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Early cisternal fibrinolysis is more effective than rescue spasmolysis for the prevention of delayed infarction after subarachnoid haemorrhage

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Stroke & Vascular Neurology 2022年第2期7卷 108-113页

作者： Roland Roelz christian Scheiwe Jürgen Grauvogel Istvan csok Volker Arnd coenen Jürgen Beck peter c Reinacher Department of Neurosurgery Medical Center-University of FreiburgFreiburgGermany Department of Stereotactic and Functional Neurosurgery Medical Center-University of FreiburgFaculty of MedicineFreiburgGermany Fraunhofer Institute for Laser Technology(ILT) AachenGermany

Background To compare the efficacy of two different concepts of cisternal therapy—PREVENTIVE fibrinolysis plus on-demand spasmolysis versus REScUE spasmolysis—for the prevention of cerebral vasospasm(cVS)and delayed cerebral infarction(DcI)in patients with aneurysmal subarachnoid haemorrhage(aSAH).Methods Retrospective analysis of 84 aSAH patients selected for cisternal therapy for DcI prevention.66 high-risk patients received PREVENTIVE cisternal therapy to enhance blood *** stereotactic catheter ventriculocisternostomy(STX-VcS)or intraoperative placement of a cisterno-ventriculostomy catheter(cVc),followed by fibrinolytic cisternal lavage using urokinase was *** case of vasospasm,nimodipine was applied intrathecally.22 low-risk patients who developed cVS against expectations were selected for STX-VcS as REScUE intervention for cisternal spasmolysis with *** of DcI and mean flow velocities of daily transcranial Doppler(TcD)ultrasonographies were *** Despite a higher prespecified DcI risk,patients selected for PREVENTIVE intervention primarily aiming at blood clearance had a lower DcI rate compared with patients selected for intrathecal spasmolysis as a REScUE therapy(11.3%vs 18.2%).After intrathecal treatment onset,cVS(TcD>160 cm/s)occurred in 45%of patients with PREVENTIVE and 77%of patients with REScUE therapy(p=0.013).A stronger response of cVS to intrathecal nimodipine was observed in patients with PREVENTIVE intervention as the mean cVS duration after start of intrathecal nimodipine was 3.2 days compared with 5.8 days in patients with REScUE therapy(p=0.026).conclusions PREVENTIVE cisternal therapy directed at blood clearance is more effective for the prevention of cVS and delayed infarction compared with cisternal REScUE spasmolysis.

关键词： prevention spasmolysis infarction

Male zebrafish(Danio rerio)odorants attract females and induce spawning

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Aquaculture and Fisheries 2018年第4期3卷 139-144页

作者： Jie Li peter c.Hubbard Adelino V.M.canario college of Fisheries and Life Science Shanghai Ocean UniversityShanghai 201306China centro de ciencias do Mar Universidade do AlgarveCampus de Gambelas8005-139FaroPortugal

In zebrafish,the chemical identity and biological roles of reproductive pheromones have yet to be *** current study assessed the role(s)of male-released odorants in a reproductive context,and evaluated the possible involvement of steroids and their *** were placed in chemical and/or visual contact with *** chemical contact,females ovulated as frequently whether they could see the males or ***,females with visual contact alone with males ovulated as frequently as isolated ***-released odorants attracted females;visual contact with males attracted females,but to a lesser extent;the two effects were *** olfactory potency of solid-phase extraction of male-and female-conditioned water was assessed by the electro-olfactogram;males released more potent odorants than females,but the most potent extract came from water in which males and females interacted *** fractionation of these extracts revealed that,while in all samples some fractions contained odorants,male-specific activity was contained in the first four fractions,suggesting that the compounds involved are relatively ***,the olfactory potency of some steroids,previously suggested to have a pheromonal role,was ***,it is unlikely that these steroids contribute significantly to the odor of fish-conditioned water.

