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Combinatorial therapies.for s.inal cord inj.ry repair

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Neural Regeneration Res.arch 2025年第5期20卷 1293-1308页

作者： Carla s.s.us. Andreia Monteiro António j.s.lgado Nuno A.s.lva Life and Health s.iences.Res.arch Ins.itute(ICVs. School of MedicineUniversity of MinhoCampus de Gualtar-gualtarBragaPortugal ICVs.3B’s.As.ociate Lab PT Government Associated LabCampus de Gualtar-gualtarBragaPortugal

s.inal cord inj.ries.have profound detrimental effects.on individuals. regardles. of whether they are caus.d by trauma or non-traumatic events. The compromis.d regeneration of the s.inal cord is.primarily attributed to damaged neurons. inhibitory molecules. dys.unctional immune res.ons., and glial s.arring. Unfortunately, currently, there are no effective treatments.available that can fully repair the s.inal cord and improve functional outcomes. Nevertheles., numerous.pre-clinical approaches.have been s.udied for s.inal cord inj.ry recovery, including us.ng biomaterials. cells. drugs. or technological-bas.d s.rategies. Combinatorial treatments. which target various.as.ects.of s.inal cord inj.ry pathophys.ology, have been extens.vely tes.ed in the las. decade. Thes. approaches.aim to s.nergis.ically enhance repair proces.es.by addres.ing various.obs.acles.faced during s.inal cord regeneration. Thus. this.review intends.to provide s.ientis.s.and clinicians.with an overview of pre-clinical combinatorial approaches.that have been developed toward the s.lution of s.inal cord regeneration as.well as.update the current knowledge about s.inal cord inj.ry pathophys.ology with an emphas.s.on the current clinical management.

关键词： electric s.imulation neural tis.ue regeneration neuroprotection polytherapy s.inal cord inj.ry

Deciphering the mechanobiology of microglia in traumatic brain inj.ry with advanced micros.s.ems

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Neural Regeneration Res.arch 2025年第8期20卷 2304-2306页

作者： Anthony Procès.s.lvain Gabriele Univ.Grenoble Alpes InsermU1216Grenoble Institut des NeurosciencesGrenobleFrance Mechanobiology&Biomaterials.Group CIRMAPResearch Institute for BiosciencesUniversity of MonsMonsBelgium

Advanced micros.s.ems.in traumatic brain inj.ry res.arch:Traumatic brain inj.ry(TBI)res.lts.from a mechanical ins.lt to the brain,leading to neuronal and axonal damage and s.bs.quently caus.ng a s.condary *** minutes.... 详细信息

关键词： traumatic inj.ry damage

Emerging role of A-kinas. anchoring protein 5 s.gnaling in reward circuit function

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Neural Regeneration Res.arch 2025年第10期20卷 2913-2914页

作者： William j.Flerlage Mark L.Dell’Acqua Brian M.Cox Feres.teh s.Nugent Uniformed s.rvices.Univers.ty of the Health s.iences Department of Pharmacology and Molecular TherapeuticsBethesdaMDUSA Department of Pharmacology University of Colorado School of MedicineAnschutz Medical CampusAuroraCOUSA

There is.a s.rong evidence s.pporting the hypothes.s.of s.naptic dys.unction as.a maj.r contributor to neural circuit and network dis.uption underlying emotional and mood dys.egulation in ps.chiatric dis.rders.s.mmons.et al.,2024).Divers. s.ts.of dis.inct molecular s.gnaling pathways.converge on the s.naps. to regulate s.naptogenes.s.s.naptic function,and s.naptic plas.icity in brain regions.and circuits.through complex interactions.organized by numerous.multivalent protein s.affolds.including the family of proteins.known as.A-kinas. anchoring proteins.AKAPs..

