检索结果-南通市图书馆

时珍国医国药 2008年第7期19卷 1737-1738页

作者：彭玉娜谭获王颖超李智钟志强刘汗欣广州医学院第一附属医院广东广州510230 英国皇家外科医学院

目的探讨灵芝孢子粉对兔移植性肿瘤的生存期及外周血的影响。方法将成功接种荷VX2乳腺癌兔随机分为灵芝组和对照组,解剖死亡或结束时的兔子,用Kaplan-Meier进行生存曲线分析,Log Rank进行生存曲线显著性检验。比较外周血的变化。结果结... 详细信息

目的探讨灵芝孢子粉对兔移植性肿瘤的生存期及外周血的影响。方法将成功接种荷VX2乳腺癌兔随机分为灵芝组和对照组,解剖死亡或结束时的兔子,用Kaplan-Meier进行生存曲线分析,Log Rank进行生存曲线显著性检验。比较外周血的变化。结果结束时灵芝组60%生存,中位生存期大于70d;而对照组只有20%生存,中位生存期为43d;两组生存期差别有统计学意义(P0.05)。结论灵芝孢子粉能够延长荷VX2乳腺癌兔的生存期,能提高白细胞。

关键词：灵芝孢子粉移植性肿瘤生存期外周血细胞

Ratio quantification of gene dosage by Agilent 2100 Bioanalyzer for detection of somatic gene deletions

在线全文

学校读者我要写书评

暂无评论

Advances in Biological Chemistry 2012年第1期2卷 70-75页

作者： peter Hwu Qiang Liu Yafan Wang Linling Chen Yawen Cheng Wanru Lin Yun Yen Department of Molecular Pharmacology City of Hope Comprehensive Cancer Center Duarte USA Institute of Medicine Chung Shan Medical University Taichung Chinese Taipei Translational Research Core Laboratory City of Hope Comprehensive Cancer Center and Beckman Research Institute Duarte USA

We applied the Agilent 2100 Bioanalyzer, a microfluidics-based electrophoresis instrument, and introduced an accurate and consistent parameter, the relative product yield ratio (ROY), to detect somatic gene deletions in tumor cells. Briefly for such purpose, the Agilent 2100 Bioanalyzer quantified the ROY of a target gene to an endogenous internal control, both of which were initially co-amplified by Robust-Dosage PCR (RD- PCR). Herein, we extensively validated this approach. We first tested the effect of well positions on the Agilent DNA chip. We found that no matter which wells the samples were loaded in, the ROY was consistent with coefficient of variation (CV) < 2%. Then we tested the effect of product concentrations that varied 8-fold, and the ROY was also consistent with CV < 3.5%. Furthermore, we applied this approach to identify six somatic KRAS deletions in non-small cell lung cancer patients, confirming our previous findings. Thus, the Agilent 2100 Bioanalyzer is simple, accurate, quick, and ultimately able to replace conventional gel electrophoresis for the detection of somatic gene deletions.

关键词： Electrophoresis Gene Deletion Detection Agilent 2100 Bioanalyzer RD-PCR NSCLC

Antibody and T cell responses against wild-type and Omicron SARS-CoV-2 after third-dose BNT162b2 in adolescents

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Signal Transduction and Targeted Therapy 2023年第1期8卷 266-275页

作者： Xiaofeng Mu Carolyn A.Cohen Daniel Leung Jaime S.Rosa Duque Samuel M.S.Cheng Yuet chung Howard H.W.Wong Amos M.T.Lee Wing Yan Li Issan Y.S.Tam Jennifer H.Y.Lam Derek H.L.Lee Sau Man Chan Leo C.H.Tsang Karl C.K.Chan John K.C.Li Leo L.H.Luk Sara Chaothai Kelvin K.H.Kwan Nym Coco Chu Masashi Mori Trushar Jeevan Ahmed Kandeil Richard JWebby Wenwei Tu Sophie A.Valkenburg Malik Peiris Yu Lung Lau Department of Paediatrics and Adolescent Medicine The University of Hong KongHong KongChina HKU-Pasteur Research Pole School of Public HealthThe University of Hong KongHong KongChina School of Public Health The University of Hong KongHong KongChina Research Institute for Bioresources and Biotechnology Ishikawa Prefectural UniversityNonoichiJapan Department of Infectious Diseases St Jude Children’s Research HospitalMemphisTNUSA Department of Microbiology and Immunology Peter Doherty Institute for Infection and ImmunityUniversity of MelbourneMelbourneVICAustralia Centre for Immunology&Infection C2i Hong KongChina