关键词： Pheromone Zebrafish Reproduction Behavior Olfaction Spawning

Impaired gluconeogenesis in a porcine model of paracetamol induced acute liver failure

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World Journal of Gastroenterology 2011年第11期17卷 1457-1461页

作者： Konstantinos J Dabos Henry R Whalen Philip N Newsome John A Parkinson Neil c Henderson Ian H Sadler peter c Hayes John N Plevris Liver cell Biology Laboratory Department of HepatologyUniversity of EdinburghEdinburghEH16 4SAUnited Kingdom Gastroenterology Unit Ioannina General Hospital Hatzikosta450-01 IoanninaGreece Gastroenterology Department Hatzikosta General HospitalLeoforos Makrygianni450-01 IoanninaGreece Department of chemistry University of EdinburghEdinburghEH16 6AAUnited Kingdom

AIM:To investigate glucose homeostasis and in particular gluconeogenesis in a large animal model of acute liver failure(ALF).METHODS:Six pigs with paracetamol induced ALF under general anaesthesia were studied over 25 *** samples were withdrawn every five hours from a central *** animals were used as controls and were maintained under anaesthesia *** 1 H NMR spectroscopy we identified most gluconeogenic amino acids along with lactate and pyruvate in the animal plasma ***:No significant changes were observed in the concentrations of the amino acids studied in the animals maintained under anaesthesia *** we look at the ALF animals,we observed a statistically significant rise of lactate(Pcally significant rises in the concentrations of alanine(Pcine(Pcine(Pcreased significantly(PcONcLUSION:Our pig model of ALF is characterized by an altered gluconeogenetic capacity,an impaired tricarboxylic acid(TcA)cycle and a glycolytic state.

关键词： Lactate Pyruvate Branch chain amino acids Aromatic amino acids

A rotating α-chain in the nucleus 12c

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Science china(Physics,Mechanics & Astronomy) 2019年第11期62卷 14-15页

作者： peter Ring Physics Department Technical University Munich State Key Laboratory of Nuclear Physics and Technology School of Physics Peking University

Because of the strong nuclear force among protons and neutrons,α-particles form a stable configuration not only in free space, but also in very light nuclei. Even in unstable configurations of heavy and super-heavy nuclei,α-decay is often observed. Obviously there is a high probability for the formation of anα-particle in such systems, which tunnels through the coulomb barrier as a combined particle.

关键词： A rotating chain in the nucleus

Morphology, Phylogeny and culture characteristics of Ganoderma gibbosum collected from Kunming, Yunnan Province, china

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Phyton-International Journal of Experimental Botany 2020年第3期89卷 743-764页

作者： Thatsanee Luangharn Samantha c.Karunarathna peter E.Mortimer Kevin D.Hyde Jianchu Xu Key Laboratory for Plant Diversity and Biogeography of East Asia Kunming Institute of BotanyChinese Academy of SciencesKunming650201China University of chinese Academy of Sciences Beijing100049China East and central Asia Regional Office World Agroforestry Centre(ICRAF)Kunming650201China centre for Mountain Futures Kunming Institute of BotanyKunming650201China center of Excellence in Fungal Research Mae Fah Luang UniversityChiang Rai57100Thailand

Ganoderma is a genus of medicinally and economically important mushrooms in the family *** species are popular medicinal mushrooms and their health benefits are *** is a cosmopolitan genus that is widely distributed in both tropical and temperate *** genus is characterized by its unique laccate or non-laccate species with double-walled ***,we report on eight collections of *** collected during surveys in Kunming,Yunnan Province,*** specimens are described and illustrated based on macro-and micro-morphological *** DNA of the eight *** strains were extracted using the Biospin Fungal Extraction Kit following manufacturer *** of the Internal Transcribed Spacer(nrITS)region was carried out using ITS5/ITS4 primers and LROR/LR5 for the nuclear ribosomal large subunit 28S rDNA gene(LSU).Phylogenetic analysis with closely related species to *** showed that all eight collections grouped with *** with 100%bootstrap *** similarity and morphological variations within the eight collections of *** are discussed.