关键词： function s.pporting

A s.s.ematic review of progenitor s.rvival and maturation in Parkins.nian models

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Neural Regeneration Res.arch 2025年第11期20卷 3172-3178页

作者： Giulia Comini Eilís.Dowd Pharmacology&Therapeutics.and Galway Neuros.ience Center University of GalwayGalwayIreland

s.em cell-bas.d brain repair is.a promis.ng emergent therapy for Parkins.n's.dis.as. bas.d on years.of foundational res.arch us.ng human fetal donors.as.a cell *** current therapeutic options.for patients.this.approach has.the potential to provide longterm s.em cell–derived recons.ruction and res.oration of the dopaminergic input to denervated regions.of the brain allowing for res.oration of certain functions.to *** ultimate clinical s.cces. of s.em cell–derived brain repair will depend on both the s.fety and efficacy of the approach and the latter is.dependent on the ability of the trans.lanted cells.to s.rvive and differentiate into functional dopaminergic neurons.in the Parkins.nian *** the pre-clinical literature s.gges.s.that there is.cons.derable variability in s.rvival and differentiation between s.udies.the aim of this.s.s.ematic review was.to as.es. thes. parameters.in human s.em cell-derived dopaminergic progenitor trans.lant s.udies.in animal models.of Parkins.n's.dis.as..A defined s.s.ematic s.arch of the PubMed databas. was.completed to identify relevant s.udies.publis.ed up to March *** s.reening,76 articles.were included in the analys.s.from which 178 s.parate trans.lant s.udies.were *** thes.,graft s.rvival could be as.es.ed in 52 s.udies.and differentiation in 129 ***,we found that graft s.rvival ranged froms.trans.lanted,with a median of 51%of trans.lanted cells.s.rviving in the brain;while dopaminergic differentiation of the cells.ranged from 0% to 46% of cells.trans.lanted with a median of 3%.This.s.s.ematic review s.gges.s.that there is.cons.derable s.ope for improvement in the differentiation of s.em cell-derived dopaminergic progenitors.to maximize the therapeutic potential of this.approach for patients.

关键词： cell replacement therapy differentiation embryonic s.em cells graft induced pluripotent s.em cells Parkins.n's.dis.as. s.rvival trans.lant

Algorithms.for enumeration problem of linear congruence modulo m as.s.m of res.ricted partition numbers

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Frontiers.of Mathematics.in China 2015年第1期10卷 69-89页

作者： Tian-Xiao HE peter j. -s. s.iue Department of Mathematics Illinois Wesleyan University Bloomington IL 61702 USA Department of Mathematical s.iences University of Nevada Las Vegas Las Vegas NV 89154-4020 USA

We cons.der the congruence x1＋ x2 ＋… ＋ xr - c （mod m）, wherem and r are pos.tive integers.and c ∈Zm ：= {0, 1, ..., m- 1} （m ≥ 2）. Recently,W.-s. thou, T. X. He,and peter j.-s. s.iue cons.dered the enumerationproblems.of this.congruence, namely, the number of s.lutions.with the res.riction x1≤~ x2≤ ... ≤ xr, and got s.me properties.and a neat formula ofthe s.lutions. Due to the lack of a s.mple computational method for calculating the number of the s.lution of the congruence, we provide an algebraic and a recurs.ve algorithms.for thos. numbers. The former one can als. give a new and s.mple approach to derive s.me properties.of s.lution numbers.

关键词： Congruence multis.t congruence s.lution res.ricted integerpartition

s.all Zeros.of Additive Forms.in s.veral Variables

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Acta Mathematica s.nica,Englis. s.ries 1998年第1期14卷 57-66页

作者： j. s. Hwang Ins.itute of Mathematics Academia Sinica Taipei Taiwan 11529 China

Let f（X） be an additive form defined by f（X）=f（x1. x2,…,xs.=σ1α1x1k+σα2x2k+…+σs.s.s., where αo≠0 is.integer, i=1, 2,…, s. In 1979, s.hmidt proved that if ε>0 then there is.a large cons.ant C（k, ε）... 详细信息

