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Genome-wide MicroRNA Expression Profiles in COPD: Early Predictors for Cancer Development

Genomics, Proteomics & Bioinformatics 2018年第3期16卷 162-171页

作者： Andreas Keller Tobias Fehlmann Nicole Ludwig Mustafa Kahraman Thomas Laufer Christina Backes Claus Vogelmeier Caroline Diener Frank Biertz christian Herr Rudolf A. Jorres Hans-peter Lenhof Eckart Meese Robert Bals Clinical Bioinformatics Saarland University 66123 Saarbriieken Germany Department of Human Genetics Saarland University Hospital 66421 Homburg Germany Hummingbird Diagnostics GmbH 69120 Heidelberg Germany Department of Internal Medicine Division for Pulmonary Diseases Philipps University of Marburg 35043 Marburg Germany Institute for Biostatistics Hannover Medical School 30625 Hanover Germany Department of Internal Medicine V- Pulmonology AlIergology Intensive Care Medicine Saarland University Hospital 66421 Homburg Germany Institute and Outpatient Clinic for Occupational Social and Environmental Medicine Comprehensive Pneumology Center Munich (CPC-M) Ludwig-Maximilians-University Munich Member of the German Center for Lung Research ( DZL) 80539 Munich Germany Bioinformatics Saarland University 66123 Saarbrucken Germany Center for Bioinformatics Saarland University 66123 Saarbrucken Germany

Chronic obstructive pulmonary disease （COPD） significantly increases the risk of developing cancer. Biomarker studies frequently follow a case-control set-up in which patients diagnosed with a disease are compared to controls. Longitudinal cohort studies such as the COPD-centered German COPD and SYstemic consequences-COmorbidities NETwork （COSYCONET） study provide the patient and biomaterial base for discovering predictive molecular markers. We asked whether microRNA （miRNA） profiles in blood collected from COPD patients prior to a tumor diagnosis could support an early diagnosis of tumor development independent of the tumor type. From 2741 participants of COSYCONET diagnosed with COPD, we selected 534 individuals including 33 patients who developed cancer during the follow-up period of 54 months and 501 patients who did not develop cancer, but had similar age, gender and smoking history. Genome-wide miRNA profiles were generated and evaluated using machine learning techniques. For patients developing cancer we identified nine miRNAs with significantly decreased abundance （two-tailed unpaired t-test adjusted for multiple testing P 〈 0.05）, including members of the miR-320 family. The identified miRNAs regulate different cancer-related pathways including the MAPK pathway （P - 2.3 × 10 -5）. We also observed the impact of confounding factors on the generated miRNA profiles, underlining the value of our matched analysis. For selected miRNAs, qRT-PCR analysis was applied to validate the results. In conclusion, we identified several miRNAs in blood of COPD patients, which could serve as candidates for biomarkers to help identify COPD patients at risk of developing cancer.

关键词： microRNA Cancer COPD Lung Biomarker COSYCONET

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Ⅲ类MHC基因及补体多态现象的复杂性

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中国免疫学杂志 1990年第3期 187-189页

作者： christian Rittner ,peter M.Schneider ,赵修竹

1989年7月27日到29日在Mainz六届补体遗传会议及在柏林免疫学会议上,来自23个国家的一个遗传学小组成员对Ⅲ类MHC基因及补体多态现象的复杂性进行了讨论.Ⅲ类基因不仅包括补体,还有其它座位,如肿瘤坏死因子(TNF)α及β、21羟化(?)(21—O... 详细信息

1989年7月27日到29日在Mainz六届补体遗传会议及在柏林免疫学会议上,来自23个国家的一个遗传学小组成员对Ⅲ类MHC基因及补体多态现象的复杂性进行了讨论.Ⅲ类基因不仅包括补体,还有其它座位,如肿瘤坏死因子(TNF)α及β、21羟化(?)(21—OH)A及B、热休克蛋白70(HSP70)的重复基因,它们并无功能的相关性。除此之外,补体基因座位也见于染色体1(H,C4BP,CR1,C8A和B)染色体9(C8G)及染色体19(C3)。可能由于发生学、缺乏症及疾病等方面的原因,与MHC连锁的补体基因仍然吸引着众多人的重视.这些研究已成为中性论者(***,Tubingen)与选择论者(T.M(?)o,巴黎)思考的主题.