The high effectiveness of the third dose of BNT162b2 in healthy adolescents against Omicron BA.1 has been reported in some studies,but immune responses conferring this protection are not yet *** this analysis,our study(NCT04800133)aims to evaluate the humoral and cellular responses against wild-type and Omicron(BA.1,BA.2 and/or BA.5)SARS-CoV-2 before and after a third dose of BNT162b2 in healthy *** 5 months after 2 doses,S IgG,S IgG Fc receptor-binding,and neutralising antibody responses waned significantly,yet neutralising antibodies remained detectable in all tested adolescents and S IgG avidity increased from 1 month after 2 *** antibody responses and S-specific IFN-γ^(+)and IL-2^(+)CD8^(+)T cell responses were significantly boosted in healthy adolescents after a homologous third dose of *** to adults,humoral responses for the third dose were non-inferior or superior in *** S-specific IFN-γ^(+)and IL-2^(+)CD4^(+)and CD8^(+)T cell responses in adolescents and adults were comparable or ***,after 3 doses,adolescents had preserved S IgG,S IgG avidity,S IgG FcγRIIIa-binding,against Omicron BA.2,as well as preserved cellular responses against BA.1 S and moderate neutralisation levels against BA.1,BA.2 and *** from 100 and 96%of adolescents tested at 1 and 5 months after two doses could also neutralise *** study found high antibody and T cell responses,including potent cross-variant reactivity,after three doses of BNT162b2 vaccine in adolescents in its current formulation,suggesting that current vaccines can be protective against symptomatic Omicron disease.

关键词： doses neutral protective

Superior antibody and membrane protein‑specific T‑cell responses to CoronaVac by intradermal versus intramuscular routes in adolescents

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Pediatrics 2024年第4期20卷 353-370页

作者： Jaime S.Rosa Duque Samuel M.S.Cheng Carolyn A.Cohen Daniel Leung Xiwei Wang Xiaofeng Mu Yuet chung Tsun Ming Lau Manni Wang Wenyue Zhang Yanmei Zhang Howard H.W.Wong Leo C.H.Tsang Sara Chaothai Tsz Chun Kwan John K.C.Li Karl C.K.Chan Leo L.H.Luk Jenson C.H.Ho Wing Yan Li Amos M.T.Lee Jennifer H.Y.Lam Sau Man Chan Wilfred H.S.Wong Issan Y.S.Tam Masashi Mori Sophie A.Valkenburg Malik Peiris Wenwei Tu Yu Lung Lau Department of Paediatrics and Adolescent Medicine The University of Hong KongHong KongChina School of Public Health The University of Hong KongHong KongChina HKU‑Pasteur Research Pole School of Public HealthThe University of Hong KongHong KongChina Research Institute for Bioresources and Biotechnology Ishikawa Prefectural UniversityNonoichiJapan Department of Microbiology and Immunology Peter Doherty Institute for Infectionand ImmunityUniversity of MelbourneMelbourneVICAustralia Center for Immunology and Infection C2i Hong KongChina