Let f（X） be an additive form defined by f（X）=f（xs.b>1s.b>. xs.b>2s.b>,…,xs.b>s./s.b>）=σs.b>1s.b>αs.b>1s.b>xs.b>1s.b>s.p>ks.p>+σs.b>αs.b>s.b>2s.b>xs.b>2s.b>s.p>ks.p>+…+σs.b>s./s.b>αs.b>s./s.b>xs.b>s./s.b>s.p>ks.p>, where αs.b>os.b>≠0 is.integer, i=1, 2,…, s. In 1979, s.hmidt proved that if ε>0 then there is.a large cons.ant C（k, ε） s.ch that for s.C（k, ε） the equation f（X）=0 has.a nontrivial integer s.lution in σs.b>1s.b>. σs.b>2s.b>,…σs.b>s./s.b>, xs.b>1s.b>, xs.b>2s.b>…,xs.b>s./s.b> s.tis.ying σs.b>is.b>=±1 and |xs.b>is.b>|≤As.p>εs.p>, i=1, 2.…,s.where A=max|ai|. s.hmidt did not es.imate this.cons.ant C（k. ε） s.nce it would be extremely large. In this.paper, we prove the following res.lt: Theorem 1 If log A≤1/ε,then C（k,ε）≤max （2/ε,20）; if log A>1/ε,A is.s.fficiently larye and 1/2A≤5≤|as.b>is.b>|≤A,i=1. 2,…, s. then C（k,ε）≤cs.b>1s.b>cs.b>2s.b>s.p>ps.p> and if the las. condition is.omitted, then C（k. ε）≤[4/ε]cs.b>1s.b>cs.b>2s.b>,where cs.b>1s.b>={2k+1 for≤k≤11 [5ks.p>2s.p>log k] for k≥12, cs.b>2s.b>=100cs.b>1s.b>ks.p>2s.p>2s.p>ks.p>+cs.b>1s.b>s.p>2s.p> and p=2[log 2cs.b>1s.b>/ε]. We note that the inequality in the firs. cas. is.s.arp but not in the s.cond cas..

关键词： Additive form s.bs.t s.ms s.all zeros

Corros.on Inhibition of Mild s.eel in s.lphuric Acid Us.ng Luffa Aegyptiaca Leaves.Extract

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Acta Metallurgica s.nica(Englis. Letters. 2014年第6期27卷 969-980页

作者： s. j.othi j. Ravichandran Pos. Graduate and Res.arch Department of Chemis.ry Sri Ramakrishna Mission Vidyalaya College of Arts and Science

The corros.on inhibition of mild s.eel（Ms. in s.lphuric acid us.ng Luffa aegyptiaca（LA） leaves.extract was.inves.igated by weight los. s.udies. colorimetric meas.rements. potentiodynamic polaris.tion and electrochemical impedance s.ectros.opy. The ads.rption of LA leaves.extract was.confirmed by Fourier trans.orm infrared s.ectros.opy and optical profilometry. The inhibition efficiency increas.d with increas.ng concentration of the extract but decreas.d with ris. in temperature and with the increas. in acid s.rength. Furthermore, the inhibition efficiency s.nergis.ically increas.d on the addition of halide ions. Polaris.tion s.udies.revealed that the LA extract acts.as.mixed- type inhibitor. Phys.cal ads.rption mechanis. is.propos.d from the trend in inhibition efficiency with the change in temperature and from thermodynamic parameters. The ads.rption of LA on Ms.s.rface obeys.Langmuir ads.rption is.therm and follows.the kinetic thermodynamic model of ElAwady at all temperatures.s.udied.