关键词： chinese medicine medicinal mushroom morphology phylogeny

Does noble metal modification improve the photocatalytic activity of BiOcl?

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Progress in Natural Science:Materials International 2013年第3期23卷 286-293页

作者： Liang Kong Zheng Jiang Henry H.-c.Lai Tiancun Xiao peter P.Edwards Department of chemistry Inorganic Chemistry LaboratoryUniversity of OxfordUK Environment and Sustainability Institute University of ExeterCornwall CampusPenrynCornwall TR10 9EZUK

Noble metal-surface-deposited BiOcl photocatalysts were prepared through photo-deposition and used for photodecomposition of Rhodamine B(RhB).The received materials were characterised using X-ray photoemission spectroscopy(XPS),UV-vis diffuse reflectance spectroscopy(UV-vis DRS),and X-ray diffraction(XRD) to understand the influence of surface deposited noble *** results showed that the noble metal species on the surface of BiOcl are in metallic state,which also brought about enhanced light absorption in broad UV-vis region due to plasmonic effects induced by the surfacedeposited noble metal *** the samples showed good activity in photodecomposition of RhB under UV-light irradiation,but only Ag/BiOcl was more active than bulk *** mechanism of the different reactivity of these noble-metal modified BiOcl was tentatively proposed based on the band structure and the interactions between noble metals and the BiOcl.

关键词： Photocatalysis BiOcl Noble metal Rhodamine B Plasmonic effect

Discussions on rockburst and dynamic ground support in deep mines

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Journal of Rock Mechanics and Geotechnical Engineering 2019年第5期11卷 1110-1118页

作者： charlie c.Li peter Mikula Brad Simser Bruce Hebblewhite William Joughin Xiaowei Feng Nuwen Xu Norwegian University of Science and Technology (NTNU) Trondheim Norway Mikula Geotechnics Pty. Ltd. Kalgoorlie Australia Glencore company Sudbury Canada The University of New South Wales (UNSW) Sydney Australia SRK consulting Johannesburg South Africa china University of Mining and Technology Xuzhou China Sichuan University Chengdu China

The paper is a summary of discussions on four topics in rockburst and dynamic ground *** 1 is the mechanisms of *** events are classified into two categories in accordance with the triggering mechanisms,*** burst and fault-slip *** burst occurs on rock surfaces when the tangential stress exceeds the rock strength in hard and brittle ***-slip burst is triggered by fault-slip induced *** 2 is prediction and forecasting of rockburst *** for a rockburst event must tell the location,timing and magnitude of the *** could simply foresee the probability of some of the three *** is extremely challenging to predict rockbursts and large seismic events with current knowledge and technologies,but forecasting is possible,for example the possible locations of strain burst in an underground *** present,the approach using seismic monitoring and numerical modelling is a promising forecasting *** 3 is preconditioning *** current preconditioning methods are blasting,relief-hole drilling and *** fault-slip seismicity is difficult and challenging but has been *** very deep locations(>3000 m),the fracturing could extend from the excavation face to a deep location ahead of the face and therefore preconditioning is usually not *** 4 is dynamic ground support against *** ground support requires that the support system be strong enough to sustain the momentum of the ejecting rock on one hand and tough enough on the other hand to absorb the strain and seismic energies released from the rock *** current dynamic support systems in underground mining are composed of yielding tendons and flexible surface retaining elements like mesh/screen and *** props and engineered timber props are also used for dynamic support.