Background Optimising the immunogenicity of COVID-19 vaccines to improve their protection against disease is *** dosing by intradermal(ID)administration has been shown to be equally immunogenic as intramuscular(IM)administration for several vaccines,but the immunogenicity of ID inactivated whole severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)at the full dose is *** study(NCT04800133)investigated the superiority of antibody and T-cell responses of full-dose CoronaVac by ID over IM administration in *** Participants aged 11–17 years received two doses of IM or ID vaccine,followed by the 3rd dose 13–42 days *** and cellular immunogenicity outcomes were measured post-dose 2(IM-CC versus ID-CC)and post-dose 3(IMCCC versus ID-CCC).Doses 2 and 3 were administered to 173 and 104 adolescents,*** Spike protein(S)immunoglobulin G(IgG),S-receptor-binding domain(RBD)IgG,S IgG Fcγreceptor IIIa(FcγRIIIa)-binding,SNM[sum of individual(S),nucleocapsid protein(N),and membrane protein(M)peptide pool]-specific interleukin-2(IL-2)+CD4^(+),SNM-specific IL-2^(+)CD8^(+),S-specific IL-2^(+)CD8^(+),N-specific IL-2^(+)CD4^(+),N-specific IL-2^(+)CD8^(+)and M-specific IL-2^(+)CD4^(+)responses fulfilled the superior and non-inferior criteria for ID-CC compared to IM-CC,whereas IgG avidity was *** ID-CCC,S-RBD IgG,surrogate virus neutralisation test,90%plaque reduction neutralisation titre(PRNT90),PRNT50,S IgG avidity,S IgG FcγRIIIa-binding,M-specific IL-2^(+)CD4^(+),interferon-γ+CD8^(+)and IL-2^(+)CD8^(+)responses were superior and non-inferior to *** estimated vaccine efficacies were 49%,52%,66%and 79%for IM-CC,ID-CC,IM-CCC and ID-CCC,*** ID groups reported more local,mild adverse *** This is the first study to demonstrate superior antibody and M-specific T-cell responses by ID inactivated SARSCoV-2 vaccination and serves as the basis for future research to improve the

关键词： CoronaVac Coronavirus disease 2019 Immunity Intradermal Vaccine

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

香港大榄郊野公园的植物组成与植被数量分类

植物学通报 2008年第1期25卷 50-58页

作者：曾绮微李海生陈桂珠叶创兴黄颂诗黄超弘中山大学环境科学与工程学院广州510275 广东教育学院生物系广州510303 中山大学生命科学学院广州510275 香港中文大学地球信息科学联合实验室中国香港

通过对香港大榄郊野公园森林群落的样地调查, 利用组平均法和除趋势对应分析两种方法, 对样方进行聚类与排序分析。把35个样地划分为11个植被类型, 森林群落可划分为台湾相思(Acacia confusa Merr.)林、红胶木(Lophostemon con- fertus ... 详细信息

通过对香港大榄郊野公园森林群落的样地调查, 利用组平均法和除趋势对应分析两种方法, 对样方进行聚类与排序分析。把35个样地划分为11个植被类型, 森林群落可划分为台湾相思(Acacia confusa Merr.)林、红胶木(Lophostemon con- fertus (R. Br.) peter G. Wilson ex J. T. Waterh.)林、木荷(Schima superba Gardner ex Champ.)林、柠檬桉(Eucalyptus citriodora Hook.)林、湿地松+鸭脚木(Pinus elliottii Engelm.+ Schefflera octophylla (Lour.) Harms.)林、土沉香(Aquilaria sinensis (Lour.) Spreng.)林、毛叶桉(Eucalyptus torelliana F. Muell.)林; 灌木群落分为山油柑+越南叶下珠(Acronychia pedunculata (L.) Miq.+ Phyllanthus cochinchinensis (Lour.) Spreng.)矮树灌丛、豺皮樟+桃金娘(Litsea rotoundifolia (Nees) Hemsl. var. oblongifolia (Nees) C. K. Allen+Rhodomyrtus tomentosa (Alton) Hassk.)矮树灌丛、大头茶(Gordonia axillaris (Roxb. ex Ker Gawl.) D. Dietr.)矮树灌丛、桃金娘+芒萁(Rhodomyrtus tomentosa (Alton) Hassk.+Dicranopteris dichotoma (Thunb.) Bernh.)灌草丛。DCA排序结果反映海拔高度与各个森林群落的分布格局和物种组成关系不大, 而环境湿度是影响森林群落物种组成的主要因素。多样性分析结果显示, 台湾相思林和土沉香林多样性指数最高, 说明台湾相思林逐渐向次生林演变, 除了红胶木林和少数郁闭度低的台湾相思林中有强阳生性树种外, 大部分人工林下植物以阳生性稍耐阴的树种为主。调查结果显示, 大榄郊野公园植物生长条件东部优于西部, 西部的物种丰富度和多样性指数较低, 主要以人工林和灌丛为主, 加上山火频繁发生, 导致长期处于先锋阶段。