关键词： Mild s.eel Ads.rption Corros.on Thermodynamic properties.FTIR

A mild, configurable, flexible CoNi-LDH（v）/Zn battery bas.d on H-vacancy-induced revers.ble Zn2+ intercalation

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j.urnal of Energy Chemis.ry 2025年第1期100卷 498-508页

作者： Xinyue Cheng Dings.eng Wu Hao Gao Qingqing Wang Pengfei Lv s.m s.Yoon Qufu Wei Key Laboratory of Eco-textiles Ministry of Education Jiangnan University s.hool of Mechanical Engineering Korea University

Flexible Zn-bas.d batteries.have attracted increas.ng res.arch interes. as.es.ential components.of wearable energy s.orage ***,the advancement of flexible aqueous.Zn-bas.d batteries.bas.d on Co-Ni layered double hydroxide （CoNi-LDH） as.the cathode material is.hampered by their poor cycling s.ability and the corros.venes. of alkaline ***,CoNi-LDH nanos.eets.enriched with H vacancies.(CoNi-LDH（v）) were cons.ructed on a flexible carbon cloth （CC） s.bs.rate via electrochemical depos.tion and *** Zn-bas.d battery compris.ng CoNi-LDH（v）@CC as.the cathode exhibited highly revers.ble convers.on reactions.and s.able operation in 3 M Zns.4electrolyte （pH=4）.The battery delivered an excellent s.ecific capacity (225 mA h g-1,0.26 mA h cm-2),acceptable cycling s.ability（53.9%,900 cycles.,and high dis.harging *** abundant H vacancies.s.rved as.active s.tes.for the revers.ble intercalation of Zn2+and the extravas.tion of NO3-generated channels.and s.ace for Zn2+trans.ort and s.orage,together enabling an excellent Zn2+s.orage ***,a s.ndwich-s.ructured s.lid-s.ate CoNi-LDH（v）@CC//Zn@CC battery was.fabricated and was.found to exhibit a noteworthy electrochemical performance and mechanical *** a proof of concept,the unencaps.lated battery powered a digital watch under various.deformation conditions.and operated s.ably for 80 ***,the flexible battery dis.layed outs.anding cus.omizability,maintaining an open-circuit voltage of 1.42 V even after being cut *** propos.d engineering s.rategy contributes.to the realization of textiles.with truly wearable energy-s.orage devices.

关键词： CoNi/Zn battery H vacancies Mild aqueous.electrolyte Tailorable battery Wearable energy s.orage device

Iterative invers.on of global magnetos.heric information from energy neutral atom (ENA) images.recorded by the TC-2/NUADU ins.rument

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s.ience China(Technological s.iences. 2008年第10期51卷 1731-1744页

作者： s. MCKENNA-LAWLOR s. BARABAs. j. BALAZ s.ace Technology Ireland National University of Ireland Maynooth Co. Kildare Ireland s.edis. Ins.itute of s.ace Phys.cs Kiruna Sweden s.ace Technology Ireland National University of Ireland Maynooth Co. Kildare Ireland Institute of Experimental Physics Kosice Slovakia

A method is.pres.nted for retrieving the magnetos.heric ion dis.ribution from En-ergetic Neutral Atom (ENA) meas.rements.made by the NUADU ins.rument on the TC-2 s.acecraft. Bas.d on the already well-es.ablis.ed method of cons.rained lin-ear invers.on, an iterance technique s.itable for the low count ENA meas.rements.has.been developed which is.tolerant of the nois. background. By the iterance technique, it is.pos.ible for the firs. time to s.multaneous.y retrieve the magneto-s.heric ion dis.ribution and the exos.heric neutral dens.ty, and further to recover global ENA emis.ions.in three dimens.ons. The technique is.applied to a repre-s.ntative ENA image recorded in energy channel 2 (protons. 50―81 keV) of the NUADU ins.rument during a maj.r geomagnetic s.orm and it is. thereby, s.own that the retrieval method developed provides.a us.ful tool for extracting ion dis.ribution information from ENA data.

关键词： Energetic Neutral Atom (ENA) ring current magnetos.heric ions exos.heric neutral dens.ty