关键词： MHC 多态现象单倍型单元型同种型基因

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Analyzing Laser-Welded NiTi-NiTi-Joints for Actuator Applications Using Design of Experiments

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Journal of Mechanics Engineering and Automation 2015年第2期5卷 76-81页

作者： Dennis Otibar christian Rathmann Konstantin Lygin Dieter Kreimeier peter Szymansky Faculty of Mechanical Engineering Ruhr-University Boehum Bochum 44801 Germany PSL Technik GmbH Oberhausen 46149 Germany

One promising joining method for NiTi-SMA （shape memory alloy）-components is laser welding. This joining technology bears huge potential regarding process automation and mechanical properties as well as durability, especially within the field of small- and medium-sized actuators. However, there is still need for research due to unsolved issues influencing the microstructure and thus effecting mechanical properties as well as SMA-characteristics of these joints. Therefore, the purpose of this paper is the evaluation of quality parameters of NiTi-NiTi-wire-joints. For this purpose, design of experiments with a fractional factorial design is used for the investigation, because of its high potential to decrease experimental effort. This paper provides a basis for future research in the field of SMA-actuators and joining.

关键词： SMA shape memory actuators NiTi-NiTi-joints laser welding joining design of experiments.

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Isolated Bell's palsy-An unusual presentation of dengue infection

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Asian Pacific Journal of Tropical Medicine 2013年第1期6卷 82-84页

作者： Soumia peter Malhotra N peter P Sood R Department of Medicine Christian Medical College & Hospital Department of Radiodiagnosis Christian Medical College & Hospital

Dengue fever is a very common arthropod-borne infection in tropical *** complications in dengue fever are relatively uncommon and among these,isolated cranial neuropathies have been reported only very *** present an unusual neurological complication of Bell’s palsy(lower motor neuron 7 th nerve palsy) associated with dengue *** the best of our knowledge,there have been very few documented cases of Flavivirus causing isolated Bell’s palsy.

关键词： Dengue infection Bell’s palsy

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Deep hyperammonemic hepatic encephalopathy precipitated by fecal microbiota transplantation for fulminant Clostridioides difficile infection

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Gastroenterology Report 2022年第1期10卷 612-614页

作者： Lotte Lindgreen Eriksen Simon Mark Dahl Baunwall peter Lykke Eriksen Kirstine Petrea Bak-Fredslund Jens Erik Nielsen Jens Frederik Dahlerup Karen Louise Thomsen Hendrik Vilstrup christian Lodberg Hvas Department of Hepatology and Gastroenterology Aarhus University HospitalAarhus NDenmark Department of Hepatology and Gastroenterology Randers Regional HospitalRandersDenmark Department of Radiology Aarhus University HospitalAarhus NDenmark

Introduction Fecal microbiota transplantation(FMT)is highly effective and potentially life-saving for recurrent Clostridioides difficile infection(CDI)[1].Recent pilot trials also reported the use of FMT to revert hepatic encephalopathy(HE)in patients with decompensated liver cirrhosis without infectious colitis[2,3].Intestinal microbiota-driven hyperammonemia is central to HE development and most treatments aim to reduce ammonia levels by modulating the intestinal ***,FMT might lead to increased intestinal ammonia production,as we describe here.