关键词：聚类郊野公园香港排序植物群落

门诊手术麻醉协会关于手术后恶心呕吐的处理指南

在线全文

学校读者我要写书评

暂无评论

麻醉与镇痛 2008年第6期4卷 12-26,43页

作者： Tong J. Gan, MD Tricia A. Meyer, PharmD, MS Christian C. Apfel, MD, PhD Frances chung, FRCPC peter J. Davis, MD Ashraf S. Habib, MB, FRCA Vallire D. Hooper,MSN, RN, CPAN, FAAN Anthony L. Kovac,MD peter Kranke, MD, PhD, MBA Paul Myles, MD Beverly K. Philip, MD Gregory Samsa, PhD Daniel I. Sessler, MD James Temo, CRNA, MSN, MBA Martin R. Tramer, MD, DPhil Craig Vander Kolk,MD Mehernoor Watcha, MD 谢郭豪(译) 方向明(校) Department of Anesthesiology Duke University Medical Center Durham North Carolina Consultant Anesthesiologist University of Wuerzburg WuerzburgGermany Department of Anesthesia and Perioperative Care UCSF Medical Center at Mt. Zion San FranciscoCalifornia Department of Anesthesia University of Toronto Toronto Canada Department of Anesthesi-ology and Pediatrics University of Pittsburgh School of Medicine Pittsburgh Pennsylvania School of Nurs-ing Medical College of Georgia Augusta Georgia Department of Anesthesiology University of KansasMedical Center Kansas City Kansas Consultant Anesthesiologist University of Wuerzburg WuerzburgGermam Department of Anesthesia and Perioperative Medicine Alfred Hospital Monash University Mel-bourne Australia Department of Anesthesiology Perioperative and Pain Medicine Brigham and Women'sHospital Harvard Medical School Boston Massachusetts Department of Biometry and Bioinformatics Duke University Medical Center Durham North Carolina Department of OUTCOMES RESEARCH TheCleveland Clinic Cleveland Ohio Duke University Nurse Anesthetist Program Durham North Caro-lina Division of Anesthesiology Geneva University Hospitals and Faculty of Medicine Geneva Switzer-land Department of Surgery Division of Plastic Surgery Johns Hopkins University School of Medicine Bal-timore Maryland Department of Anesthesiology Texas Children's Hospital Houston Texas 不详

本指南是在门诊手术麻醉协会发起下，由国际专家组编撰而成。该专家组成员涉及与手术后恶心、呕吐（PONV）相关的多个学科，他们审慎的评估了当前关于PONV的医学文献，为PONV高风险的成年及儿童外科手术患者提供了循证医学的参考工具。... 详细信息

本指南是在门诊手术麻醉协会发起下，由国际专家组编撰而成。该专家组成员涉及与手术后恶心、呕吐（PONV）相关的多个学科，他们审慎的评估了当前关于PONV的医学文献，为PONV高风险的成年及儿童外科手术患者提供了循证医学的参考工具。指南的重点是识别成人及儿童患者中发生PONV的危险因素；推荐降低PONV基础风险的方法；甄别出对PONV进行预防性治疗最为有效的单一药物及联合用药方案；推荐对已发生的PONV的治疗方法；并为具有较高PONV风险的患者提供了处理流程。

关键词：手术后恶心呕吐手术麻醉指南协会门诊 PONV 外科手术患者联合用药方案

一种用于增加制程范围的新型FFS液晶显示器件结构

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

现代显示 2008年第4期 40-43页

作者：毛联波乔艳冰戴文君李佑俊廖家德钟德镇简廷宪昆山龙腾光电有限公司江苏215301

FFS(fringing field switching)技术作为三大主流广视角液晶显示技术之一,与IPS/VA相比有高开口率的优势。然而由于其存储电容易受制程偏移的影响而较容易产生显示不均,因此在制造过程中对设备精度要求十分严格。本文介绍一种新的FFS器... 详细信息