关键词： Rockburst Seismic event Dynamic ground support Forecasting Preconditioning

Effect of coronary artery dynamics on the wall shear stress vector field topological skeleton in fluid–structure interaction analyses

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International Journal of Mechanical System Dynamics 2023年第1期3卷 48-57页

作者： Harry J.carpenter Mergen H.Ghayesh Anthony c.Zander peter J.Psaltis School of Electrical and Mechanical Engineering University of AdelaideAdelaideSouth AustraliaAustralia Vascular Research centre Lifelong Health ThemeSouth Australian Health and Medical Research Institute(SAHMRI)AdelaideSouth AustraliaAustralia Adelaide Medical School University of AdelaideAdelaideSouth AustraliaAustralia Department of cardiology Central Adelaide Local Health NetworkAdelaideSouth AustraliaAustralia

In this paper,we investigate the impact of coronary artery dynamics on the wall shear stress(WSS)vector field topology by comparing fluid–structure interaction(FSI)and computational fluid dynamics(cFD)*** one of the most common causes of death globally,coronary artery disease(cAD)is a significant economic burden;however,novel approaches are still needed to improve our ability to predict its *** can include the unique dynamical factors present in the coronary *** investigate the impact of these dynamical factors,we study an idealized artery model with sequential *** transient simulations made use of the hyperelastic artery and lipid constitutive equations,non‐Newtonian blood viscosity,and the characteristic out‐of‐phase pressure and velocity distribution of the left anterior descending coronary *** compare changes to established metrics of time‐averaged WSS(TAWSS)and the oscillatory shear index(OSI)to changes in the emerging WSS divergence,calculated here in a modified version to handle the deforming mesh of FSI *** suggest that the motion of the artery can impact downstream patterns in both divergence and *** magnitude is also decreased by up to 57%due to motion in some *** divergence patterns varied most significantly between simulations over the systolic period,the time of the largest *** investigation highlights that coronary dynamics could impact markers of potential cAD progression and warrants further detailed investigations in more diverse geometries and patient cases.

关键词： computational fluid dynamics divergence fluid–structure interaction topology wall shear stress

Mapping wetlands in Indonesia using Landsat and PALSAR data-sets and derived topographical indices

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Geo-Spatial Information Science 2014年第1期17卷 60-71页

作者： Belinda A.MARGONO Jean-Robert B.BWANGOY peter V.POTAPOV Matthew c.HANSEN Department of Geographical Sciences University of Maryland4321 Hartwick Bld.College ParkMD 20742USA GIS center of Excellence South Dakota State University1021 Medary Ave.Wecota HallBrookingsSD 57007USA The Ministry of Forestry(MoF)of Indonesia Manggala Wanabhkati Bld.Jakarta 10270Indonesia

Wetlands play an important role in the provision of ecosystem services,ranging from the regulation of hydrological systems to carbon sequestration and biodiversity *** paper reports the mapping of Indonesia’s wetland cover as a single thematic class,including peatlands,freshwater wetlands,and ***-interpreted training data were used to identify wetland formations including areas of likely past wetland extent that have been converted to other land *** indices(Shuttle Radar Topography Mission-derived)and optical(Landsat)and radar(PALSAR)image inputs were used to build a bagged classification tree model based on training data in order to generate a national-scale map of wetland extent at a 60 m spatial *** resulting wetland map covers 21.0%(39.6 Mha)of Indonesia’s land,including 25.2% of Sumatra(11.9 Mha),22.9% of Kalimantan(12.2 Mha),and 28.9% of Papua(11.8 Mha).Results agree with existing image-interpreted products from Indonesia’s Ministries of Forestry and Agriculture and Wetlands International(89% overall agreement),and with the Ministry of Forestry forest inventory data for Sumatra and Kalimantan(91% overall agreement).An internally consistent algorithm-derived national wetland extent map can be used to quantify changing rates of land conversion inside and outside of ***,wetlands extent can be used to efficiently allocate field resources in national assessments of wetland sub-types such as peatlands,which are a current focus of policies aiming to reduce carbon emissions from land use change.

关键词： wetlands Indonesia remote sensing Landsat digital elevation model(DEM) PALSAR Shuttle Radar Topography Mission(SRTM)