关键词： hepatic infection encephalopathy

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Precision medicine in Parkinson's disease patients with LRRK2 and GBA risk variants-Let's get even more personal

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Translational Neurodegeneration 2020年第4期9卷 499-508页

作者： christian U.von Linstow Ziv Gan-Or Patrik Brundin Center for Neurodegenerative Science Van Andel InstituteGrand RapidsMI 49503USA Montreal Neurological Institute McGill UniversityMontrealQC H3A 2B4Canada Department of Human Genetics McGill UniversityMontrealQC H3A 0C7Canada Department of Neurology and Neurosurgery McGill UniversityMontrealQC H3A 2B4Canada

Parkinson's disease(PD)is characterized by motor deficits and a wide variety of non-motor *** age of onset,rate of disease progression and the precise profile of motor and non-motor symptoms display considerable individual ***,the loss of substantia nigra dopaminergic neurons is a key feature of *** vast majority of PD patients exhibit alpha-synuclein aggregates in several brain regions,but there is also great variability in the neuropathology between *** the dopamine replacement therapies can reduce motor symptoms,current therapies do not modify the disease *** clinical trials using a wide variety of approaches have failed to achieve disease *** has been suggested that the heterogeneity of PD is a major contributing factor to the failure of disease modification trials,and that it is unlikely that a single treatment will be effective in all *** medicine,using drugs designed to target the pathophysiology in a manner that is specific to each individual with PD,has been suggested as a way *** patients can be stratified according to whether they carry one of the risk variants associated with elevated PD *** this review we assess current clinical trials targeting two enzymes,leucine-rich repeat kinase 2(LRRK2)and glucocerebrosidase(GBA),which are encoded by two most common PD risk *** the details of the pathogenic processes coupled to the different LRRK2 and GBA risk variants are not fully understood,we ask if these precision medicinebased intervention strategies will prove"precise"or"personalized"enough to modify the disease process in PD *** also consider at what phases of the disease that such strategies might be effective,in light of the genes being primarily associated with the risk of developing disease in the first place,and less clearly linked to the rate of disease ***,we critically evaluate the notion that therapies target

关键词： Parkinson's disease Precision medicine Personalized medicine Glucocerebrosidase GCase Leucine-rich repeat kinase-2 Dopamine PD drug trials PD risk variants

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以EUDRAGIT~聚合物为载体采用热熔挤出技术提高模型药物硝苯地平溶解度的处方放大

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中国医药工业杂志 2014年第6期45卷 I0011-I0012页

作者： Nollenberger Kathrin Dorairaju Gowri Brunnengraber christian Niepoth peter Listro Tony Evonik Rohm GmbH 药用树脂和服务德国达姆施塔特 Foster公司美国康涅狄格州帕特南

以EUDRAGIT聚合物为载体，采用热熔挤出技术制备固体分散体，可以用于提高难溶药物的溶解度。通过选择不同的EUDRAGIT聚合物，可以达到对消化道不同位点的靶向。例如，EUDRAGIT E PO可以用于提高药物在酸性介质中的溶出速率。

关键词：水溶性聚合物难溶药物挤出技术溶解度硝苯地平热熔载体放大

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How to Make the Plants of Today Comply with the Requirements of Tomorrow

How to Make the Plants of Today Comply with the Requirements...

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Asia Steel International Conference 2012(Asia Steel 2012)

作者： FROHLING christian BUTTENBENDER Berthold HEMMLING peter JANNASCH Otmar Energy and Environmental Technology SMS Siemag AG

＜正＞SMS Siemag expects the future to hold great potential for the field of energy and environmental *** the last two years,the company has brought different innovative ecoplants concepts to market and has already been awarded orders for the corresponding technologies（*** recovery from EAF off-gas heat and a new generation of electric filters for primary BOF dedusting）. We further reinforced our traditional dedication to energy-efficient and environment-friendly plants and equipment. Consequently,we extended our specialists team to offer an integrated solution how to use different energy sources available in a metallurgical plant complex most efficiently. Steelmaking processes generate a large range of gaseous byproducts like blast furnace gas,coke oven gas and converter gas that have a high energy content in the form of combustible *** these gases as primary fuel in a firing plant contributes significantly to increased energy efficiency in steelworks,and therefore reduces the overall steel manufacturing costs and saves CO,emissions. For the systematic utilization of these gases to generate *** for production and/or to generate electricity in a complete power station process,SMS Siemag offers a wide range of part-standardized steam generators. The presentation will sum up the ecoplants technologies introduced so far and give an outlook on the potentials of the new industrial power *** Siemag is committed to effective,eco-friendly production methods and technologies for all its plants. That also includes the whole area of water *** water circuits at the heart of steelmaking plants carry large quantities of fresh,process,and waste *** instance,a conventional hot rolling mill uses approx.25,000 m3 of water per hour- as much as a city with one million *** 98%of this water is cooled,cleaned,treated,and fed back into the *** recycling quota can be raised with special technologies to more tha