FFS(fringing field switching)技术作为三大主流广视角液晶显示技术之一,与IPS/VA相比有高开口率的优势。然而由于其存储电容易受制程偏移的影响而较容易产生显示不均,因此在制造过程中对设备精度要求十分严格。本文介绍一种新的FFS器件结构,能很大程度上降低由于制程偏移造成的显示不均。

关键词：边缘切换回踢电压制程偏移

在线全文

学校读者我要写书评

暂无评论

伊森伯格管理学院商业创新中心

当代建筑 2020年第2期 122-127页

作者：无 Yu Inamoto Pauline Lavie-Luong Hung Kai Liao Alice Cladet Amina Blacksher Barbara Stallone Cheyenne Vandevoorde Daniel Kidd Davide Maggio Deborah Campbell Denys Kozak Derek Wong Domenic Schmid Douglass Alligood Elena Bresciani Emily Mohr Fabian Lorenz Francesca Portesine Ibrahim Salman Jan Leenknegt Justyna Mydlak Kai-Uwe Bergmann Ku Hun chung Linda Halim Lucas Hong Manon Otto Maria Eugenia Dominguez Mustafa Khan Nicolas Gustin Pei Pei Yang peter Lee Seoyoung Shin Simon Lee Terrence Chew Tianqi Zhang Yixin Li BIG建筑事务所不详

位于马萨诸塞州艾摩斯特市的商业创新中心外墙为覆铜设计,极具现代艺术之感。该建筑为伊森伯格管理学院(全美排名前30的公立商学院)增加了7万***(约为0.6万m2)的超协作研究与社交空间。此次扩建和部分翻新使得伊森伯格管理学院的既有空... 详细信息

位于马萨诸塞州艾摩斯特市的商业创新中心外墙为覆铜设计,极具现代艺术之感。该建筑为伊森伯格管理学院(全美排名前30的公立商学院)增加了7万***(约为0.6万m2)的超协作研究与社交空间。此次扩建和部分翻新使得伊森伯格管理学院的既有空间几乎扩大了一倍,不仅能够满足该学院在过去十年间的快速发展需求,同时也为学院150多名教职人员和5000名本科、硕士及博士生引进了新的设施。

关键词：商业创新教职人员马萨诸塞州协作研究外墙社交空间伊森商学院

在线全文

学校读者我要写书评

暂无评论

伊森伯格管理学院商业创新中心

城市环境设计 2019年第2期118卷 54-61页

作者： Alice Cladet Amina Blacksher Barbara Stallone Beat Schenk Cheyenne Vandevoorde Daniel Kidd Davide Maggio Deborah Campbell Denys Kozak Derek Wong Domenic Schmid Douglass Alligood Elena Bresciani Emily Mohr Fabian Lorenz Francesca Portesine Ibrahim Salman Jan Leenknegt Justyna Mydlak Kai-Uwe Bergmann Kristoffer Negendahl Ku Hun chung Linda Halim Lucas Hong Manon Otto Maria Eugenia Dominguez Mustafa Khan Nicolas Gustin Pei Pei Yang peter Lee Seoyoung Shin Simon Lee Terrence Chew Tianqi Zhang Tore Banke Yehezkiel Wiliardy Yixin Li Max Touhey Laurian Ghinitoiu 曲鸿

这座有着铜质外观的商业创新中心坐落于马萨诸塞大学阿默斯特分校的核心地带,是由BIG建筑事务所和建筑师Goody Clancy共同设计的。它的建成为这所全美排名前30的商学院增加了70000平方英尺(约6503平方米)的学习合作和社交的空间。新的... 详细信息

这座有着铜质外观的商业创新中心坐落于马萨诸塞大学阿默斯特分校的核心地带,是由BIG建筑事务所和建筑师Goody Clancy共同设计的。它的建成为这所全美排名前30的商学院增加了70000平方英尺(约6503平方米)的学习合作和社交的空间。新的扩建和部分翻新使伊森伯格管理学院现有的空间扩大了近一倍,为学院过去十

关键词：建筑事务所阿默斯特商业创新