fourier-transform infrared spectroscopic imaging

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near-net-Shaped Objects of RE123 Superconductors byInfiltration Processing

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Tsinghua Science and Technology 2003年第3期8卷 292-306页

作者： E.S.Reddy G.j.Schmitz ACCESS Materials and Processes D-52056 AachenGermanyACCESS Materials and ProcessesD-52056 AachenGermany

The fabrication of near-net-shaped objects of RE123 superconductors by 'infiltration processing' is discussed. near-net-shape processing involves the infiltration of preshaped porous green bodies of either 211 or yttria phases by liquids containing barium cuprates and copper oxides followed by a controlled peritectic solidification. The process yields poly- and also single-crystalline superconducting objects with a shrinkage of less than half of one percent of the green bodies. The preservation of the initial structure of the green bodies results in fabrication of RE 123 in a wide variety of dimensions and complex shapes. The demonstrated products include bulk components like cylinders, single domain thick films on a variety of substrates, freestanding fabrics and open porous superconducting foams. This paper presents a comprehensive description of the infiltration processing technique and the resulting microstructures of the superconducting bodies. The advantages of this technique and practical applications of the processed superconducting structures are highlighted.

关键词： infiltration processing near-net shape shaping joining single domain crystal growth thick films foams applications

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