关键词： environmental technology energy recovery energy efficiency

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Factors Influencing the Use of Outcome Measures for Patients with Low Back Pain: A Survey of Nigerian Physiotherapists

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Open Journal of Therapy and Rehabilitation 2020年第3期8卷 83-97页

作者： christian Arinze Okonkwo peter Olanrewaju Ibikunle Joseph Onuwa Umunnah Kenneth Umezulike Ani Gloria Ukamaka Mgbeojedo peter Agba Awhen Department of Medical Rehabilitation Faculty of Health Sciences and Technology College of Health Sciences Nnamdi Azikiwe University Nnewi Campus Anambra State Nigeria Department of Medical Rehabilitation Faculty of Health Sciences College of Medicine University of Nigeria Enugu Campus Enugu State Nigeria Department of Physiotherapy Faculty of Allied Medical Sciences College of Medical Sciences University of Calabar Calabar Cross River State Nigeria

Background: Low back pain is one of the important patients’ presenting complain that requires expert management from the physiotherapists. Yet no work was available for reference on the use of outcome measures for its evaluation by Nigeria physiotherapists. Objective: This study, therefore, investigated the outcome measures used by Nigerian physiotherapists to evaluate patients with Low Back Pain and the factors that influenced their use. Methods: A survey questionnaire was posted to 306 randomly selected mem- bers of the Nigeria Society of Physiotherapy (NSP). Data were analyzed using frequency, percentages, mean, ANOVA, and Pearson’s Chi-square. P-value was placed at 0.05. Results: 52.9% of the respondents (221) used a pain visual analog scale. Only 36.1% used LBP-

关键词： Outcome Measures Factors Influencing Their Use Low Back Pain Patients Nigeria Physiotherapists

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Real-time high-resolution mid-infrared optical coherence tomography

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Light(Science & Applications) 2019年第1期8卷 1076-1088页

作者： Niels M.Israelsen christian R.petersen Ajanta Barh Deepak Jain Mikkel Jensen Gunther Hannesschlager peter Tidemand-Lichtenberg christian Pedersen Adrian Podoleanu Ole Bang DTU Fotonik Technical University of Denmark2800 KgsLyngbyDenmark NORBLIS IVS Virumgade 35 DVirum 2830Denmark Research Center for Non-Destructive Testing(RECENDT) Altenberger Straße 694040 LinzAustria NLIR ApS Hirsemarken 1Farum 3520Denmark Applied Optics Group School of Physical SciencesUniversity of KentCanterbury CT27NHUK

The potential for improving the penetration depth of optical coherence tomography systems by using light sources with longer wavelengths has been known since the inception of the technique in the early ***,the development of mid-infrared optical coherence tomography has long been challenged by the maturity and fidelity of optical components in this spectral region,resulting in slow acquisition,low sensitivity,and poor axial *** this work,a mid-infrared spectral-domain optical coherence tomography system operating at a central wavelength of 4μm and an axial resolution of 8.6μm is *** system produces two-dimensional cross-sectional images in real time enabled by a high-brightness 0.9-to 4.7-μm mid-infrared supercontinuum source with a pulse repetition rate of 1 MHz for illumination and broadband upconversion of more than 1-μm bandwidth from 3.58–4.63μm to 820–865 nm,where a standard 800-nm spectrometer can be used for fast *** images produced by the mid-infrared system are compared with those delivered by a state-of-the-art ultra-high-resolution near-infrared optical coherence tomography system operating at 1.3μm,and the potential applications and samples suited for this technology are *** doing so,the first practical mid-infrared optical coherence tomography system is demonstrated,with immediate applications in real-time non-destructive testing for the inspection of defects and thickness measurements in samples that exhibit strong scattering at shorter wavelengths.

关键词： resolution repetition illumination

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